Development of exercise therapy for reduction of arterial stiffness by exercise-induced secretion of myokines
| Project/Area Number |
26282199
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
真田 樹義 立命館大学, スポーツ健康科学部, 教授 (50421227)
浜岡 隆文 東京医科大学, 医学部, 教授 (70266518)
橋本 健志 立命館大学, スポーツ健康科学部, 准教授 (70511608)
藤田 聡 立命館大学, スポーツ健康科学部, 教授 (80451863)
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| Co-Investigator(Renkei-kenkyūsha) |
SATO Koji 神戸大学, 大学院・人間発達環境学研究科, 准教授 (20584022)
HAYANO Toshiya 立命館大学, 生命科学部, 教授 (90332303)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | マイオカイン / 中高齢者 / 動脈硬化 / 有酸素性運動 / 骨格筋 |
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| Outline of Final Research Achievements |
This study aimed to clarify whether the association with regular aerobic exercise-induced reduction of arterial stiffness to circulating levels of myokines (apelin and irisin) in middle-aged and older adults. Thirty-four healthy middle-aged and older subjects were divided into two groups: exercise intervention and sedentary controls. Subjects in the training group completed 8-week of aerobic exercise (60-70% peak oxygen uptake for 45 min, 3 days/week). In the training group, arterial stiffness indexes were significantly decreased, and circulating levels of apelin and irisin were significantly increased after the intervention. Additionally, significant negative correlations between the training effects of circulating apelin and irisin levels and arterial stiffness indexes were observed. These results suggest that the increased in circulating apelin and irisin levels may be associated with exercise training-induced alternation of arterial stiffness in middle-aged and older adults.
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Report
(4 results)
Research Products
(92 results)
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[Journal Article] A common genetic variant of the chromogranin A-derived peptide catestatin is associated with atherogenesis and hypertension in a Japanese population2015
Author(s)
Choi Y, Miura M, Nakata Y, Sugasawa T, Nissato S, Otsuki T, Sugawara J, Iemitsu M, Kawakami Y, Shimano H, Iijima Y, Tanaka K, Kuno S, Allu PK, Mahapatra NR, Maeda S, Takekoshi K.
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Journal Title
Endocrine Journal
Volume: 62
Issue: 9
Pages: 797-804
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] 日本人成人肥満男女を対象としたサルコペニア簡易評価法の開発.2015
Author(s)
古嶋大詩,中山侑紀, 井門あゆみ, 家光素行, 栗原俊之, 本間俊行, 佐藤幸治, 藤本雅大, 浜岡隆文, 石井好二郎, 浅原哲子, 真田樹義．
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Journal Title
肥満研究
Volume: 21
Pages: 167-176
Related Report
Peer Reviewed
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[Journal Article] Low-volume, high-intensity, aerobic interval exercise for sedentary adults: VO2max, cardiac mass, and heart rate recovery.2014
Author(s)
Matsuo T, Saotome K, Seino S, Eto M, Shimojo N, Matsushita A, Iemitsu M, Ohshima H, Tanaka K, Mukai C.
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Journal Title
Eur J Appl Physiol
Volume: 114
Issue: 9
Pages: 1963-1972
DOI
Related Report
Peer Reviewed
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[Presentation] Ageing-induced reduction in muscle cross-sectional area is associated with serum C1q concentration.2014
Author(s)
Watanabe S, Sato K, Fujita S, Hasegawa N, Fujie S, Sanada K, Kurihara T, Hamaoka T, Iemitsu M.
Organizer
61th American College of Sports Medicine
Place of Presentation
Orlando, Florida, (USA).
Year and Date
2014-05-30
Related Report
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[Presentation] Effects of cardiorespiratory fitness level, age, and sex on intramyocellular and extramyocellular lipid contents.2014
Author(s)
Hasegawa N, Kurihara T, Watanabe S, Sato K, Fujita S, Sanada K, Hamaoka T, Iemitsu M.
Organizer
61th American College of Sports Medicine
Place of Presentation
Orlando, Florida, (USA).
Year and Date
2014-05-29
Related Report
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