Development of C-H Transformations Using Noncovalent Interactions
| Project/Area Number |
26288014
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Kyushu University (2015-2017)
The University of Tokyo (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | C-H結合変換 / 非共有結合性相互作用 / 水素結合 / Lewis酸－塩基相互作用 / ボリル化 / シリル化 / メタ位 / オルト位 / 位置選択性 |
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| Outline of Final Research Achievements |
I conducted researches aimed at developing high regioselective carbon-hydrogen (C-H) bond transformations using noncovalent interactions, such as a Lewis acid-base interaction or a hydrogen bonding. As a result, I developed meta-selective C(sp2)-H bond transformation utilizing the hydrogen bonding and ortho-selective C(sp2)-H bond transformation using the Lewis acid-base interaction. These reactions are the first examples that control the regioselectivity of C-H bond transformations by hydrogen bonding or Lewis acid-base interaction between a ligand of the catalyst and a substrate. In addition, I could achieve to creat a new regiocontrol method in C-H bond transformations.
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Report
(5 results)
Research Products
(83 results)
