Control of Molecular Recognition by Light-induced Force and Development of Ultrafast Highly-sensitive Biosensor
| Project/Area Number |
26286029
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Nanobioscience
|
|---|
| Research Institution | Osaka Prefecture University |
|---|
Principal Investigator |
Iida Takuya 大阪府立大学, 理学(系)研究科(研究院), 准教授 (10405350)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
床波 志保 大阪府立大学, 工学(系)研究科(研究院), 准教授 (60535491)
伊都 将司 大阪大学, 基礎工学研究科, 准教授 (10372632)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
IMURA KOHEI 早稲田大学, 理工学術院, 教授 (80342632)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
|
|---|
| Keywords | ナノバイオ / 分析科学 / 分子認識 / 光ピンセット / 計測工学 |
|---|
| Outline of Final Research Achievements |
The purpose of this research was to elucidate the control principle of the biomolecular recognition by the light-induced force, and we aimed at development of a rapid and highly sensitive innovative biosensor. Especially, utilizing the synergetic effect of light-induced force and light-induced convection under laser irradiation, we have revealed that the submillimeter macroscopic assembly can be formed via the acceleration of a specific binding of probe nanomaterial and zmol-level DNA as a target biomolecule. The obtained result would be the foundation of a label-free, ultrafast, highly-sensitive biosensor based on the optical guiding process, and would be used for the progress of technologies that are strongly required in medical and food related fields, for example, the early diagnosis in genetic diseases and allergies, and the separation methods of drugs.
|
| Academic Significance and Societal Importance of the Research Achievements |
DNAなど極微量のターゲット生体分子の特異的結合をレーザー照射により加速してわずか数分程度の短時間でマクロな集合体形成が可能な「光誘起力による分子認識制御」の原理の一端を解明し、迅速・高感度な光誘導型バイオセンサの研究開発における重要な基礎的知見を得たことが本研究成果の学術的意義である。これらの成果は遺伝子疾患やアレルギーなどの検査・診断技術や医薬品等の分離分析技術の革新を目指す研究開発に新たな選択肢を与え、医療・食品検査・創薬などの発展に繋がる高い社会的意義があるものと考える。
|
Report
(4 results)
Research Products
(145 results)
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] A High Performance Photothermal Film with Spherical Shell-type Metallic Nanocomposites for Solar Thermoelectric Conversion2015
Author(s)
A.Kosuga*, Y.Yamamoto, M.Miyai, M.Matsuzawa, Y.Nishimura, S.Hidaka, K.Yamamoto, S.Tanaka, Y.Yamamoto, S.Tokonami, T.Iida*
-
Journal Title
Nanoscale
Volume: 7
Issue: 17
Pages: 7580-7584
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Densely Fixed Bacteria Using Photoinduced Convection2016
Author(s)
Sinya Kurita, Yushi Nishimura, Yasuyuki Yamamoto, Olaf Karthaus, Takuya Iida, Shiho Tokonami
Organizer
OPU-KIST Joint Symposium on Next Generation Photochemistry and Photophysics: From Materials to Applications
Place of Presentation
Seoul（South Korea）
Year and Date
2016-09-25
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Assembling of Porphyrin-based Molecules by Laser-induced Convection2016
Author(s)
Takuya Iida, Yasuyuki Yamamoto, Yushi Nishimura, Shiho Tokonami, Norihito Fukui, Takayuki Tanaka, Atsuhiro Osuka, Hideki Yorimitsu
Organizer
KJF International Conference on Organic Materials for Electronics and Photonics 2016 (KJF-ICOMEP 2016)
Place of Presentation
Fukuoka（Japan）
Year and Date
2016-09-04
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Photothermal assembling of porphyrin dimers”2015
Author(s)
Y. Yamamoto, Y. Nishimura, T. Tanaka, H. Yorimitsu, A. Osuka, S. Tokonami, T. Iida
Organizer
The International Chemical Congress of Pacific Basin Societies 2015（Pacifichem2015)
Place of Presentation
Hawaii Convention Center, Honolulu, Hawaii, USA
Year and Date
2015-12-15
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Selective Assembly of Microstructures of Uniform Silver Nanoparticles by Using Radiation Pressure of CW lasers2014
Author(s)
S. Ito, H. Yamauchi, M. Tamura, S. Hidaka, H. Hattori, T. Hamada, K. Nishida, S. Tokonami, T. Itoh, H. Miyasaka, T.
Organizer
The 1st International Symposium on Interactive Materials Science Cadet Program
Place of Presentation
Hotel Hankyu Expo Park, Osaka, Japan
Year and Date
2014-11-16 – 2014-11-19
Related Report
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Selective assembly of microstructures of anisotropic silver nanoparticles by using radiation pressure2014
Author(s)
S.Ito, H. Yamauchi, M. Tamura, S. Hidaka, H. Hattori, T. Hamada, K. Nishida, S. Tokonami, T. Itoh, H. Miyasaka, T. Iida
Organizer
日本分析化学会中国四国支部広島地区・外国人学者講演会 Dr. Sophie Sobanska, Dr. Michel Sliwa講演会
Place of Presentation
広島大学理学部
Year and Date
2014-08-22
Related Report
-
[Presentation] Bio-inspired selective assembling of plasmonic nanoparticles under designed light and fluctuations2014
Author(s)
T.Iida, M.Tamura, S.Hidaka, H.Hattori, T.Hamada, K.Nishida, S.Tokonami, T.Itoh, H.Yamauchi, H.Miyasaka, S.Ito
Organizer
The 25th IUPAC Symposium on Photochemistry
Place of Presentation
The Congress Center, Bordeaux, France
Year and Date
2014-07-13 – 2014-07-18
Related Report
-
-
-
-
-
-
-
-
-
-
[Presentation] Theory for Bio-inspired Optical Manipulation under Fluctuations2014
Author(s)
T. Iida, M. Tamura, S. Hidaka , H. Hattori , T. Hamada , K. Nishida , S. Tokonami, T. Itoh , H. Yamauhi , H. Miyasaka, S. Ito
Organizer
Optical Manipulation Conference'14 OMC ’14
Place of Presentation
Pacifico Yokohama
Year and Date
2014-04-22 – 2014-04-25
Related Report
-
[Presentation] Selective assembly of microstructures of plasmonic nanorods with radiation pressure2014
Author(s)
S. Ito , H. Yamauchi , M. Tamura, S. Hidaka , H. Hattori, T. Hamada , K. Nishida , S. Tokonami , T. Itoh , H. Miyasaka , and T. Iida
Organizer
Optical Manipulation Conference'14 OMC ’14
Place of Presentation
Pacifico Yokohama
Year and Date
2014-04-22 – 2014-04-25
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
