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Development of metal nanoalloy embedded carbon film electrode and its application for sugar markers of intestinal permeability test

Research Project

Project/Area Number 26288074
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Analytical chemistry
Research InstitutionSaitama Institute of Technology (2015-2017)
National Institute of Advanced Industrial Science and Technology (2014)

Principal Investigator

Niwa Osamu  埼玉工業大学, 先端科学研究所, 教授 (70392644)

Co-Investigator(Kenkyū-buntansha) 吉岡 恭子  国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 (50358321)
加藤 大  国立研究開発法人産業技術総合研究所, 生命工学領域, 研究グループ付 (80533190)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords電気化学分析 / ナノアロイ / カーボン薄膜 / スパッタリング / 腸疾患マーカー / 糖類検出 / 電気化学 / 分析化学 / バイオ分析 / 炭素材料 / 腸疾患マーカ―
Outline of Final Research Achievements

We report the fabrication of a nickel (Ni)-copper (Cu) bimetallic nanoalloy embedded carbon film electrode with the unbalanced magnetron (UBM) co-sputtering in order to detect clinical sugar markers of intestinal diseases. The sensitivity and stability of the electrode for detecting clinical sugar markers were greatly improve by changing With changing Ni/Cu ratio. Then, the concentration of Ni/Cu nanoalloy was optimized and applied for an electrochemical detector of high performance liquid chromatography. As a results, the detection limits of 5 kind of clinical supar makers was greatly improved by 2 order of magnitude compared with conventional Au electrode.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (33 results)

All 2018 2017 2016 2015 2014 Other

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (28 results) (of which Int'l Joint Research: 14 results,  Invited: 16 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Chromatographic Determination of Sugar Probes Used for Gastrointestinal Permeability Test by Employing Nickel-Copper Nanoalloy Embedded in Carbon Film Electrodes2018

    • Author(s)
      芝駿介、丸山莉奈、鎌田智之、加藤大、丹羽修
    • Journal Title

      Electroanalysis

      Volume: in press Issue: 7 Pages: 1407-1415

    • DOI

      10.1002/elan.201800072

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Co-Sputter Deposited Nickel-Copper Bimetallic Nanoalloy Embedded Carbon Films for Electrocatalytic Biomarker Detection2016

    • Author(s)
      芝駿介、加藤大、鎌田智之、丹羽修
    • Journal Title

      Nanoscale

      Volume: 8 Issue: 26 Pages: 12887-12891

    • DOI

      10.1039/c6nr02287a

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Au Nanoparticle-embedded carbon films for electrochemical As3+ detection with high sensitivity and selectivity2016

    • Author(s)
      加藤大喜、鎌田智之、加藤大、柳澤博幸、丹羽修
    • Journal Title

      Analytical Chemistry

      Volume: 88 Issue: 5 Pages: 2944-2951

    • DOI

      10.1021/acs.analchem.6b00136

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Metal Nanoparticles Embedded Carbon Film Electrodes for Electroanalysis2017

    • Author(s)
      丹羽修, 芝駿介, 鎌田智之, 加藤 大
    • Organizer
      International congress on analytical sciences 2017
    • Place of Presentation
      中国、海南島 海口
    • Year and Date
      2017-05-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Metal nanoparticles embedded carbon film electrodes for electroanalysis2017

    • Author(s)
      丹羽修、芝駿介、鎌田智之、加藤大
    • Organizer
      International congress on analytical sciences 2017(ICAS2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ハイブリッドナノカーボン薄膜電極による電気化学分析2017

    • Author(s)
      丹羽修、加藤大
    • Organizer
      第77回分析化学討論会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Electroanalysis with surface terminated carbon film2017

    • Author(s)
      丹羽修、鎌田智之、蔵屋英介、西見大成、国武雅司、加藤大
    • Organizer
      The 16th International Symposium on Electroanalytical Chemistry (16th ISEAC)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 微小電極や新規電極材料を用いる電気化学分析センシング法の研究2017

    • Author(s)
      丹羽修
    • Organizer
      日本分析化学会第66年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ニッケル銅ナノアロイ埋め込みカーボン薄膜電極の開発と糖分析への応用2017

    • Author(s)
      芝駿介、丸山莉奈、鎌田智之、加藤大、丹羽修
    • Organizer
      2017電気化学秋季討論会(長崎)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Sputter deposited metal nanoalloy embedded carbon film for urine saccharide detection2017

    • Author(s)
      芝駿介、丸山莉奈、鎌田智之、加藤大、丹羽修
    • Organizer
      Bio4Apps 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ニッケル銅ナノアロイ埋め込みカーボン薄膜電極を用いた臨床糖マーカーの高感度検出2017

    • Author(s)
      芝駿介、加藤大、鎌田智之、丹羽修
    • Organizer
      電気化学会第84回大会
    • Place of Presentation
      首都大学東京
    • Related Report
      2016 Annual Research Report
  • [Presentation] ナノカーボン薄膜電極をベースとした生体・食品分子センシング2016

    • Author(s)
      加藤大、丹羽修
    • Organizer
      日本分析化学会第65年会
    • Place of Presentation
      北大
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 金属ナノ粒子埋め込みカーボン薄膜電極の化学センシングへの応用2016

    • Author(s)
      丹羽修, 芝駿介, 加藤大喜, 鎌田智之, 山口直人, 今屋浩志, 加藤 大
    • Organizer
      日本分析化学会第65年会
    • Place of Presentation
      北大
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Biochemical detection based on SPR and electrochemical measurements2016

    • Author(s)
      丹羽修、加藤大、芝駿介、栗田僚二
    • Organizer
      International Conference on Biosensorsm BioMedical Devices (Invited talk), BioMEMS/NEMS & Applications
    • Place of Presentation
      ゴールドコースト
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Nanostructured electrode materials for bioanalytical applications2016

    • Author(s)
      丹羽修、加藤大
    • Organizer
      The 11th BK21+ International Symposium on Materials Chemistry 2016
    • Place of Presentation
      釜山国立大学
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Metal nanoparticles embedded carbon film electrodes for environmental and biochemical analysis2016

    • Author(s)
      丹羽修, 芝駿介, 加藤大喜, 鎌田智之、加藤大
    • Organizer
      67th Annual Meeting of the International Society of Electrochemistry
    • Place of Presentation
      オランダ、ハーグ
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nanocarbon film-based electrodes for foods/biomolecules sensing2016

    • Author(s)
      加藤大、丹羽修
    • Organizer
      The 2016 China-Japan-Korea Symposium on Analytical Chemistry (CJK 2016)
    • Place of Presentation
      中国、武夷山(Wuyi Villa)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Terminated and hybrid nanocarbon film electrodes for electrochemical biosensors2016

    • Author(s)
      丹羽修、加藤大、小田侑、芝駿介、戸所正美、鎌田智之、蔵屋英介、国武雅司
    • Organizer
      The 16th International Meeting on Chemical Sensors (IMCS 2016)
    • Place of Presentation
      韓国 済州島
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of the nickel(Ni)-copper(Cu) nanoalloy embedded carbon film electrodes for electrocatalytic detection of supar markers2015

    • Author(s)
      芝駿介、加藤大、鎌田智之、丹羽修
    • Organizer
      BCEIA 2015
    • Place of Presentation
      北京
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Electrochemical applications of surface terminated and hybrid sputtered carbon film electrodes2015

    • Author(s)
      丹羽修、加藤大、鎌田智之、芝駿介、廣野滋、蔵屋英介、国武雅司
    • Organizer
      BCEIA 2015
    • Place of Presentation
      北京
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Hybrid carbon film electrodes for electroanalytical applications(Keynote talk)2015

    • Author(s)
      丹羽修、加藤大、鎌田智之、加藤大喜、芝駿介、廣野滋、蔵屋英介、国武雅司、山口直人、今屋弘志
    • Organizer
      66th Annual Meeting of ISE
    • Place of Presentation
      台北
    • Year and Date
      2015-10-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 臨床糖マーカー検出を目的としたナノアロイ埋め込み型カーボン薄膜電極の開発2015

    • Author(s)
      芝駿介、加藤大、鎌田智之、丹羽修
    • Organizer
      日本分析化学会第64年会
    • Place of Presentation
      九州大
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Co-sputter deposited nickel-copper nanoalloy embedded carbon films for electrocatalytic detection of sugar markers2015

    • Author(s)
      芝駿介、加藤大、鎌田智之、丹羽修
    • Organizer
      RSC Tokyo Conference 2015
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Surface terminated carbon film electrodes for electroanalytical applications2015

    • Author(s)
      丹羽修、加藤大、鎌田智之、梅村茂、蔵屋英介、国武雅司
    • Organizer
      15th ISEAC
    • Place of Presentation
      長春
    • Year and Date
      2015-08-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ナノアロイ埋め込み型カーボン薄膜電極による臨床糖マーカーの高感度安定検出2015

    • Author(s)
      芝駿介、加藤大、鎌田智之、丹羽修
    • Organizer
      第75回分析化学討論会
    • Place of Presentation
      山梨大
    • Year and Date
      2015-05-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] Electrochemical properties of surface terminated and hybrid carbon films and their application to electroanalysis2015

    • Author(s)
      丹羽修
    • Organizer
      16th Topical Meeting of ISE
    • Place of Presentation
      Angra dos Reis, ブラジル
    • Year and Date
      2015-03-22 – 2015-03-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 臨床糖マーカ―の検出に向けたナノアロイ分散カーボン電極の開発2014

    • Author(s)
      芝駿介、加藤大、鎌田智之、丹羽修
    • Organizer
      本分析化学会関東支部 第11回茨城地区技術交流会
    • Place of Presentation
      いばらき量子ビーム研究センター
    • Year and Date
      2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] カーボン薄膜電極を用いた電気化学分析法、 バイオセンサの開発2014

    • Author(s)
      丹羽修
    • Organizer
      本分析化学会関東支部 第11回茨城地区技術交流会
    • Place of Presentation
      いばらき量子ビーム研究センター
    • Year and Date
      2014-12-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Nanomaterials and microdevices for electrochemical and optical biosensors2014

    • Author(s)
      丹羽修
    • Organizer
      UK-Japan Workshop on biosensing technologies for innovative healthcare
    • Place of Presentation
      英国大使館
    • Year and Date
      2014-12-01 – 2014-12-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ナノアロイ分散カーボン電極の開発と腸疾患糖マーカ―検出への応用2014

    • Author(s)
      芝駿介、加藤大、鎌田智之、丹羽修
    • Organizer
      化学とマイクロ・ナノ学会第30回研究会
    • Place of Presentation
      北大フロンティア応用科学研究棟
    • Year and Date
      2014-10-02 – 2014-10-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] ナノカーボン薄膜やファイバーを利用した電気化学分析法の開発2014

    • Author(s)
      丹羽 修
    • Organizer
      日本分析化学会関東支部 第28回新潟地区部会発表会
    • Place of Presentation
      新潟市4大学メディアキャンパス
    • Year and Date
      2014-09-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Remarks] マイクロ・ナノ化学研究室HP

    • URL

      http://www.sit.ac.jp/user/niwa/research.html

    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 合金ナノ粒子含有カーボン電極、当該電極を含む装置、及び、当該電極の製造方法2014

    • Inventor(s)
      加藤大、芝駿介、鎌田智之、丹羽修
    • Industrial Property Rights Holder
      産総研
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-203328
    • Filing Date
      2014-10-01
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2019-03-29  

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