N-heterocyclic carbene-modified gold nanoparticles for biosensing

• Project/Area Number: 26288023
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Inorganic chemistry
• Research Institution: Nagoya University
• Principal Investigator: Crudden Cathleen 名古屋大学, トランスフォーマティブ生命分子研究所, 客員教授 (10721029)
• Co-Investigator(Renkei-kenkyūsha): HIGASHIYAMA Tetsuya 名古屋大学, トランスフォーマティブ生命分子研究所, 教授 (00313205) ; NAMBO Masakazu 名古屋大学, トランスフォーマティブ生命分子研究所, 特任講師 (10705528)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000); Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
• Keywords: ナノ材料 / 金ナノ粒子 / N-ヘテロサイクリックカルベン / バイオイメージング / 安定性 / 二座配位子 / Nano Material / Gold Nanoparticles / N-Heterocyclic Carbene / bidentate ligand / Stability / Bio-imaging / Photoacoustic Properties / nano materials / gold nanoparticles / N-heterocyclic carbene / bio-imaging / gold nanoparticle / gold nanocluster / nanoparticle / nanocluster / gold / bioimaging / bioconjugation

Outline of Final Research Achievements

The goal of this grant was to prepare and test stable gold nanoparticles for potential biosensing applications. We have prepared new gold nanoparticles that were protected by carboxylate-functionalized N-heterocyclic carbenes (NHCs) to be water-souble. The resulting gold particles were stable in the presence of electrolytes and gave photoacoustic signals. In addition, we successfully increased stability of gold nanoparticles against thiols by employing bidentate NHC ligands functionalized with long alkyl chains.

Research Products

• [Int'l Joint Research] Queen's University(Canada)
• [Int'l Joint Research] China University of Political Science(China)
• [Int'l Joint Research] クイーンズ大学(カナダ)
• [Int'l Joint Research] セント・アンドルーズ大学(英国)
• [Int'l Joint Research]
• [Int'l Joint Research] Queen's Univerisity(Canada)
• [Journal Article] Ultrastable Gold Nanoparticles Modified by Bidentate N-Heterocyclic Carbene Ligands (2018)
  • Author(s): Man Renee W. Y.、Li Chien-Hung、MacLean Michael W. A.、Zenkina Olena V.、Zamora Matthew T.、Saunders Lisa N.、Rousina-Webb Alexander、Nambo Masakazu、Crudden Cathleen M.
  • Journal Title: Journal of the American Chemical Society Volume: 140 Issue: 5 Pages: 1576-1579
  • DOI: 10.1021/jacs.7b08516
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Azaborines: synthesis and use in the generation of stabilized boron-substituted carbocations (2018)
  • Author(s): Clarke J. J.、Eisenberger P.、Piotrkowski S. S.、Crudden C. M.
  • Journal Title: Dalton Transactions Volume: 47 Issue: 6 Pages: 1791-1795
  • DOI: 10.1039/c7dt01329a
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] N-Heterocyclic Carbene Self-assembled Monolayers on Copper and Gold: Dramatic Effect of Wingtip Groups on Binding, Orientation and Assembly (2017)
  • Author(s): Larrea Christian R.、Baddeley Christopher J.、Narouz Mina R.、Mosey Nicholas J.、Horton J. Hugh、Crudden Cathleen M.
  • Journal Title: ChemPhysChem Volume: 18 Issue: 24 Pages: 3536-3539
  • DOI: 10.1002/cphc.201701045
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Preparation of Quaternary Centers via Nickel-Catalyzed Suzuki?Miyaura Cross-Coupling of Tertiary Sulfones (2017)
  • Author(s): Ariki Zachary T.、Maekawa Yuuki、Nambo Masakazu、Crudden Cathleen M.
  • Journal Title: Journal of the American Chemical Society Volume: 140 Issue: 1 Pages: 78-81
  • DOI: 10.1021/jacs.7b10855
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Enantiospecific and Iterative Suzuki?Miyaura Cross-Couplings (2017)
  • Author(s): Rygus Jason P. G.、Crudden Cathleen M.
  • Journal Title: Journal of the American Chemical Society Volume: 139 Issue: 50 Pages: 18124-18137
  • DOI: 10.1021/jacs.7b08326
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Amphiphilic N-Heterocyclic Carbene-Stabilized Gold Nanoparticles and Their Self-Assembly in Polar Solvents (2017)
  • Author(s): Narouz Mina R.、Li Chien-Hung、Nazemi Ali、Crudden Cathleen M.
  • Journal Title: Langmuir Volume: 33 Issue: 50 Pages: 14211-14219
  • DOI: 10.1021/acs.langmuir.7b02248
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] N-Heterocyclic Carbene Self-Assembled Monolayers on Gold as Surface Plasmon Resonance Biosensors (2017)
  • Author(s): Li Zhijun、Munro Kim、Ebralize Iraklli I.、Narouz Mina R.、Padmos J. Daniel、Hao Hongxia、Crudden Cathleen M.、Horton J. Hugh
  • Journal Title: Langmuir Volume: 33 Issue: 49 Pages: 13936-13944
  • DOI: 10.1021/acs.langmuir.7b03280
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Carboxymethylated Dextran-Modified N-Heterocyclic Carbene Self-Assembled Monolayers on Gold for Use in Surface Plasmon Resonance Biosensing (2017)
  • Author(s): Li Zhijun、Narouz Mina R.、Munro Kim、Hao Bin、Crudden Cathleen M.、Horton J. Hugh、Hao Hongxia
  • Journal Title: ACS Appl. Mater. Interfaces Volume: 9 Issue: 45 Pages: 39223-39234
  • DOI: 10.1021/acsami.7b13114
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Synthesis of Tetraarylmethanes by the Triflic Acid-Promoted Formal Cross-Dehydrogenative Coupling of Triarylmethanes with Arenes (2017)
  • Author(s): Nambo Masakazu、Crudden Cathleen、Yim Jacky、Fowler Kevin
  • Journal Title: Synlett Volume: 28 Issue: 20 Pages: 2936-2940
  • DOI: 10.1055/s-0036-1588563
  • NAID: 120006473514
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Pd-Catalyzed Desulfonative Cross-Coupling of Benzylic Sulfone Derivatives with 1,3-Oxazoles (2017)
  • Author(s): Yim Jacky C.-H.、Nambo Masakazu、Crudden Cathleen M.
  • Journal Title: Organic Letters Volume: 19 Issue: 14 Pages: 3715-3718
  • DOI: 10.1021/acs.orglett.7b01510
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Water-Soluble N-Heterocyclic Carbene-Protected Gold Nanoparticles: Size-Controlled Synthesis, Stability, and Optical Properties (2017)
  • Author(s): Kirsi Salorinne, Renee W. Y. Man, Chien-Hung Li, Masayasu Taki, Masakazu Nambo, Cathleen M. Crudden
  • Journal Title: Angewandte Chemie International Edition Volume: 印刷中 Issue: 22 Pages: 6198-6202
  • DOI: 10.1002/anie.201701605
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Borocation catalysis (2017)
  • Author(s): Patrick Eisenberger, Cathyleen M. Crudden
  • Journal Title: Dalton Transactions Volume: 46 Issue: 15 Pages: 4874-4887
  • DOI: 10.1039/c6dt04232e
  • Peer Reviewed
• [Journal Article] 1. Development of Versatile Sulfone Electrophiles for Suzuki-Miyaura Cross-Coupling Reactions (2017)
  • Author(s): Masakazu Nambo, Eric C. Keske, Jason P. G. Rygus, Jacky, C.-H. Yim, Cathleen M. Crudden
  • Journal Title: ACS Catalysis Volume: 7 Issue: 2 Pages: 1108-1112
  • DOI: 10.1021/acscatal.6b03434
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Installing Stable Molecular Chirality within the Walls of Periodic Mesoporous Organosilicas via Self-Assembly (2016)
  • Author(s): Lacey M. Reid, Cathleen M. Crudden
  • Journal Title: Chemistry of Materials Volume: 28 Issue: 21 Pages: 7605-7612
  • DOI: 10.1021/acs.chemmater.6b02153
  • Peer Reviewed
• [Journal Article] Simple direct formation of self-assembled N-heterocyclic carbene monolayers on gold and their application in biosensing (2016)
  • Author(s): C. M. Crudden, J. H. Horton, M. R. Narouz, Z. Li, C. A. Smith, K. Munro, C. J. Baddeley, C. R. Larrea, B. Drevniok, B. Thanabalasingam, A. B. McLean, O. V. Zenkina, I. I. Ebralidze, Z. She, H.-B. Kraatz, N. J. Mosey, L. N. Saunders, A. Yagi
  • Journal Title: Nature Communications Volume: 7 Issue: 1 Pages: 12654-12654
  • DOI: 10.1038/ncomms12654
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Chiral carbene-borane adducts: precursors for borenium catalysts for asymmetric FLP hydrogenations (2016)
  • Author(s): Jolie Lam, Benjamin A. R. Gunther, Jeffrey M. Farrell, Patrick Eisenberger, Brian P. Bestvater, Paul D. Newman, Rebecca L. Melen, Cathleen M. Crudden, Douglas W. Stephan
  • Journal Title: Dalton Transactions Volume: 45 Issue: 39 Pages: 15303-15316
  • DOI: 10.1039/c6dt02202b
  • Peer Reviewed
• [Journal Article] Accessible bidentate diol functionality within highly ordered composite periodic mesoporous organosilicas (2016)
  • Author(s): Lacey M. Reid, Gang Wu, Cathleen M. Crudden
  • Journal Title: New journal of Chemistry Volume: 40 Issue: 7 Pages: 6487-6497
  • DOI: 10.1039/c6nj00401f
  • Peer Reviewed
• [Journal Article] 4. Arylative Desulfonation of Diarylmethyl Phenyl Sulfones with Arenes Catalyzed by Scandium Triflate (2016)
  • Author(s): Masakazu Nambo, Zachary T. Ariki, Daniel Canseco-Gonzalez, D. Dawson Beattie, Cathleen M. Crudden
  • Journal Title: Organic Letters Volume: 18 Issue: 10 Pages: 2339-2342
  • DOI: 10.1021/acs.orglett.6b00744
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Iterative protecting group-free cross-coupling leading to chiral multiply arylated structures (2016)
  • Author(s): Cathleen M. Crudden, Christopher Ziebenhaus, Jason P. G. Rygus, Kazem Ghozati, Phillip J. Unsworth,Masakazu Nambo, Samantha Both, Marieke Hutchinson, Veronique S. Laberge, Yuuki Maekawa, Daisuke Imao
  • Journal Title: Nature communication Volume: 7 Issue: 1 Pages: 1-7
  • DOI: 10.1038/ncomms11065
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Chiral periodic mesoporous organosilica in a smectic-A liquid crystal: source of the electrooptic response (2016)
  • Author(s): Ian R. Nemitza, Kevin McEleneyb, Cathleen M. Cruddenb, Robert P. Lemieuxc, Rolfe G. Petscheka & Charles Rosenblatta
  • Journal Title: Liquid Crystals Volume: 43 Issue: 4 Pages: 497-504
  • DOI: 10.1080/02678292.2015.1119321
  • Peer Reviewed
• [Journal Article] Room Temperature and Atmospheric Pressure Hydrogenations with Meso-Ionic Carbene-stabilized Borenium Catalysts (2015)
  • Author(s): P. Eisenberger, B. P. Bestvater, E. C. Keske, C.M. Crudden
  • Journal Title: Angewandte Chemie International Edition Volume: 54 Issue: 8 Pages: 2467-2471
  • DOI: 10.1002/anie.201409250
  • Peer Reviewed
• [Journal Article] Recent Advances in the Synthesis of Triarylmethanes by Transition Metal Catalysis (2015)
  • Author(s): Masakazu Nambo, Cathleen M. Crudden
  • Journal Title: ACS catalysis Volume: 5 Issue: 8 Pages: 4734-4742
  • DOI: 10.1021/acscatal.5b00909
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Highly Selective Functionalization of the Mesopores of SBA-15 (2015)
  • Author(s): J. .D. Webb, T. Seki, J.F. Goldston, M. Pruski, C.M. Crudden
  • Journal Title: Microporous and Mesoporous Materials Volume: 203 Pages: 123-131
  • DOI: 10.1016/j.micromeso.2014.10.032
  • Peer Reviewed
• [Journal Article] Chirality in Ordered Organosilica Hybrid Materials (2015)
  • Author(s): M.W.A. MacLean, L.M. Reid, X. Wu, C.M. Crudden
  • Journal Title: Chemistry an Asian Journal Volume: 10 Issue: 1 Pages: 70-82
  • DOI: 10.1002/asia.201402682
  • Peer Reviewed
• [Journal Article] The Concise Synthesis of Unsymmetric Triarylacetonitriles via Pd-Catalyzed Sequential Arylation: A New Synthetic Approach to Tri-and Tetraarylmethanes (2015)
  • Author(s): M. Nambo, M. Yar, J.D. Smith, C.M. Crudden
  • Journal Title: Organic Letters Volume: 17 Issue: 1 Pages: 50-53
  • DOI: 10.1021/ol503213z
  • Peer Reviewed
• [Journal Article] Ultra Stable Self-Assembled Monolayers of N-Heterocyclic Carbenes on Gold (2014)
  • Author(s): C.M. Crudden, J.H. Horton*, I.I. Ebralidze, O.V. Zenkina, A.B. McLean, B. Drevniok, Z. She, H.-B. Kraatz, N.J. Mosey, T. Seki, E.C. Keske, J.D. Leake, A. Rousina-Webb, G. Wu
  • Journal Title: Nature Chemistry Volume: 6 Issue: 5 Pages: 409-414
  • DOI: 10.1038/nchem.1891
  • Peer Reviewed
• [Journal Article] Synthesis of enantiomerically enriched triarylmethanes by enantiospecific Suzuki-Miyaura cross coupling reactions (2014)
  • Author(s): S.C. Mathew, B.W. Glasspoole, P. Eisenberger, C.M. Crudden
  • Journal Title: Journal of the American Chemical Society Volume: 136 Issue: 16 Pages: 5828-5831
  • DOI: 10.1021/ja412159g
  • Peer Reviewed
• [Journal Article] Highly Selective Directed Arylation Reactions via Back-to-Back Dehydrogenative C-H Borylation/Arylation Reactions (2014)
  • Author(s): E.C. Keske, B.D. Moore, O.V. Zenkina, R. Wang, G. Schatte and C.M. Crudden
  • Journal Title: Chemical Communications Volume: - Pages: 9883-9886
  • Peer Reviewed
• [Journal Article] Chiral Periodic Mesoporous Organosilicas: Probing Chiral Induction in the Solid State (2014)
  • Author(s): M.W.A. MacLean, T.K. Wood, G. Wu, R.P. Lemieux, C.M. Crudden
  • Journal Title: Chemistry of Materials Volume: 26 Issue: 20 Pages: 5852-5859
  • DOI: 10.1021/cm501826b
  • Peer Reviewed
• [Presentation] Metal catalysts, clusters and surfaces: Catalytic preparation of chiral bio-molecules and carbon-based self assembled monolayers (2018)
  • Author(s): Cathleen M. Crudden
  • Organizer: Core-to-Core meetings
• [Presentation] N-heterocyclic carbenes as ligands for metal surfaces” and “Organoboron compounds in cross coupling chemistry and as catalysts for FLP reductions (2018)
  • Author(s): Cathleen M. Crudden
  • Organizer: 255th ACS National Meeting
  • Int'l Joint Research / Invited
• [Presentation] Metal catalysts, clusters and surfaces from carbon-based self assembled monolayers (2018)
  • Author(s): Cathleen M. Crudden
  • Organizer: Southern Ontario Undergraduate Student Chemistry Conference
• [Presentation] Metal catalysts, clusters and surfaces: From the synthesis of chiral bio-molecules to carbon-based self assembled monolayers (2017)
  • Author(s): Cathleen M. Crudden
  • Organizer: 12th International Conference for Heteroatom Chemistry
  • Int'l Joint Research / Invited
• [Presentation] Chirality in Coupling Reactions: Stereoetentive Suzuki-Miyaura Cross-couplings and the Development of New Electrophiles for Cross-coupling Chemistry, (2017)
  • Author(s): Cathleen M. Crudden
  • Organizer: 100th Canadian Society for Chemistry conference
  • Invited
• [Presentation] N-heterocyclic Carbenes as Supporting Ligands for Borenium-based Catalysts and on Metal Surfaces (2017)
  • Author(s): Cathleen M. Crudden
  • Organizer: 100th Canadian Society for Chemistry conference
  • Invited
• [Presentation] Metal catalysts, clusters and surfaces: From the synthesis of chiral bio-molecules to carbon-based self assembled monolayers (2017)
  • Author(s): Cathleen M. Crudden
  • Organizer: 12th International Conference on Heteroatom Chemistry
  • Int'l Joint Research
• [Presentation] Metal catalysts, clusters and surfaces: From the synthesis of chiral bio-molecules to carbon-based self assembled monolayers (2017)
  • Author(s): Cathleen M. Crudden
  • Organizer: International Symposium on Monolayer Protected Clusters
  • Int'l Joint Research
• [Presentation] Impact of Research on Training of Highly Qualified Personnel (HQP) (2017)
  • Author(s): Cathleen M. Crudden
  • Organizer: 9th Canadian Science Policy Conference
• [Presentation] Water-soluble N-heterocyclic carbene protected gold nanoparticles for biological applications (2017)
  • Author(s): Kirsi Salorinne, Renee Man, Henry Li, Masayasu Taki, Masakazu Nambo, Cathleen M. Crudden
  • Organizer: 96th CSJ meeting
  • Place of Presentation: Keio Univeristy
• [Presentation] Enhanced stability: Synthesis and characterizations of N-heterocyclic carbene-stabilized gold nanoparticles (2017)
  • Author(s): Renee Man, Henry Li, Masakazu Nambo, Cathleen M. Crudden
  • Organizer: 96th CSJ meeting
  • Place of Presentation: Keio Univeristy
• [Presentation] Pd-Catalyzed Sequential Arylation of Methyl Sulfone Derivatives toward Straightforward Synthesis of Multiply-arylated Methanes (2016)
  • Author(s): Masakazu Nambo, Eric, C. Keske, Jason, P. G. Ryugus, Jacky C.-H. Yim, Cathleen M. Crudden
  • Organizer: Gordon Research Conference, Stereochemistry
  • Place of Presentation: Boston, United States
  • Year and Date: 2016-07-27
  • Int'l Joint Research
• [Presentation] Pd-Catalyzed Sequential Arylation of Methyl Sulfone Derivatives toward Straightforward Synthesis of Multiply-arylated Methanes (2016)
  • Author(s): Masakazu Nambo, Jacky C.-H. Yim, Cathleen M. Crudden
  • Organizer: 第96春季年会
  • Place of Presentation: 同志社大学
  • Year and Date: 2016-03-25
• [Presentation] Pd-catalyzed Desulfonative Cross-Coupling of Diarylmethyl Sulfones with Oxazoles (2016)
  • Author(s): Jacky C.-H. Yim, Masakazu Nambo, Cathleen M. Crudden
  • Organizer: 第96春季年会
  • Place of Presentation: 同志社大学
  • Year and Date: 2016-03-25
• [Presentation] Organometallic chemistry at the interfaces: Preparation of biologically active molecules using enantiospecific cross coupling and the design of novel carbon-based monolayers on gold (2016)
  • Author(s): Cathleen M. Crudden
  • Organizer: 4th International Symposium on New Frontiers in Materials Science
  • Place of Presentation: Hokkaido, Japan
  • Int'l Joint Research / Invited
• [Presentation] Catalysis from Molecules to Materials (2016)
  • Author(s): Cathleen M. Crudden
  • Organizer: Connaught Industry Alliance Symposium
  • Place of Presentation: Toronto, Canada
  • Invited
• [Presentation] New Trends in Organometallic Chemistry leading to Organic Synthesis (2016)
  • Author(s): Cathleen M. Crudden
  • Organizer: American Chemical Society Conference
  • Place of Presentation: Philidelphia, United States
  • Int'l Joint Research / Invited
• [Presentation] Organometallic chemistry for the preparation of biologically important molecules and for the design of novel self assembled monolayers on gold (2016)
  • Author(s): Cathleen M. Crudden
  • Organizer: Centre in Green Chemistry and Catalysis annual meeting
  • Place of Presentation: Montreal, Canada
  • Invited
• [Presentation] Organometallic chemistry: Surfaces and Catalysts (2016)
  • Author(s): Cathleen M. Crudden
  • Organizer: IRTG Symposium
  • Place of Presentation: Muenster, Germany
  • Invited
• [Presentation] N-Heterocyclic carbenes as valuable supporting ligands in catalysis: From cross-coupling to borenium catalysis to materials chemistry (2016)
  • Author(s): Cathleen M. Crudden
  • Organizer: Catalysis Division Conference
  • Place of Presentation: Ottawa, Canada
  • Invited
• [Presentation] Challenges and Strategies for increasing participation of women and girls in STEM fields (2015)
  • Author(s): Crudden CM
  • Organizer: Pacifichem 2015
  • Place of Presentation: Honolulu, Hawaii
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Selectivity in Suzuki-Miyaura cross-coupling reactions (2015)
  • Author(s): Crudden CM
  • Organizer: Pacifichem 2015
  • Place of Presentation: Honolulu, Hawaii
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] N-Heterocyclic Carbenes as Novel Ligands for Self Assembled Monolayers on Gold (2015)
  • Author(s): Crudden CM
  • Organizer: American Vacuum Society 62nd International Symposium & Exhibition
  • Place of Presentation: San Jose, California
  • Year and Date: 2015-10-18
  • Int'l Joint Research / Invited
• [Presentation] Advances in the catalytic functionalization of organoboron compounds and the application of organoboranes as catalysts (2015)
  • Author(s): Crudden CM
  • Organizer: 18th Organometallic Chemistry Directed Towards Organic Synthesis
  • Place of Presentation: Sitges, Spain
  • Year and Date: 2015-07-19
  • Int'l Joint Research / Invited
• [Presentation] N-Heterocyclic Carbenes as Novel Ligands for High Stability Self-Assembled Monolayers on Gold (2015)
  • Author(s): Crudden CM
  • Organizer: International Symposium on Monolayer Protected Clusters
  • Place of Presentation: Hakone, Japan
  • Year and Date: 2015-07-13
  • Int'l Joint Research / Invited
• [Presentation] Mild, Easy Deposition Method for the Production of Highly Ordered, Ultra Stable NHC-based Films on Gold (2015)
  • Author(s): Crudden CM, Horton JH, Narouz M, Smith C, McLean AB, Drevniok B, Zenkina OV, Ebralidze II, Kraatz HB, She Z, Saunders L, Li Z, Alashred A, Munro K, Baddeley CJ, Larrea CR, Mosey NP.
  • Organizer: 98th Canadian Society for Chemistry conference
  • Place of Presentation: Ottawa, Canada
  • Year and Date: 2015-06-13
  • Invited
• [Presentation] Development of Rh-NHC Catalysts for the CH Borylation Reaction (2015)
  • Author(s): Crudden CM, Keske EC, Zenkina OV, Moore BD
  • Organizer: 98th Canadian Society for Chemistry conference
  • Place of Presentation: Ottawa, Canada
  • Year and Date: 2015-06-13
  • Invited
• [Presentation] Scandium Triflate-Catalyzed Arylative Desulfonation of Diarylmethyl Phenyl Sulfones (2015)
  • Author(s): Zachary, T. Ariki, Masakazu Nambo, Daniel Canseco-Gonzalez, Dawson Beattie, Cathleen M. Crudden
  • Organizer: The 95th Annual Meeting
  • Place of Presentation: Nihon University
  • Year and Date: 2015-03-27
• [Presentation] The Concise Synthesis of Unsymmetric Triarylacetonitriles via Pd-Catalyzed Sequential Arylation (2015)
  • Author(s): Masakazu Nambo, Muhammad Yar, Joel D. Smith, Cathleen M. Crudden
  • Organizer: The 95th Annual Meeting
  • Place of Presentation: Nihon University
  • Year and Date: 2015-03-26
• [Presentation] Organometallic Chemistry in the Service of Catalysis and Materials (2014)
  • Author(s): Cathleen M. Crudden
  • Organizer: Tateshina Conference
  • Place of Presentation: Japan
  • Year and Date: 2014-11-07 – 2014-11-09
  • Invited
• [Presentation] Modular Synthesis of Triarylmethanes through Pd-Catalyzed Sequential Arylation of Methyl Phenyl Sulfone (2014)
  • Author(s): Masakazu Nambo, Cathleen M. Crudden
  • Organizer: 61th Symposium on Organometallic Chemistry
  • Place of Presentation: Kyushu University
  • Year and Date: 2014-09-25
• [Presentation] Novel Carbon-based Ligands for Ultra-Stable Self-assembled Monolayers (2014)
  • Author(s): Cathleen M. Crudden
  • Organizer: Nanoscience Symposium
  • Place of Presentation: Queen's Physics
  • Year and Date: 2014-06-12
• [Presentation] N-Heterocyclic Carbenes in the Synthesis of Chiral Triarylmethanes and in the Preparation of Ultra Stable Self-Assembled Monolayers on Gold (2014)
  • Author(s): Cathleen M. Crudden
  • Organizer: 19th International Symposium on Homogeneous Catalysis
  • Place of Presentation: Ottawa
  • Year and Date: 2014-06-06 – 2014-06-11
• [Presentation] Modular Synthesis of Triarylmethanes through Pd-Catalyzed Sequential Arylation of Methyl Phenyl Sulfone (2014)
  • Author(s): Masakazu Nambo, Cathleen M. Crudden
  • Organizer: IGER International Symposium on Chemical Science in Asia
  • Place of Presentation: Nagoya University
  • Year and Date: 2014-05-26
• [Presentation] Modular Synthesis of Triarylmethanes through Pd-Catalyzed Sequential Arylation of Methyl Phenyl Sulfone (2014)
  • Author(s): Masakazu Nambo, Cathleen M. Crudden
  • Organizer: The 2nd International Symposium on Transformative Bio-Molecules
  • Place of Presentation: Nagoya University
  • Year and Date: 2014-05-12
• [Book] New Trends in cross Coupling: Theory and Applications (2014)
  • Author(s): B.W. Glasspoole, E.C. Keske and C.M. Crudden
  • Total Pages: 30
  • Publisher: Royal Society for Chemistry
• [Remarks] IPMI Carol Tyler Award
  • URL: https://www.ipmi.org
• [Remarks] 2017 Queen’s Prize for Excellence in Research
  • URL: http://www.chem.queensu.ca
• [Remarks] Congratulations to SYNLETT Best Paper Award 2017
  • URL: https://www.thieme.de/en/thieme-chemistry/2017-winners-123200.htm
• [Remarks] SYNLETT Best Paper Award 2017
  • URL: http://www.itbm.nagoya-u.ac.jp/en/news/2018/02/Crudden-Synlett.php
• [Remarks] Chemical bonds
  • URL: http://www.queensu.ca/research/innovating/crudden
• [Patent(Industrial Property Rights)] Production of Triarylacetonitrile (2015)
  • Inventor(s): Nambo, Yar, Cathleen
  • Industrial Property Rights Holder: Nambo, Yar, Cathleen
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-12-04
  • Overseas
• [Patent(Industrial Property Rights)] トリアリールメタン化合物の製造方法 (2014)
  • Inventor(s): M. Nambo, C. M. Crruden
  • Industrial Property Rights Holder: M. Nambo, C. M. Crruden
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-10-28
• [Patent(Industrial Property Rights)] トリ（ヘテロ）アリールアセトニトリル化合物の製造方法 (2014)
  • Inventor(s): M. Nambo, M. Yar, C. M. Crruden
  • Industrial Property Rights Holder: M. Nambo, M. Yar, C. M. Crruden
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-12-12