| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
To clarify the mechanism of effectivenesss of exercise therapy in progressive organ diseases, the present study examined the effects of exercise training in high salt-fed Dahl-salt sensitive rats and high fructose-fed Sprague-Dawley rats. High salt diet and high fructose diet induced blood pressure elevation, renal dysfunction, proteinuria, glomerular sclerosis and renal interstitial fibrosis. Exercise training with treadmill running diminished the high salt- or high fructose-induced renal dysfunction and histological changes with an amelioration of renin-angiotensin (RA) system, reduction of triglyceride contents and inhibition of xanthine oxidase activity in the kidney. These results suggest that the renoprotective effects of exercise training are related to improvement of renal RA system, lipid metabolism and oxidative stress.
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