| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2014: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Outline of Final Research Achievements |
Ionotropic glutamate receptors (iGluR) play a central role in the excitatory neurotransmission in the central nervous system. In the present study, we have studied synthesis and evaluation of the inhibitory nature of the analogs of our original ligand IKM-159, to develop novel compound that would be used for therapeutic treatment of neuronal disorders.
We first developed synthetic route for diverse analogs of IKM-159, and we identified IKM-154 acts as an excitatory agent in vivo. Like the inhibitory IKM-159, the excitatory IKM-154 is supposed to be also a ligand for AMPA receptor which is one of the subtype protein of iGluR. With IKM-154 and IKM-159 in hand, it is now possible to explore the detailed biological function and the macinery of AMPA receptor, by selective activation and inactivation.
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