Designing Nb-containing phosphate invert glasses with controlled ions-releasability

• Project/Area Number: 26289238
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Inorganic materials/Physical properties
• Research Institution: Nagoya Institute of Technology
• Principal Investigator: Kasuga Toshihiro 名古屋工業大学, 工学(系)研究科(研究院), 教授 (30233729)
• Co-Investigator(Kenkyū-buntansha): 前田 浩孝 名古屋工業大学, 工学(系)研究科(研究院), 准教授 (20431538) ; 小幡 亜希子 名古屋工業大学, 工学(系)研究科(研究院), 准教授 (40402656)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000); Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2014: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
• Keywords: リン酸塩ガラス / インバートガラス / ニオブイオン / マグネシウムイオン / 亜鉛イオン / 生体親和性 / 抗菌性 / ガラス構造

Outline of Final Research Achievements

New types of bio-functional glasses were designed using Nb-containing calcium phosphate invert glasses. MgO in the glasses was shown to form P-O-Mg bonds, which crosslink short phosphate groups. The bonds weakened the glass network structure and induced hydrolysis: a new type of glass with ions-releasability for enhancing cell activity could be successfully prepared. ZnO-containing glasses were prepared for antibacterial coating. Their chemical durability were improved with increasing ZnO content. The glasses showed antibacterial ability on E. coli. MD simulation was performed for understanding the structural role of TiO2 in the glasses. The presence of TiO2 influenced the phosphate units and CaO polyhedral structures. The formation of the Ti-O-P bonds caused an increase in the network connectivity of the glasses. Some of the glasses could be successfully prepared as the thin films on metallic titanium by rf-magnetron sputtering.

Research Products

• [Int'l Joint Research] Imperial College London/University of Manchester(United Kingdom)
• [Int'l Joint Research] Friedrich Schiller Universitat Jena(Germany)
• [Int'l Joint Research] イエナ大学(ドイツ)
• [Int'l Joint Research] インペリアルカレッジロンドン/マンテェスター大学(英国)
• [Journal Article] Formation and structural analysis of 15Mgo-15CaO-8P2O5-4SiO2 glass (2017)
  • Author(s): Sungho Lee, Takayoshi Nakano, Toshihiro Kasuga
  • Journal Title: Journal of Non-Crystaline Solids Volume: 457 Pages: 73-76
  • DOI: 10.1016/j.jnoncrysol.2016.11.020
  • Peer Reviewed
• [Journal Article] Synthesis and Dissolution Behaviour of CaO/SrO-Containing Sol-Gel-derived 58S glasses (2017)
  • Author(s): Anthony L.B. Macon, Sungho Lee, Gowsihan Poologasundarampillai, Toshihiro Kasuga, Julian R. Jones
  • Journal Title: J. Mater. Sci. Volume: - Issue: 15 Pages: 8858-8870
  • DOI: 10.1007/s10853-017-0869-0
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Preparation of orthophosphate glasses in the MgO-CaO-SiO2-Nb2O5-P2O5 system. (2017)
  • Author(s): S.Lee, K. Ueda, T. Narushima, T. Nakano, T. Kasuga
  • Journal Title: International Journal BIOMEDICAL MATERIALS AND ENGINEERING Volume: 28 Issue: 1 Pages: 23-30
  • DOI: 10.3233/bme-171652
  • Peer Reviewed
• [Journal Article] Structure and dissolution behavior of orthophosphate MgO-CaO-P2O5-Nb2O5 glass and glass-ceramic (2016)
  • Author(s): Sungho LEE, Anthony L. B. MACON, Toshihiro KASUGA
  • Journal Title: Materials Letters Volume: Accepted Pages: 135-138
  • DOI: 10.1016/j.matlet.2016.04.027
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Preparation of Antibacterial ZnO-CaO-P₂O₅-Nb₂O₅ Invert Glasses (2016)
  • Author(s): Sungho Lee, Hirotaka Uehara, Anthony L.B. Macon, Hirotaka Maeda, Akiko Obata, Kyosuke Ueda, Takayuki Narushima, Toshihiro Kasuga
  • Journal Title: MATERIALS TRANSACTIONS Volume: 57 Issue: 12 Pages: 2072-2076
  • DOI: 10.2320/matertrans.MI201503
  • NAID: 130005284387
  • ISSN: 1345-9678, 1347-5320
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] ガラスを用いたバイオマテリアルデザイン (2016)
  • Author(s): 春日敏宏
  • Journal Title: バイオマテリアル－生体材料－ Volume: 34 Pages: 66-70
  • Peer Reviewed
• [Journal Article] Structure and physicochemical properties of CaO-P2O5-Nb2O5-Na2O glasses (2016)
  • Author(s): H. Maeda, S. Lee, T. Miyajima, A. Obata, K. Ueda, T. Narushima and T. Kasuga
  • Journal Title: J. Non-Cryst. Solids Volume: 432 Pages: 60-64
  • DOI: 10.1016/j.jnoncrysol.2015.06.003
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Structures and dissolution behaviors of MgO-CaO-P2O5-Nb2O5 glasses (2016)
  • Author(s): S. Lee, H. Maeda, A. Obata, K. Ueda, T. Narushima and T. Kasuga
  • Journal Title: J. Non-Cryst. Solids Volume: 438 Pages: 18-25
  • DOI: 10.1016/j.jnoncrysol.2016.02.006
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Proton Conduction of MO-P2O5 Glasses (M = Zn, Ba) Containing a Large Amount of Water (2015)
  • Author(s): H. Sumi, Y. Nakano, Y. Fujishiro, T. Kasuga
  • Journal Title: Solid State Science Volume: 45 Pages: 5-8
  • DOI: 10.1016/j.solidstatesciences.2015.04.009
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Structures and dissolution behaviors of CaO-P2O5-TiO2/Nb2O5 (Ca/P≧1) invert glasses (2015)
  • Author(s): S. Lee, H. Maeda, A. Obata, K. Ueda, T. Narushima and T. Kasuga
  • Journal Title: J. Non-Cryst. Solids Volume: 426 Pages: 35-42
  • DOI: 10.1016/j.jnoncrysol.2015.06.024
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Structure and dissolution behavior of MgO–P₂O₅–TiO₂/Nb₂O₅ (Mg/P ≥ 1) invert glasses (2015)
  • Author(s): S. Lee, H. Maeda, A. Obata, K. Ueda, T. Narushima and T. Kasuga
  • Journal Title: Journal of the Ceramic Society of Japan Volume: 123 Issue: 1442 Pages: 942-948
  • DOI: 10.2109/jcersj2.123.942
  • NAID: 130005102225
  • ISSN: 1348-6535, 1882-0743
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Dissolution behavior of alkali-free MgO-CaO-SrO-TiO2-P2O5 glasses for biomedical applications (2015)
  • Author(s): Sungho LEE, Akiko Obata, Delia S. Brauer, Toshihiro Kasuga
  • Journal Title: Biomedical Glasses Volume: 1 Issue: 1 Pages: 151-158
  • DOI: 10.1515/bglass-2015-0015
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Preparation of highly-soluble SO3-P2O5-Na2O-CaO glasses (2015)
  • Author(s): Hayato Sasaki, Toshihiro Kasuga, Arnulf Thieme, Delia S. Brauer, Lothar Wondraczeck
  • Journal Title: Proc. 24th Inter. Conf. on Processing and Fabrication of Advanced Materials (PFAM24) Volume: 24 Pages: 133-136
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Preparation of calcium pyrophosphate glass-ceramics containing Nb₂O₅ (2014)
  • Author(s): Hirotaka MAEDA, Tomohiro MIYAJIMA, Sungho LEE, Akiko OBATA, Kyosuke UEDA, Takayuki NARUSHIMA, Toshihiro KASUGA
  • Journal Title: Journal of the Ceramic Society of Japan Volume: 122 Issue: 1421 Pages: 122-124
  • DOI: 10.2109/jcersj2.122.122
  • NAID: 130004950895
  • ISSN: 1348-6535, 1882-0743
  • Peer Reviewed / Open Access
• [Journal Article] Changes in Structure and Thermal Properties with Phosphate Content of Ternary Calcium Sodium Phosphate Glasses (2014)
  • Author(s): Armando Mandlule, Franziska Döhler, Leo van Wüllen, Toshihiro Kasuga, Delia S. Brauer
  • Journal Title: J. Non-Cryst. Solids Volume: 392-393 Pages: 31-38
  • DOI: 10.1016/j.jnoncrysol.2014.04.002
  • Peer Reviewed
• [Journal Article] リン酸塩ガラス系バイオマテリアルの細胞親和性 (2014)
  • Author(s): 小幡亜希子、前田 浩孝、春日 敏宏
  • Journal Title: Phosporus Lett. Volume: 79 Pages: 27-35
  • NAID: 40019975925
• [Presentation] 亜鉛含有リン酸塩インバートガラスの作製 (2017)
  • Author(s): 渡邊 俊希ほか
  • Organizer: 日本セラミックス協会2017年会
  • Place of Presentation: 東京
  • Year and Date: 2017-03-17
• [Presentation] 亜鉛含有ケイリン酸塩インバートガラスの作製 (2017)
  • Author(s): 李 誠鎬ほか
  • Organizer: 日本セラミックス協会2017年会
  • Place of Presentation: 東京
  • Year and Date: 2017-03-17
• [Presentation] 70SiO2-30CaO系ゾルゲルガラスの綿状繊維構造体 (2017)
  • Author(s): 小幡亜希子ほか
  • Organizer: 日本セラミックス協会2017年会
  • Place of Presentation: 東京
  • Year and Date: 2017-03-17
• [Presentation] 元素添加非晶質リン酸カルシウム膜の構造と溶解性の関係 (2017)
  • Author(s): 上田ほか
  • Organizer: 日本金属学会春期講演大会（2017）
  • Place of Presentation: 東京
  • Year and Date: 2017-03-15
• [Presentation] 銀添加ケイ酸カルシウムガラスの綿状繊維構造体の作製 (2017)
  • Author(s): 小幡ほか
  • Organizer: 日本金属学会春期講演大会（2017）
  • Place of Presentation: 東京
  • Year and Date: 2017-03-15
• [Presentation] 15MgO-15CaO-8P2O5-4SiO2インバートガラスの作製 (2016)
  • Author(s): 李 誠鎬ほか
  • Organizer: 生体関連セラミックス討論会
  • Place of Presentation: 大阪
  • Year and Date: 2016-12-02
• [Presentation] リン酸塩ガラスの特徴と用途展開 (2016)
  • Author(s): 春日敏宏
  • Organizer: ニューガラスフォーラム 第124回若手懇談会
  • Place of Presentation: 東京
  • Year and Date: 2016-10-07
  • Invited
• [Presentation] Preparation of Highly-Soluble Na2O-CaO-P2O5-SO3 Glasses for Biomedical Applications (2016)
  • Author(s): H. Sasaki, A.L.B. Macon, T. Kasuga, D.S. Brauer, L. Wondraczeck
  • Organizer: 9th International Symposium on Inorganic Phosphate Materials
  • Place of Presentation: 東京
  • Year and Date: 2016-09-25
  • Int'l Joint Research / Invited
• [Presentation] 抗菌性 ZnO-CaO-P2O5-Nb2O5 インバートガラスの作製 (2016)
  • Author(s): 李 誠鎬ほか
  • Organizer: 日本金属学会秋期講演大会（2016）
  • Place of Presentation: 大阪
  • Year and Date: 2016-09-21
• [Presentation] 6配位ケイ素を含むケイリン酸塩ガラスの溶解性 (2016)
  • Author(s): 三浦 淳弘ほか
  • Organizer: 日本セラミックス協会秋季シンポジウム
  • Place of Presentation: 広島
  • Year and Date: 2016-09-07
• [Presentation] オルトリン酸塩インバートガラス及び結晶化ガラスの溶出挙動 (2016)
  • Author(s): 李誠鎬、前田浩孝、小幡亜希子、上田恭介、成島尚之、春日敏宏
  • Organizer: 日本金属学会 2015年(第158回)春期講演大会
  • Place of Presentation: 東京理科大学（東京都葛飾区）
  • Year and Date: 2016-03-23
• [Presentation] 亜鉛含有抗菌性リン酸塩インバートガラスの作製 (2016)
  • Author(s): 李誠鎬、上原拓峻、Macon Anthony L.B.、前田浩孝、小幡亜希子、上田恭介、成島尚之、春日敏宏
  • Organizer: 日本セラミックス協会 2016年年会
  • Place of Presentation: 早稲田大学
  • Year and Date: 2016-03-14
• [Presentation] 生体材料の親水化を目的とした硫リン酸塩ガラスの作製 (2015)
  • Author(s): 佐々木勇人, 春日敏宏, Delia S. Brauer, Lothar Wondraczeck
  • Organizer: 日本セラミックス協会東海支部学術研究発表会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2015-12-12
• [Presentation] 亜鉛含有リン酸塩インバートガラスの溶出挙動 (2015)
  • Author(s): 上原拓峻、李誠鎬、前田浩孝、小幡亜希子、春日敏宏
  • Organizer: 日本セラミックス協会東海支部学術研究発表会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2015-12-12
• [Presentation] Dissolution behaviors of MgO-CaO-P2O5-Nb2O5-SiO2 glasses (2015)
  • Author(s): S. Lee, H. Maeda, A. Obata, K. Ueda, T. Narushima, T. Kasuga
  • Organizer: 32th International Korea-Japan Seminar on Ceramics
  • Place of Presentation: 長岡
  • Year and Date: 2015-11-18
  • Int'l Joint Research
• [Presentation] Effect of phosphate chain length on dissolution behaviors in CaO-MgO-P2O5-Nb2O5 glasses (2015)
  • Author(s): S. Lee, H. Maeda, A. Obata, K. Ueda, T. Narushima, T. Kasuga
  • Organizer: 14th International Union of Materials Research Societies-International Conference on Advanced Materials
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2015-10-25
  • Int'l Joint Research
• [Presentation] Crystallization of MgO-CaO-P2O5-Nb2O5 invert glasses (2015)
  • Author(s): S. Lee, H. Maeda, A. Obata, K. Ueda, T. Narushima, T. Kasuga
  • Organizer: 11th International Symposium on Crystallization in Glasses and Liquids
  • Place of Presentation: 長岡
  • Year and Date: 2015-10-11
  • Int'l Joint Research
• [Presentation] マグネシウム置換によるリン酸塩カルシウムガラスの溶出への影響 (2015)
  • Author(s): 李誠鎬、前田浩孝、小幡亜希子、上田恭介、成島尚之、春日敏宏
  • Organizer: 第２５回無機リン化学討論会
  • Place of Presentation: 山形大学
  • Year and Date: 2015-09-28
• [Presentation] CaO-MgO-P2O5-Nb2O5ガラスの溶出挙動 (2015)
  • Author(s): 李誠鎬、前田浩孝、小幡亜希子、上田恭介、成島尚之、春日敏宏
  • Organizer: 日本金属学会 2015年(第157回)秋期講演大会
  • Place of Presentation: 九州大学
  • Year and Date: 2015-09-16
• [Presentation] Structure and dissolution behavior of sol-gel-derived 58S glasses containing SrO (2015)
  • Author(s): S. Lee, G. Poologasundarampillai, A.L.B. Macon, T. Kasuga, J.R. Jones
  • Organizer: XVIII International Sol-Gel Conference
  • Place of Presentation: 京都
  • Year and Date: 2015-09-06
  • Int'l Joint Research
• [Presentation] Dissolution behaviors of MgO-P2O5-TiO2/Nb2O5 glasses in MgO-rich region (2015)
  • Author(s): S. Lee, H. Maeda, A. Obata, K. Ueda, T. Narushima, T. Kasuga
  • Organizer: 27th European Conference on Biomaterials
  • Place of Presentation: Toredo, Spain
  • Year and Date: 2015-08-30
  • Int'l Joint Research
• [Presentation] Phosphate invert glasses with improved processing (2015)
  • Author(s): S. Lee, H. Maeda, A. Obata, K. Ueda, T. Narushima, T. Kasuga
  • Organizer: 14th International Conference European Ceramic Society
  • Place of Presentation: 長岡
  • Year and Date: 2015-06-21
  • Int'l Joint Research
• [Presentation] MgO/CaOを多量に含有するリン酸塩インバートガラスの作製 (2015)
  • Author(s): 李 誠鎬、前田浩孝、小幡亜希子、上田恭介、成島尚之、春日敏宏
  • Organizer: 日本金属学会２０１５年（第１５６回）春期講演大会
  • Place of Presentation: 東京
  • Year and Date: 2015-03-18 – 2015-03-20
• [Presentation] ドライプロセスによるチタンの骨適合化表面改質 (2015)
  • Author(s): 上田恭介、成島尚之、後藤 孝、春日敏宏、小幡亜希子、小笠原康悦
  • Organizer: 日本金属学会２０１５年（第１５６回）春期講演大会
  • Place of Presentation: 東京
  • Year and Date: 2015-03-18 – 2015-03-20
  • Invited
• [Presentation] Effect of Ag2O substitution on solubility and structure of CaO-P2O5-Nb2O5 glasses (2014)
  • Author(s): Sungho LEE, Hirotaka Maeda, Akiko Obata, Kyosuke Ueda, Takayuki Narushima, Toshihiro Kasuga
  • Organizer: The 31st International Korea-Japan Seminar on Ceramics
  • Place of Presentation: Changwon, Korea
  • Year and Date: 2014-11-26 – 2014-11-29
• [Presentation] Preparation of Antibacterial Phosphate Invert Glasses (2014)
  • Author(s): S. Lee, H. Maeda, A. Obata, K. Ueda, T. Narushima, T. Kasuga
  • Organizer: 26th Symposium and Annual Meeting of the International Society for Ceramics in Medicine
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-11-06 – 2014-11-08
• [Presentation] Preparation of calcium pyrophosphate glasses (2014)
  • Author(s): S. Lee, H. Maeda, A. Obata, K. Ueda, T. Narushima, T. Kasuga
  • Organizer: 6th International Workshop on Advanced Ceramics
  • Place of Presentation: Erlangen, Germany
  • Year and Date: 2014-09-28 – 2014-09-30
• [Presentation] カルシウム成分を多量に含有するリン酸塩ガラスの作製 (2014)
  • Author(s): 李 誠鎬、前田浩孝、小幡亜希子、上田恭介、成島尚之、春日敏宏
  • Organizer: 日本金属学会２０１４年秋期講演大会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-09-24 – 2014-09-26
• [Presentation] カルシウム成分を多量に含有するリン酸塩ガラスの作製 (2014)
  • Author(s): 李 誠鎬、前田浩孝、小幡亜希子、春日敏宏、上田恭介、成島尚之
  • Organizer: 日本セラミックス協会第２７回秋季シンポジウム
  • Place of Presentation: 鹿児島
  • Year and Date: 2014-09-09 – 2014-09-11
• [Remarks] 名古屋工業大学生命・応用化学専攻環境調和セラミックス分野環境共生材料研究室
  • URL: http://ebm.web.nitech.ac.jp/PB/top.html