Research for unknown mechanism of insulin resistance in non-obese subject and its clinical application.

• Project/Area Number: 26282197
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Juntendo University
• Principal Investigator: Tamura Yoshifumi 順天堂大学, 医学部, 准教授 (80420834)
• Co-Investigator(Kenkyū-buntansha): 筧 佐織 順天堂大学, 医学(系)研究科(研究院), 特任助教 (00450560) ; 竹野 景海 順天堂大学, 医学部, 助教 (50459062)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000); Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
• Keywords: インスリン抵抗性 / 異所性脂肪 / インスリンクリアランス / メタボリックシンドローム / 非肥満者 / 非肥満

Outline of Final Research Achievements

One feature of metabolic diseases common in most of Asian countries is the development of metabolic abnormalities in subjects with normal BMI (<25 kg/m2) Although the role of insulin resistance is considered to be an important pathogenesis of type 2 diabetes and metabolic abnormalities in both obese subjects and normal weight subjects, the features and roles of insulin resistance in such specific population are totally unknown. In this research, we searched for unknown mechanism of insulin resistance in such population. As a result, we found several specific candidate characteristics which may induce insulin resistance in skeletal muscle. More researches are required to confirm causal relationships between insulin resistance and metabolic parameters we found.

Research Products

• [Int'l Joint Research] Toronto University(Canada)
• [Journal Article] Effects of alcohol abstinence on glucose metabolism in Japanese men with elevated fasting glucose: A pilot study. (2017)
  • Author(s): Funayama T, Tamura Y, Takeno K, Kawaguchi M, Kakehi S, Watanabe T, Furukawa Y, Kaga H, Yamamoto R, Kanazawa A, Fujitani Y, Kawamori R, Watada H.
  • Journal Title: Sci Rep. Volume: 9 Issue: 1 Pages: 40277-40277
  • DOI: 10.1038/srep40277
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Correlates of insulin clearance in apparently healthy non-obese Japanese men. (2017)
  • Author(s): Kaga H, Tamura Y, Takeno K, Kakehi S, Funayama T, Furukawa Y, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Giacca A, Kanazawa A, Kawamori R, Watada H.
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 1462-1462
  • DOI: 10.1038/s41598-017-01469-x
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant