| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Outline of Final Research Achievements |
We developed a Mechanical Electro-Magneto Nerve Regeneration Device with Biocompatible Piezoelectric Material MgSiO3, as demonstrated below: (1) Cellular Automaton Simulation code. (2) Bio-MEMS device for activate the axonal extension of nerve cell PC12 to study the influence of cell interval and zenith corner angle. (3) Multi-layer diaphragm using the biocompatible piezoelectric material MgSiO3 to generate mechanical static electro magneto field. (4) AC magneto field stimulation device for PC12 axonal extension acceleration. (5) Electro magneto mechanical stimulation device in the extra-cellular environment to activate PC12 cell and axonal extension. We confirmed that increases of 25.2% in case of mechanical stimulation, 37.4% in the uniform magneto field stimulation and 70.0% in the mechanical electro magneto hybrid stimulation.
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