| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2014: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
Imaging of biomolecules is a useful method to elucidate biological phenomena in living cells. So far, fluorescent proteins have been used for live-cell imaging of proteins. In this research, to overcome limitations of existing methods, we developed fluorogenic probes, which emit fluorescence upon binding to biomolecules. By using the fluorogenic probes, we succeeded in analyzing protein trafficking, glycan function, and chemical modification of nucleic acids.
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