| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
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| Outline of Final Research Achievements |
In order to develop highly functionalized artificial catalysts in organic synthesis, which are comparable to biological enzymes, at the small molecule level, it is necessary to change the cut angle of catalyst design. In order to overcome the limitation of the conventional single-molecule catalysts, in this research, acid and base sites would be appropriately designed in a plurality of small molecules. As a result, we successfully developed a chiral self-assembled catalysts based on dynamic affinity between acid and base and conformational flexibility of the their structures. In particular, we developed multiselective asymmetric catalyses by taking advantage of chiral cavity effect of the self-assembled catalysts, which would be unlike for conventional single molecular catalysts. Overall, conformationally flexible chiral self-assembled catalysts could maximize reaction efficiency and make it possible from difficult or impossible to synthesize new compounds.
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