Control of cell functions at the tissue level using micro/nanotechnologies

• Project/Area Number: 26286031
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Nano/Microsystems
• Research Institution: Tohoku University
• Principal Investigator: Kaji Hirokazu 東北大学, 工学(系)研究科(研究院), 准教授 (70431525)
• Co-Investigator(Kenkyū-buntansha): 藤枝 俊宣 早稲田大学, 理工学術院, 助教 (70538735) ; 阿部 俊明 東北大学, 医学(系)研究科(研究院), 教授 (90191858) ; 岩瀬 英治 早稲田大学, 理工学術院, 准教授 (70436559)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000); Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000); Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
• Keywords: ナノマイクロバイオシステム / マイクロ・ナノデバイス

Outline of Final Research Achievements

Applying micro/nanotechnologies including microfluidic devices and polymeric nanosheets to the ophthalmologic field, an organ on a chip that mimics the ocular fundus was developed. Also, based on findings on cell functions at the tissue level obtained by the analysis of the organ on a chip, cell delivery therapy was investigated. In order to recapitulate the ocular fundus functions, neural supporting cells such as retinal pigment epithelial (RPE) cells were cultured within a three-dimensional microfluidic device, and cell responses at the tissue level to changes in the microenvironment were analyzed. Also, the obtained results were applied to control the tissue functions of RPE cells cultured on the polymeric nanosheets, which was extended to a method to deliver an RPE sheet into the subretinal space.

Research Products

• [Journal Article] A self-deploying drug release device using polymeric films (2017)
  • Author(s): Taro Kondo, Zhaleh Kashkouli Nezhad, Jin Suzuki, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji
  • Journal Title: Journal of Biomedical Materials Research Part B: Applied Biomaterials Volume: in press Issue: 2 Pages: 780-786
  • DOI: 10.1002/jbm.b.33887
  • Peer Reviewed / Open Access
• [Journal Article] Electrochemical manipulation of cell populations supported by biodegradable polymeric nanosheets for cell transplantation therapy (2017)
  • Author(s): Jin Suzuki, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji
  • Journal Title: Biomater. Sci. Volume: 5 Issue: 2 Pages: 216-222
  • DOI: 10.1039/c6bm00852f
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Long-term Protection of Genetically-Ablated Rabbit Retinal Degeneration by Sustained Transscleral Unoprostone Delivery (2017)
  • Author(s): Nobuhiro Nagai, Eri Koyanagi, Yasuko Izumida, Junjun Liu, Aya Katsuyama, Hirokazu Kaji, Matsuhiko Nishizawa, Noriko Osumi, Mineo Kondo, Hiroko Terasaki, Yukihiko Mashima, Toru Nakazawa, Toshiaki Abe
  • Journal Title: Investigative Ophthalmology & Visual Science Volume: 57(15) Issue: 15 Pages: 6527-6538
  • DOI: 10.1167/iovs.16-20453
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Totally shape-conformable electrode/hydrogel composite for on-skin electrophysiological measurements (2016)
  • Author(s): Kuniaki Nagamine, Shun Chihara, Hiroyuki Kai, Hirokazu Kaji, Matsuhiko Nishizawa
  • Journal Title: Sens. Actuator B-Chem. Volume: 237 Pages: 49-53
  • DOI: 10.1016/j.snb.2016.06.076
  • Peer Reviewed
• [Journal Article] Minimally-invasive transepidermal potentiometry with microneedle salt bridge (2016)
  • Author(s): Yuina Abe, Kuniaki Nagamine, Mayu Nakabayashi, Hiroyuki Kai, Hirokazu Kaji, Takeshi Yamauchi, Kenshi Yamasaki, Matsuhiko Nishizawa
  • Journal Title: Biomed. Microdevices Volume: 18 Issue: 4 Pages: 55-55
  • DOI: 10.1007/s10544-016-0080-0
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Protective effects of transscleral sustained unoprostone delivery against retinal degeneration in S334ter rhodopsin mutant rats (2015)
  • Author(s): Nobuhiro Nagai, Satoru Iwata, Kaori Sampei, Hideyuki Onami, Hirokazu Kaji, Matsuhiko Nishizawa, Toru Nakazawa, Yukihiko Mashima, Toshiaki Abe
  • Journal Title: Journal of Biomedical Materials Research Part B: Applied Biomaterials Volume: in press Issue: 8 Pages: 1730-1737
  • DOI: 10.1002/jbm.b.33522
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Application of clotrimazole via a novel controlled release device provides potent retinal protection (2015)
  • Author(s): Zhaleh Kashkouli Nezhad, Nobuhiro Nagai, Kotaro Yamamoto, Hirokazu Kaji, Matsuhiko Nishizawa, Hideyuki Saya, Toru Nakazawa, Toshiaki Abe
  • Journal Title: J Mater Sci Mater Med Volume: 26 Issue: 9 Pages: 5561-5561
  • DOI: 10.1007/s10856-015-5561-9
  • Peer Reviewed / Open Access
• [Journal Article] Highly Stretchable Cell-Cultured Hydrogel Sheet (2015)
  • Author(s): K. Nagamine et al.
  • Journal Title: RSC Advances Volume: 5 Issue: 81 Pages: 66334-66338
  • DOI: 10.1039/c5ra11059a
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Portable Micropatterns of Neuronal Cells Supported by Thin Hydrogel Films (2015)
  • Author(s): K. Nagamine et al.
  • Journal Title: ACS Biomaterials Science & Engineering Volume: 1 Issue: 5 Pages: 329-334
  • DOI: 10.1021/acsbiomaterials.5b00020
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Three-dimensional co-culture of C2C12/PC12 cells improves skeletal muscle tissue formation and function (2015)
  • Author(s): Serge Ostrovidov, Samad Ahadian, Javier Ramon-Azcon, Vahid Hosseini, Toshinori Fujie, S. Prakash Parthiban, Hitoshi Shiku, Tomokazu Matsue, Hirokazu Kaji, Murugan Ramalingam, Hojae Bae, Ali Khademhosseini
  • Journal Title: J. Tissue Eng. Regen. Med. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Three-dimensional co-culture of C2C12/PC12 cells improves skeletal muscle tissue formation and function. (2014)
  • Author(s): Ostrovidov, S., Ahadian, S., Ramon-Azcon, J., Hosseini, V., Fujie, T., Prakash Parthiban, S., Shiku, H., Matsue, T., Kaji, H., Ramalingam, M., Bae, H., Khademhosseini, A.
  • Journal Title: Journal of Tissue Engineering and Regenerative Medicine Volume: - Issue: 2 Pages: 582-595
  • DOI: 10.1002/term.1956
  • Peer Reviewed
• [Journal Article] A polymeric device for controlled transscleral multi-drug delivery to the posterior segment of the eye (2014)
  • Author(s): Nobuhiro Nagai, Hirokazu Kaji, Hideyuki Onami, Yumi Ishikawa, Matsuhiko Nishizawa, Noriko Osumi, Toru Nakazawa, Toshiaki Abe
  • Journal Title: Acta Biomaterialia Volume: 10(2) Issue: 2 Pages: 680-6877
  • DOI: 10.1016/j.actbio.2013.11.004
  • NAID: 40020425298
  • Peer Reviewed
• [Journal Article] Micropatterned polymeric nanosheets for local delivery of an engineered epithelial monolayer (2014)
  • Author(s): Toshinori Fujie, Yoshihiro Mori, Shuntaro Ito, Matsuhiko Nishizawa, Hojae Bae, Nobuhiro Nagai, Hideyuki Onami, Toshiaki Abe, Ali Khademhosseini, Hirokazu Kaji
  • Journal Title: Adv. Mater Volume: 26 Issue: 29 Pages: 1699-1705
  • DOI: 10.1002/adma.201301300
  • Peer Reviewed
• [Journal Article] Skeletal muscle tissue engineering: Methods to form skeletal myotubes and their applications (2014)
  • Author(s): Serge Ostrovidov, Vahid Hosseini, Samad Ahadian, Toshinori Fujie, S. Prakash Parthiban, Murugan Ramalingam, Hojae Bae, Hirokazu Kaji, Ali Khademhosseini
  • Journal Title: Tissue Eng. B Volume: (in press) Issue: 5 Pages: 403-436
  • DOI: 10.1089/ten.teb.2013.0534
  • Peer Reviewed
• [Journal Article] Hydrogel-based bioassay sheets for in vitro evaluation of contraction-dependent metabolic regulation in skeletal muscle cells (2014)
  • Author(s): Kuniaki Nagamine, Kohei Okamoto, Shingo Otani, Hirokazu Kaji, Makoto Kanzaki, Matsuhiko Nishizawa
  • Journal Title: Biomater. Sci. Volume: 2 Issue: 2 Pages: 252-256
  • DOI: 10.1039/c3bm60179j
  • Peer Reviewed
• [Journal Article] Electrically regulated differentiation of skeletal muscle cells on ultrathin graphene-based films (2014)
  • Author(s): Samad Ahadian, Javier Ramón-Azcón, Haixin Chang, Xiaobin Liang, Hirokazu Kaji, Hitoshi Shiku, Ken Nakajima, Murugan Ramalingam, Hongkai Wu, Tomokazu Matsue, Ali Khademhosseini
  • Journal Title: RSC Advances Volume: 4 Issue: 19 Pages: 9534-9541
  • DOI: 10.1039/c3ra46218h
  • Peer Reviewed
• [Journal Article] Bonding of synthetic hydrogels with fibrin as the glue to engineer hydrogel-based biodevices (2014)
  • Author(s): Kuniaki Nagamine, Kohei Okamoto, Hirokazu Kaji, Matsuhiko Nishizawa
  • Journal Title: J. Biosci. Bioeng. Volume: (in press) Issue: 1 Pages: 94-97
  • DOI: 10.1016/j.jbiosc.2013.12.024
  • NAID: 110009838776
  • Peer Reviewed
• [Journal Article] A Platform for Controlled Dual-Drug Delivery to the Retina : Protective Effects against Light-Induced Retinal Damage in Rats (2014)
  • Author(s): N Nagai, H Kaji, H Onami, Y Katsukura, Y Ishikawa, ZK Nezhad, K Sampei, S Iwata, S Ito, M Nishizawa, T Nakazawa, N Osumi, Y Mashima, T Abe
  • Journal Title: Advanced Healthcare Materials Volume: in press Issue: 10 Pages: 680-687
  • DOI: 10.1002/adhm.201400114
  • Peer Reviewed / Open Access
• [Journal Article] Highly Conductive Stretchable and Biocompatible Electrode-Hydrogel Hybrids for Advanced Tissue Engineering (2014)
  • Author(s): Masato Sasaki, Bijoy Chandapillai Karikkineth, Kuniaki Nagamine, Hirokazu Kaji, Keiichi Torimitsu, and Matsuhiko Nishizawa
  • Journal Title: Advanced Healthcare Materials Volume: 3 Issue: 11 Pages: 1919-1927
  • DOI: 10.1002/adhm.201400209
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Fiber-assisted molding (FAM) of surfaces with tunable curvature to guide cell alignment and complex tissue architecture (2014)
  • Author(s): Vahid Hosseini, Philip Kollmannsberger, Samad Ahadian, Serge Ostrovidov, Hirokazu Kaji, Viola Vogel, Ali Khademhosseini
  • Journal Title: Small Volume: 10 Issue: 23 Pages: 4851-4857
  • DOI: 10.1002/smll.201400263
  • Peer Reviewed
• [Presentation] 自己展開型薬剤徐放シートの網膜疾患治療への応用 (2016)
  • Author(s): 近藤太郎, Zhaleh Kashkouli Nezhad, 陳俐君, 鈴木 仁, 永井展裕, 西澤松彦, 阿部俊明, 梶 弘和
  • Organizer: 日本バイオマテリアル学会シンポジウム2016
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2016-11-21
• [Presentation] マイクロ・ナノ技術の開発と眼科領域における医工連携 (2016)
  • Author(s): 梶 弘和
  • Organizer: みちのく分析科学シンポジウム2016
  • Place of Presentation: 仙台
  • Year and Date: 2016-10-22
  • Invited
• [Presentation] Drug delivery system using injectable polymeric nanosheets (2016)
  • Author(s): Taro Kondo, Zhaleh Kashkouli Nezhad, Jin Suzuki, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji
  • Organizer: PRiME 2016
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2016-10-02
  • Int'l Joint Research
• [Presentation] In vitro angiogenesis: co-culture model of the retina in microfluidic devices (2016)
  • Author(s): Li-Jiun Chen, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji
  • Organizer: PRiME 2016
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2016-10-02
  • Int'l Joint Research
• [Presentation] Electrochemical manipulation of living cells supported by polymeric nanosheets (2016)
  • Author(s): Jin Suzuki, Taro Kondo, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji
  • Organizer: PRiME 2016
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2016-10-02
  • Int'l Joint Research
• [Presentation] 高分子デバイスを用いる薬剤・細胞デリバリー (2016)
  • Author(s): 梶 弘和
  • Organizer: 日本バイオマテリアル学会東北地域講演会
  • Place of Presentation: 仙台
  • Year and Date: 2016-09-26
  • Invited
• [Presentation] Injectable polymeric nanosheets for subretinal cell delivery (2016)
  • Author(s): Hirokazu Kaji, Jin Suzuki, Matsuhiko Nishizawa, Nobuhiro Nagai, Toshiaki Abe
  • Organizer: IEEE NANO 2016
  • Place of Presentation: Sendai
  • Year and Date: 2016-08-22
  • Int'l Joint Research
• [Presentation] 自己展開型薬剤徐放シートの眼科領域への応用 (2016)
  • Author(s): 近藤太郎, Zhaleh Kashkouli Nezhad, 陳俐君, 鈴木 仁, 永井展裕, 西澤松彦, 阿部俊明, 梶 弘和
  • Organizer: 第32回日本DDS学会学術集会
  • Place of Presentation: 静岡
  • Year and Date: 2016-06-30
• [Presentation] Cell delivery system using injectable polymeric films (2016)
  • Author(s): Hirokazu Kaji, Taro Kondo, Jin Suzuki, Nobuhiro Nagai, Toshiaki Abe
  • Organizer: 10th World Biomaterials Congress
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2016-05-17
  • Int'l Joint Research
• [Presentation] Microfludic cell culture model of the ocular fundus (2016)
  • Author(s): Li-Jiun Chen, Shunich Tsunajima, Matsuhiko Nishizawa, Nobuhiro Nagai, Toshiaki Abe, Hirokazu Kaji
  • Organizer: 10th World Biomaterials Congress
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2016-05-17
  • Int'l Joint Research
• [Presentation] Development of self-deployment and drug release polymeric film device (2016)
  • Author(s): Taro Kondo, Zhaleh Kashkouli Nezhad, Li-Jiun Chen, Jin Suzuki, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji
  • Organizer: 10th World Biomaterials Congress
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2016-05-17
  • Int'l Joint Research
• [Presentation] マイクロ・ナノ技術を用いた細胞操作と医工領域への展開 (2016)
  • Author(s): 梶 弘和
  • Organizer: 化学とマイクロ・ナノシステム学会第33回研究会
  • Place of Presentation: 東京
  • Year and Date: 2016-04-25
  • Invited
• [Presentation] インジェクション可能な薬剤徐放シートの眼科領域への応用 (2016)
  • Author(s): 近藤太郎, Zhaleh Kashkouli Nezhad, 鈴木 仁, 陳俐君, 永井展裕, 西澤松彦, 阿部俊明, 梶 弘和
  • Organizer: 化学とマイクロ・ナノシステム学会第33回研究会
  • Place of Presentation: 東京
  • Year and Date: 2016-04-25
• [Presentation] 細胞担持高分子ナノ薄膜の電気化学的マニピュレーション (2016)
  • Author(s): 鈴木 仁, 近藤太郎, 永井展祐, 西澤松彦, 阿部俊明, 梶 弘和
  • Organizer: 化学とマイクロ・ナノシステム学会第33回研究会
  • Place of Presentation: 東京
  • Year and Date: 2016-04-25
• [Presentation] Cell and drug delivery systems for retinal diseases (2016)
  • Author(s): Hirokazu Kaji
  • Organizer: EMN Meeting on Biomaterials
  • Place of Presentation: Phuket, Thailand
  • Year and Date: 2016-04-04
  • Int'l Joint Research / Invited
• [Presentation] Polymeric thin films for cell and drug delivery (2015)
  • Author(s): Hirokazu Kaji
  • Organizer: IEEE-NANOMED 2015
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2015-11-15
  • Int'l Joint Research / Invited
• [Presentation] Injectable ultrathin polymeric films for subretinal cell delivery (2015)
  • Author(s): Hirokazu Kaji, Taro Kondo, Nobuhiro Nagai, Toshiaki Abe
  • Organizer: 2015 BMES Annual Meeting
  • Place of Presentation: Tampa, Florida, USA
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] Injectable polymeric nanosheets for subretinal cell delivery (2015)
  • Author(s): Hirokazu Kaji, Taro Kondo, Yoshihiro Mori, Nobuhiro Nagai, Toshiaki Abe
  • Organizer: 4th TERMIS World Congress
  • Place of Presentation: Boston, MA, USA
  • Year and Date: 2015-09-08
  • Int'l Joint Research
• [Presentation] 高分子薄膜を用いた上皮細胞への力学的負荷システムの開発 (2015)
  • Author(s): 綱嶋俊一, Li-Jiun Chen, 近藤太郎, 藤枝俊宣, 永井展裕, 西澤松彦, 阿部俊明, 梶 弘和
  • Organizer: 第22回HAB研究機構学術年会
  • Place of Presentation: 昭和大学, 東京
  • Year and Date: 2015-06-26
• [Presentation] Cell manipulation based on micro/nanotechnologies and biomedical application (2015)
  • Author(s): Hirokazu Kaji
  • Organizer: 7th International Symposium on Microchemistry and Microsystems (ISMM)
  • Place of Presentation: Kyoto, Kyoto Univ
  • Year and Date: 2015-06-08
  • Int'l Joint Research / Invited
• [Presentation] A microfluidic cell culture model of the ocular fundus (2015)
  • Author(s): Li-Liun Chen, Shunichi Tsunajima, Kuniaki Nagamine, Matsuhiko Nishizawa, Nobuhiro Nagai, Toshiaki Abe, Hirokazu Kaji
  • Organizer: 7th International Symposium on Microchemistry and Microsystems (ISMM)
  • Place of Presentation: Kyoto, Kyoto Univ
  • Year and Date: 2015-06-08
  • Int'l Joint Research
• [Presentation] Subretinal injection of micropatterned nanosheets for effective cell delivery (2015)
  • Author(s): Hirokazu Kaji, Yoshihiro Mori, Toshinori Fujie, Nobuhiro Nagai, Toshiaki Abe
  • Organizer: 2015 Annual Meeting of the Society For Biomaterials
  • Place of Presentation: Charlotte, NC, USA
  • Year and Date: 2015-04-15
  • Int'l Joint Research
• [Presentation] マイクロ・ナノ技術を用いた細胞操作と医工領域への展開 (2015)
  • Author(s): 梶 弘和
  • Organizer: 電気化学会第82回大会
  • Place of Presentation: 横浜, 横浜国立大学
  • Year and Date: 2015-03-15 – 2015-03-17
  • Invited
• [Presentation] ナノシートを用いる眼内細胞送達システムの開発 (2015)
  • Author(s): 森 好弘, 藤枝俊宣, 永井展裕, 西澤松彦, 阿部俊明, 梶 弘和
  • Organizer: 第27回バイオエンジニアリング講演会
  • Place of Presentation: 新潟、朱鷺メッセ
  • Year and Date: 2015-01-09 – 2015-01-10
• [Presentation] Characterization of retinal pigment epithelial cells and endothelial cells within a microfluidic device towards a retina on a chip (2014)
  • Author(s): Hirokazu Kaji, Shuntaro Ito, Kuniaki Nagamine, Matsuhiko Nishizawa, Nobuhiro Nagai, Toshiaki Abe
  • Organizer: MicroTAS 2014
  • Place of Presentation: San Antonio, TX, USA
  • Year and Date: 2014-10-26 – 2014-10-30
• [Presentation] Development of a cell-based model of the ocular fundus within a microfluidic device (2014)
  • Author(s): Hirokazu Kaji, Shuntaro Ito, Kuniaki Nagamine, Matsuhiko Nishizawa, Nobuhiro Nagai, Toshiaki Abe
  • Organizer: 2014 BMES Annual Meeting
  • Place of Presentation: San Antonio, TX, USA
  • Year and Date: 2014-10-22 – 2014-10-25
• [Presentation] 圧力負荷機構を用いた上皮細胞の力学的評価システムの開発 (2014)
  • Author(s): 綱嶋俊一, 森 好弘, 藤枝俊宣, 永井展裕, 西澤松彦, 阿部俊明, 梶 弘和
  • Organizer: 化学とマイクロ・ナノシステム学会第30回研究会
  • Place of Presentation: 札幌、北海道大学
  • Year and Date: 2014-10-02 – 2014-10-03
• [Presentation] Local delivery of an engineered epithelial monolayer by micropatterned polymeric Nanosheets (2014)
  • Author(s): Hirokazu Kaji, Toshinori Fujie, Nobuhiro Nagai, Toshiaki Abe
  • Organizer: ARVO 2014 Annual Meeting
  • Place of Presentation: Orland, Florida, USA
  • Year and Date: 2014-05-04 – 2014-05-08
• [Presentation] Cell delivery system using micropatterned polymeric nanosheets (2014)
  • Author(s): Hirokazu Kaji, Toshinori Fujie, Yoshinori Mori, Nobuhiro Nagai, Ali Khademhosseini, Toshiaki Abe
  • Organizer: 2014 Annual Meeting of the Society For Biomaterials
  • Place of Presentation: Denver, CO, USA
  • Year and Date: 2014-04-16 – 2014-04-19
• [Book] “Transscleral controlled delivery of geranylgeranylaceton using a polymeric device protects rat retina against light injury” In Retinal Degenerative Diseases (2016)
  • Author(s): Nobuhiro Nagai, Hirokazu Kaji, Matsuhiko Nishizawa, Toru Nakazawa, Toshiaki Abe
  • Publisher: Springer
• [Book] “Microfabrication and nanofabrication techniques”, In Stem Cell Biology and Tissue Engineering in Dental Sciences (2015)
  • Author(s): Samad Ahadian, Serge Ostrovidov, Toshinori Fujie, Selvakumar Prakash Parthiban, Hirokazu Kaji, Kaarunya Sampathkumar, Murugan Ramalingam, Ali Khademhosseini
  • Total Pages: 11
  • Publisher: Elsevier Publishing
• [Book] Bioinspired Muscle Tissue Devices (2015)
  • Author(s): Toshinori Fujie, Serge Ostrovidov, Samad Ahadian, S. Prakash Parthiban, Ali Khademhosseini, Hirokazu Kaji
  • Publisher: World Scientific Publishing
• [Book] Microfluidic systems for controlling stem cell microenvironments (2015)
  • Author(s): Seila Selimovic, Hirokazu Kaji, Hojae Bae, Ali Khademhosseini
  • Publisher: Elsevier Publishing
• [Book] Intrascleral transplantation of a collagen sheet with cultured brain-derived neurotrophic factor expressing cells partially rescues the retina from damage due to acute high intraocular pressure (2014)
  • Author(s): Toshiaki Abe, Yumi Tokita-Ishikawa, Hideyuki Onami, Yuki Katsukura, Hirokazu Kaji, Matsuhiko Nishizawa, Nobuhiro Nagai
  • Total Pages: 862
  • Publisher: Springer
• [Patent(Industrial Property Rights)] 細胞・薄膜複合体の製造技術 (2016)
  • Inventor(s): 梶 弘和, 鈴木 仁, 永井展裕, 阿部俊明
  • Industrial Property Rights Holder: 梶 弘和, 鈴木 仁, 永井展裕, 阿部俊明
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-086455
  • Filing Date: 2016-04-22
• [Patent(Industrial Property Rights)] 形状制御されたナノシート及びその製造方法 (2015)
  • Inventor(s): 岩瀬英治,新保創太,武岡真司,藤枝俊宣,梶弘和,阿部俊明
  • Industrial Property Rights Holder: 岩瀬英治,新保創太,武岡真司,藤枝俊宣,梶弘和,阿部俊明
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-043990
  • Filing Date: 2015-03-05
• [Patent(Industrial Property Rights)] 細胞担持パターン化ナノ薄膜 (2014)
  • Inventor(s): 梶弘和,藤枝俊宣,森好弘,西澤松彦,阿部俊明,永井展裕
  • Industrial Property Rights Holder: 梶弘和,藤枝俊宣,森好弘,西澤松彦,阿部俊明,永井展裕
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-06-27
  • Overseas