Development of X-Ray Optics for establishment of X-ray Pathology
| Project/Area Number |
26286079
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Quantum beam science
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
Ando Masami 東京理科大学, 研究推進機構総合研究院, 教授 (30013501)
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 芳文 九州工業大学, 工学(系)研究科(研究院), 教授 (10206550)
市原 周 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), 病理検査科, 科長 (30426499)
曽我 公平 東京理科大学, 基礎工学部, 教授 (50272399)
相川 直幸 東京理科大学, 基礎工学部, 教授 (60192829)
湯浅 哲也 山形大学, 理工学研究科, 教授 (30240146)
砂口 尚輝 群馬大学, 理工学研究科, 助教 (60536481)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Keywords | X線光学 / 病理学検査 / 乳がん検診 / X線暗視野法 / X線医用画像 / 放射光 / シリコン単結晶 / 薄板 / 人体軟組織 / 2D像 / 3D像 / 光学 / 超精密計測 / X線 / 画像 / 可視化 / X線光学系 / 病理学 / X線回折 / X線動力学理論 / 機械研削 / 医用画像 / 屈折原理 / 2次元画像 / 3次元画像 / 空間解像度 |
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| Outline of Final Research Achievements |
Using X-ray Dark-Field Imaging optics we have developed improvement of the spatial resolution. The system comprises 2 crystals, one is called asymmetric-cut monochromator-collimator (MC) and the second one is called Laue angle analyzer (LAA). MC has asymmetric angle of 10.2 deg while the Bragg angle was 10.6 deg for 440 diffraction and 35 keV X-rays. As a result of this selection b has become 0.02 that has made the divergence of outgoing beam from MC was 0.05 arc sec. LAA has a relation between its thickness and the spatial resolution by calculation based on Takagi-Taupin theory. The theoretical limit of thickness of LAA is 60 micrometers while in practice there is some technical limit so that we have achieved the spatial resolution of 8.5 micrometers.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Dark-Field Imaging: Recent Developments and Potential Clinical Application2016
Author(s)
Masami Ando, Naoki Sunaguchi, Daisuke Shimao, Adam Pan, Tetsuya Yuasa, Kensaku Mori, Yoshifumi Suzuki, Ge Jin, Jong-Ki Kim, Jae-Hong Lim, Seung-Jun Seo, Shu Ichihara, Norihiko Ohura and Rajiv Gupta
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Journal Title
Physics Medical
Volume: 32
Pages: 1801-1812
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Operational Experience of X-Ray Dark-Field Imaging Optics for Medicine at BL14C of Photon Factory and at BL6C of Pohang Light Source2015
Author(s)
ANDO M., GUO J., GUPTA R., HAN S.-M., ICHIHARA S., JIN G., KIM J.-K., KIM H., LIM J.-H., SEO S.-J., SUNAGUCHI N., SUZUKI Y., YUASA T.
Organizer
KOSUA (韓国放射光利用者会議)
Place of Presentation
浦項市（韓国）
Year and Date
2015-11-20
Related Report
Int'l Joint Research / Invited
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[Presentation] X-Ray Optics ‘XDFI (x-ray dark-field imaging)’ Suitable for Visualizing Human Soft Tissue and Its Clinical and Pathological Attempt2015
Author(s)
M.Ando, T.Yuasa, N. Sunaguchi, K. Mori, Y. Suzuki, G. Jin, J.-K. Kim, H. Kim, J.H. Lim, S.-J. Seo, G. Jin, G. Li
Organizer
MASR2015 (8TH MADICAL APPLICATION OF SYNCHROTRON RADIATION)
Place of Presentation
グルノーブル（フランス）
Year and Date
2015-10-05
Related Report
Int'l Joint Research / Invited
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[Presentation] Collaboration between Korea and Japan on Synchrotron Radiation Based Biomedical Imaging2014
Author(s)
安藤正海, Lim J.-H., Seo S.-J., Kim J.-K., Kim H.-T., Kim K.-H., Choi C.-H., Choi G.-H., Park S.-H., Han S.-M., Jheon S.-H., Yuasa T., Suzuki Y., Jin G., Sunaguchi N., Ichihara S., Sugiyama H
Organizer
Pohang Accelerator Laboratory Users Meeting
Place of Presentation
韓国浦項市国際会館
Year and Date
2014-11-20
Related Report
Invited
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[Presentation] How to achieve higher spatial resolution in X-ray pathology imaging2014
Author(s)
安藤正海, Lim J.-H., Seo S.-J., Han S.-M., Kim J.-K., Kim H.-T., Guo J., Li G., Yuasa T., Suzuki Y., Jin G., Sugiyama H., Hirano K., Sunaguchi N., Takahashi T., Sung Y., Ichihara S., Jheon S., Gupta R
Organizer
9th Asian Meeting on Synchrotron Radiation BioMedical Imaging
Place of Presentation
中国雲南省シャングリラ市
Year and Date
2014-11-05 – 2014-11-08
Related Report
Invited
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[Book] Crystal-based X-ray Medical Imaging Using Synchrotron Radiation and Its Future Prospect2017
Author(s)
Masami Ando, Naoki Sunaguchi, Yongjin Sung,Daisuke Shimao, Jong-Ki Kim, Gang Li, Yoshifumi Suzuki, Tetsuya Yuasa, Kensaku Mori, Shu Ichihara, and Rajiv Gupta
Total Pages
1000
Publisher
World Scientific Publisher
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