Elucidation of role of tissue or cellular Nrf2 in regulating NASH onset and progression using genetically modified mice.

• Project/Area Number: 26282191
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: University of Tsukuba
• Principal Investigator: SHODA JUNICHI 筑波大学, 医学医療系, 教授 (90241827)
• Co-Investigator(Kenkyū-buntansha): 柳川 徹 筑波大学, 医学医療系, 准教授 (10312852) ; 酒井 俊 筑波大学, 医学医療系, 講師 (30282362) ; 磯辺 智範 筑波大学, 医学医療系, 准教授 (70383643) ; 蕨 栄治 筑波大学, 医学医療系, 講師 (70396612)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000); Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
• Keywords: 肥満 / 脂肪性肝炎 / 転写因子 / 酸化ストレス / エンドトキシン / 遺伝子改変マウス / 生活習慣病 / 非アルコール性脂肪性肝炎 / 腸内細菌 / インスリン抵抗性 / 遺伝子レスキューマウス

Outline of Final Research Achievements

p62:Nrf2 double knockout mice (DKO) fed with normal diet develop spontaneous NASH in association with mature-onset hyperphagic obesity. Therefore, to elucidate the onset mechanism of NASH, we focused interests on the intestines and Kupffer cells. In the analysis of intestinal microflora, the number of gram-negative bacteria species was increased in DKO and the serum and fecal LPS concentrations were also increased. The intestinal permeability was increased in Nrf2-KO mice and DKO. The inflammatory cytokine production was increased in the Kupffer cells. It is likely that the onset mechanism of NASH is attributed to an increase in gram-negative bacteria species due to p62 deficiency and a weakness of intestinal barrier function due to Nrf2 defeciency, which in turn let an increased influx of LPS into the liver.

Research Products

• [Journal Article] p62 modulates the intrinsic signaling of UVB-induced apoptosis. (2016)
  • Author(s): Ito S, Kimura S, Warabi E, Kawachi Y, Yamatoji M, Uchida F, Ishibashi-Kanno N, Yamagata K, Hasegawa S, Shoda J, Tabuchi K, Sakai S, Bukawa H, Sekido M, Yanagawa T.
  • Journal Title: Journal of Dermatological Science Volume: 83 Issue: 3 Pages: 226-233
  • DOI: 10.1016/j.jdermsci.2016.05.005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] High-intensity aerobic exercise improves both hepatic fat content and stiffness in sedentary obese men with non-alcoholic fatty liver disease: A randomized controlled study. (2016)
  • Author(s): Oh S, So R, Shida T, Matsuo T, Kim B, Akiyama K, Isobe T, Okamoto Y, Tanaka K, Shoda J.
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 43029-43029
  • DOI: 10.1038/srep43029
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Wisteria floribunda Agglutinin-Sialylated Mucin Core Polypeptide 1 is a Sensitive Biomarker for Biliary Tract Carcinoma and Intrahepatic Cholangiocarcinoma: A Multicenter Study. (2016)
  • Author(s): Shoda J, Matsuda A, Shida T, Yamamoto M, Nagino M, Tsuyuguchi T, Yasaka T, Tazuma S, Uchiyama K, Unno M, Ohkohchi N, Nakanuma Y, Kuno A, Narimatsu H.
  • Journal Title: J Gastroenterol Volume: 52 Issue: 2 Pages: 218-228
  • DOI: 10.1007/s00535-016-1230-0
  • Peer Reviewed / Open Access
• [Journal Article] Verification of WFA-Sialylated MUC1 as a Sensitive Biliary Biomarker for Human Biliary Tract Cancer. (2016)
  • Author(s): Yamaguchi T, Yokoyama Y, Ebata T, Matsuda A, Kuno A, Ikehara Y,Shoda J, Narimatsu H, Nagino M.
  • Journal Title: Ann Surg Oncol. Volume: 23(2) Issue: 2 Pages: 671-677
  • DOI: 10.1245/s10434-015-4878-4
  • Peer Reviewed / Open Access
• [Journal Article] Cytoprotective Role of Nrf2 in Electrical Pulse Stimulated C2C12 Myotube. (2015)
  • Author(s): Horie M, Warabi E, Komine S, Oh S, Shoda J.
  • Journal Title: PLoS One Volume: 10 Issue: 12 Pages: 12-12
  • DOI: 10.1371/journal.pone.0144835
  • NAID: 120007127849
  • Peer Reviewed / Open Access
• [Journal Article] Viwatthanasittiphong C, Srivatanakul P, Miwa M, Shoda J, Narimatsu H. Lectin Microarray-Based Sero-Biomarker Verification Targeting Aberrant O-Linked Glycosylation on Mucin 1. (2015)
  • Author(s): Matsuda A, Kuno A, Nakagawa T, Ikehara Y, Irimura T, Yamamoto M, Nakanuma Y, Miyoshi E, Nakamori S, Nakanishi H.
  • Journal Title: Anal Chem. Volume: 87(14) Issue: 14 Pages: 7274-7281
  • DOI: 10.1021/acs.analchem.5b01329
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Therapeutic effect of hybrid training of voluntary and electrical muscle contractions on middle-aged obese women with NAFLD: a pilot study. (2015)
  • Author(s): Oh S, Shida T, Ikeda A, Maruyama T, Eguchi K, Isobe T, Okamoto Y, Arai E, Shiba N, Shoda J.
  • Journal Title: Ther Clin Risk Manag Volume: 11 Pages: 371-380
  • DOI: 10.2147/tcrm.s75109
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Moderate to vigorous physical activity is an important factor for managing non-alcoholic fatty liver disease: a retrospective study (2015)
  • Author(s): Oh S, Tanaka K, Chiaki K, Tsujimoto T, So R, Shida T, Shoda J
  • Journal Title: Hepatology Volume: 61 Pages: 1205-1215
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Overexpression and Gene Amplification of HER1, HER2 and HER3 in Biliary Tract Carcinomas and the Possibility for Therapy with a HER2-Targeting Antibody Pertuzumab (2015)
  • Author(s): Kawamoto T, Thomas M, Yamashita-Kashima Y, Shu S, Ishikura N, Ariizumi S, Yamamoto M, Kurosaki K, Shoda J
  • Journal Title: J Gastroenterrol Volume: 50 Pages: 467-479
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Expression of insulin-like growth factor receptor (IGFR) as a useful biomarker for predicting prognosis in biliary tract cancer patients (2015)
  • Author(s): Suzuki H, Roa JC, Kawamoto T, Ishige K, Shoda J, Wistuba II, Li D, Thomas MB
  • Journal Title: Mol & Clin Oncol Volume: 3 Pages: 464-470
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Moderate to vigorous physical activity volume is an important factor for managing non-alcoholic fatty liver disease : A retrospec tive study (2014)
  • Author(s): Oh S, Shida T, Tanaka K, Y amagishi K, So R, Tsujimoto T, Shoda J:
  • Journal Title: Hepatology 2014, Volume: 61(4) Issue: 4 Pages: 1205-1215
  • DOI: 10.1002/hep.27544
  • Peer Reviewed / Open Access
• [Journal Article] 茨城県における肝細胞癌疫学調査 (2014)
  • Author(s): 佐野直樹，田村孝史，福永 潔，高野恵輔，山岸良匡，正田純一，相川達也，大河内信弘
  • Journal Title: 肝臓 Volume: 55 Pages: 771-773
  • NAID: 130004897340
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Changes in diffusion tensor imaging (DTI) eigenvalues of skeletal muscle due to hybrid exercise training Magnetic Resonance Imaging (2014)
  • Author(s): Okamoto Y, Kemp GJ, Isobe T, Sato E, Hirano Y, Shoda J, Minami M
  • Journal Title: Magnetic Resonance Imaging Volume: 32 Pages: 1297-1300
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Abdominal obesity: causal factor or simply a symptom of obesity-related healyh risk (2014)
  • Author(s): Oh S, Tanaka K, Noh J, So R, Tsujimoto T, Sasai H, Kim M, Shoda J
  • Journal Title: Diabetes, Metab Syn & Obesity Volume: 7 Pages: 289-296
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Acceleration training for management of non-alcoholic fatty liver disease: a pilot study (2014)
  • Author(s): Oh S, Shida T, Onozuka T, Maruyama T, Eguchi K, Isobe T, Okamoto Y, Someya N, Tanaka K, Tozawa A, Arai E, Shoda J
  • Journal Title: Ther Clin Risk Manag Volume: 10 Pages: 925-936
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Interaction of Muc4 and ErbB2 in a transgenic mouse model of gallbladder carcinoma: potential pathobiological implications (2014)
  • Author(s): Miyahara N, Ishida H, Ueda T, Kawamoto T, Akimoto Y, Kawakami H, Irimura T, Shoda J
  • Journal Title: Oncol Rep Volume: 32 Pages: 1796-1802
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Regular Exercise Coupled to Diet Regimen Accelerates Reduction of Hepatic Steatosis and Associated Pathological Conditions in Non-Alcoholic Fatty Liver Disease (2014)
  • Author(s): Oh S, Tanaka K, Tsujimoto T, So R, Eto M, Shoda J
  • Journal Title: Metabolic Syndrome & Related Disorders Volume: 12 Pages: 290-298
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Therapeutic effect of hybrid training of voluntary and electrical muscle contractions on middle-aged obese women with NAFLD: a pilot study (2014)
  • Author(s): Oh S, Shida T, Ikeda A, Maruyama T, Eguchi K, Isobe T, Okamoto Y, Arai E, Shiba N, Shoda J
  • Journal Title: Ther Clin Risk Manag Volume: 11 Pages: 371-380
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in biliary tract cancer cells (2014)
  • Author(s): Seto K, Shoda J, Horibe T, Warabi E, Kohno M, Yanagawa T, Bukawa H, Nakanuma Y, Kawakami K
  • Journal Title: Int J Hepatol Volume: 未定 Pages: 584650-584650
  • DOI: 10.1155/2014/584650
  • Peer Reviewed / Open Access
• [Journal Article] Peroxidoxin I plays a ptotective role against UVA irradiation through reduction of oxidative stress (2014)
  • Author(s): Ito T, Kimura S, Seto K, Warabi E, Kawauchi Y, Shoda J, Tabuchi K, Yamagata K, Hasegawa S, Bukawa H, Ishii T, Yanagawa T
  • Journal Title: J Dermatol Sci Volume: 74 Pages: 9-17
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder (2014)
  • Author(s): Onuki K, Sugiyama H, Ishige K, Kawamoto T, Ota T, Ariizumi S, Yamato M, Kadota S, Takeuchi K, Ishikawa A, Onodera M, Onizawa K, Yamamoto M, Miyoshi E, Shoda J
  • Journal Title: J Gastroenterol Volume: 49 Pages: 702-714
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] スポーツ医学より診たNAFLD肥満者における運動療法の有用性 (2016)
  • Author(s): 呉世昶，志田隆史，正田純一
  • Organizer: 第24回 日本消化器関連学会週間
  • Place of Presentation: 神戸国際会議場（兵庫県・神戸市）
  • Year and Date: 2016-11-03
• [Presentation] 認定指導医養成講座１ 胆石の自然史 (2016)
  • Author(s): 正田純一
  • Organizer: 日本胆道学会学術集会
  • Place of Presentation: 横浜プリンスホテル（神奈川県・横浜市）
  • Year and Date: 2016-09-29
  • Invited
• [Presentation] 非アルコール性脂肪性肝疾患に効果的な運動プログラムの検討ー前向きランダム化比較試験よりー (2016)
  • Author(s): 蘇リナ，田中 喜代次，正田 純一．
  • Organizer: 第52回日本肝臓学会総会
  • Place of Presentation: ホテルニューオータニ幕張（千葉県・千葉市）
  • Year and Date: 2016-05-19
• [Presentation] 骨格筋が非アルコール性脂肪性肝疾患（NAFLD）における代謝病態因子に及ぼす影響 (2016)
  • Author(s): 呉世昶，石原瑞穂，志田隆史，正田純一，
  • Organizer: 第52回日本肝臓学会総会
  • Place of Presentation: ホテルニューオータニ幕張（千葉県・千葉市）
  • Year and Date: 2016-05-19
• [Presentation] 非アルコール性脂肪性肝炎(NASH)自然発症マウスにおける Kupffer 細胞の表現形質 の変化と発症機序との関連性． (2016)
  • Author(s): 秋山健太郎，蕨栄治，正田純一．
  • Organizer: 第102回日本消化器病学会総会
  • Place of Presentation: 京王プラザホテル（東京都・新宿区）
  • Year and Date: 2016-04-21
• [Presentation] NAFLDに随伴する中高度肥満と糖尿病がKupffer細胞機能に及ぼす影響と運動療法の効果． (2016)
  • Author(s): 志田隆史，秋山健太郎，内田文彦，蘇 リナ，呉 世昶，田中弘教，飯島尋子，正田純一．
  • Organizer: 第102回日本消化器病学会総会
  • Place of Presentation: 京王プラザホテル（東京都・新宿区）
  • Year and Date: 2016-04-21
• [Presentation] p62:Nrf2 double knockout mice develop steatohepatitis through the serum endotoxin overload. (2016)
  • Author(s): Kentaro Akiyama, Eiji Warabi, Kosuke Okada, Syunnichi Ariizumi, Masakazu Yamamoto, Junnichi Shoda.
  • Organizer: 25th Conference of the Asian Pacific Association for the Study of the Liver
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2016-02-23
  • Int'l Joint Research
• [Presentation] The effect of female hormones on NAFLD in p62 knockout mice. (2016)
  • Author(s): Miho Ikeuchi, Eiji Warabi, Tsugumi Nagaoka, Syunichi Ariizumi, Masakazu Yamamoto, Junichi Shoda.
  • Organizer: 25th Conference of the Asian Pacific Association for the Study of the Liver
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2016-02-23
  • Int'l Joint Research
• [Presentation] p62: Nrf2遺伝子二重欠損マウスは血清中エンドトキシンが増加し，脂肪性肝炎を発症する. (2015)
  • Author(s): 秋山健太郎、蕨栄治、岡田浩介、正田純一.
  • Organizer: 第88回日本生化学会大会
  • Place of Presentation: 神戸，ポートピアホテル
  • Year and Date: 2015-12-08
• [Presentation] メスp62/Sqstm1遺伝子欠損マウスを用いたEstradiolとNAFLDとの関係の解析 (2015)
  • Author(s): 池内美穂、蕨栄治、長岡亜実、秋山健太郎、正田純一
  • Organizer: 第88回日本生化学会大会
  • Place of Presentation: 神戸，ポートピアホテル
  • Year and Date: 2015-12-08
• [Presentation] NASH自然発症モデルマウスの腸内環境よりみた疾病病態の解析と発症機序の解明. (2015)
  • Author(s): 秋山健太郎、池内美穂、青山希、蕨栄治、正田純一
  • Organizer: 第19回日本肝臓学会総会大会
  • Place of Presentation: 東京，東京フォーラム
  • Year and Date: 2015-10-08
• [Presentation] 雌性p62遺伝子欠損マウスの表現型の解析-女性ホルモンの過食肥満と肝脂肪化に及ぼす影響の検討 (2015)
  • Author(s): 池内美穂、蕨栄治、正田純一
  • Organizer: 第19回日本肝臓学会総会大会
  • Place of Presentation: 東京，東京フォーラム
  • Year and Date: 2015-10-08
• [Presentation] 非アルコール性脂肪性肝炎自然発症モデルマウスにおける腸内環境の変化とNASH発症機序の解明 (2015)
  • Author(s): 秋山健太郎、池内美穂、青山希、蕨栄治、正田純一
  • Organizer: 第51回日本肝臓学会総会
  • Place of Presentation: 熊本，日航熊本ホテル
  • Year and Date: 2015-05-18
• [Presentation] 雌性 p62 遺伝子欠損マウスの表現型の解析と中高齢女性におけるメタボリック症候群の発症機序の解明 (2015)
  • Author(s): 池内美穂、蕨栄治、柳川徹、石井哲郎、正田純一
  • Organizer: 第51回日本肝臓学会総会
  • Place of Presentation: 熊本，日航熊本ホテル
  • Year and Date: 2015-05-18
• [Presentation] NASH自然発症マウスにおける腸内環境の変化と発症機序との関係 (2015)
  • Author(s): 秋山健太郎，池内美穂，青山希，蕨栄治，正田純一
  • Organizer: 第101回日本消化器病学会総会
  • Place of Presentation: 仙台，仙台国際会議場
  • Year and Date: 2015-04-23
• [Presentation] 筋萎縮予防法ハイブリッド訓練の女性NAFLD患者に対する有用性の検討 (2015)
  • Author(s): 丸山 剛，呉 世昶，志田隆史，新井恵美，志波直人，正田純一
  • Organizer: 第163回日本体力医学会関東地方会
  • Place of Presentation: 東京
  • Year and Date: 2015-02-28
• [Presentation] 肥満者におけるirisinの分泌動態と身体活動量の関連性 (2015)
  • Author(s): 蘇 リナ，呉 世昶，志田隆史，辻本健彦，田中喜代次，正田純一
  • Organizer: 第163回日本体力医学会関東地方会
  • Place of Presentation: 東京
  • Year and Date: 2015-02-28
• [Presentation] 非アルコール性脂肪性肝疾患に対する３次元加速度トレーニングの効果 (2014)
  • Author(s): 丸山 剛，呉 世昶，佐治朱美，染谷典子，志田隆史，新井恵美，磯辺智範，岡本嘉一，正田純一
  • Organizer: 第162回日本体力医学会関東地方会
  • Place of Presentation: 東京
  • Year and Date: 2014-12-20
• [Presentation] 非アルコール性脂肪性肝疾患における新規筋由来生理活性物質Irisinの分泌動態と病態因子との関連性 (2014)
  • Author(s): 蘇 リナ，志田隆史，正田純一
  • Organizer: 第40回日本肝臓学会東部会
  • Place of Presentation: 東京
  • Year and Date: 2014-11-27 – 2014-11-28
• [Presentation] 肥満者の肝臓，筋肉，インスリン抵抗性：運動の効果 (2014)
  • Author(s): 正田純一
  • Organizer: Metabolic Syndrome と肝疾患研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-11-15
  • Invited
• [Presentation] NAFLDを有する肥満者に対する加速度トレーニングの臨床的有用性 (2014)
  • Author(s): 澤井朱美，呉 世昶，白木 仁，田中喜代次，正田純一
  • Organizer: 第25回臨床スポーツ医学会
  • Place of Presentation: 東京
  • Year and Date: 2014-11-08 – 2014-11-09
• [Presentation] Moderate-Vigorous Physical Activity (MVPA) Volume in a Week is an Important Factor for Management of Non-Alcoholic Fatty Liver Disease: A Retrospective Study (2014)
  • Author(s): Oh S, Shida T, So R, Tsujimoto T, Tanaka K, Shoda J
  • Organizer: The 65th Annual Meeting of the American Association for the Study of Liver Disesaes
  • Place of Presentation: Boston
  • Year and Date: 2014-11-07 – 2014-11-11
• [Presentation] Deletion of both p62 and Nrf2 spontaneously leads to development of steatohepatitis in mice (2014)
  • Author(s): Akiyama K, Warabi E, Okada K, Ikeuchi M, Kose K, Shoda J
  • Organizer: The 65th Annual Meeting of the American Association for the Study of Liver Disesaes
  • Place of Presentation: Boston
  • Year and Date: 2014-11-07 – 2014-11-11
• [Presentation] Irisin is associated with physical activity and hepatic steatosis in non-alcoholic fatty disease patients (2014)
  • Author(s): So R, Oh S, Shida T, Tanaka K, Shoda J
  • Organizer: The 65th Annual Meeting of the American Association for the Study of Liver Disesaes
  • Place of Presentation: Boston
  • Year and Date: 2014-11-07 – 2014-11-11
• [Presentation] 肥満者の肝臓，筋肉，インスリン抵抗性：運動の効果 (2014)
  • Author(s): 正田純一
  • Organizer: 第10回愛媛軽症糖尿病懇話会
  • Place of Presentation: 松山
  • Year and Date: 2014-10-31
  • Invited
• [Presentation] 非アルコール性脂肪性肝疾患を有する肥満者における新しいレジスタンス運動の臨床的有用性 (2014)
  • Author(s): 呉 世昶，田中喜代次，正田純一
  • Organizer: 第18回日本肝臓学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2014-10-23 – 2014-10-26
• [Presentation] 非アルコール性脂肪性肝炎（NASH）自然発症モデルマウスにおける腸肝相関からみた病態評価と機序の解明 (2014)
  • Author(s): 秋山健太郎，蕨 栄治，正田純一
  • Organizer: 第18回日本肝臓学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2014-10-23 – 2014-10-26
• [Presentation] NAFLD肥満者における中高強度身体活動量の増加が血中脂肪酸組成に及ぼす影響について (2014)
  • Author(s): 呉 世昶，田中喜代次，蘇 リナ，加藤千晶，澤井朱美，正田純一
  • Organizer: 第18回日本肝臓学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2014-10-23 – 2014-10-26
• [Presentation] HER3陽性の胆道癌に対する分子標的治療pertuzumabの効果 (2014)
  • Author(s): 川本 徹，山本雅一，正田純一
  • Organizer: 第18回日本肝臓学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2014-10-23 – 2014-10-26
• [Presentation] 胆道癌における高感度診断システムの開発：新しい腫瘍マーカーとしてのWFA-sialyl MUC1の意義 (2014)
  • Author(s): 樋口亮太，正田純一，山本雅一
  • Organizer: 第50回日本胆道学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-09-26 – 2014-09-27
• [Presentation] 肥満者の肝臓，筋肉，インスリン抵抗性：運動の効果 シンポジウム「メデイカルフィットネス：過去，現在，未来」 (2014)
  • Author(s): 正田純一
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎
  • Year and Date: 2014-09-19 – 2014-09-21
  • Invited
• [Presentation] 減量による血中Irisin濃度の変動が肥満病態の改善に及ぼす影響 (2014)
  • Author(s): 蘇 リナ，辻本健彦，呉 世昶，金 甫建，蕨 栄治，田中喜代次，正田 純一
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] 肥満予防を目的とした全身振動刺激の有用性の基礎的検討 (2014)
  • Author(s): 堀江正樹，小峰昇一，蘇 リナ，蕨 栄治，正田純一
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] 運動による肝・骨格筋におけるNrf2活性化の解析 (2014)
  • Author(s): 小峰昇一，蕨栄治，呉 世昶，堀江正樹，岩脇隆夫，正田純一
  • Organizer: 第69回日本体力医学会大会
  • Place of Presentation: 長崎
  • Year and Date: 2014-09-19 – 2014-09-21
• [Presentation] NAFLD肥満成人男性の肝および代謝異常の改善を目指した適切な身体活動量の検討 (2014)
  • Author(s): 呉 世昶，田中喜代次，正田純一
  • Organizer: 第33回日本臨床運動療法学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-09-06
• [Presentation] Clinical benefits of acceleration training for management of obese subjects with non-alcoholic fatty liver disease (2014)
  • Author(s): Oh S, Shida T, Sawai A, Eguchi K, Maruyama T, So T, Komine S, Horie M, Akiyama K, Tanaka K, Shoda J
  • Organizer: INCHEON ASIAN GAMES INTERNATIONAL SPORT SCIENCE CONGRESS
  • Place of Presentation: Korea
  • Year and Date: 2014-08-28
• [Presentation] 肥満・生活習慣病と胆道疾患（胆石・胆道がん）シンポジウム「生活習慣が消化器がんの発生に与える影響：最近の知見」 (2014)
  • Author(s): 正田純一
  • Organizer: 第52回日本癌治療学会
  • Place of Presentation: 横浜
  • Year and Date: 2014-08-25
  • Invited
• [Presentation] 胆管がん患者血清中MUC1 の比較糖鎖プロファイリング (2014)
  • Author(s): 松田厚志，久野 敦，中川知美，池原 譲，入村達郎，正田純一，成松 久
  • Organizer: 第12回日本プロテオーム学会
  • Place of Presentation: つくば
  • Year and Date: 2014-07-17 – 2014-07-18
• [Presentation] NASH の最近の知見 基礎と臨床 (2014)
  • Author(s): 正田純一，竹井謙之，橋本悦子
  • Organizer: 「最新医学」座談会
  • Place of Presentation: 東京
  • Year and Date: 2014-06-26
  • Invited
• [Presentation] 肥満・生活習慣病と肝疾患 ― その対策 (2014)
  • Author(s): 正田純一
  • Organizer: 消化器と生活習慣病フォーラム
  • Place of Presentation: つくば
  • Year and Date: 2014-06-23
  • Invited
• [Presentation] 加速度トレーニングの臨床的有用性 (2014)
  • Author(s): 正田純一
  • Organizer: プロテイアジャパン主催情報交換会
  • Place of Presentation: 東京
  • Year and Date: 2014-06-15
  • Invited
• [Presentation] 非アルコール性脂肪性肝疾患（NAFLD）における効果的な運動療法のための適切な身体活動量の検討 (2014)
  • Author(s): 呉世昶，山岸良匡，田中喜代次，正田純一
  • Organizer: 第22回肝病態生理研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-31
• [Presentation] 非アルコール性脂肪性肝疾患（NAFLD）における中高度肥満と糖尿病が肝病態に及す影響 (2014)
  • Author(s): 志田隆史，小野塚太郎，呉 世昶，磯辺智範，岡本嘉一，矢藤 繁，島野 仁，正田純一
  • Organizer: 第22回肝病態生理研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-31
• [Presentation] NASH自然発症モデルマウスにおける腸肝相関よりみたNASH発症とその進展機序の解析 (2014)
  • Author(s): 秋山健太郎，蕨 栄治，池内美穂，後藤直弘，拝師智之，巨瀬勝美，正田純一
  • Organizer: 第22回肝病態生理研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-31
• [Presentation] 非アルコール性脂肪性肝疾患（NAFLD）における中高度肥満と糖尿病が肝病態に及す影響と病態関連因子の解析 (2014)
  • Author(s): 志田隆史，小野塚太郎，呉 世昶，磯辺智範，岡本嘉一，矢藤 繁，島野 仁，正田純一
  • Organizer: 第50回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-29 – 2014-05-30
• [Presentation] NAFLD肥満者に効果的な運動療法を実践するための中高強度身体活動量の検討 (2014)
  • Author(s): 呉世昶, 田中喜代次, 正田純一
  • Organizer: 第50回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-29 – 2014-05-30
• [Presentation] 脂肪肝合併2型糖尿病患者における血中脂肪酸組成と肝弾性度・脂肪量の関係についての検討 (2014)
  • Author(s): 矢藤 繁，志田隆史，正田純一，松坂 賢，岩崎 仁，小林和人，鈴木浩明，島野 仁
  • Organizer: 第57回糖尿病学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] Non-invasive assessment of ectopic fat in non-alcoholic fatty liver disease using 1H-MR (2014)
  • Author(s): Isobe T, Okamoto Y, Sihda T, Hirano Y, Sato E, Shoda J
  • Organizer: The 23rd Annual Meeting of the Section of Magnetic Resonance Technologists
  • Place of Presentation: Italy
  • Year and Date: 2014-05-10 – 2014-05-12
• [Presentation] 肥満と糖尿病が肝脂肪化と線維化に及す影響と病態関連因子の解析 (2014)
  • Author(s): 志田隆史，小野塚太郎，呉 世昶，磯辺智範，岡本嘉一，矢藤 繁，島野 仁，正田純一
  • Organizer: 第87回日本超音波医学会
  • Place of Presentation: 横浜
  • Year and Date: 2014-05-09 – 2014-05-11
• [Presentation] 非アルコール性脂肪性肝疾患（NAFLD）における最適な運動療法の検討 (2014)
  • Author(s): 呉世昶，田中喜代次，正田純一
  • Organizer: 第100回日本消化器病学会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-23 – 2014-04-26
• [Presentation] p62およびNrf2遺伝子の二重欠損マウスにおけるNASH発症機序の解明―肝と腸管の臓器連関の観点より (2014)
  • Author(s): 秋山健太郎，蕨 栄治，池内美穂，後藤直弘，拝師智之，巨瀬勝美，正田純一
  • Organizer: 第100回日本消化器病学会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-23 – 2014-04-26
• [Book] 肥満の治療 (2016)
  • Author(s): 正田 純一
  • Publisher: 日本消化器病学会
• [Book] New Horizon of Herbal Medicines (2016)
  • Author(s): Shoda J, Warabi E, Okada K, Yamamoto M.
  • Publisher: Springer
• [Book] 今日の治療指針2017 (2016)
  • Author(s): 正田 純一
  • Publisher: 医学書院
• [Book] 運動療法 肥満と消化器疾患 市民向けガイド 日本消化器病学会編集企画 (2016)
  • Author(s): 正田 純一
  • Publisher: 金原出版
• [Book] 総胆管結石 特集：結石症の診断と治療 (2016)
  • Author(s): 正田 純一
  • Publisher: 医学と薬学
• [Book] 肝胆膵 HER family：肝内胆管癌のpotential drug targets (2016)
  • Author(s): 川本 徹，山本雅一，正田純一
  • Publisher: メディカルビュー社
• [Book] 胆汁酸とその分画 新・検査値のみかた (2015)
  • Author(s): 正田純一
  • Publisher: 中外医学社（東京）
• [Book] 胆管細胞がんの疫学 最近肝癌学 (2015)
  • Author(s): 正田純一
  • Publisher: 日本臨床
• [Book] 生活習慣と胆道癌 膵癌・胆道癌 (2015)
  • Author(s): 正田純一
  • Publisher: 日本臨床
• [Book] Epidemiology and Pathogenesis of Hepatocellular Carcinoma. In: Hepatocellular Carcinoma (2014)
  • Author(s): Shoda, J., Ohokohchi, N
  • Publisher: NOVA Science Publishers
• [Book] 肥満・生活習慣病と肝胆道疾患，運動による予防と治療 (2014)
  • Author(s): 正田純一，田中喜代次
  • Total Pages: 158
  • Publisher: 体力科学
• [Book] 肝内胆管癌の新規バイオマーカー Hepatology Practice (2014)
  • Author(s): 正田純一，松田厚志，久野 敦，池原 譲，成松 久，大河内信弘，山本雅一，中沼安二
  • Publisher: 文光堂（東京）
• [Book] 生活習慣と胆道癌-胆管癌集団発症への対策も含めて Annual Review 消化器 2014 (2014)
  • Author(s): 正田純一
  • Publisher: 中外医学社（東京）