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Establishment of the production method of highly polarized 3He gas for the Hyperpolarized 3He-MRI

Research Project

Project/Area Number 26287050
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Particle/Nuclear/Cosmic ray/Astro physics
Research InstitutionKobe Tokiwa University

Principal Investigator

Tanaka Masayoshi  神戸常盤大学, 保健科学部, その他 (70071397)

Co-Investigator(Kenkyū-buntansha) 上田 国寛  神戸常盤大学, 保健科学部, 教授 (00027070)
藤原 守  大阪大学, 核物理研究センター, 協同研究員 (00030031)
太田 岳史  東京大学, 大学病院, 助教 (20727408)
牧野 誠司  和歌山県立医科大学, 医学部, 教授 (70222289)
與曽井 優  大阪大学, 核物理研究センター, 教授 (80183995)
藤村 寿子  和歌山県立医科大学, 医学部, 准教授 (90378589)
Research Collaborator Frossati Georgio  ライデン・ライデンクライオジェニックス社
de Waard Arlette  ライデン・ライデンクライオジェニックス社
Rouillé Gérard  パリー大学南校, 研究員
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywords超偏極3HeーMRI / 3He/4He希釈冷凍機 / 強制偏極法 / 無冷媒3He/4He希釈冷凍機 / 高速融解法 / 無冷媒希釈冷凍機 / ポメランチュク冷却 / 常温超偏極3Heガス / 常温冷媒ガス循環系 / 磁気結合型ロータリポンプ / 59Coゼロ磁場NMR / 実験核物理 / 低温物性 / 極低温物理学 / 強制核偏極法 / 核スピンイメージング / 原子・分子物理学 / 結晶成長 / 低温物理 / 物性実験 / 国際情報交換(蘭、仏)
Outline of Final Research Achievements

The final goal of our project is to produce hyperpolarized, i.e. highly polarized 3He gas for MRI(Magnetic Resonance Imaging) by means of the Brute Force Method with the 3He/4He dilution refrigerator(DRS2500), the 17 T superconducting solenoid coil, a menbrane type Pomeranchuk cell, and the rapid melting equipment which allows rapid conversion of solid 3He to 3He gas at room temperature without significant depolarization.
During the development, we found that it is not an efficient method to use the DRS2500 before fundamental research on, for example, the Pomeranchuk cell often required many revisions of the experimental equipmen. For this purpose, we introduced an easily accessible cryofree 3He/4He dilution refrigerator(Kobe10μ). However, many serious troubles occured in the circulation line of Kobe10μ. It took almost two years for recovering this failure. Now, the development got restarted toward our goal.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (17 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results)

  • [Int'l Joint Research] ライデン大学低温物理研究所/ライデンクライオジェニックス社(オランダ)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] パリー大学南校オルセー原子核研究所(フランス)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Progress in creation of hyperpolarized nuclei for highly sensitive MRI2017

    • Author(s)
      Masayoshi Tanaka, Seiji Makino, Hisako Fujimura, Takeshi Ohta, M. Yosoi, Mamoru Fujiwara, and Kunihiro Ueda
    • Journal Title

      J. Astrophysics, Aerospace Technology 2017

      Volume: 5:2 (Suppl.) Pages: 41-41

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Research activity on experimental nuclear physics aided by atomic physics2017

    • Author(s)
      Masayoshi Tanaka
    • Journal Title

      J. Astrophysics, Aerospace Technology 2017

      Volume: 5:2 (Suppl.) Issue: 02 Pages: 17-17

    • DOI

      10.4172/2329-6542-c1-007

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Production of Hyperpolarized 3He Gas for Medical Imaging2016

    • Author(s)
      M. Tanaka, S. Makino, H. Fujimura, T. Ohta, M. Yosoi, M. Fujiwara, Y. Kasamatsu, K. Ueda, G. Rouille, G. Frossati, and A. de Waard
    • Journal Title

      PoS (Proceedings of Science), Italy

      Volume: PSTP2015 Pages: 1-6

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of 17T-NMR system for measurement of polarized HD and 3He targets2016

    • Author(s)
      T. Ohta, H. Kohri, M. Yosoi, M. Fujiwara, and M. Tanaka
    • Journal Title

      PoS (Proceedings of Science), Italy

      Volume: PSTP2015 Pages: 1-5

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 核スピンイメージング研究の基礎と医用画像研究への展開2014

    • Author(s)
      田中正義、牧野誠司、藤村寿子、太田岳史
    • Journal Title

      電子情報通信学会技術研究報告(IEICE Technical Report)

      Volume: 114 No.311 Pages: 23-29

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Presentation] Progress in creation of hyperpolarized nuclei for highly sensitive MRI2017

    • Author(s)
      Masayoshi Tanaka
    • Organizer
      Atomic Physics 2017, Las Vegas, USA
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Research activity on experimental nuclear physics aided by atomic physics2017

    • Author(s)
      Masayoshi Tanaka
    • Organizer
      Atomic Physics 2017, Las Vegas, USA
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Production of Hyperpolarized Nuclei for Advanced MRI2016

    • Author(s)
      Masayoshi Tanaka
    • Organizer
      BIT's 5th Annual World Congress of Advanced Materials-2016, Chongqing, China
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Production of Hyperpolarized 3He Gas for Medical Imaging2015

    • Author(s)
      田中正義
    • Organizer
      PSTP2015
    • Place of Presentation
      ドイツ・ボッフム大学
    • Year and Date
      2015-09-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of 17T-NMR system for measurement of polarized HD and 3He targets2015

    • Author(s)
      太田岳史
    • Organizer
      PSTP2015
    • Place of Presentation
      ドイツ・ボッフム大学
    • Year and Date
      2015-09-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] 核スピンイメージング研究と医用画像研究への展開2014

    • Author(s)
      田中正義
    • Organizer
      電子情報通信学会
    • Place of Presentation
      イーグレひめじ、姫路
    • Year and Date
      2014-11-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 超偏極-MRIを目指した超偏極3He生成の現状2014

    • Author(s)
      牧野誠司
    • Organizer
      電子情報通信学会
    • Place of Presentation
      イーグレひめじ、姫路
    • Year and Date
      2014-11-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 超偏極-MRIを目指したパラ水素誘導法による超偏極核生成の現状2014

    • Author(s)
      藤村寿子
    • Organizer
      電子情報通信学会
    • Place of Presentation
      イーグレひめじ、姫路
    • Year and Date
      2014-11-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] ポータブルNMRシステム2014

    • Author(s)
      太田岳史
    • Organizer
      電子情報通信学会
    • Place of Presentation
      イーグレひめじ、姫路
    • Year and Date
      2014-11-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Pomeranchuk cell for hyperpolarized 3He based on the brute force2014

    • Author(s)
      牧野誠司
    • Organizer
      日米合同物理学会
    • Place of Presentation
      米国ハワイ州
    • Year and Date
      2014-10-08 – 2014-10-11
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2019-03-29  

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