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Development of novel platform for enzyme utilization in the body based on polymeric nanocapsules

Research Project

Project/Area Number 26288082
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Bio-related chemistry
Research InstitutionKyushu University

Principal Investigator

Kishimura Akihiro  九州大学, 工学(系)研究科(研究院), 准教授 (70422326)

Research Collaborator TANG Hengmin  九州大学, 大学院システム生命科学府
NAOYAMA Kenshiro  九州大学, 大学院システム生命科学府
YAMASAKI Hokuto  九州大学, 大学院システム生命科学府
TERAUCHI Mikio  九州大学, 大学院システム生命科学府
OGAWA Atsushi  
LIU Yiwei  九州大学, 大学院システム生命科学府
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Keywords酵素 / ナノリアクター / ベシクル / タンパク質デリバリー / ナノ医薬品 / Biodetoxification / ナノメディシン
Outline of Final Research Achievements

In this research, a novel platform for enzyme application, which allows for expansion of its scope and durability of enzyme activity in in vivo conditions, was pioneered, particularly using polymeric hollow capsule PICsomes with a size of ~100 nm. In this project, the following three topics were mainly investigated: (1) Enzyme-based biodetoxification nanosystem, (2) Nano-delivery system for enzyme replacement therapy, (3) Nano-delivery system of light source in in vivo conditions. In the topic of (1), PICsome containing histamine degradation enzyme was developed, and successful performance was confirmed in in vivo experiments using model mice. In the topic of (2), milder methods for enzyme encapsulation was developed, and effective factor for cellular internalization of the PICsome system was revealed. In the topic (3), bioluminescent enzyme, Nano-Luc, was successfully encapsulated into PICsomes, and its activity was confirmed for future development of light-driven nanosystem.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (78 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (12 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 11 results,  Acknowledgement Compliant: 5 results,  Open Access: 2 results) Presentation (55 results) (of which Int'l Joint Research: 12 results,  Invited: 15 results) Book (2 results) Remarks (7 results)

  • [Int'l Joint Research] National Chung Hsing University(台湾)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Chung Yuan Christian University(台湾)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Development of Enzyme Loaded Polyion Complex Vesicle (PICsome): Thermal Stability of Enzyme in PICsome compartment and Effect of Co-Encapsulation of Dextran on Enzyme Activity2017

    • Author(s)
      1.Hengmin Tang, Yuki Sakamura, Takeshi Mori, Yoshiki Katayama, and Akihiro Kishimura
    • Journal Title

      Macromol. Biosci.

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Facile Preparation of Delivery Platform of Water-Soluble Low-Molecular-Weight Drugs Based on Polyion Complex Vesicle (PICsome) Encapsulating Mesoporous Silica Nanoparticle2017

    • Author(s)
      2.Akinori Goto, Hung-Chi Yen, Yasutaka Anraku, Shigeto Fukushima, Ping-Shan Lai, Masaru Kato, Akihiro Kishimura, and Kazunori Kataoka
    • Journal Title

      ACS Biomater. Sci. Eng.

      Volume: 印刷中 Issue: 5 Pages: 807-815

    • DOI

      10.1021/acsbiomaterials.6b00562

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A Membrane-integrated Microfluidic Device to Study Permeation of Nanoparticles through Straight Micropores toward Rational Design of Nanomedicines2016

    • Author(s)
      Naoki Sasaki, Mariko Tatanou, Tomoko Suzuki, Yasutaka Anraku, Akihiro Kishimura, Kazunori Kataoka, and Kae Sato
    • Journal Title

      Analytical Sciences

      Volume: 32 Issue: 12 Pages: 1307-1314

    • DOI

      10.2116/analsci.32.1307

    • NAID

      130005433411

    • ISSN
      0910-6340, 1348-2246
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Fabrication of Dendrimer-based Polyion Complex Submicrometer-scaled Structures with Enhanced Stability under Physiological Conditions2016

    • Author(s)
      Kenshiro Naoyama, Takeshi Mori, Yoshiki Katayama, and Akihiro Kishimura
    • Journal Title

      Macromol. Rapid Commun.

      Volume: 37 Issue: 13 Pages: 1087-1093

    • DOI

      10.1002/marc.201600171

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] エマージングマテリアル・PICsome ~PEGとPEGのはざまで~2016

    • Author(s)
      岸村顕広
    • Journal Title

      Drug Delivery System

      Volume: 31 Pages: 308-309

    • NAID

      130006846567

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calcium phosphate-based organic-inorganic hybrid nanocarriers with pH-responsive on/off switch for photodynamic therapy2016

    • Author(s)
      T. Nomoto, S. Fukushima, M. Kumagai, K. Miyazaki, A. Inoue, P. Mi, Y. Maeda, K. Toh, Y. Matsumoto, Y. Morimoto, A. Kishimura, N. Nishiyama, K. Kataoka
    • Journal Title

      Biomater. Sci.

      Volume: 印刷中 Issue: 5 Pages: 826-838

    • DOI

      10.1039/c6bm00011h

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systemically Injectable Enzyme-Loaded Polyion Complex Vesicles as In Vivo Nanoreactors Functioning in Tumors.2016

    • Author(s)
      Anraku Y, Kishimura A, Kamiya M, Tanaka S, Nomoto T, Toh K, Matsumoto Y, Fukushima S, Sueyoshi D, Kano MR, Urano Y, Nishiyama N, Kataoka K.
    • Journal Title

      Angew Chem Int Ed Engl.

      Volume: 55 Issue: 2 Pages: 560-565

    • DOI

      10.1002/anie.201508339

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of Secondary Structure through Micellization of an Oppositely Charged Pair of Homochiral Block- and Homopolypeptides in an Aqueous Medium2015

    • Author(s)
      Omer F. Mutaf, Akihiro Kishimura, Yuki Mochida, Ahram Kim, and Kazunori Kataoka
    • Journal Title

      Macromol. Rapid Commun.

      Volume: 36 Issue: 22 Pages: 1958-1964

    • DOI

      10.1002/marc.201500368

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Density-Tunable Conjugation of Cyclic Rgd Ligands with Polyion Complex Vesicles for the Neovascular Imaging of Orthotopic Glioblastomas2015

    • Author(s)
      Kawamura W, Miura Y, Kokuryo D, Toh K, Yamada N, Nomoto T, Matsumoto Y, Sueyoshi D, Liu X, Aoki I, Kano MR, Nishiyama N, Saga T, Kishimura A, Kataoka K
    • Journal Title

      Science and Technology of Advanced Materials

      Volume: 16 Issue: 3 Pages: 035004-035004

    • DOI

      10.1088/1468-6996/16/3/035004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fabrication of Polyion Complex Vesicles with Enhanced Salt and Temperature Resistance and Their Potential Applications as Enzymatic Nanoreactors2014

    • Author(s)
      Sayan Chuanoi, Yasutaka Anraku, Mao Hori, *Akihiro Kishimura, *Kazunori Kataoka
    • Journal Title

      Biomacromolecules

      Volume: 15 Issue: 7 Pages: 2389-2397

    • DOI

      10.1021/bm500127g

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ポリイオンコンプレックス型透過膜を有する中空カプセルPICsomeの開発とその応用2014

    • Author(s)
      岸村顕広
    • Journal Title

      膜

      Volume: 39 Pages: 296-301

    • NAID

      130005069441

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Nanodevices for Studying Nano-pathophysiology2014

    • Author(s)
      *Horacio Cabral, Kanjiro Miyata, *Akihiro Kishimura,
    • Journal Title

      Advanced Drug Delivery Reviews

      Volume: 74 Pages: 35-52

    • DOI

      10.1016/j.addr.2014.06.003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] 酵素封入型ナノリアクターによる生理活性物質の除去に基づく病態制御法開発:生体内ヒスタミン分解・除去機能の評価2017

    • Author(s)
      唐 ヘンミン、森 健、片山 佳樹、田中 智之、岸村 顕広
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台市(仙台国際センター)
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of nanostructured coacervates based on double hydrophilic block copolymers and the behavior of site-selective incorporation of functional nanoparticles.2017

    • Author(s)
      Akihiro Kishimura, Kenshiro Naoyama, Yujiro Hamada, Takeshi Mori, Yoshiki Katayama
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      横浜市(慶応義塾大学日吉キャンパス)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] コアセルベートを基盤としたタンパク質複合化材料の開発2017

    • Author(s)
      寺内幹雄、森健、片山佳樹、岸村顕広
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      横浜市(慶応義塾大学日吉キャンパス)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Design of nano-structured PICs using all-hydrophilic block copolymers and their site-specific incorporation of functional nanomaterial.2016

    • Author(s)
      Yujiro Hamada, Takeshi Mori, Yoshiki Katayama and Akihiro Kishimura
    • Organizer
      The 11th SPSJ International Polymer Conference (IPC2016)
    • Place of Presentation
      Fukuoka Convention Center, Fukuoka
    • Year and Date
      2016-12-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Enhanced Protein Encapsulation by Polyion Complex Vesicle Induction on Protein-Polyion Complex Particle2016

    • Author(s)
      Yiwei Liu, Hengmin Tang, Takeshi Mori, Yoshiki Katayama and Akihiro Kishimura
    • Organizer
      The 11th SPSJ International Polymer Conference (IPC2016)
    • Place of Presentation
      Fukuoka Convention Center, Fukuoka
    • Year and Date
      2016-12-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 親水-親水相分離によるナノ構造創製とその機能化2016

    • Author(s)
      岸村顕広
    • Organizer
      日本化学会新領域研究グループ「エキゾチック自己組織化材料」・「金属と分子集合」第1回合同シンポジウム
    • Place of Presentation
      鳥取県鳥取市
    • Year and Date
      2016-11-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 粘膜上皮突破に向けた膜機能強化型PEG化ポリマーベシクルの開発とその機能評価2016

    • Author(s)
      小川敦嗣、唐 ヘン敏、森健、片山佳樹、岸村顕広
    • Organizer
      日本バイオマテリアル学会シンポジウム2016
    • Place of Presentation
      福岡市(福岡国際会議場)
    • Year and Date
      2016-11-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] ABA型ブロック共重合体を用いたナノ構造化コアセルベートの設計と金ナノ粒子の空間配置制御2016

    • Author(s)
      濱田祐次朗、森健、片山佳樹、岸村顕広
    • Organizer
      九州地区高分子若手研究会・冬の講演会
    • Place of Presentation
      熊本市(菊南温泉ユウベルホテル)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of Self-assembled Nano-structured Materials for Biomedical Applications2016

    • Author(s)
      Akihiro Kishimura
    • Organizer
      The 2nd Materials Research Society of Indonesia (MRS-Id) Meeting
    • Place of Presentation
      Bandung, Indonesia
    • Year and Date
      2016-10-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of novel supramolecular hollow capsules “PICsomes” for biomedical applications2016

    • Author(s)
      Akihiro Kishimura
    • Organizer
      The 2nd International Conference on Nanomedicine (ChinaNanomedicine 2016)
    • Place of Presentation
      Wuhan, China
    • Year and Date
      2016-10-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 粘膜上皮細胞層透過に向けたPEG 化ポリマーベシクルの膜機能強化とその評価2016

    • Author(s)
      小川敦嗣、唐 ヘン敏、森健、片山佳樹、岸村顕広
    • Organizer
      日本バイオマテリアル学会九州講演会2016
    • Place of Presentation
      熊本市(熊本大学薬学部)
    • Year and Date
      2016-09-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] ABA型ブロック共重合体を用いたナノ構造コアセルベートの設計と機能性素材の内包挙動解明2016

    • Author(s)
      濱田祐次朗、森健、片山佳樹、岸村顕広
    • Organizer
      第65回高分子討論会
    • Place of Presentation
      横浜市(神奈川大学)
    • Year and Date
      2016-09-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] ミクロ構造を持つコアセルベートを用いた生体関連材料開発2016

    • Author(s)
      岸村顕広、寺内幹雄、濱田祐次朗、尚山堅士郎、劉一イ、森健、片山佳樹
    • Organizer
      第10回バイオ関連化学シンポジウム
    • Place of Presentation
      金沢市(石川県立音楽堂)
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of polyion complex nanostructures based on all-hydrophilic block copolymers2016

    • Author(s)
      Akihiro Kishimura
    • Organizer
      22nd Ostwald-Colloquium of the German Colloid Society
    • Place of Presentation
      Aachen, Germany
    • Year and Date
      2016-09-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ポリカチオンリッチ条件下におけるポリイオンコンプレックスベシクル形成とその物性評価2016

    • Author(s)
      劉 一イ、唐 衡敏、森 健、片山佳樹、岸村 顕広
    • Organizer
      第53回化学関連支部合同九州大会
    • Place of Presentation
      北九州市(北九州国際会議場)
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] トリブロックコポリマーを用いたナノ構造化コアセルベート形成と金ナノ粒子の空間配置制御2016

    • Author(s)
      濱田祐次朗,尚山堅士郎、森健、片山佳樹、岸村顕広
    • Organizer
      第53回化学関連支部合同九州大会
    • Place of Presentation
      北九州市(北九州国際会議場)
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] 粘膜上皮突破に向けた膜機能強化型PEG化ポリマーベシクルの開発とその機能評価2016

    • Author(s)
      小川敦嗣、唐 ヘン敏、森健、片山佳樹、岸村顕広
    • Organizer
      第53回化学関連支部合同九州大会
    • Place of Presentation
      北九州市(北九州国際会議場)
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] 物質透過性ナノ膜を利用した生体高分子送達カプセルの設計と開発2016

    • Author(s)
      岸村 顕広
    • Organizer
      第32回日本DDS学会学術集会
    • Place of Presentation
      静岡コンベンションアーツセンター・グランシップ、静岡市
    • Year and Date
      2016-06-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 生体分子の効率的捕捉・送達のための高分子ナノカプセルの開発2016

    • Author(s)
      岸村 顕広、秦 智貴、唐 ヘン敏、劉 一イ、森 健、片山 佳樹
    • Organizer
      第32回日本DDS学会学術集会
    • Place of Presentation
      静岡市(静岡コンベンションアーツセンター・グランシップ)
    • Year and Date
      2016-06-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 酵素機能を活かす材料開発2016

    • Author(s)
      岸村 顕広
    • Organizer
      ミニワークショップ「生体関連機能化学の最先端」
    • Place of Presentation
      横浜市(東京工業大学すずかけ台キャンパス)
    • Year and Date
      2016-06-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Engineering of enzyme nano-capsules for biomedical applications2016

    • Author(s)
      Akihiro Kishimura
    • Organizer
      International Conferences on Modern Materials and Technologies (CIMTEC) 2016: 11th International Conference Medical Applications of Novel Biomaterials and Nanotechnology
    • Place of Presentation
      Perugia, Italy
    • Year and Date
      2016-06-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 酵素封入型ナノリアクターの機能強化に向けた検討~ナノコンパートメントへの格納および非荷電高分子共存による酵素反応挙動の評価~2016

    • Author(s)
      唐 衡敏、坂村 有紀、森 健、片山佳樹、岸村 顕広
    • Organizer
      第65回高分子学会年次大会
    • Place of Presentation
      神戸市(神戸国際会議場)
    • Year and Date
      2016-05-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] ABA型ブロックコポリマーを用いたナノ構造化コアセルベートの設計と機能性素材の空間配置制御2016

    • Author(s)
      濱田祐次朗、尚山堅士郎、森健、片山佳樹、岸村顕広
    • Organizer
      第65回高分子学会年次大会
    • Place of Presentation
      神戸市(神戸国際会議場)
    • Year and Date
      2016-05-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] AB型ブロック共重合体を用いたナノ構造化コアセルベートの調整と部位特異的な酸化鉄ナノ粒子包含挙動2016

    • Author(s)
      尚山堅士郎、濱田祐次朗、森健、片山佳樹、岸村顕広
    • Organizer
      第65回高分子学会年次大会
    • Place of Presentation
      神戸市(神戸国際会議場)
    • Year and Date
      2016-05-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] ブロックポリアニオン/ホモポリカチオンの混合比率がポリイオンコンプレックスベシクルの性質に与える影響2016

    • Author(s)
      劉 一イ、唐 衡敏、森 健、片山佳樹、岸村 顕広
    • Organizer
      第65回高分子学会年次大会
    • Place of Presentation
      神戸市(神戸国際会議場)
    • Year and Date
      2016-05-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] ポリアミノ酸デンドリマー型ポリカチオンを用いたポリイオンコンプレックス形成とその特異な自己組織化挙動2016

    • Author(s)
      尚山堅士郎、黒木奏子、森健、片山佳樹、岸村顕広
    • Organizer
      第65回高分子学会年次大会
    • Place of Presentation
      神戸市(神戸国際会議場)
    • Year and Date
      2016-05-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 分子運動の制御による超分子カプセルの作製とその応用2016

    • Author(s)
      岸村 顕広
    • Organizer
      日本化学会第96春季年会・特別企画
    • Place of Presentation
      同志社大学京田辺キャンパス、京田辺市
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Development of enzyme-loaded polymeric nano-capsules as a versatile platform for enzyme applications: Effect of co-encapsulation of neutral macromolecules.2015

    • Author(s)
      Yuki Sakamura, Hengmin Tang, Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura
    • Organizer
      THE INTERNATIONAL CHEMICAL CONGRESS OF PACIFIC BASIN SOCIETIES 2015 (Pacifichem2015)
    • Place of Presentation
      Hawaii Convention Center, Honolulu, Hawaii, USA
    • Year and Date
      2015-12-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Site-selective incorporation of nanoparticles into the complex coacervate utilizing self-assembly of block copolymers in aqueous solution.2015

    • Author(s)
      Kenshiro Naoyama, Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura
    • Organizer
      THE INTERNATIONAL CHEMICAL CONGRESS OF PACIFIC BASIN SOCIETIES 2015 (Pacifichem2015)
    • Place of Presentation
      Hawaii Convention Center, Honolulu, Hawaii, USA
    • Year and Date
      2015-12-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a novel enzymatic nano-reactors as biodetoxification nanomedicine.2015

    • Author(s)
      Hengmin Tang, Yuki Sakamura, Satoshi Tanaka, Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura
    • Organizer
      THE INTERNATIONAL CHEMICAL CONGRESS OF PACIFIC BASIN SOCIETIES 2015 (Pacifichem2015)
    • Place of Presentation
      Hawaii Convention Center, Honolulu, Hawaii, USA
    • Year and Date
      2015-12-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of polyion complex vesicle “PICsomes” and their unique self-assembling behavior2015

    • Author(s)
      Akihiro Kishimura
    • Organizer
      THE INTERNATIONAL CHEMICAL CONGRESS OF PACIFIC BASIN SOCIETIES 2015 (Pacifichem2015)
    • Place of Presentation
      Hawaii Convention Center, Honolulu, Hawaii, USA
    • Year and Date
      2015-12-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of enzyme-loaded polyion complex vesicles for in vivo nanoreactor.2015

    • Author(s)
      Yasutaka Anraku, Mako Kamiya, Sayaka Tanaka, Takahiro Nomoto, Kazuko Toh, Yu Matsumoto, Shigeto Fukushima, Daiki Sueyoshi, Akihiro Kishimura, Mitsunobu Kano, Yasuteru Urano, Nobuhiro Nishiyama, Kazunori Kataoka
    • Organizer
      THE INTERNATIONAL CHEMICAL CONGRESS OF PACIFIC BASIN SOCIETIES 2015 (Pacifichem2015)
    • Place of Presentation
      Hawaii Convention Center, Honolulu, Hawaii, USA
    • Year and Date
      2015-12-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 腫瘍環境制御に向けた生理活性物質を捕捉可能なヘパリン包含ナノデバイスの開発2015

    • Author(s)
      秦智貴、唐 ヘン敏、森健、片山佳樹、岸村顕広
    • Organizer
      第25回日本MRS年次大会
    • Place of Presentation
      横浜市中区(横浜市開港記念会館)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 高分子透過膜からなるベシクルの創製と次世代DDSへの応用生体膜2015

    • Author(s)
      岸村 顕広
    • Organizer
      第37回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      熊本大学 大江キャンパス、熊本
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Rational design of polyion complex nano-architectures for development of functional materials.2015

    • Author(s)
      Akihiro Kishimura
    • Organizer
      2015 Pusan-Gyeongnam/Kyushu-Seibu Joint Symposium on High Polymer (17th) and Fiber (15th)
    • Place of Presentation
      Dong-A University, Busan, Korea
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ポリイオンコンプレックスナノ構造体の創製とそのユニークな物性2015

    • Author(s)
      岸村 顕広
    • Organizer
      日本化学会新領域研究グループ「エキゾチック自己組織化材料(ExOM)」全体講演会
    • Place of Presentation
      つくばセミナーハウス、つくばみらい市、茨城
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Study on site-selective incorporation of Fe2O3-nanoparticle into the block copolymer based coacervate2015

    • Author(s)
      尚山堅士郎、森 健、片山佳樹、岸村顕広
    • Organizer
      日本化学会新領域研究グループ「エキゾチック自己組織化材料(ExOM)」全体講演会
    • Place of Presentation
      茨城県つくばみらい市(つくばセミナーハウス)
    • Year and Date
      2015-11-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of polyion complex nano-vesicles for biomedical applications2015

    • Author(s)
      Akihiro Kishimura
    • Organizer
      Polymers in Medicine and Biology: 2015
    • Place of Presentation
      Hilton Sonoma Wine Country, Santa Rosa, Califronia, USA
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 酵素封入型ナノリアクターの機能開発・酵素のナノコンパートメントへの格納と非荷電水溶性高分子共存の効果2015

    • Author(s)
      坂村有紀、唐 ヘン敏、山﨑北斗、森健、片山佳樹、岸村顕広
    • Organizer
      第9回バイオ関連化学シンポジウム
    • Place of Presentation
      熊本市中央区(熊本大学工学部)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of a novel enzymatic nano-reactor for the application of biodetoxification2015

    • Author(s)
      Hengmin Tang, Takeshi Mori, Satoshi Tanaka, Yoshiki Katayama and Akihiro Kishimura
    • Organizer
      42nd CRS Annual Meeting & Exposition
    • Place of Presentation
      Edinburgh, the Edinburgh International Conference Centre, Scotland, UK
    • Year and Date
      2015-07-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 糖タンパク質をビルディングブロックとした分子集合体の構造制御2015

    • Author(s)
      寺内 幹雄、尚山 堅士郎、森 健、片山佳樹、岸村 顕広
    • Organizer
      第52回化学関連支部合同九州大会
    • Place of Presentation
      北九州市小倉北区(北九州国際会議場)
    • Year and Date
      2015-06-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of novel polymeric vesicles with light-responsive properties for switching their in vivo functions2015

    • Author(s)
      山﨑北斗、唐衡敏、森健、片山佳樹、岸村顕広
    • Organizer
      第52回化学関連支部合同九州大会
    • Place of Presentation
      北九州市小倉北区(北九州国際会議場)
    • Year and Date
      2015-06-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] PEG-ポリペプチドブロック共重合体から形成されるコアセルベートへの部位選択的な無機微粒子内包挙動2015

    • Author(s)
      尚山堅士郎、森健、片山佳樹、岸村顕広
    • Organizer
      第64回高分子学会年次大会
    • Place of Presentation
      札幌コンベンションセンター、札幌市
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of enzymatic nano-reactor for removing physiological active substance2015

    • Author(s)
      唐 衡敏、森 健、田中 智之、片山佳樹、岸村 顕広
    • Organizer
      第64回高分子学会年次大会
    • Place of Presentation
      札幌コンベンションセンター、札幌市
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 光刺激による生体内機能スイッチングを可能とする新規ポリマーベシクルの開発2015

    • Author(s)
      山﨑 北斗、坂村 有紀、唐 衡敏、森 健、片山佳樹、岸村 顕広
    • Organizer
      第64回高分子学会年次大会
    • Place of Presentation
      札幌コンベンションセンター、札幌市
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] ポリイオンコンプレックスを基盤とする高分子ナノ構造材料の開発と応用2015

    • Author(s)
      岸村 顕広
    • Organizer
      第151回東海高分子研究会講演会
    • Place of Presentation
      名古屋工業大学、名古屋
    • Year and Date
      2015-04-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Development of a novel biodetoxification nano-reactor for removing histamine2014

    • Author(s)
      Hengmin Tang, Takeshi Mori, Satoshi Tanaka, Yoshiki Katayama and Akihiro Kishimura
    • Organizer
      The 2014 Biomedical Engineering International Conference
    • Place of Presentation
      福岡市東区(九大馬出キャンパス)
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 酵素封入型ナノリアクターを用いた生体内生理活性物質除去技術の開発2014

    • Author(s)
      唐 衡敏、森 健、田中 智之、片山佳樹、岸村 顕広
    • Organizer
      第36回日本バイオマテリアル学会大会
    • Place of Presentation
      東京都江戸川区
    • Year and Date
      2014-11-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 物性制御可能なナノカプセルの開発と新しい生理学の可能性2014

    • Author(s)
      岸村 顕広
    • Organizer
      第二回生体分子サイエンスセミナー
    • Place of Presentation
      すずかけ台ホール、東京工業大学
    • Year and Date
      2014-09-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Enzyme-loaded polyion complex vesicles (PICsomes) and their use as biodetoxification nano-reactor2014

    • Author(s)
      Hengmin Tang, Takeshi Mori, Satoshi Tanaka, Yoshiki Katayama and Akihiro Kishimura
    • Organizer
      The 15 th IUMRS International Conference in Asia
    • Place of Presentation
      Fukuoka University, Fukuoka, Japan
    • Year and Date
      2014-08-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 高分子中空ナノカプセルPICsomeを用いた新しいDDSのアプローチ2014

    • Author(s)
      岸村 顕広
    • Organizer
      第30回日本DDS学会学術集会
    • Place of Presentation
      慶応義塾大学(芝共立キャンパス)、東京
    • Year and Date
      2014-07-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ジアミンオキシダーゼ封入PICsomeの開発とヒスタミン分解・除去機能の評価2014

    • Author(s)
      唐 衡敏、森 健、田中智之、片山佳樹、岸村顕広
    • Organizer
      第30回日本DDS学会学術集会
    • Place of Presentation
      慶応義塾大学(芝共立キャンパス)、東京
    • Year and Date
      2014-07-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of Polyion Complex Vesicles “PICsomes” with Semipermeable Properties As a Novel Platform for Nano-medicine2014

    • Author(s)
      Akihiro Kishimura
    • Organizer
      The 5th International Conference on the Development of Biomedical Engineering in Vietnam
    • Place of Presentation
      Ho Chi Minh City, Vietnam
    • Year and Date
      2014-06-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ポリイオンコンプレックスを用いた水中での簡便なポリマーナノ構造形成と生体材料応用2014

    • Author(s)
      岸村 顕広
    • Organizer
      第86回千葉地域活動高分子研究交流講演会
    • Place of Presentation
      出光会館、市原市、千葉
    • Year and Date
      2014-06-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ポリイオンコンプレックス型透過膜を有する中空カプセルPICsomeの開発とDDSへの応用2014

    • Author(s)
      岸村 顕広
    • Organizer
      日本膜学会第36年会
    • Place of Presentation
      早稲田大学(西早稲田キャンパス)、東京
    • Year and Date
      2014-05-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Book] 自己組織化マテリアルのフロンティア2015

    • Author(s)
      岸村顕広
    • Total Pages
      336
    • Publisher
      フロンティア出版
    • Related Report
      2015 Annual Research Report
  • [Book] DDSキャリア作製プロトコル集2015

    • Author(s)
      岸村顕広
    • Total Pages
      262
    • Publisher
      シーエムシー出版
    • Related Report
      2015 Annual Research Report
  • [Remarks] 九州大学大学院工学研究院応用化学部門片山研究室ホームページ(研究紹介)

    • URL

      http://www.chem.kyushu-u.ac.jp/~katayama/research.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 九州大学大学院工学研究院応用化学部門片山研究室ホームページ(研究紹介・英語版)

    • URL

      http://www.chem.kyushu-u.ac.jp/~katayama/en/research.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] ResearchGate 個人ページ

    • URL

      https://www.researchgate.net/profile/Akihiro_Kishimura

    • Related Report
      2016 Annual Research Report
  • [Remarks] 九州大学大学院工学研究院 応用化学部門分子教室(片山研)

    • URL

      http://www.chem.kyushu-u.ac.jp/~katayama/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 分子システム科学センター (CMS)

    • URL

      http://www.chem.kyushu-u.ac.jp/~cms/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 九州大学大学院工学研究院応用化学部門(分子) 片山研

    • URL

      http://www.chem.kyushu-u.ac.jp/~katayama/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 九州大学分子システム科学センター

    • URL

      http://www.chem.kyushu-u.ac.jp/~cms/

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2022-02-16  

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