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Development of biomimetic super-low friction articulating tissue and evaluation of its mechanical and tribological function

Research Project

Project/Area Number 26289029
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Design engineering/Machine functional elements/Tribology
Research InstitutionKyushu University

Principal Investigator

Sawae Yoshinori  九州大学, 工学(系)研究科(研究院), 教授 (10284530)

Co-Investigator(Kenkyū-buntansha) 山口 哲生  九州大学, 工学(系)研究科(研究院), 准教授 (20466783)
森田 健敬  九州大学, 工学(系)研究科(研究院), 助教 (70175636)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords低摩擦 / 細胞・組織 / 関節軟骨 / トライボロジー / 再生医療
Outline of Final Research Achievements

The novel culture method for cartilage regeneration was explored to obtain highly functional articulating tissue with the cartilage-like super-low friction characteristic by reproducing the loading condition within the cartilage tissue under walking and exposing chondrocytes being cultured in the scaffold to it. A glass roller was indented into the flat scaffold surface and make a rolling-sliding motion to exert inhomogeneous and transient stress and strain field in the scaffold, which thought to be essential to simulate the mechanical condition inside the cartilage tissue under walking. The experimental system for evaluating the frictional characteristic of elaborated articular tissue was also developed. This system was enabled to measure the deformation of each chondrocyte in the cultured tissue during sliding test since the relationship between the cellular deformation caused by friction at the tissue surface and subsequent functional development of cultured tissue quantitatively.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (42 results)

All 2017 2016 2015 2014

All Journal Article (11 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 9 results,  Acknowledgement Compliant: 3 results,  Open Access: 3 results) Presentation (31 results) (of which Int'l Joint Research: 10 results,  Invited: 5 results)

  • [Journal Article] The Influence of Proteins and Speed on Friction and Adsorption of Metal/UHMWPE Contact Pair2017

    • Author(s)
      Necas,D, Sawae,Y, Fujisawa,T., Nakashima, K., Morita,T., Yamaguchi,T., Vrbka, M., Krupka, I., Hartl, M.
    • Journal Title

      Biotribology

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Importance of Adaptive Multimode Lubrication Mechanism in Natural Synovial Joints2017

    • Author(s)
      T. Murakami, S. Yarimitsu, N. Sakai, K. Nakashima, T. Yamaguchi, Y. Sawae
    • Journal Title

      Tribology International

      Volume: 印刷中 Pages: 306-315

    • DOI

      10.1016/j.triboint.2016.12.052

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Improved wear resistance of functional diamond like carbon coated Ti–6Al–4V alloys in an edge loading conditions2016

    • Author(s)
      Choudhury, D., Lackner, J.M., Major, L., Morita, T., Sawae, Y., Bin Mamat, A., Stavness, I., Roy, C.K., Krupka, I.
    • Journal Title

      J Mech Behav Biomed Mater

      Volume: 59 Pages: 586-595

    • DOI

      10.1016/j.jmbbm.2016.04.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Influence of Elastic Recovery of Machining Surface Asperities on the Contact Stress and Plastic Strain of Polyethylene Tibial Insert in Virgin Knee Prosthesis2016

    • Author(s)
      Cho, C., Murakami, T., Sawae, Y.
    • Journal Title

      Tribology Online

      Volume: 11 Issue: 2 Pages: 320-325

    • DOI

      10.2474/trol.11.320

    • NAID

      130005149914

    • ISSN
      1881-218X, 1881-2198
    • Related Report
      2016 Annual Research Report
    • Open Access
  • [Journal Article] A novel functional layered diamond like carbon coating for orthopedics applications2016

    • Author(s)
      Choudhury, D., Morita, T., Sawae, Y., Lackner, J.M., Towler, M., Krupka, I.
    • Journal Title

      Diamond and Related Materials

      Volume: 61 Pages: 56-59

    • DOI

      10.1016/j.diamond.2015.11.011

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A functional effect of the superficial mechanical properties of articular cartilage as a load bearing system in a sliding condition2016

    • Author(s)
      N. Sakai, C. Hashimoto, S. Yarimitsu, Y. Sawae, M. Komori, T. Murakami
    • Journal Title

      Biosurface and Biotribology

      Volume: 2 Issue: 1 Pages: 26-39

    • DOI

      10.1016/j.bsbt.2016.02.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effect of radiationdose on depth-dependent oxidation and wear of shelf-aged gamma-irradiated ultra-high molecular weight polyethylene (UHMWPE)2015

    • Author(s)
      Zhang, L., Sawae, Y., Yamaguchi, T., Murakami, T., Yang, H.
    • Journal Title

      Tribology International

      Volume: 89 Pages: 78-85

    • DOI

      10.1016/j.triboint.2014.12.011

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Investigation on Oxidation of Shelf-Aged Crosslinked Ultra-High Molecular Weight Polyethylene (UHMWPE) and Its Effects on Wear Characteristics2015

    • Author(s)
      L. Zhang, Y. Sawae, T. Yamaguchi, T. Murakami and H. Yang
    • Journal Title

      Tribology Online

      Volume: 10 Issue: 1 Pages: 1-10

    • DOI

      10.2474/trol.10.1

    • NAID

      130004948471

    • ISSN
      1881-218X, 1881-2198
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect ofradiationdoseondepth-dependentoxidationandwear of shelf-agedgamma-irradiatedultra-highmolecularweight polyethylene(UHMWPE)2015

    • Author(s)
      Lei Zhang, YoshinoriSawae, TetsuoYamaguchi, TeruoMurakami, HongYang
    • Journal Title

      Tribology International

      Volume: *

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Superior Lubricity in Articular Cartilage and Artificial Hydrogel Cartilage2014

    • Author(s)
      T. Murakami, S. Yarimitsu, K. Nakashima, T. Yamaguchi, Y. Sawae, N. Sakai and A. Suzuki
    • Journal Title

      Proc IMechE Part J : J Engineering Tribology

      Volume: 228 Issue: 10 Pages: 1099-1111

    • DOI

      10.1177/1350650114530273

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 人工関節における高分子材料のトライボロジー2014

    • Author(s)
      澤江義則
    • Journal Title

      高分子

      Volume: 63 Pages: 285-287

    • Related Report
      2014 Annual Research Report
  • [Presentation] 摺動負荷培養下での再生軟骨組織モデル内部応力分布変化による ECM 産生への影響2017

    • Author(s)
      福田圭祐,小俣誠二,澤江義則
    • Organizer
      第37回バイオトライボロジシンポジウム
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
  • [Presentation] 培養軟骨組織のトライボロジー評価2017

    • Author(s)
      執行佳史,福田圭祐,澤江義則
    • Organizer
      第37回バイオトライボロジシンポジウム
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
  • [Presentation] Frictional Characteristics of Hip Joint Prosthesis with Hydrogel Acetabular Liner2016

    • Author(s)
      Ryosuke Baba, Yoshinori Sawae, Takehiro Morita, Tetsuo Yamaguchi, Teruo Murakami
    • Organizer
      International Conference on Engineering Tribology and Applied Technology 2016
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2016-11-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 歩行条件下におけるハイドロゲル人工軟骨を有する人工股関節の摩擦評価2016

    • Author(s)
      馬場亮佑,澤江義則,森田健敬,山口哲生
    • Organizer
      サステイナブルトライボロジー会議2016奄美大島
    • Place of Presentation
      鹿児島県奄美市
    • Year and Date
      2016-10-31
    • Related Report
      2016 Annual Research Report
  • [Presentation] 歩行条件下におけるハイドロゲル人工軟骨を有する人工股関節の摩擦評価2016

    • Author(s)
      馬場亮佑,澤江義則,森田建敬,山口哲生,小俣誠二,村上 輝夫
    • Organizer
      日本機械学会2016年度年次大会
    • Place of Presentation
      福岡市
    • Year and Date
      2016-09-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] Influence of protein adsorption on friction of metal/UHMWPE sliding pair2016

    • Author(s)
      D. Necas, Y. Sawae, T. Fujisawa, K. Nakashima, T. Morita, T. Yamaguchi, M. Vrbka, I. Krupka, M. Hartl
    • Organizer
      3rd International Conference on BioTribology 2016
    • Place of Presentation
      London, UK
    • Year and Date
      2016-09-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] FRICTIONAL CHARACTERISTICS OF HIGHLY HYDRATED HYDROGEL ARTIFICIAL CARTILAGE2016

    • Author(s)
      Y. Sawae, R. Baba, Y. Hong, T. Yamaguchi, T. Morita
    • Organizer
      4th Malaysia-Japan Tribology Symposium 2016
    • Place of Presentation
      Kuala Lumpur, Malaysia
    • Year and Date
      2016-08-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Wear Mechanism of Polyethylene in Joint Prosthesis2016

    • Author(s)
      Yoshinori Sawae, Lei Zhang
    • Organizer
      The 7th Advanced Forum on Tribology 2016, Nara
    • Place of Presentation
      奈良県橿原市
    • Year and Date
      2016-04-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 人工関節用超高分子量ポリエチレン の摩擦に及ぼす血清タンパク質の影 響2016

    • Author(s)
      藤澤寿洋,澤江義則, David Necas,森田健敬,中嶋和弘, 山口哲生
    • Organizer
      日本機械学会 九州支部第69期総会・講演会
    • Place of Presentation
      熊本
    • Year and Date
      2016-03-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] Influence of the traction loads on ECM production and distribution in regenerated cartilage tissue2016

    • Author(s)
      K. Fukuda, S. Omata, Y. Sawae
    • Organizer
      3rd International Conference on BioTribology 2016
    • Place of Presentation
      London, UK
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ローラーによるしゅう動負荷が再生軟骨組織モデルのECM産生に及ぼす影響2016

    • Author(s)
      福田圭祐,澤江義則
    • Organizer
      第38回バイオトライボロジ研究会
    • Place of Presentation
      静岡県裾野市
    • Related Report
      2016 Annual Research Report
  • [Presentation] 培養軟骨組織モデルの表面性状評価2016

    • Author(s)
      執行佳史,澤江義則
    • Organizer
      第38回バイオトライボロジ研究会
    • Place of Presentation
      静岡県裾野市
    • Related Report
      2016 Annual Research Report
  • [Presentation] 培養再生軟骨組織への定量的動的せん断ひずみ負荷と内部細胞の変形定量に関する研究2016

    • Author(s)
      有浦秀昭,澤江義則
    • Organizer
      第38回バイオトライボロジ研究会
    • Place of Presentation
      静岡県裾野市
    • Related Report
      2016 Annual Research Report
  • [Presentation] Effects of oxidative degradation on the wear and wear particles of cross-linked UHMWPE2015

    • Author(s)
      Lei Zhang, Yoshinori Sawae, Tetsuo Yamaguchi, Teruo Murakami
    • Organizer
      Malaysian International Tribology Conference 2015
    • Place of Presentation
      Penang, Malaysia
    • Year and Date
      2015-11-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 表面に対する摺動負荷が再生軟骨組織形成に及ぼす影響2015

    • Author(s)
      福田圭祐,小俣誠 二,澤江義則
    • Organizer
      第 26 回バイオフロンティア講演会
    • Place of Presentation
      福岡
    • Year and Date
      2015-10-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] Behavior of Protein Film Adsorbed on Joint Prosthesis Material under Rubbing2015

    • Author(s)
      Kazuhiro Nakashima, Yoshinori Sawae, Susumu Kudo, Teruo Murakami
    • Organizer
      The 8th International Biotribology Forum
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2015-09-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ECM Production in Chondrocyte-Agarose Construct Cultured under Traction Loading2015

    • Author(s)
      Keisuke Fukuda, Seiji Omata, Yoshinori Sawae
    • Organizer
      The 8th Asian-Pacific Conference on Biomechanics
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2015-09-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of High Gamma-Ray Irradiation Dose on Oxidation and Wear of Cross-Linked Polyethylene2015

    • Author(s)
      Lei Zhang, Yoshinori Sawae, Tetsuo Yamaguchi, Teruo Murakami
    • Organizer
      International Tribology Conference, Tokyo 2015
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2015-09-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ECM produc6on and distribu6on in regenerated car6lage 6ssue cultured under trac6on loading2015

    • Author(s)
      Keisuke Fukuda, Yoshinori Sawae
    • Organizer
      IUPESM World Congress 2015
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2015-06-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 人工関節材料の摩擦摩耗特性へ影響 する蛋白質吸着膜の観察2015

    • Author(s)
      中嶋和弘,澤江義則,工藤奨,村上 輝夫
    • Organizer
      トライボロジー会議 2015春 姫路
    • Place of Presentation
      姫路市
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Biotribology Research in Japan2014

    • Author(s)
      Yoshinori Sawae
    • Organizer
      Czech-Japan Tribology Workshop
    • Place of Presentation
      Mikulov, Czech Republic
    • Year and Date
      2014-11-24 – 2014-11-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Development of anisotropic cartilage tissue in chondrocyte-agarose construct cultured under traction loading2014

    • Author(s)
      Keisuke Fukuda, Seiji Omata, Yoshinori Sawae
    • Organizer
      2014 International Conference on Engineering Tribology Technology
    • Place of Presentation
      Taiwan
    • Year and Date
      2014-11-21 – 2014-11-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Investigation of wear and wear particles from shelf-aged crosslinked UHMWPE under different contact pressures2014

    • Author(s)
      Lei Zhang, Yoshinori Sawae, Teruo Murakami, Ken Yuki
    • Organizer
      3rd Malaysia-Japan Tribology Symposium 2014
    • Place of Presentation
      Kuala lumpr, Malaysia
    • Year and Date
      2014-11-12 – 2014-11-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 架橋ポリエチレンの酸化劣化と摩耗への影響2014

    • Author(s)
      張磊,澤江義則,山口哲生,森田健敬,村上輝夫
    • Organizer
      トライボロジー会議 2014秋 盛岡
    • Place of Presentation
      岩手県盛岡市
    • Year and Date
      2014-11-05 – 2014-11-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 再生軟骨組織モデル表面に対する摺動負荷によるECMの分布への影響2014

    • Author(s)
      福田圭祐,小俣誠二,澤江義則
    • Organizer
      第25回バイオフロンティア講演会
    • Place of Presentation
      鳥取県鳥取市
    • Year and Date
      2014-10-03 – 2014-10-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Characterisation of regenerated cartilage tissue model cultured with traction loading on its surface2014

    • Author(s)
      Keisuke Fukuda, Seiji Omata, Yoshinori Sawae
    • Organizer
      The 4th Japan-Switzerland Workshop on Biomechanics
    • Place of Presentation
      三重県志摩市
    • Year and Date
      2014-09-01 – 2014-09-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 人工関節材料と関節液成分のバイオトライボロジ2014

    • Author(s)
      澤江義則
    • Organizer
      第36回バイオトライボロジ研究会
    • Place of Presentation
      静岡県裾野市
    • Year and Date
      2014-08-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 人工関節材料のトライボロジー特性に対する生体内環境の影響2014

    • Author(s)
      澤江義則
    • Organizer
      第53 回日本生体医工学会大会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2014-06-24 – 2014-06-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Friction characterization of ceramic-on-hydrogel hip joint in pendulum test2014

    • Author(s)
      Y. Sawae, M. Vrbka, F. Urban, D. Necas, S. Yarimitsu, K. Nakashima, T. Murakami, M. Hartl
    • Organizer
      2nd International Conference on BioTribology
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2014-05-12 – 2014-05-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effect of radiation dose on depth-dependent oxidation and wear of gamma-irradiated ultra-high molecular weight polyethylene (UHMWPE)2014

    • Author(s)
      L. Zhang, Y. Sawae, T. Yamaguchi, T. Murakami, H. Yang
    • Organizer
      2nd International Conference on BioTribology
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2014-05-12 – 2014-05-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Protein adsorbed film formation and frictional characteristics of CoCrMo-on-UHMWPE sliding pair in reciprocating sliding test2014

    • Author(s)
      D. Necas, Y. Sawae, S. Yarimitsu, K. Nakashima, M. Vrbka, M. Hartl, T. Murakami
    • Organizer
      2nd International Conference on BioTribology
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2014-05-12 – 2014-05-14
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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