Mechanism of effectiveness of exercise training in progressive organ diseases
| Project/Area Number |
26282152
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
Ito Osamu 東北大学, 医学(系)研究科(研究院), 准教授 (00361072)
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| Co-Investigator(Kenkyū-buntansha) |
森 信芳 東北大学, 医学(系)研究科(研究院), 助教 (50463790)
上月 正博 東北大学, 医学(系)研究科(研究院), 教授 (70234698)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | リハビリテーション / 進行性臓器障害 / 腎臓 / 循環器・高血圧 / 酸化ストレス / 動物 / ストレス / 細胞・組織 |
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| Outline of Final Research Achievements |
To clarify the mechanism of effectivenesss of exercise therapy in progressive organ diseases, the present study examined the effects of exercise training in high salt-fed Dahl-salt sensitive rats and high fructose-fed Sprague-Dawley rats. High salt diet and high fructose diet induced blood pressure elevation, renal dysfunction, proteinuria, glomerular sclerosis and renal interstitial fibrosis. Exercise training with treadmill running diminished the high salt- or high fructose-induced renal dysfunction and histological changes with an amelioration of renin-angiotensin (RA) system, reduction of triglyceride contents and inhibition of xanthine oxidase activity in the kidney. These results suggest that the renoprotective effects of exercise training are related to improvement of renal RA system, lipid metabolism and oxidative stress.
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Report
(4 results)
Research Products
(66 results)
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[Journal Article] Chronic Running Exercise Alleviates Early Progression of Nephropathy with Upregulation of Nitric Oxide Synthases and Suppression of Glycation in Zucker Diabetic Rats2015
Author(s)
Ito D, Cao P, Kakihana T, Sato E, Suda C, Muroya Y, Ogawa Y, Hu G, Ishii T, Ito O, Kohzuki M, Kiyomoto H
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Journal Title
PLoS One
Volume: 10
Issue: 9
Pages: 0138037-0138037
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] The expression of (pro)renin receptor is upregulated in the kidney of Dahl salt-sensitive rats by high salt intake2016
Author(s)
Yamakoshi S, Ito O, Rong R, Osaki Y, Muroya Y, Mori T, Ito S, Takahashi K, Totsune K, Kohzuki M
Organizer
ISH 2016 satellite symposium, Renin-angiotensin-aldosterone system (RAAS)
Place of Presentation
コングレススクエア日本橋（千代田区・東京）
Year and Date
2016-09-23
Related Report
Int'l Joint Research
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[Presentation] 腎臓リハビリテーション2016
Author(s)
上月正博, 伊藤 修
Organizer
第53回日本リハビリテーション医学会
Place of Presentation
国立京都会議場(京都市・京都府)
Year and Date
2016-06-09
Related Report
Invited
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[Presentation] Pitavastatin has antihypertensive and renoprotective effects with upregulation of NO system and down-regulation of oxidative stress in the kidney of spontaneously hypertensive rats2016
Author(s)
Hu G, Ito O, Rong R, Xu B, Sakuyama A, Miura A, Ogawa Y, Ito D, Kohzuki M
Organizer
International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
Place of Presentation
仙台国際センター（仙台市・宮城県）
Year and Date
2016-05-20
Related Report
Int'l Joint Research
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