| Budget Amount *help |
¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Outline of Final Research Achievements |
Age-related bone diseases such as osteoporosis are serious problem in an aged society. Mechanical stress and resistance exercise is useful for preventing bone loss. To investigate the relationships between mechanical stress, nervous system and the changes in membrane potential, we overexpressed light-sensitive ion channel and pump in osteoblasts and osteoclasts and identified the targeting molecules via molecular screening based on membrane potential. In invivo experiments, invivo transfection for light-sensitive molecules and cell transplantation were used for investigating bone remodeling. In summary, our results indicate that changes in membrane potential and the receptor for neuronal transmitter affect bone mehanosignaling.
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