Molecular Chemistry on Cell Membrane Using Functional Nucleic Acid
| Project/Area Number |
26288081
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bio-related chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SANDO SHINSUKE 東京大学, 工学(系)研究科(研究院), 教授 (20346084)
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| Co-Investigator(Kenkyū-buntansha) |
岡本 晃充 東京大学, 先端科学技術研究センター, 教授 (60314233)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 細胞膜 / センサー / 生体分子 |
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| Outline of Final Research Achievements |
Cell membrane is an essential component of cells and there has been a continuing demand on method to analyze molecular functions on the cell membrane. In this research, we tried to design fluorescent aptamer sensors with a high performance and developed BODIPY dye-labeled fluorescent aptamer sensors that emit an enhanced fluorescence upon interaction with target biomolecule (adenine compound or interferon gamma). In addition, it was demonstrated that these fluorescence aptamer sensors work on cell membrane and can be used for a fluorescent molecular imaging.
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Report
(4 results)
Research Products
(6 results)
