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Research on CMOS Paper Chromatography and Its Application to Small Biosensing System

Research Project

Project/Area Number 26289111
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Electron device/Electronic equipment
Research InstitutionRitsumeikan University

Principal Investigator

UNO Shigeyasu  立命館大学, 理工学部, 教授 (40420369)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Keywordsバイオセンサー / 半導体集積回路 / 電気化学 / クロマトグラフィペーパー / CMOS / 電子デバイス・機器 / バイオ関連機器 / マイクロ・ナノデバイス
Outline of Final Research Achievements

In this research project, we aimed to combine the semiconductor integrated circuit technology and chromatography paper technology to realize electrochemical biomolecule sensing. The integrated circuit technology is known to be beneficial for fabricating microscale devices and electrodes, as well as high level of electronic circuit integration, which is indispensable for readout, signal processing, and communication. Meanwhile, chromatography paper is widely used in analytical chemistry and clinical medicine, and it is suitable for collection, filtration, transfer, and chemical reaction of sample solution under test. In this research, we have investigated various aspects regarding paper-based electrochemical sensor, paper-based fluidic devices, and their integration with semiconductor integrated circuits.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (38 results)

All 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Open Access: 9 results,  Acknowledgement Compliant: 7 results) Presentation (25 results) (of which Int'l Joint Research: 10 results,  Invited: 1 results) Book (1 results)

  • [Int'l Joint Research] Indian Institute of Technology Hyderabad(インド)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] (招待論文)モバイルヘルスケアのためのCMOS集積回路とペーパーバイオセンサーの統合2018

    • Author(s)
      宇野重康, 河原翔梧, 藤本拓也, 釜堀政男
    • Journal Title

      電子情報通信学会和文論文誌

      Volume: J101-C Pages: 156-165

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Redox Cycling Realized in Paper-Based Biochemical Sensor for Selective Detection of Reversible Redox Molecules Without Micro/Nano Fabrication Process2018

    • Author(s)
      So Yamamoto, Shigeyasu Uno
    • Journal Title

      Sensors

      Volume: 18 Issue: 3 Pages: 730-742

    • DOI

      10.3390/s18030730

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improvement in Limit of Detection of Enzymatic Biogas Sensor Utilizing Chromatography Paper for Breath Analysis2018

    • Author(s)
      Masanobu Motooka, Shigeyasu Uno
    • Journal Title

      Sensors

      Volume: 18 Issue: 2 Pages: 440-449

    • DOI

      10.3390/s18020440

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Paper-based Potentiometric pH Sensor using Carbon Electrode Drawn by Pencil2018

    • Author(s)
      Ryotaro Kawahara, Parikshit Sahatiya, Sushmee Badhulika and Shigeyasu Uno
    • Journal Title

      Jpn. J. Appl. Phys

      Volume: 57 Issue: 4S Pages: 04FM08-04FM08

    • DOI

      10.7567/jjap.57.04fm08

    • NAID

      210000148980

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] An Electrochemical Gas Biosensor Based on Enzymes Immobilized on Chromatography Paper for Ethanol Vapor Detection2017

    • Author(s)
      Tatsumi Kuretake, Shogo Kawahara, Masanobu Motooka and Shigeyasu Uno
    • Journal Title

      Sensors

      Volume: 17 Issue: 2 Pages: 281-281

    • DOI

      10.3390/s17020281

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Potentiometric Glucose Detection by Paper-based Electrochemical Sensor on CMOS Chip2017

    • Author(s)
      Katsuyuki Yamaoka, Jun Eguchi, and Shigeyasu Uno
    • Journal Title

      TELKOMNIKA

      Volume: 15 Issue: 2 Pages: 836-836

    • DOI

      10.12928/telkomnika.v15i1.6129

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Electrochemical Redox Cycling Realized by Chromatography Paper-based Sensor2017

    • Author(s)
      Kenichi Fukayama, Sou Yamamoto, Shigeyasu Uno
    • Journal Title

      TELKOMNIKA

      Volume: 15 Issue: 2 Pages: 842-842

    • DOI

      10.12928/telkomnika.v15i1.6130

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Simultaneous Electrochemical Measurement using Paper Fluidic Channel on CMOS Chip2017

    • Author(s)
      Jun Eguchi, Katsuyuki Yamaoka, Shigeyasu Uno
    • Journal Title

      TELKOMNIKA

      Volume: 15 Issue: 2 Pages: 847-847

    • DOI

      10.12928/telkomnika.v15i1.6131

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Portable Electrochemical Gas Sensing System with a Paper-Based Enzyme Electrode2017

    • Author(s)
      Shogo Kawahara, Yukio Fuchigami, Shoji Shimokawa, Yousuke Nakamura, Tatsumi Kuretake, Masao Kamahori, Shigeyasu Uno
    • Journal Title

      TELKOMNIKA

      Volume: 15 Issue: 2 Pages: 895-895

    • DOI

      10.12928/telkomnika.v15i1.6142

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Portable Electrochemical Sensing System Attached to Smartphones and Its Incorporation with Paper-based Electrochemical Glucose Sensor2017

    • Author(s)
      Takuya Fujimoto, Shogo Kawahara, Yukio Fuchigami, Shoji Shimokawa, Yosuke Nakamura, Kenichi Fukayama, Masao Kamahori, Shigeyasu Uno
    • Journal Title

      International Journal of Electrical and Computer Engineering

      Volume: 7

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Impedance Analysis of Colloidal Gold Nanoparticles in Chromatography Paper for Quantitation of an Immunochromatographic Assay2016

    • Author(s)
      Fumitaka Hori, Yuji Harada, Tatsumi Kuretake, and Shigeyasu Uno
    • Journal Title

      Analytical Sciences

      Volume: 32 Issue: 3 Pages: 355-359

    • DOI

      10.2116/analsci.32.355

    • NAID

      130005131639

    • ISSN
      0910-6340, 1348-2246
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Electrochemical Biosensors based on CMOS LSI Chips2018

    • Author(s)
      S. Uno
    • Organizer
      233rd ECS Meeting, Seattle, USA (May 15 2018), 1471 (to be presented)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Paper-based Potentiometric pH Sensor using Carbon Electrode Drawn by Pencil2017

    • Author(s)
      R. Kawahara, P. Sahatiya, S. Badhulika and S. Uno
    • Organizer
      International Conference on Solid State Devices and Materials (SSDM2017), Sendai, Japan
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Redox Cycling Realized in Paper-based Electrochemical Biosensor for highly-selective Detection of Potassium Ferrocyanide in the presence of Ascorbic Acid2017

    • Author(s)
      S. Yamamoto and S. Uno
    • Organizer
      5th International Symposium on Sensor Science (I3S2017), Barcelona, Spain (September 27, 2017), S1-5.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Improvement in Limit of Detection of Paper-Based Electrochemical Enzymatic Biogas Sensor2017

    • Author(s)
      M. Motooka and S. Uno
    • Organizer
      5th International Symposium on Sensor Science (I3S2017), Barcelona, Spain (September 27, 2017), P-9.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Electrochemical Current Measurement by CMOS Potentiostat Integrating Chrompatography Paper Fluidic Channel and CMOS LSI Chip for Small Biosensors2017

    • Author(s)
      J. Eguchi, K. Yamaoka and S. Uno
    • Organizer
      5th International Symposium on Sensor Science (I3S2017), Barcelona, Spain(September 27, 2017), P-53.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Enhancement of Electrochemical Current by Redox Cycling Realized by Chromatography Paper-based Biochemical Sensor2016

    • Author(s)
      K. Fukayama, S. Uno, and S. Yamamoto
    • Organizer
      The International Conference on Electrical, Electronic, Communication and Control Engineering
    • Place of Presentation
      Johor Bahru, Malaysia
    • Year and Date
      2016-12-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Potentiometric Detection of Glucose in Liquid Sample by Chromatography Paper Fluidic Channel and CMOS LSI Chip2016

    • Author(s)
      K. Yamaoka, J. Eguchi, and S. Uno
    • Organizer
      The International Conference on Electrical, Electronic, Communication and Control Engineering
    • Place of Presentation
      Johor Bahru, Malaysia
    • Year and Date
      2016-12-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Simultaneous Electrochemical Current Measurement Using Chromatography Paper Fluidic Channel and CMOS LSI Chip for Biosensor Applications2016

    • Author(s)
      J. Eguchi, K. Yamaoka, and S. Uno
    • Organizer
      The International Conference on Electrical, Electronic, Communication and Control Engineering
    • Place of Presentation
      Johor Bahru, Malaysia
    • Year and Date
      2016-12-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Portable Electrochemical Sensing System Attached to Smartphones and Its Incorporation with Paper-based Electrochemical Glucose Sensor2016

    • Author(s)
      T. Fujimoto, S. Kawahara, Y. Fuchigami, S. Shimokawa, Y. Nakamura, K. Fukayama, M. Kamahori, and S. Uno
    • Organizer
      The International Conference on Electrical, Electronic, Communication and Control Engineering
    • Place of Presentation
      Johor Bahru, Malaysia
    • Year and Date
      2016-12-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Electrochemical Quantitative Analysis of Ethanol Gas Using Paper-Based Electrode with Immobilized2016

    • Author(s)
      S. Kawahara, Y. Fuchigami, S. Shimokawa, Y. Nakamura, T. Kuretake, M. Kamahori, and S. Uno
    • Organizer
      The International Conference on Electrical, Electronic, Communication and Control Engineering
    • Place of Presentation
      Johor Bahru, Malaysia
    • Year and Date
      2016-12-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] (依頼講演)電気化学的バイオセンサーを用いた簡易迅速診断のためのデバイスと集積回路2016

    • Author(s)
      宇野重康
    • Organizer
      応用物理学会有機分子・バイオエレクトロニクス分科会講習会「バイオセンシングの新展開」
    • Place of Presentation
      東京理科大学 森戸記念館 (東京都新宿区)
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] (依頼講演)モバイルヘルスケアのためのCMOS 集積回路とペーパーバイオセンサーの統合2016

    • Author(s)
      宇野重康, 河原翔梧, 藤本拓也, 釜堀政男
    • Organizer
      2016年電子情報通信学会ソサエティ大会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2016-09-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] スマートフォン取付型センシングシステムによるクロマトグラフィ―ペーパー酵素電極を用いたエタノールガスの電気化学的検出2016

    • Author(s)
      河原翔梧, 渕上幸男, 下川翔士, 中村瑛甫, 呉竹龍巳, 釜堀政男, 宇野重康
    • Organizer
      春季第63回応用物理学会学術講演会, 19p-W331-2
    • Place of Presentation
      東京工業大学(東京都目黒区)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] CMOSチップ上微小流路に向けたクロマトグラフィペーパーとシリコーンによる流路作製2016

    • Author(s)
      山岡克行, 江口潤, 宇野重康
    • Organizer
      春季第63回応用物理学会学術講演会, 19p-W331-6
    • Place of Presentation
      東京工業大学(東京都目黒区)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] クロマトグラフィーペーパー流路とCMOSバイオセンサチップの統合2016

    • Author(s)
      江口潤, 山岡克行, 宇野重康
    • Organizer
      春季第63回応用物理学会学術講演会, 19p-W331-7
    • Place of Presentation
      東京工業大学(東京都目黒区)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] ペーパーバイオケミカルセンサにおける電極構造 が電気化学特性に与える影響2015

    • Author(s)
      深山賢一, 宇野重康
    • Organizer
      秋季第76 回応用物理学会学術講演, 13a-2B-3
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 針型電極による電気化学インピー ダンス法を用いた溶液中金ナノ粒子の検出2015

    • Author(s)
      飯田智貴, Qatrun Nada, 宇野重康
    • Organizer
      秋季第76 回応用物理学会学術講演, 13a-2B-4
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] An Enzymatic Amperometric Alcohol Sensor on CMOS Chip using Carbon Ink Electrode and Chromatography Paper2014

    • Author(s)
      Q.N. Hassanuddin, M. Miki, and S. Uno
    • Organizer
      Malaysia Japan Academic Scholar Conference 2014 (MJASC 2014), M14-P20-B
    • Place of Presentation
      慶應大学(東京都)
    • Year and Date
      2014-11-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dependence of Electrochemical Impedance on Latex Beads Density of Electrolytic Solution in Chromatography Paper2014

    • Author(s)
      Shohei Iwahara, Yuji Harada, Shigeyasu Uno
    • Organizer
      10th International Symposium on Electrochemical Micro & Nanosystem Technologies (EMNT2014), P-074
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県)
    • Year and Date
      2014-11-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Basic Study of Electrochemical Measurement with Chromatography Paper2014

    • Author(s)
      Yuji Harada, Shohei Iwahara, Shigeyasu Uno
    • Organizer
      10th International Symposium on Electrochemical Micro & Nanosystem Technologies (EMNT2014)
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県)
    • Year and Date
      2014-11-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] クロマトグラフィーペーパー浸透溶液中金ナノ粒子のインピーダンス法による検出2014

    • Author(s)
      堀文貴, 岩原昇平, 宇野重康
    • Organizer
      秋季第75回応用物理学会学術講演会, 19p-A2-15
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] クロマトグラフィーペーパーとフロー制御装置を用いた酵素センサによるアルコールガスの電気化学的検出2014

    • Author(s)
      呉竹龍巳, Muhammad Syakirin Musa, 宇野重康
    • Organizer
      秋季第75回応用物理学会学術講演会, 19p-A2-16
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] クロマトグラフィーペーパーを用いたサイクリックボルタンメトリー測定の基礎実験2014

    • Author(s)
      原田裕司, 宇野重康
    • Organizer
      秋季第75回応用物理学会学術講演会, 19p-A2-17
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] クロマトグラフィーペーパーを用いた電気化学測定のコンピュータシミュレーション2014

    • Author(s)
      朴康太, 原田裕司, 宇野重康
    • Organizer
      秋季第75回応用物理学会学術講演会, 19p-A2-18
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Electrochemical Impedance Spectroscopy of Colloidal Gold Nanoparticles in Chromatography Paper for Immunochromatographic Assay2014

    • Author(s)
      F. Hori and S. Uno
    • Organizer
      International Conference on Solid State Devices and Materials (SSDM 2014), PS-11-14
    • Place of Presentation
      つくば国際会議場(神奈川県)
    • Year and Date
      2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Book] 細胞・生体分子の固定化と機能発現 (第一章:紙ベースの酵素固定化とバイオケミカルセンサー)2018

    • Author(s)
      宇野重康、河原翔梧、藤本拓也
    • Total Pages
      294
    • Publisher
      シーエムシー出版
    • ISBN
      9784781313269
    • Related Report
      2017 Annual Research Report

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Published: 2014-04-04   Modified: 2019-03-29  

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