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Real-time in situ measurements of free radicals during Plasma sterilization

Research Project

Project/Area Number 26286071
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Plasma electronics
Research InstitutionNagoya University

Principal Investigator

Ishikawa Kenji  名古屋大学, 工学(系)研究科(研究院), 教授 (60417384)

Co-Investigator(Renkei-kenkyūsha) OHTA Takayuki  名城大学, 理工学部, 准教授 (10379612)
TANAKA Hiromasa  名古屋大学, 大学院工学研究科, 特任講師 (00508129)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywordsプラズマ滅菌 / 電子スピン共鳴 / プラズマ化学 / 代謝解析 / プラズマ加工 / 代謝
Outline of Final Research Achievements

The low-temperature plasma sterilization have advantages for applications. However, complexity of plasma processes arises from the involvement of a myriad of species including: electrons, ions, radicals, and photons. Such plasma components are needed to be measured and analyzed for fine-tuning the process. To determine the best practice for the sterilization, plasma diagnostics were conducted on clarifying the relationship between the control parameters and the plasma parameters.
Penicillium digitatum spores, which causes green mold on citrus, are inactivated by contribution of extracellular reactive oxygen species (ROS). The stable free radical as semiquinone in the spores decreases during oxygen atom irradiation observed using real time in situ electron spin resonance (ESR). The plasma electrical discharge induce metabolic modification. Also, intracellular metabolites induce the inactivation of spores. These understanding provides the development of plasma sources.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (26 results)

All 2017 2016 2015 2014

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (24 results) (of which Int'l Joint Research: 8 results,  Invited: 10 results)

  • [Journal Article] Cold plasma interactions with enzymes in foods and model systems2016

    • Author(s)
      N. N. Misra, S. K. Pankaj, Annalisa Segat, Kenji Ishikawa
    • Journal Title

      Trends in Food Science & Technology

      Volume: 55 Pages: 39-47

    • DOI

      10.1016/j.tifs.2016.07.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Quantitative clarification of inactivation mechanism of Penicillium digitatum spores treated with neutral oxygen radicals2014

    • Author(s)
      Hiroshi Hashizume, Takayuki Ohta, Keigo Takeda, Kenji Ishikawa, Masaru Hori, Masafumi Ito
    • Journal Title

      Jpn. J. Appl. Phys.

      Volume: 54 Issue: 1S Pages: 01AG05-01AG05

    • DOI

      10.7567/jjap.54.01ag05

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 医療・バイオ応用プラズマ技術2017

    • Author(s)
      石川健治
    • Organizer
      電子情報技術部会 エレクトロニクス交流会エレクトロニクス応用技術講演会「プラズマエレクトロニクスの新展開」
    • Place of Presentation
      東京都千代田区
    • Year and Date
      2017-03-29
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Plasma technology for medicine and bio application2017

    • Author(s)
      Kenji Ishikawa
    • Organizer
      International Workshop on advanced plasma applications on bio and nanomaterials
    • Place of Presentation
      Nagoya, Japan
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Plasma-activated Medium (PAM) and Metabolic Analysis of Glioblastoma (U251SP)2016

    • Author(s)
      Kenji Ishikawa
    • Organizer
      International Symposium on Material Research Society Japan (MRS-J)
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2016-12-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] なぜプラズマは生体に作用するか2016

    • Author(s)
      石川健治
    • Organizer
      第17回プラズマ医療 サイエンスの扉&サイエンスカフェ
    • Place of Presentation
      名古屋
    • Year and Date
      2016-12-16
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] CE-TOF-MS analysis of aerobic glycolysis metabolism on glioblastoma (U251SP) modified in electrically discharged plasma activated medium (PAM) cultivation2016

    • Author(s)
      Kenji Ishikawa
    • Organizer
      6th NU-SKKU Joint Symposium on Neuroscience was held at Center of Neuroscience Imaging Research
    • Place of Presentation
      Suwon, Korea
    • Year and Date
      2016-11-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] プラズマが照射された液体中の活性種の分析2016

    • Author(s)
      石川健治
    • Organizer
      プラズマ・核融合学会第33回年会
    • Place of Presentation
      仙台
    • Year and Date
      2016-11-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Metabolic profiles on glioblastoma (U251SP) modified in plasma-activated medium (PAM) cultivation2016

    • Author(s)
      Kenji Ishikawa, N. Kurake, H. Tanaka, H. Hashizume, K. Takeda, K. Nakamura, H. Kajiyama, H. Kondo, M. Sekine, M. Kato, M. Mizuno, F. Kikkawa, M. Hori
    • Organizer
      International Conference on Plasma Medicine (ICPM)
    • Place of Presentation
      Blatislava, Slovakia
    • Year and Date
      2016-09-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] プラズマ活性化溶液(PAM)培養した 脳腫瘍細胞(U251SP)の 代謝プロファイル2016

    • Author(s)
      石川健治, 倉家 尚之, 田中 宏昌, 橋爪 博司, 竹田 圭吾, 中村 香江, 梶山 広明, 近藤 博基, 関根 誠, 加藤 昌志, 水野 正明, 吉川 史隆, 堀 勝
    • Organizer
      日本酸化ストレス学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-08-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Latent Chemistry in Plasma activated medium (PAM)2016

    • Author(s)
      Kenji Ishikawa
    • Organizer
      20th International Vacuum congress (IVC-20)
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diagnostics of activated species generated by non-equilibrium atmospheric pressure plasmas for plasma biomedical applications2016

    • Author(s)
      Kenji Ishikawa
    • Organizer
      International Workshop on Plasma Spectroscopy (IPS)
    • Place of Presentation
      Inuyama, Japan
    • Year and Date
      2016-06-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Sterilization efficiency enhancement by using magnet-assisted-plasma jet2016

    • Author(s)
      Chih-Tung Liu, Takumi Kumakura, Kenji Ishikawa, Hiroshi Hashizume, Keigo Takeda, Masafumi Ito, Masaru Hori, and Jong-Shinn Wu
    • Organizer
      ISPlasma 2016/9th IC-PLANTS
    • Place of Presentation
      Nagoya University
    • Year and Date
      2016-03-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 医療バイオ応用プラズマ2015

    • Author(s)
      石川健治
    • Organizer
      第26回プラズマエレクトロニクス講習会
    • Place of Presentation
      東京大学武田先端知
    • Year and Date
      2015-12-20
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Nonlinear optical spectroscopic measurements of plasma-treated bio-surfaces2015

    • Author(s)
      Kenji Ishikawa, Ryo Furuta, K. Takeda, T. Ohta, H. Hashizume, H. Kondo, M. Ito, M. Sekine, and M. Hori
    • Organizer
      第25回日本MRS年次大会 国際シンポジウムC-5
    • Place of Presentation
      横浜市開港記念会館、横浜情報文化センター
    • Year and Date
      2015-12-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nonlinear Optical Spectroscopic Observation of Plasma-Treated Bio- Specimen2015

    • Author(s)
      Kenji Ishikawa, Ryo Furuta, K. Takeda, T. Ohta, H. Hashizume, H. Kondo, M. Ito, M. Sekine, and M. Hori
    • Organizer
      International Symposimum on American Vacuum Scoiety (AVS)
    • Place of Presentation
      San Jose, CA, USA
    • Year and Date
      2015-10-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sterilization efficiency of the Atmospheric Pressure Jet Entrained Ambient Air2015

    • Author(s)
      Chih-Tung Liu, Meng-Hua Hu, Kenji Ishikawa, Masaru Hori, J. S. Wu
    • Organizer
      第76回応用物理学会秋季学術講演会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 非平衡大気圧プラズマ照射培養液中の酸窒化活性種の計測と抗腫瘍効果2015

    • Author(s)
      石川 健治   倉家 尚之, 田中 宏昌, 近藤 隆, 水野 寛子, 大沼 章子, 加藤 昌志, 中村 香江, 梶山 広明, 竹田 圭吾, 近藤 博基, 関根 誠, 吉川 史隆, 水野 正明, 堀 勝
    • Organizer
      第68回日本酸化ストレス学会学術集会
    • Place of Presentation
      鹿児島県民交流センター
    • Year and Date
      2015-06-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Plasma-Biological Surface Interaction for Food Hygiene2014

    • Author(s)
      Kenji Ishikawa, Hiroshi Hashizume, Takayuki Ohta, Masafumi Ito, Keigo Takeda, Hiromasa Tanaka, Hiroki Kondo, Makoto Sekine, and Masaru Hori
    • Organizer
      E-MRS and MRS-J Joint Symposium
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Electron spin resonance(ESR) Study of edible meat irradiated atmospherics-pressure-plasmas2014

    • Author(s)
      Kenji Ishikawa, Hiroshi Hashizume, Takayuki Ohta, Masafumi Ito, Hiromasa Tanaka, Keigo Takeda, Hiroki Kondo, Makoto Sekine, and Masaru Hori
    • Organizer
      IUMRS-ICA Symposium D-2 Frontier of Nano-Materials Based on Advanced Plasma Technologies
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2014-08-26 – 2014-08-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Plasma-Biological Material Interactions Studied by Employing Electron Spin Resonance (ESR) Technique2014

    • Author(s)
      Kenji Ishikawa, Hiroshi Hashizume, Takayuki Ohta, Masafumi Ito, Hiromasa Tanaka, Keigo Takeda, Satomi Tajima, Hiroki Kondo, Makoto Sekine, and Masaru Hori
    • Organizer
      The XXII Europhysics Conference on Atomic and Molecular Physics of Ionized Gases (ESCAMPIG)
    • Place of Presentation
      Greifswald, Germany
    • Year and Date
      2014-07-15 – 2014-07-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Microscopic observation of inactivation process of fungal spores treated with oxygen radicals produced from an atmospheric-pressure plasma2014

    • Author(s)
      Hiroshi Hashizume, Takuya Towatari, Takayuki Ohta, Keigo Takeda, Kenji Ishikawa, Masaru Hori, and Masafumi Ito
    • Organizer
      The 17th Biennial Meeting for the Society for Free Radical Research International (SFRRI 2014)
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2014-05-24 – 2014-05-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Quantitative evaluation of the inactivation process of P. digitatumspores on the basis of dose of ground-state atomic oxygen2014

    • Author(s)
      Hiroshi Hashizume, Takuya Towatari, Takayuki Ohta, Keigo Takeda, Kenji Ishikawa, Masaru Hori, and Masafumi Ito
    • Organizer
      International Workshop on Diagnostics and Modelling for Plasma Medicine (DMPM2014)
    • Place of Presentation
      Nara, Japan
    • Year and Date
      2014-05-23 – 2014-05-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Inactivation process of P. digitatum spores evaluated by dose of ground-state atomic oxygen2014

    • Author(s)
      Hiroshi Hashizume, Takuya Towatari, Takayuki Ohta, Keigo Takeda, Kenji Ishikawa, Masaru Hori, and Masafumi Ito
    • Organizer
      The 5th International Conference on Plasma Medicine (ICPM5)
    • Place of Presentation
      Nara, Japan
    • Year and Date
      2014-05-17 – 2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Inactivation of microorganism in liquid treated with neutral reactive oxygen species2014

    • Author(s)
      Takuya Towatari, Hiroshi Hashizume, Takayuki Ohta, Keigo Takeda, Kenji Ishikawa, Masaru Hori, and Masafumi Ito
    • Organizer
      The 5th International Conference on Plasma Medicine (ICPM5)
    • Place of Presentation
      Nara, Japan
    • Year and Date
      2014-05-17 – 2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Electron Spin Resonance Study of Plasma-Biological Surface Interactions under Atmospheric Pressure Plasmas2014

    • Author(s)
      Kenji Ishikawa, Hiroshi Hashizume, Takayuki Ohta, Masafumi Ito, Hiromasa Tanaka, Keigo Takeda, Satomi Tajima, Hiroki Kondo, Makoto Sekine, and Masaru Hori
    • Organizer
      The 5th International Conference on Plasma Medicine (ICPM5)
    • Place of Presentation
      Nara, Japan
    • Year and Date
      2014-05-17 – 2014-05-23
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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