N-heterocyclic carbene-modified gold nanoparticles for biosensing
| Project/Area Number |
26288023
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Inorganic chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
Crudden Cathleen 名古屋大学, トランスフォーマティブ生命分子研究所, 客員教授 (10721029)
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| Co-Investigator(Renkei-kenkyūsha) |
HIGASHIYAMA Tetsuya 名古屋大学, トランスフォーマティブ生命分子研究所, 教授 (00313205)
NAMBO Masakazu 名古屋大学, トランスフォーマティブ生命分子研究所, 特任講師 (10705528)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Keywords | ナノ材料 / 金ナノ粒子 / N-ヘテロサイクリックカルベン / バイオイメージング / 安定性 / 二座配位子 / Nano Material / Gold Nanoparticles / N-Heterocyclic Carbene / bidentate ligand / Stability / Bio-imaging / Photoacoustic Properties / nano materials / gold nanoparticles / N-heterocyclic carbene / bio-imaging / gold nanoparticle / gold nanocluster / nanoparticle / nanocluster / gold / bioimaging / bioconjugation |
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| Outline of Final Research Achievements |
The goal of this grant was to prepare and test stable gold nanoparticles for potential biosensing applications. We have prepared new gold nanoparticles that were protected by carboxylate-functionalized N-heterocyclic carbenes (NHCs) to be water-souble. The resulting gold particles were stable in the presence of electrolytes and gave photoacoustic signals. In addition, we successfully increased stability of gold nanoparticles against thiols by employing bidentate NHC ligands functionalized with long alkyl chains.
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Report
(5 results)
Research Products
(79 results)
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[Journal Article] Simple direct formation of self-assembled N-heterocyclic carbene monolayers on gold and their application in biosensing2016
Author(s)
C. M. Crudden, J. H. Horton, M. R. Narouz, Z. Li, C. A. Smith, K. Munro, C. J. Baddeley, C. R. Larrea, B. Drevniok, B. Thanabalasingam, A. B. McLean, O. V. Zenkina, I. I. Ebralidze, Z. She, H.-B. Kraatz, N. J. Mosey, L. N. Saunders, A. Yagi
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Journal Title
Nature Communications
Volume: 7
Issue: 1
Pages: 12654-12654
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Iterative protecting group-free cross-coupling leading to chiral multiply arylated structures2016
Author(s)
Cathleen M. Crudden, Christopher Ziebenhaus, Jason P. G. Rygus, Kazem Ghozati, Phillip J. Unsworth,Masakazu Nambo, Samantha Both, Marieke Hutchinson, Veronique S. Laberge, Yuuki Maekawa, Daisuke Imao
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Journal Title
Nature communication
Volume: 7
Issue: 1
Pages: 1-7
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Ultra Stable Self-Assembled Monolayers of N-Heterocyclic Carbenes on Gold2014
Author(s)
C.M. Crudden, J.H. Horton*, I.I. Ebralidze, O.V. Zenkina, A.B. McLean, B. Drevniok, Z. She, H.-B. Kraatz, N.J. Mosey, T. Seki, E.C. Keske, J.D. Leake, A. Rousina-Webb, G. Wu
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Journal Title
Nature Chemistry
Volume: 6
Issue: 5
Pages: 409-414
DOI
Related Report
Peer Reviewed
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[Presentation] Mild, Easy Deposition Method for the Production of Highly Ordered, Ultra Stable NHC-based Films on Gold2015
Author(s)
Crudden CM, Horton JH, Narouz M, Smith C, McLean AB, Drevniok B, Zenkina OV, Ebralidze II, Kraatz HB, She Z, Saunders L, Li Z, Alashred A, Munro K, Baddeley CJ, Larrea CR, Mosey NP.
Organizer
98th Canadian Society for Chemistry conference
Place of Presentation
Ottawa, Canada
Year and Date
2015-06-13
Related Report
Invited
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