Creation of agents that selectively photo-degrade certain proteins and oligosaccharides and its application to control of cell functions
| Project/Area Number |
26282212
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | 生物活性分子 / 分子設計 / 合成 / タンパク / 糖 / 光分解 / 細胞 / 生体機能光制御分子 / アントラキノン / シアリルルイスA / ハイブリッド / がん細胞 / 抗体 / 生体機能分子 / 光制御 / 糖鎖 / 糖転移酵素 / 有機合成 / キノリン / ガラクトース / ノロウイルス / レクチン / 糖タンパク / 細胞毒性 |
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| Outline of Final Research Achievements |
Several agents, that target-selectively photo-degrade certain disease-related proteins and oligosaccharides, were designed and synthesized. Furthermore, it was found the agents thus developed work not only in test tube but also in disease-related cells. From these studies, a new approach for the design of light-activated and molecular-targeted medicines has been established.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Total Synthesis of Aquayamycin2016
Author(s)
S. Kusumi, H. Nakayama, T. Kobayashi, H. Kuriki, Y. Matsumoto, D. Takahashi, K. Toshima
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Journal Title
Chemistry - A European Journal
Volume: 22
Issue: 52
Pages: 18733-18736
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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