• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of X-Ray Optics for establishment of X-ray Pathology

Research Project

Project/Area Number 26286079
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Quantum beam science
Research InstitutionTokyo University of Science

Principal Investigator

Ando Masami  東京理科大学, 研究推進機構総合研究院, 教授 (30013501)

Co-Investigator(Kenkyū-buntansha) 鈴木 芳文  九州工業大学, 工学(系)研究科(研究院), 教授 (10206550)
市原 周  独立行政法人国立病院機構(名古屋医療センター臨床研究センター), 病理検査科, 科長 (30426499)
曽我 公平  東京理科大学, 基礎工学部, 教授 (50272399)
相川 直幸  東京理科大学, 基礎工学部, 教授 (60192829)
湯浅 哲也  山形大学, 理工学研究科, 教授 (30240146)
砂口 尚輝  群馬大学, 理工学研究科, 助教 (60536481)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
KeywordsX線光学 / 病理学検査 / 乳がん検診 / X線暗視野法 / X線医用画像 / 放射光 / シリコン単結晶 / 薄板 / 人体軟組織 / 2D像 / 3D像 / 光学 / 超精密計測 / X線 / 画像 / 可視化 / X線光学系 / 病理学 / X線回折 / X線動力学理論 / 機械研削 / 医用画像 / 屈折原理 / 2次元画像 / 3次元画像 / 空間解像度
Outline of Final Research Achievements

Using X-ray Dark-Field Imaging optics we have developed improvement of the spatial resolution. The system comprises 2 crystals, one is called asymmetric-cut monochromator-collimator (MC) and the second one is called Laue angle analyzer (LAA). MC has asymmetric angle of 10.2 deg while the Bragg angle was 10.6 deg for 440 diffraction and 35 keV X-rays. As a result of this selection b has become 0.02 that has made the divergence of outgoing beam from MC was 0.05 arc sec. LAA has a relation between its thickness and the spatial resolution by calculation based on Takagi-Taupin theory. The theoretical limit of thickness of LAA is 60 micrometers while in practice there is some technical limit so that we have achieved the spatial resolution of 8.5 micrometers.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (29 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (5 results) Journal Article (7 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 7 results,  Open Access: 7 results,  Acknowledgement Compliant: 6 results) Presentation (13 results) (of which Int'l Joint Research: 6 results,  Invited: 13 results) Book (2 results) Funded Workshop (2 results)

  • [Int'l Joint Research] デグカソリック大学医学部/ソウル国立大学医学部(韓国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] 中国科学院高能物理研究所北京放射光施設(中国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] デグカソリック大学医学部/ソウル国立大学医学部(韓国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] 中国科学院北京高能物理学研究所放射光研究施設(中国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] ハーバード大学マサチューセッツ総合病院(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Dark-Field Imaging: Recent Developments and Potential Clinical Application2016

    • Author(s)
      Masami Ando, Naoki Sunaguchi, Daisuke Shimao, Adam Pan, Tetsuya Yuasa, Kensaku Mori, Yoshifumi Suzuki, Ge Jin, Jong-Ki Kim, Jae-Hong Lim, Seung-Jun Seo, Shu Ichihara, Norihiko Ohura and Rajiv Gupta
    • Journal Title

      Physics Medical

      Volume: 32 Pages: 1801-1812

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] An Efficient Reconstruction Algorithm for Differential Phase-contrast Tomographic images from a Limited Number of Views2015

    • Author(s)
      Naoki Sunaguchi, Tetsuya Yuasa, Rajiv Gupta, and Masami Ando
    • Journal Title

      Applied Physics Letters

      Volume: 107 Pages: 253701-253703

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] In vitro Validation of an Artefact Suppression Algorithm in X-ray Phase-contrast Computed Tomography2015

    • Author(s)
      Naoki Sunaguchi, Tetsuya Yuasa, Shin-ichi Hirano, Rajiv Gupta, Masami Ando
    • Journal Title

      PLOS ONE

      Volume: 10 Pages: 35654-35664

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Limited View Reconstruction for Differential Phase-contrast Computed Tomography2015

    • Author(s)
      Naoki Sunaguchi, Tetsuya Yuasa, Fengrong Sun, Rajiv Gupta, and Masami Ando
    • Journal Title

      Optics Express

      Volume: 23 Pages: 9717-9729

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Limited view reconstruction for differential phase-contrast computed tomography2015

    • Author(s)
      Naoki Sunaguchi, Tetsuya Yuasa, Fengrong Sun, Rajiv Gupta, and Masami Ando
    • Journal Title

      Optics Express

      Volume: 23 Pages: 9717-9729

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] In vitro validation of an artefact suppression algorithm in x-ray phase-contrast computed tomography2015

    • Author(s)
      Naoki Sunaguchi, Tetsuya Yuasa, Shin-ichi Hirano, Rajiv Gupta, Masami Ando
    • Journal Title

      PLOS ONE

      Volume: 12 Pages: 1-5

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Three-dimensional observation of sclerosing adenosis involved by lobular carcinoma in situ using crystal analyzer-based X-ray phase contrast CT2014

    • Author(s)
      Shu Ichihara, Kensaku Mori, Naoki Sunaguchi, Yuasa Tetsuya, Yanlin Wu, Masami Ando
    • Journal Title

      Archiv

      Volume: 465 Supplement 1

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] XDFI光学系における空間解像度評価2016

    • Author(s)
      中尾悠基、安藤正海
    • Organizer
      AMSI2015 (10TH ASIAN MEETING ON SYNCHROTRON RADIATION BIOMEDICAL IMAGING)
    • Place of Presentation
      山形大学医学部
    • Year and Date
      2016-02-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Recent Attempt at Achieving Higher Spatial Resolution in X-Ray Dark-Field Imaging for Hits-Pathological Applications2016

    • Author(s)
      Masami Ando
    • Organizer
      10th Asian Meeting on Synchrotron Radiation BioMedical Imaging (AMSI2016)
    • Place of Presentation
      ソウル国立大学平昌キャンパス
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 病理検査への応用を指向するX線暗視野法光学系開発2015

    • Author(s)
      安藤正海
    • Organizer
      第54回臨床細胞学会シンポジウム 高精度X線撮影の理論と実用性
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Operational Experience of X-Ray Dark-Field Imaging Optics for Medicine at BL14C of Photon Factory and at BL6C of Pohang Light Source2015

    • Author(s)
      ANDO M., GUO J., GUPTA R., HAN S.-M., ICHIHARA S., JIN G., KIM J.-K., KIM H., LIM J.-H., SEO S.-J., SUNAGUCHI N., SUZUKI Y., YUASA T.
    • Organizer
      KOSUA (韓国放射光利用者会議)
    • Place of Presentation
      浦項市(韓国)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] X-Ray Optics ‘XDFI (x-ray dark-field imaging)’ Suitable for Visualizing Human Soft Tissue and Its Clinical and Pathological Attempt2015

    • Author(s)
      M.Ando, T.Yuasa, N. Sunaguchi, K. Mori, Y. Suzuki, G. Jin, J.-K. Kim, H. Kim, J.H. Lim, S.-J. Seo, G. Jin, G. Li
    • Organizer
      MASR2015 (8TH MADICAL APPLICATION OF SYNCHROTRON RADIATION)
    • Place of Presentation
      グルノーブル(フランス)
    • Year and Date
      2015-10-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of X-ray Dark-Field Imaging for Clinical and Pathological Applications2015

    • Author(s)
      M. Ando, T. Yuasa, N. Sunaguchi, Y. Suzuki, G. Jin, S. Ichihara, K. Mori, R. Gupta
    • Organizer
      第54回日本生体医工学会大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-05-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Collaboration between Korea and Japan on Synchrotron Radiation Based Biomedical Imaging2014

    • Author(s)
      安藤正海, Lim J.-H., Seo S.-J., Kim J.-K., Kim H.-T., Kim K.-H., Choi C.-H., Choi G.-H., Park S.-H., Han S.-M., Jheon S.-H., Yuasa T., Suzuki Y., Jin G., Sunaguchi N., Ichihara S., Sugiyama H
    • Organizer
      Pohang Accelerator Laboratory Users Meeting
    • Place of Presentation
      韓国浦項市国際会館
    • Year and Date
      2014-11-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Opening Remark2014

    • Author(s)
      安藤正海
    • Organizer
      9th Asian Meeting on Synchrotron Radiation BioMedical Imaging
    • Place of Presentation
      中国雲南省シャングリラ市
    • Year and Date
      2014-11-05 – 2014-11-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] How to achieve higher spatial resolution in X-ray pathology imaging2014

    • Author(s)
      安藤正海, Lim J.-H., Seo S.-J., Han S.-M., Kim J.-K., Kim H.-T., Guo J., Li G., Yuasa T., Suzuki Y., Jin G., Sugiyama H., Hirano K., Sunaguchi N., Takahashi T., Sung Y., Ichihara S., Jheon S., Gupta R
    • Organizer
      9th Asian Meeting on Synchrotron Radiation BioMedical Imaging
    • Place of Presentation
      中国雲南省シャングリラ市
    • Year and Date
      2014-11-05 – 2014-11-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Concluding Remark2014

    • Author(s)
      安藤正海
    • Organizer
      9th Asian Meeting on Synchrotron Radiation BioMedical Imaging
    • Place of Presentation
      中国雲南省シャングリラ市
    • Year and Date
      2014-11-05 – 2014-11-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] X線暗視野法開発その後 ー高解像度へ向かってー2014

    • Author(s)
      安藤正海
    • Organizer
      ナノ粒子造影CTによる肺2次小葉の細血管ネットワークの解明に関する研究打合せ
    • Place of Presentation
      徳島市徳島大学工学部光応用工学科棟
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Three-dimensional observation of sclerosing adenosis involved by lobular carcinoma in situ using crystal analyzer-based X-ray phase contrast CT2014

    • Author(s)
      Shu Ichihara, Kensaku Mori, Naoki Sunaguchi, Yuasa Tetsuya, Yanlin Wu, Masami Ando
    • Organizer
      欧州病理学会
    • Place of Presentation
      連合王国London市ExCel
    • Year and Date
      2014-08-30 – 2014-09-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] X線暗視野法:過去・現在・未来 ー医用画像開発ー2014

    • Author(s)
      安藤正海
    • Organizer
      位相コントラストによる高精度医用画像研究会
    • Place of Presentation
      名古屋市名古屋駅前科学技術交流財団研究交流センター
    • Year and Date
      2014-07-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Book] Crystal-based X-ray Medical Imaging Using Synchrotron Radiation and Its Future Prospect2017

    • Author(s)
      Masami Ando, Naoki Sunaguchi, Yongjin Sung,Daisuke Shimao, Jong-Ki Kim, Gang Li, Yoshifumi Suzuki, Tetsuya Yuasa, Kensaku Mori, Shu Ichihara, and Rajiv Gupta
    • Total Pages
      1000
    • Publisher
      World Scientific Publisher
    • Related Report
      2016 Annual Research Report
  • [Book] Application of Synchrotron Radiation: 1st chapter: Crystal-based X-ray Medical Imaging Using Synchrotron Radiation and Its Future Prospect2015

    • Author(s)
      Masami Ando, Naoki Sunaguchi, Yongjin Sung, Jong-Ki Kim, Li Gang, Yoshifumi Suzuki, Tetsuya Yuasa, Kensaku Mori Shu Ichihara, and Rajiv Gupta
    • Total Pages
      300
    • Publisher
      World Scientific Publisher
    • Related Report
      2014 Annual Research Report
  • [Funded Workshop] AMSI2015 (10TH ASIAN MEETING ON SYNCHROTRON RADIATION BIOMEDICAL IMAGING)2016

    • Place of Presentation
      山形大学医学部
    • Year and Date
      2016-02-19
    • Related Report
      2015 Annual Research Report
  • [Funded Workshop] 10th Asian Meeting on Synchrotron Radiation BioMedical Imaging (AMSI2016)2016

    • Place of Presentation
      ソウル国立大学平昌キャンパス
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi