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Construction of muscle glycogen depletion model using carbon magnetic resonance spectroscopy

Research Project

Project/Area Number 26282187
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Sports science
Research InstitutionNational Agency for the Advancement of Sports and Health

Principal Investigator

Takahashi Hideyuki  独立行政法人日本スポーツ振興センター国立スポーツ科学センター, スポーツ研究部, 主任研究員 (00292540)

Co-Investigator(Kenkyū-buntansha) 亀井 明子  独立行政法人日本スポーツ振興センター国立スポーツ科学センター, スポーツメディカルセンター, 先任研究員 (10276636)
大澤 拓也  日本女子体育大学, 体育学部, 准教授 (70613496)
塩瀬 圭佑  福岡大学, スポーツ科学部, 助教 (70708106)
岩山 海渡  天理大学, 体育学部, 講師 (30781249)
川原 貴  独立行政法人日本スポーツ振興センター国立スポーツ科学センター, メディカルセンター, 主任研究員 (60169753)
Research Collaborator MARUYAMA Katsuya  
Project Period (FY) 2014-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Keywords筋グリコーゲン / 骨格筋 / 磁気共鳴分光法 / 短時間・高強度運動 / 持久性運動 / 競技者
Outline of Final Research Achievements

Using carbon magnetic resonance spectroscopy to non-invasively measure muscle glycogen (Gly), we investigated the changes in muscle Gly during different exercise conditions (exercise intensity and duration) and constructed a model which can achieve specific levels of muscle Gly depletion. Furthermore, we measured muscle Gly content in athletes, who played different sporting events, during actual training sessions or competitive events and obtained the basic sport-specific knowledge about the kinetics involved in muscle Gly decrease and subsequent recovery. We observed that the rate of muscle Gly recovery tended to be faster when the aerobic capacity of the muscles was greater. These findings would potentially assist further research on muscle Gly metabolism and help develop effective nutritional strategies for athletes.

Academic Significance and Societal Importance of the Research Achievements

本研究で明らかにした、特定の運動条件と筋Gly減少の程度の間の関係は、特定の筋Glyレベルを作り出すことのできる運動モデルの構築に繋がり、そのモデルは、筋Gly枯渇と運動パフォーマンスとの関係や筋Gly回復動態メカニズムの解明、そして、より速い筋Gly回復方策創出のために必要となる学術的研究において有用になると考えられる。さらに、実際の競技者を対象とした筋Gly動態に関する知見は、特定の競技種目の競技者、あるいは、異なる能力を有する個人のための効果的な筋Gly回復戦略を立案する上で大きく貢献すると期待できる。

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (38 results)

All 2019 2018 2017 2016 2015

All Journal Article (6 results) (of which Peer Reviewed: 4 results) Presentation (30 results) (of which Int'l Joint Research: 8 results,  Invited: 5 results) Book (2 results)

  • [Journal Article] スキー・コンバインドナショナルチーム選手のレースを想定した滑走運動が上腕三頭筋および大腿筋のグリコーゲン含有量に及ぼす影響2019

    • Author(s)
      石橋彩, 山辺芳, 谷中拓哉, 北村隆, 河野孝典, 石毛勇介, 髙橋英幸
    • Journal Title

      トレーニング科学

      Volume: 31 Pages: 53-60

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Muscle glycogen depletion does not alter segmental extracellular and intracellular water distribution measured using bioimpedance spectroscopy2018

    • Author(s)
      Shiose K, Yamada Y, Motonaga K, Takahashi H
    • Journal Title

      Journal of Applied Physiology

      Volume: 印刷中 Issue: 6 Pages: 1420-1425

    • DOI

      10.1152/japplphysiol.00666.2017

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Energy deficit required for rapid weight loss in elite collegiate wrestlers2018

    • Author(s)
      Emi Kondo, Hiroyuki Sagayama, Yosuke Yamada, Keisuke Shiose, Takuya Osawa, Keiko Motonaga, Shiori Ouchi, Akiko Kamei, Kohei Nakajima, Yasuki Higaki, Hiroaki Tanaka, Hideyuki Takahashi, Koji Okamur
    • Journal Title

      Nutrients

      Volume: 10 Issue: 5 Pages: 536-536

    • DOI

      10.3390/nu10050536

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 炭素磁気共鳴分光法による肝臓のグリコーゲン評価方法の確立及び日内変動の検討2018

    • Author(s)
      岩山海渡, 髙橋英幸
    • Journal Title

      デサントスポーツ科学

      Volume: 39 Pages: 152-157

    • NAID

      40021591818

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Segmental extracellular and intracellular water distribution and muscle glycogen after 72-h carbohydrate loading using spectroscopic techniques2016

    • Author(s)
      K Shiose, Yosuke Yamada, K Motonaga, H Sagayama, Y Higaki, H Tanaka, H Tanakashi
    • Journal Title

      Journal of Applied Physiology

      Volume: 121 Issue: 1 Pages: 205-211

    • DOI

      10.1152/japplphysiol.00126.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 筋の代謝化合物濃度を測る:定量的MRS2016

    • Author(s)
      髙橋英幸
    • Journal Title

      体育の科学

      Volume: 66 Pages: 249-251

    • Related Report
      2015 Annual Research Report
  • [Presentation] Effect of low energy availability during three consecutive days of endurance training on muscle glycogen content and serum hepcidin levels in male long distance runners2018

    • Author(s)
      Aya Ishibashi, Chihiro Kojima, Akiko Kamei, Kaito Iwayama, Yoko Tanabe, Shiori Ouchi, Keisuke Shiose, Hideyuki Takahashi, Kazushige Goto
    • Organizer
      65th Annual Meeting of the American College of Sports Medicine
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 急速減量後の高炭水化物食が筋グリコーゲンおよび運動パフォーマンスの回復に及ぼす影響2018

    • Author(s)
      近藤衣美, 塩瀬圭佑, 西牧未央, 山下大地, 元永恵子, 下山寛之, 亀井明子, 中嶋耕平, 髙橋英幸
    • Organizer
      第73回日本体力医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 運動前の高脂肪食摂取がグリコーゲン利用に及ぼす影響2018

    • Author(s)
      岩山海渡, 田名辺陽子, 矢島克彦, 丹治史弥, 大西貴弘, 丸山克也, 髙橋英幸
    • Organizer
      第73回日本体力医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 3日間の持久性トレーニング期間中における食事量の減少が筋グリコーゲン量、内分泌応答および運動パフォーマンスに及ぼす影響2018

    • Author(s)
      小島千尋, 石橋彩, 田名辺陽子, 岩山海渡, 亀井明子, 髙橋英幸, 後藤一成
    • Organizer
      第73回日本体力医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 低酸素環境下での高強度運動が筋グリコーゲン量に及ぼす影響2018

    • Author(s)
      笠井信一, 丹治史弥, 石橋彩, 大沼勇人, 髙橋英幸, 後藤一成, 鈴木康弘
    • Organizer
      第73回日本体力医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 1週間に3試合の試合日程における高炭水化物食摂取と大腿部筋グリコーゲン量の回復動向2018

    • Author(s)
      中村大輔, 石橋彩, 中村真理子, 石井泰光, 岩山海渡, 髙橋英幸, 安松幹展
    • Organizer
      日本フットボール学会16th Congress
    • Related Report
      2018 Annual Research Report
  • [Presentation] 国際競技力向上支援のためのMRI/MRS を用いた筋コンディション評価2017

    • Author(s)
      髙橋英幸
    • Organizer
      第30回日本トレーニング科学会大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Effects of the Olympic match schedule on football performance, dehydration level and muscle glycogen in hot environments2017

    • Author(s)
      Mikinobu Yasumatsu, Daisuke Nakamura, Yoko Tanabe, Yoko Kondo, Keisuke Shiose, Aya Ishibashi, Toshiyuki Oya, Mariko Nakamura, Yasumitsu Ishi, Hideyuki Takahashi
    • Organizer
      World Conference on Science and Soccer 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 運動後1時間以内の炭水化物摂取における筋グリコーゲン回復の違い2017

    • Author(s)
      大内志織, 塩瀬圭佑, 大澤拓也, 元永恵子, 亀井明子, 川原貴, 田口素子, 髙橋英幸
    • Organizer
      日本スポーツ栄養学会第4回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 異なるEnergy Availabilityが鉄代謝に及ぼす影響-骨格筋グリコーゲン量に着目して-2017

    • Author(s)
      石橋彩, 小島千尋, 岩山海渡, 田名辺陽子, 塩瀬圭佑, 大内志織, 亀井明子, 後藤一成, 髙橋英幸
    • Organizer
      日本スポーツ栄養学会第4回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 13C-MRSによる非侵襲的な肝グリコーゲン濃度の評価方法の確立2017

    • Author(s)
      岩山海渡, 大西貴弘, 丸山克也, 髙橋英幸
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] オリンピックサッカー競技の試合日程がゲームパフォーマンスおよびコンディションに与える影響2017

    • Author(s)
      中村大輔, 安松幹展,中村真理子, 石橋彩, 石井泰光, 星川雅子, 田名辺陽子, 塩瀬圭佑, 大家利之, 髙橋英幸
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 持久性トレーニングに伴う呼気中アセトン濃度の変化:筋グリコーゲン量との関連2017

    • Author(s)
      後藤一成, 石橋彩, 小島千尋, 岩山海渡, 田名辺陽子, 塩瀬圭佑, 大内志織, 亀井明子, 辻俊樹, 髙橋英幸
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Diurnal variation in the glycogen content of human liver and muscle using 13C MRS2017

    • Author(s)
      Kaito Iwayama, Takahiro Onishi, Katsuya Maruyama, Hideyuki Takahashi
    • Organizer
      4th International Recent Advances and Controversies in Measurement of Energy Metabolism Conference
    • Related Report
      2017 Annual Research Report
  • [Presentation] 女子陸上中長距離選手の通常練習時における筋グリコーゲン動態と炭水化物摂取量2017

    • Author(s)
      亀井明子, 大内志織, 塩瀬圭佑, 岩山海渡, 近藤衣美, 石橋彩, 元永恵子, 川原貴, 髙橋英幸
    • Organizer
      第28回日本臨床スポーツ医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Difference in muscle glycogen recovery in the carbohydrate intake within one hour post-exercise2017

    • Author(s)
      Shiori Ouchi, Keisuke Shiose, Takuya Osawa, Keiko Motonaga, Yoko Tanabe, Kaito Iwayama, Emi Kondo, Akiko Kamei, Motoko Taguchi, Hideyuki Takahashi
    • Organizer
      International Sport and Exercise Nutrition Conference 2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 試合後の高炭水化物摂取による筋グリコーゲン量の回復動向(炭素磁気共鳴分光法を用いた検討)2017

    • Author(s)
      中村大輔, 中村真理子, 田名辺陽子, 石橋彩, 石井泰光, 塩瀬圭佑, 髙橋英幸
    • Organizer
      日本フットボール学会15th Congress
    • Related Report
      2017 Annual Research Report
  • [Presentation] 筋グリコーゲンの視点からの疲労予防と回復2017

    • Author(s)
      髙橋英幸
    • Organizer
      第13回疲労研究会
    • Place of Presentation
      東京大学(東京)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 最先端MRSを用いた栄養・コンディショニング:ヒト筋グリコーゲンのモニタリング法2017

    • Author(s)
      髙橋英幸
    • Organizer
      ヒューマン・ハイ・パフォーマンスフォーラム2017
    • Place of Presentation
      筑波大学(茨城)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Body water assessment using bioimpedance spectroscopy during rapid weight loss and recovery in Japanese wrestlers2016

    • Author(s)
      Keisuke Shiose, Emi Kondo, Hroyuki Sagayama, Yosuke Yamada, Takuya Osawa, Keiko Motonaga, Shiori Ouchi, Akiko Kamei, Kohei Naikajima, Yasuki Higaki, Hiroaki Tanaka, Hideyuki Takahashi
    • Organizer
      International Sport and Exercise Nutrition Conference 2016
    • Place of Presentation
      Newcastle upon Tyne(England)
    • Year and Date
      2016-12-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of the time of carbohydrate intake on muscle glycogen recovery post-exercise2016

    • Author(s)
      Shiori Ouchi, Keisuke Shiose, Takuya Osawa, Keiko Motonaga, Akiko Kamei, Takashi Kawahara, Motoko Taguchi, Hideyuki Takahashi
    • Organizer
      International Sport and Exercise Nutrition Conference 2016
    • Place of Presentation
      Newcastle upon Tyne(England)
    • Year and Date
      2016-12-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 低酸素環境は筋グリコーゲンの回復を遅延させるか?2016

    • Author(s)
      大澤拓也, 髙橋英幸
    • Organizer
      第71回日本体力医学会大会
    • Place of Presentation
      いわて県民情報交流センター・盛岡市民文化ホール(岩手)
    • Year and Date
      2016-09-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] パフォーマンス向上のための糖質摂取ー筋グリコーゲン貯蔵量に着目した手法とその応用性ー2016

    • Author(s)
      塩瀬圭佑
    • Organizer
      第71回日本体力医学会大会
    • Place of Presentation
      いわて県民情報交流センター・盛岡市民文化ホール(岩手)
    • Year and Date
      2016-09-23
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 13C MRSを用いた急速減量と回復による筋グリコーゲン動態の描出2016

    • Author(s)
      髙橋英幸, 近藤衣美, 塩瀬圭佑, 大澤拓也, 元永恵子, 大内志織, 亀井明子, 中嶋耕平, 丸山克也
    • Organizer
      第44回日本磁気共鳴医学会大会
    • Place of Presentation
      大宮ソニックシティ(埼玉)
    • Year and Date
      2016-09-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] Changes in muscle glycogen, body somposition, and endurance performance during 72-hour carbohydrate loading with excess energy intake2016

    • Author(s)
      Keisuke Shiose, Yosuke Yamada, Keiko Motonaga, Hiroyuki Sagayama, Yasuki Higaki, Horoaki Tanaka, Hideyuki Takahashi
    • Organizer
      21st Annual Congress of the European College of Sport Science
    • Place of Presentation
      Vienna(Austria)
    • Year and Date
      2016-07-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 運動および栄養摂取による筋グリコーゲンの変化と疲労回復:ヒトを対象として2015

    • Author(s)
      髙橋英幸
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山県民文化会館/ホテルアバローム紀の国(和歌山)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Repeatability of the depletion of muscle glycogen after prolonged and high intensity exercise2015

    • Author(s)
      Takuya Osawa, Keisuke Shiose, Keiko Motonaga, Emi Kondo, Akiko Kamei, Motoko Taguchi, and Hideyuki Takahashi
    • Organizer
      20th Annual Congress of the European College of Sport Science
    • Place of Presentation
      Malmo (Sweden)
    • Year and Date
      2015-07-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] トップ競技者における練習時の筋グリコーゲン動態と糖質摂取量(事例報告)2015

    • Author(s)
      大内志織, 亀井明子, 大澤拓也, 塩瀬圭佑, 川原貴, 髙橋英幸
    • Organizer
      日本スポーツ栄養学会第2回大会
    • Place of Presentation
      立命館大学 (滋賀)
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] Influence of carbohydrate intake on muscle glycogen recovery after exercise in endurance-trained subjects2015

    • Author(s)
      Keiko Motonaga, Takuya Osawa, Keisuke Shiose, Emi Kondo, Akiko Kamei, Shiori Ouchi, Takashi Kawahara, Motoko Taguchi, and Hideyuki Takahashi
    • Organizer
      62th Annual Meeting of the American College of Sports Medicine
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Body water status and muscle glycogen recovery: effect of different amounts of carbohydrate intake2015

    • Author(s)
      Keisuke Shiose, Takuya Osawa, Keiko Motonaga, Emi Kondo, Akiko Kamei, Takashi Kawahara, Motoko Taguchi, Yosuke Yamada, and Hideyuki Takahashi
    • Organizer
      62th Annual Meeting of the American College of Sports Medicine
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Book] 筋グリコーゲンと疲労―運動・栄養摂取による変化, 運動と疲労の科学2018

    • Author(s)
      髙橋英幸, 塩瀬圭佑
    • Publisher
      大修館
    • ISBN
      9784469268478
    • Related Report
      2018 Annual Research Report
  • [Book] 新・スポーツ生理学2015

    • Author(s)
      髙橋英幸、山中亮
    • Publisher
      市村出版
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2020-03-30  

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