Non-invasive chemical diagnostic methods by flow breath analysis
| Project/Area Number |
26288072
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Analytical chemistry
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| Research Institution | Aichi Institute of Technology |
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Principal Investigator |
Teshima Norio 愛知工業大学, 工学部, 教授 (30292501)
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| Co-Investigator(Kenkyū-buntansha) |
梅村 知也 東京薬科大学, 生命科学部, 教授 (10312901)
澤野 誠 埼玉医科大学, 医学部, 准教授 (40242143)
村上 博哉 愛知工業大学, 工学部, 講師 (40515128)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | 非侵襲分析 / 呼気分析 / 流れ分析 / 呼気アセトン / 吸光光度法 / HPLC / 検査診断法 / 流れ分析法 / アルデヒドガス / ケトンガス / 分析科学 / 化学診断 / 癌 / 糖尿病 / 化学診断法 / 低侵襲分析 |
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| Outline of Final Research Achievements |
We have proved so far that flow injection analysis (FIA) and related techniques are useful for human breath analysis. In this project, a flow injection fluorometric determination of acetone in human breath was developed. Gaseous acetone in breath was sampled with a porous membrane based diffusion scrubber, then the absorbing solution including acetone merged with an alkaline salicylaldehyde, and the fluorescence intensity of salicylaldehyde decreased with increasing the acetone concentration. On the other hand, SIEMA systems we conceived can minimize the amount of sample solution and the reagent consumption. Also, it is a useful concept for automatic solution handling. We also proposed a SIEMA system for automatic pre-column derivatization HPLC determination of formaldehyde, acetaldehyde, acrolein and acetone. In the near future, an automated pre-column derivatization HPLC method for the determination of aldehydes and acetone in human breath using a SIEMA system would be developed.
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Report
(4 results)
Research Products
(109 results)
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[Presentation] 極性化合物へ適用可能な新規吸着剤の開発2016
Author(s)
三木雄太, 村上博哉, 青柳 拓哉, 井上嘉則, 手嶋紀雄
Organizer
「分析中部・ゆめ21」若手交流会・第16回高山フォーラム
Place of Presentation
高山市図書館（岐阜県・高山市）
Year and Date
2016-11-11
Related Report
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[Presentation] 懸濁物共存試料中の全窒素定量法の改良2015
Author(s)
作田成久, 藤井亮輔, 大野慎介, 村上博哉, 手嶋紀雄
Organizer
「分析中部・ゆめ21」若手交流会 第14回高山フォーラム
Place of Presentation
高山市図書館（岐阜県高山市）
Year and Date
2015-11-13
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[Presentation] CNET誘導体化アルデヒド類,アセトンのHPLC2015
Author(s)
一杉理香, Ketsarin Seebunrueng, 村上博哉, Supalax Srijaranai, 梅村知也, 酒井忠雄, 手嶋紀雄
Organizer
第34回分析化学中部夏期セミナー
Place of Presentation
三保園ホテル（静岡県静岡市）
Year and Date
2015-08-31
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[Book] 基礎分析化学2015
Author(s)
小熊幸一, 酒井忠雄編著, 手嶋紀雄分担執筆
Total Pages
208
Publisher
朝倉書店
Related Report
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[Book] 環境分析化学2014
Author(s)
中村栄子, 酒井忠雄, 本水昌二, 手嶋紀雄
Total Pages
224
Publisher
裳華房
Related Report
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