Mechanism to exert multi-functions of molecular hydrogen for health-care and the prevention of diseases
| Project/Area Number |
26282198
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Nippon Medical School |
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Principal Investigator |
Ohta Shigeo 日本医科大学, 医学(系)研究科(研究院), 教授 (00125832)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMIMURA Naomi 日本医科大学, 先端医学研究所, 准教授 (60283800)
WOLF Alexander 日本医科大学, 先端医学研究所, 講師 (20434136)
IUCHI Katsuya 日本医科大学, 先端医学研究所, 助教 (40553847)
NISHIMAKI Kiyomi 日本医科大学, 先端医学研究所, その他 (00465345)
ICHIMIYA Harumi (YOKOTA Takashi) 日本医科大学, 先端医学研究所, その他 (40553251)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Keywords | 分子状水素 / 遺伝子発現制御 / 情報伝達機構 / 生活習慣病 / 酸化脂質 / 脂質メディエーター / ミトコンドリア / 酸化ストレス / 水素 |
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| Outline of Final Research Achievements |
We previously reported that molecular hydrogen (H2) acts as a novel antioxidant to exhibit multiple functions. H2 regulates various signal transduction pathways and the expression of many genes for health-care and the prevention of life style related diseases. However, the primary targets of H2 in the signal transduction pathways are unknown. Here, we attempted to determine how H2 regulates gene expression.
We found that H2 regulates gene expression via the Ca(2+) signal transduction pathway by modifying the free radical-dependent generation of oxidized phospholipid mediators. This mechanism explains the decrease in inflammatory cytokines. In addition, to suppress metabolic syndrome,H2 induces expression of the PGC-1α gene, followed by stimulation of the PPARα pathway that regulates FGF21, and the fatty acid and steroid metabolism. The expression of PGC-1α might be regulated indirectly through sequential regulation by H2, 4-hydroxy-2-nonenal, and Akt/FoxO1 signaling.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure2017
Author(s)
Ono T, Kamimura N, Matsuhashi T, Nagai T, Nishiyama T, Endo J, Hishiki T, Nakanishi T, Shimizu N, Tanaka H, Ohta S, Suematsu M, Ieda M, Sano M, Fukuda K, Kaneda R
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Journal Title
Sci Rep.
Volume: 7
Issue: 1
Pages: 39752-39752
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Effects of Hydrogenized Water on Intracellular Biomarkers for Antioxidants, Glucose Uptake, Insulin Signaling and SIRT 1 and Telomerase Activity2016
Author(s)
Settineri R, Ji J, Luo C, Ellithorpe RR, Mattos GFd, Rosenblatt S, LaValle J, Jinenez A, Ohta S, Nicolson GL
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Journal Title
American J Food Nutr.
Volume: 4
Pages: 161-168
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome – First-in-Human Pilot Study –2016
Author(s)
Tamura T, Hayashida K, Sano M, Suzuki M, Shibusawa T, Yoshizawa J, Kobayashi Y, Suzuki T, Ohta S, Morisaki H, Fukuda K, Hori S.
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Journal Title
Circulation Journal
Volume: 80
Issue: 8
Pages: 1870-1873
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed / Open Access
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[Journal Article] Intravenous transplantation of bone marrow-derived mononuclear cells prevents memory impairment in transgenic mouse models of Alzheimer's disease.2015
Author(s)
Kanamaru T, Kamimura N, Yokota T, Nishimaki K, Iuchi K, Lee H, Takami S, Akashiba H, Shitaka Y, Ueda M, Katsura K, Kimura K, Ohta S.
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Journal Title
Brain Res.
Volume: 1605
Pages: 49-58
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Oxidative stress accelerates amyloid deposition and memory impairment in a double-transgenic mouse model of Alzheimer's disease.2015
Author(s)
Kanamaru T, Kamimura N, Yokota T, Iuchi K, Nishimaki K, Takami S, Akashiba H, Shitaka Y, Katsura K, Kimura K, Ohta S.
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Journal Title
Neurosci Lett.
Volume: 587
Pages: 126-131
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesity.2014
Author(s)
Yokoyama M, Okada S, Nakagomi A, Moriya J, Shimizu I, Nojima A, Yoshida Y, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Fruttiger M, Lozano G, Minamino T.
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Journal Title
Cell Rep
Volume: 7
Issue: 5
Pages: 1691-1703
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] How To 水素治療2014
Author(s)
太田成男
Organizer
第14回日本抗加齢医学会総会
Place of Presentation
大阪府大阪市
Year and Date
2014-06-06 – 2014-06-08
Related Report
Invited
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