Evaluation method for analysis of heating mechanism of intercellular magnetic nanoparticles

• Project/Area Number: 26289124
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Measurement engineering
• Research Institution: Yokohama National University
• Principal Investigator: TAKEMURA Yasushi 横浜国立大学, 工学(系)研究科(研究院), 教授 (30251763)
• Co-Investigator(Kenkyū-buntansha): 山田 努 横浜国立大学, 工学(系)研究科(研究院), 助手 (70251767)
• Co-Investigator(Renkei-kenkyūsha): KAMI Daisuke 京都府立医科大学, 大学院医学研究科, 講師 (80415588)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000); Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2014: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
• Keywords: 計測工学 / 磁性 / ナノ粒子 / 磁性ナノ粒子 / ナノ材料

Outline of Final Research Achievements

Hyperthermia is a cancer therapy which heats temperature of a cancer tissue at over 42.5 deg. C to kill the cancer cells selectively. It poses a low risk to the body and causes few side effects as compared to surgery, chemotherapy, and radiation therapy. This study contributed for development of highly efficient heating of magnetic nanoparticles. The heating mechanism of intercellular magnetic nanoparticles was successfully analyzed.

Research Products

• [Int'l Joint Research] Florida International University(米国)
• [Int'l Joint Research] Anna University(India)
• [Journal Article] Layer-by-layer assembled magnetic prednisolone microcapsules (MPC) for controlled and targeted drug release at rheumatoid arthritic joints (2017)
  • Author(s): C. Prabu, S. Latha, P. Selvamani, F. Ahrentorp, C. Johansson, R. Takeda, Y. Takemura, S. Ota
  • Journal Title: Journal of Magnetism and Magnetic Materials Volume: 427 Pages: 258-267
  • DOI: 10.1016/j.jmmm.2016.11.030
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain (2017)
  • Author(s): A. Tomitaka, H. Arami, A. Raymond, A. Arias, A. Kaushik, R. Jayant, Y. Takemura, Y. Cai, M. Toborek, M. Nair
  • Journal Title: Nanoscale Volume: 9 Issue: 2 Pages: 764-773
  • DOI: 10.1039/c6nr07520g
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effect of particle size and structure on harmonic intensity of blood-pooling multi-core magnetic nanoparticles for magnetic particle imaging (2017)
  • Author(s): Satoshi Ota, Ryoji Takeda, Tsutomu Yamada, Ichiro Kato, Satoshi Nohara, Yasushi Takemura
  • Journal Title: International Journal on Magnetic Particle Imaging Volume: 3 Pages: 1703003-1703003
  • DOI: 10.18416/ijmpi.2017.1703003
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Rotation of magnetization derived from Brownian relaxation in magnetic fluids of different viscosity evaluated by dynamic hysteresis measurements over a wide frequency range (2016)
  • Author(s): S. Ota, R. Kitaguchi, R. Takeda, T. Yamada, Y. Takemura
  • Journal Title: Nanomaterials Volume: 6 Issue: 9 Pages: 170-170
  • DOI: 10.3390/nano6090170
  • Peer Reviewed / Open Access
• [Journal Article] Coupling of transient near infrared photonic with magnetic nanoparticle for potential dissipation-free biomedical application in brain (2016)
  • Author(s): V. Sagar, V.S.R. Atluri, A. Tomitaka, P. Shah, A. Nagasetti, S. Pilakka-Kanthikeel, N. El-Hage, A. McGoron, Y. Takemura, M. Nair
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 29792-29792
  • DOI: 10.1038/srep29792
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Magnetization Reversal and Specific Loss Power of Magnetic Nanoparticles in Cellular Environment Evaluated by AC Hysteresis Measurement (2015)
  • Author(s): Satoshi Ota, Tsutomu Yamada, and Yasushi Takemura
  • Journal Title: Journal of Nanomaterials Volume: 2015 Issue: 1 Pages: 1-8
  • DOI: 10.1155/2015/836761
  • Peer Reviewed / Open Access
• [Journal Article] Measurement of specific loss power from intracellular magnetic nanoparticles for hyperthermia (2015)
  • Author(s): Asahi Tomitaka, Yasushi Takemura
  • Journal Title: Journal of Personalized NanoMedicine Volume: 1(1) Pages: 33-37
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Recent advances in magnetoliposomes as drug delivery carriers (2015)
  • Author(s): Asahi Tomitaka, Yasushi Takemura, Zaohua Huang, Upal Roy, Madhavan Nair
  • Journal Title: Journal of Personalized NanoMedicine Volume: 1(2) Pages: 51-57
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 抗体を修飾した磁性ナノ粒子のがん治療への応用 (2015)
  • Author(s): 大多哲史、竹村泰司
  • Journal Title: 医学のあゆみ Volume: 252 Pages: 287-291
• [Journal Article] Dipole-dipole interaction and its concentration dependence of magnetic fluid evaluated by alternating current hysteresis measurement (2015)
  • Author(s): Satoshi Ota, Tsutomu Yamada and Yasushi Takemura
  • Journal Title: Journal of Applied Physics Volume: 117 Issue: 17
  • DOI: 10.1063/1.4914061
  • Peer Reviewed / Open Access
• [Presentation] Effect of particle size and structure on harmonic intensity of blood-pooling multi-core magnetic nanoparticles for magnetic particle imaging (2017)
  • Author(s): S. Ota, Ryoji Takeda, Tsutomu Yamada, Ichiro Kato, Satoshi Nohara, Y. Takemura
  • Organizer: 7th International Workshop on Magnetic Particle Imaging (IWMPI)
  • Place of Presentation: Prague, Czech
  • Year and Date: 2017-03-23
  • Int'l Joint Research
• [Presentation] 金属系磁性粒子を用いたシート材の交流磁場による加温 (2017)
  • Author(s): 星山弘樹、柴田優花、青戸知広、山田努、深瀬美紀子、藤田雄一郎、竹村泰司
  • Organizer: 平成29年電気学会全国大会
  • Place of Presentation: 富山
  • Year and Date: 2017-03-15
• [Presentation] Temperature rise of magnetic nanoparticles excited by using a body-size pancake-type applicator (2016)
  • Author(s): K. Takahashi, H. Hoshiyama, T. Aoto, Y. Shibata, S. Ota, T. Yamada, Y. Ikehata, S. Yamada, Y. Takemura
  • Organizer: International Workshop on Magnetic Bio-sensing (IWMBS)
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2016-10-12
  • Int'l Joint Research
• [Presentation] Magnetic Relaxation of Rotatable and Non-Rotatable Magnetic Nanoparticles Evaluated by Dynamic Hysteresis Measurement (2016)
  • Author(s): K. Nishimoto, R. Takeda, R. Kitaguchi, S. Ota, T. Yamada, and Y. Takemura
  • Organizer: International Workshop on Magnetic Bio-sensing (IWMBS)
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2016-10-12
  • Int'l Joint Research
• [Presentation] Effect of Carboxylated Fe3O4 Magnetic Nanoparticles and Docetaxel on Prostate Cancer Cells via NFκB-Independent Pathways (2016)
  • Author(s): K. Kojima, S. Hashimoto, K. Yamamoto, S. Ota, Y. Takemura, and M. Watanabe
  • Organizer: International Workshop on Magnetic Bio-sensing (IWMBS)
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2016-10-12
  • Int'l Joint Research
• [Presentation] 交流ヒステリシス測定による磁性ナノ粒子の磁気緩和の評価 (2016)
  • Author(s): 竹田遼二、大多哲史、北口了一、山田努、竹村泰司
  • Organizer: 電気学会マグネティックス研究会
  • Place of Presentation: 横浜
  • Year and Date: 2016-09-20
• [Presentation] 磁性ナノ粒子の磁気緩和とパンケーキ型コイルを用いた誘導加温 (2016)
  • Author(s): 青戸知広、高橋克希、星山弘樹、由岡友太、山田努、大多哲史、池畑芳雄、山田外史、竹村泰司
  • Organizer: 第40回 日本磁気学会学術講演会
  • Place of Presentation: 金沢
  • Year and Date: 2016-09-05
• [Presentation] 磁性ナノ粒子の形態に依存した磁気緩和機構の評価 (2016)
  • Author(s): 大多哲史、大橋成美、Subbiah Latha、Chakrapani Prabu、Palanisamy Selvamani、竹村泰司
  • Organizer: 第40回 日本磁気学会学術講演会
  • Place of Presentation: 金沢
  • Year and Date: 2016-09-05
• [Presentation] 周波数及び磁界強度に依存した超常磁性ナノ粒子の磁化ダイナミクス計測 (2016)
  • Author(s): 大多哲史、竹田遼二、山田努、竹村泰司
  • Organizer: 第40回 日本磁気学会学術講演会
  • Place of Presentation: 金沢
  • Year and Date: 2016-09-05
• [Presentation] Magnetic properties of intercellular magnetic nanoparticles for biomedical applications (2016)
  • Author(s): Y. Takemura and S. Ota
  • Organizer: European Advanced Materials Congress (EAMC)
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2016-08-23
  • Int'l Joint Research / Invited
• [Presentation] Static and dynamic magnetic properties of intercellular magnetic nanoparticles for biomedical applications (2016)
  • Author(s): Y. Takemura
  • Organizer: The 4th International Conference of Asian Union of Magnetics Societies (IcAUMS 2016)
  • Place of Presentation: Tainan, Taiwan
  • Year and Date: 2016-08-01
  • Int'l Joint Research / Invited
• [Presentation] Neel relaxation and its anisotropic behavior in superparamagnetic nanoparticle evaluated by dynamic hysteresis measurement (2016)
  • Author(s): Ryoji Takeda, S. Ota, Yiliang Wang, Tsutomu Yamada and Y. Takemura
  • Organizer: The 11th International Conference on the Scientific and Clinical Applications of Magnetic Carriers
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2016-05-31
  • Int'l Joint Research
• [Presentation] Magnetic loss and constant magnetic rotation of magnetic nanoparticles in viscosity dependence evaluated by dynamic hysteresis measurement (2016)
  • Author(s): Ryoji Takeda, Ryoichi Kitaguchi, S. Ota, Tsutomu Yamada and Y. Takemura
  • Organizer: The 11th International Conference on the Scientific and Clinical Applications of Magnetic Carriers
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2016-05-31
  • Int'l Joint Research
• [Presentation] Magnetization dynamics of magnetic nanoparticle associated with magnetic relaxation characterized by alternating current hysteresis measurement (2016)
  • Author(s): S. Ota, Ryoji Takeda, Tsutomu Yamada and Y. Takemura
  • Organizer: The 11th International Conference on the Scientific and Clinical Applications of Magnetic Carriers
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2016-05-31
  • Int'l Joint Research
• [Presentation] Development of magneto-plasmonic nanoparticles for brain-targeted image-guided drug delivery (2016)
  • Author(s): A. Tomitaka, H. Arami, Y. Takemura, Y. Cai, M. Nair
  • Organizer: 3rd Personalized NanoMedicine Symposium
  • Place of Presentation: Miami, USA
  • Year and Date: 2016-05-19
• [Presentation] Materials characterization by their magnetic properties - from nanoparticles in biomedical applications to fatigue-damaged rail (2016)
  • Author(s): Y. Takemura
  • Organizer: The 10th International Materials Technology Conference & Exhibition
  • Place of Presentation: Kuala Lumpur, Malaysia
  • Year and Date: 2016-05-16
  • Int'l Joint Research / Invited
• [Presentation] Magnetic relaxation of intercellular magnetic nanoparticles for biomedical applications (2016)
  • Author(s): Y. Takemura and S. Ota
  • Organizer: EMN (Energy, Materials and Nanotechnology) Conference
  • Place of Presentation: Dubrovnik, Croatia
  • Year and Date: 2016-05-04
  • Int'l Joint Research / Invited
• [Presentation] Synthesis and characterization of multi-functional nanoparticles for image-guided drug delivery to the brain (2016)
  • Author(s): A. Tomitaka, Y. Takemura, Y Cai, M. Nair
  • Organizer: The 13th Annual World Congress of The Society for Brain Mapping and Therapeutics
  • Place of Presentation: Miami, USA
  • Year and Date: 2016-04-08
  • Int'l Joint Research
• [Presentation] Localization of magnetic nanoparticles and its effect on magnetic relaxation evaluated by dynamic magnetization measurement for magnetic particle imaging (2016)
  • Author(s): Yasushi Takemura, Satoshi Ota
  • Organizer: 6th International Workshop on Magnetic Particle Imaging (IWMPI 2016)
  • Place of Presentation: Luebeck, Germany
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Evaluation of harmonic signal from blood-pooling magnetic nanoparticles for magnetic particle imaging (2016)
  • Author(s): Satoshi Ota, Ryoji Takeda, Tsutomu Yamada, Yasushi Takemura
  • Organizer: 6th International Workshop on Magnetic Particle Imaging (IWMPI 2016)
  • Place of Presentation: Luebeck, Germany
  • Year and Date: 2016-03-17
  • Int'l Joint Research
• [Presentation] Evaluation of intercellular magnetic nanoparticles for hyperthermia and magnetic particle imaging (2016)
  • Author(s): Yasushi Takemura
  • Organizer: 2nd Annual World Congress of Smart Materials 2016
  • Place of Presentation: Singapore
  • Year and Date: 2016-03-05
  • Int'l Joint Research / Invited
• [Presentation] Measurement of magnetization relaxation of intercellular magnetic nanoparticles for magnetic particle imaging (2015)
  • Author(s): Yasushi Takemura
  • Organizer: Workshop on Magnetic-fluids and Magnetic Particle Imaging 2015 (WMMPI2015)
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-11-23
  • Int'l Joint Research / Invited
• [Presentation] Relaxation time and heat dissipation of magnetic nanoparticles and their dependences on fluid density and viscosity (2015)
  • Author(s): Ryoichi Kitaguchi, Satoshi Ota, Tsutomu Yamada, Yasushi Takemura
  • Organizer: Workshop on Magnetic-fluids and Magnetic Particle Imaging 2015 (WMMPI2015)
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-11-22
  • Int'l Joint Research
• [Presentation] Quantitative analysis on heating ability of magnetic nanoparticles evaluated by area of ac hysteresis loops (2015)
  • Author(s): Ryoji Takeda, Satoshi Ota, Tsutomu Yamada, Yasushi Takemura
  • Organizer: Workshop on Magnetic-fluids and Magnetic Particle Imaging 2015 (WMMPI2015)
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-11-22
  • Int'l Joint Research
• [Presentation] Evaluation of magnetic nanoparticles for hyperthermia and magnetic particle imaging by their dynamic hysteresis curves (2015)
  • Author(s): Satoshi Ota, Yiliang Wang, Ryoichi Kitaguchi, Tsutomu Yamada and Yasushi Takemura
  • Organizer: Biomedical Engineering Society 2015 Annual Meeting
  • Place of Presentation: Tampa, USA
  • Year and Date: 2015-10-08
  • Int'l Joint Research
• [Presentation] 磁性ナノ粒子等を用いた磁気ハイパーサーミアの現状と展望 (2015)
  • Author(s): 竹村泰司
  • Organizer: 日本ハイパーサーミア学会第32回大会、シンポジウム「ハイパーサーミアにおける工学：現状と将来への展望」
  • Place of Presentation: 大阪
  • Year and Date: 2015-09-05
• [Presentation] Evaluation of magnetization rotation under ac field with biasing dc field (2015)
  • Author(s): Satoshi Ota, Tsutomu Yamada and Yasushi Takemura
  • Organizer: The 5th International Symposium on Organic and Inorganic Electronic Materials and Related Nanotechnologies (EM-NANO 2015)
  • Place of Presentation: Niigata, Japan
  • Year and Date: 2015-06-18
  • Int'l Joint Research
• [Presentation] Heat dissipation of magnetic nanoparticle in cellular environment evaluated by ac hysteresis measurement (2015)
  • Author(s): Satoshi Ota, Tsutomu Yamada and Yasushi Takemura
  • Organizer: The 5th International Symposium on Organic and Inorganic Electronic Materials and Related Nanotechnologies (EM-NANO 2015)
  • Place of Presentation: Niigata, Japan
  • Year and Date: 2015-06-17
  • Int'l Joint Research
• [Presentation] 交流磁場下における液中・固体中の磁性ナノ粒子の磁化反転の検出 (2014)
  • Author(s): 大多哲史、山田努、竹村泰司
  • Organizer: 電気学会マグネティックス研究会
  • Place of Presentation: 岡山
  • Year and Date: 2014-12-03
• [Presentation] Dipole-dipole interaction and its concentration dependence of magnetic fluid evaluated by ac hysteresis measurement (2014)
  • Author(s): Satoshi Ota, Tsutomu Yamada and Yasushi Takemura
  • Organizer: The 59th Annual Magnetism and Magnetic Materials (MMM) Conference
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2014-11-07
• [Presentation] Magnetization reversal and specific loss power of intracellular magnetic nanoparticles evaluated by ac hysteresis measurement (2014)
  • Author(s): Satoshi Ota, Tsutomu Yamada and Yasushi Takemura
  • Organizer: The 59th Annual Magnetism and Magnetic Materials (MMM) Conference
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2014-11-07
• [Presentation] Heat dissipation and magnetic loss in magnetic nanoparticles for biomedical applications (2014)
  • Author(s): Yasushi Takemura
  • Organizer: The 3rd International Conference of Asian Union of Magnetics Societies (IcAUMS)
  • Place of Presentation: Haikou, China
  • Year and Date: 2014-10-30
  • Invited
• [Presentation] Biocompatibility and biofunctionality of magnetic nanoparticles (2014)
  • Author(s): Yasushi Takemura
  • Organizer: 226th Meeting of The Electrochemical Society (ECS), ECS and SMEQ Joint International Meeting
  • Place of Presentation: Cancun, Mexico
  • Year and Date: 2014-10-07
  • Invited
• [Presentation] Measurement of ac hysteresis curves of magnetic nanoparticles for biomedical applications (2014)
  • Author(s): Yasushi Takemura
  • Organizer: 2014 EMN (Energy, Materials and Nanotechnology) Open Access Meeting
  • Place of Presentation: Chengdu, China
  • Year and Date: 2014-09-22
  • Invited
• [Presentation] 培養細胞内における磁性ナノ粒子の発熱量の評価 (2014)
  • Author(s): 大多哲史、山田努、竹村泰司
  • Organizer: 第38回日本磁気学会学術講演会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-04
• [Presentation] 磁性ナノ粒子の交流ヒステリシス測定と磁気損失 (2014)
  • Author(s): 大多哲史、山田努、竹村泰司
  • Organizer: 第38回日本磁気学会学術講演会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-04
• [Remarks] 研究者詳細（竹村泰司）
  • URL: http://er-web.jmk.ynu.ac.jp/html/TAKEMURA_Yasushi/ja.html
• [Remarks] 横浜国立大学 竹村研究室 研究室情報
  • URL: http://www.takemura.ynu.ac.jp/laboratory.html