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Development of Noble Micro Reaction Process using Impinging Droplets

Research Project

Project/Area Number 26289295
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Reaction engineering/Process system
Research InstitutionKyoto University

Principal Investigator

Taisuke Maki  京都大学, 工学(系)研究科(研究院), 准教授 (10293987)

Co-Investigator(Kenkyū-buntansha) 前 一廣  京都大学, 工学(系)研究科(研究院), 教授 (70192325)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Keywordsマイクロ化学プロセス / ナノ粒子 / マイクロミキサー / マイクロリアクター / 迅速混合 / インクジェット / 微小液滴 / 新規反応場 / 混合 / 反応工学 / 液滴制御 / マイクロ反応工学 / 3Dプリンタ
Outline of Final Research Achievements

For a liquid-liquid phase process, uniformly sized water droplets were stably produced by a micro channel, and two produced small droplets were continuously merged in the channel. For a gas-liquid phase process, water droplets injected by two inkjet apparatus were impinged and merged continuously and stably in air. It was confirmed that the mixing rate of components in a merged droplets was much more rapid comparing to conventional homogeneous liquid mixing. The developed method was applied to nano-particle synthesis which requires rapid and uniform mixing. As the results, uniformly sized particles of Pt (1.4 nm) and RhPd (2.7 nm) were successfully produced.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (37 results)

All 2017 2016 2015 2014

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 2 results) Presentation (33 results) (of which Int'l Joint Research: 9 results,  Invited: 5 results)

  • [Journal Article] Synthesis of zeolitic imidazolate framework-8 particles of controlled sizes, shapes, and gate adsorption characteristics using a central collision-type microreactor2017

    • Author(s)
      Satoshi Watanabe, Shuji Ohsaki, Tatsuya Hanafusa, Kento Takada, Hideki Tanaka, Kazuhiro Mae, and Minoru T. Miyahara
    • Journal Title

      Chemical Engineering Journal

      Volume: 313 Pages: 724-733

    • DOI

      10.1016/j.cej.2016.12.118

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Continuous crystallization using a sonicated tubular system for controlling particle size in an API manufacturing process Chemical Engineering and Processing2016

    • Author(s)
      M. Furuta, K. Mukai, D. Cork, K. Mae
    • Journal Title

      Chemical Engineering and Processing

      Volume: 102 Pages: 210-218

    • DOI

      10.1016/j.cep.2016.02.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Mixing Profiles for a New Micromixer Design Strategy2016

    • Author(s)
      Shusaku Asano, Taisuke Maki, and Kazuhiro Mae
    • Journal Title

      AIChE J.

      Volume: 62 Issue: 4 Pages: 1154-1161

    • DOI

      10.1002/aic.15082

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Flow Synthesis of Plasmonic Gold Nanoshells via a Microreactor2015

    • Author(s)
      Satoshi Watanabe, Tatsumasa Hiratsuka, Yusuke Asahi, Asumi Tanaka, Kazuhiro Mae and Minoru T. Miyahara
    • Journal Title

      Particle & Particle Systems Characterization

      Volume: 32 Issue: 2 Pages: 234-242

    • DOI

      10.1002/ppsc.201400126

    • NAID

      120005657932

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] 流体の流量比・物性差が混合挙動に及ぼす影響の解析2017

    • Author(s)
      浅野 周作、山田 悟司、牧 泰輔、前 一廣
    • Organizer
      化学工学会 第82年会
    • Place of Presentation
      芝浦工業大学(江東区)
    • Year and Date
      2017-03-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] マイクロ反応器のインライン測定による混合・反応挙動解析2017

    • Author(s)
      池田 晃輝、浅野 周作、牧 泰輔、村中 陽介、前 一廣
    • Organizer
      化学工学会 第82年会
    • Place of Presentation
      芝浦工業大学(江東区)
    • Year and Date
      2017-03-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Block Copolymer Synthesis in a Microreactor by Precise Analysis and Design of Polymerization Kinetics2016

    • Author(s)
      Shusaku Asano, Taisuke Maki, Kazuhiro Mae
    • Organizer
      2016 AIChE Annual Meeting
    • Place of Presentation
      サンフランシスコ(米国)
    • Year and Date
      2016-11-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Flow Microreactor Synthesis of ZIF-8 Particles with Controlled Size, Shape, and Adsorption Properties2016

    • Author(s)
      S. Watanabe, S. Ohsaki, H. Tanaka, K. Mae, M. Miyahara
    • Organizer
      2016 AIChE Annual Meeting
    • Place of Presentation
      サンフランシスコ(米国)
    • Year and Date
      2016-11-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Continuous synthesis of alloyed nanoparticles based on rapid heating and mixing2016

    • Author(s)
      S. Asano, T. Maki, V. Sebastian, K. Jensen, K. Mae
    • Organizer
      Japan-Korea symposium on Materials & Interfaces
    • Place of Presentation
      御殿場高原 時之栖(御殿場市)
    • Year and Date
      2016-11-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Quantitative estimation of mass transfer in Gas-Liquid segmented flow for designing efficient CO2 micro absorber2016

    • Author(s)
      R. Masaki, T. Fukuda, T. Maki, K. Mae
    • Organizer
      14th International Conference on Micro Reaction Technology(IMRET14)
    • Place of Presentation
      北京(中国)
    • Year and Date
      2016-09-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Microreactor flow process and inline optical measurements of gold nanoshell synthesis2016

    • Author(s)
      S. Watanabe, J. Hosokawa, K. Mae, M. T. Miyahara
    • Organizer
      14th International Conference on Micro Reaction Technology(IMRET14)
    • Place of Presentation
      北京(中国)
    • Year and Date
      2016-09-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Control of indomethacin polymorph by a circulated flow method with anti-solvent mixing2016

    • Author(s)
      T. Maki, T. Oya, J. Katayama, M. Furuta, K. Mae
    • Organizer
      14th International Conference on Micro Reaction Technology(IMRET14)
    • Place of Presentation
      北京(中国)
    • Year and Date
      2016-09-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of Metal-Organic Framework particles with controlled size, shape and adsorption properties2016

    • Author(s)
      S. Ohsaki, S. Watanabe, H. Tanaka, K. Mae, M. T. Miyahara
    • Organizer
      14th International Conference on Micro Reaction Technology(IMRET14)
    • Place of Presentation
      北京(中国)
    • Year and Date
      2016-09-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Direct and quantitative analysis of mixing and reaction in microchannels by inline spectroscopy2016

    • Author(s)
      S. Asano, K. Ikeda, T. Maki, K. Mae
    • Organizer
      14th International Conference on Micro Reaction Technology(IMRET14)
    • Place of Presentation
      北京(中国)
    • Year and Date
      2016-09-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 迅速混合を活用した貴金属合金ナノ粒子の合成2016

    • Author(s)
      浅野 周作、牧 泰輔、Sebastian Victor、Jensen Klavs、前 一廣
    • Organizer
      化学工学会第48回秋季大会
    • Place of Presentation
      徳島大学(徳島市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] インクジェット吐出液滴の合一による新規反応操作法2016

    • Author(s)
      生田 佳奈子、村中 陽介、牧 泰輔、前 一廣
    • Organizer
      化学工学会第48回秋季大会
    • Place of Presentation
      徳島大学(徳島市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 気液スラグ流を用いたガス吸収操作設計論2016

    • Author(s)
      正木 理恵、福田 貴史、牧 泰輔、前 一廣
    • Organizer
      化学工学会 第81回年会
    • Place of Presentation
      吹田
    • Year and Date
      2016-03-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] マイクロデバイスの開発と応用2016

    • Author(s)
      牧 泰輔
    • Organizer
      岡山マイクロリアクターネット第26回例会
    • Place of Presentation
      岡山国際交流センター(岡山市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] マイクロ化学プロセスとマイクロデバイス設計の基礎2015

    • Author(s)
      牧 泰輔
    • Organizer
      合成技術講演会
    • Place of Presentation
      和歌山
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] マイクロデバイスを利用した反応操作2015

    • Author(s)
      牧 泰輔
    • Organizer
      合成技術講演会
    • Place of Presentation
      和歌山
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Fabrication of Effective Microchannels using 3D-Printer Based on New Design Concept of Micromixers2015

    • Author(s)
      Shusaku Asano, Taisuke Maki, Kazuhiro Mae
    • Organizer
      Asian Pacific Confederation of Chemical Engineering (APCChE) congress 2015
    • Place of Presentation
      オーストラリア メルボルン
    • Year and Date
      2015-09-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マイクロリアクターにおける混合速度と反応速度の関係性評価2015

    • Author(s)
      浅野 周作、牧 泰輔、永木 愛一郎、吉田 潤一、前 一廣
    • Organizer
      化学工学会 第47回秋季大会
    • Place of Presentation
      札幌
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] マイクロリアクターを利用した重合速度解析と、それに基づくブロックコポリマー合成の試み2015

    • Author(s)
      中山 竜太郎、浅野 周作、宇都宮 竜司、久保山 俊治、牧 泰輔、前 一廣
    • Organizer
      化学工学会 第47回秋季大会
    • Place of Presentation
      札幌
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] マイクロリアクターでの混合状態の評価とミキサー設計法の検討2015

    • Author(s)
      浅野 周作, 牧 泰輔, 前 一廣
    • Organizer
      化学工学第80回年会
    • Place of Presentation
      江東区
    • Year and Date
      2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Evaluation of the Mixing State for a New Design Procedure of Micromixers2015

    • Author(s)
      Shusaku Asano, Taisuke Maki, and Kazuhiro Mae
    • Organizer
      The Kyoto University SGU-CH 1st International Workshop - Micro/Flow Chemistry & Engineering -
    • Place of Presentation
      京都市
    • Year and Date
      2015-01-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Size Effect of Micro Channel for Rapid Heating, Rapid Quenching and Isothermal Operation with a Focus on Thermal Conduction2015

    • Author(s)
      Takashi Fukuda, Atsushi Minato, Shusaku Asano, Akira Nishihara, Taisuke Maki, and Kazuhiro Mae
    • Organizer
      The Kyoto University SGU-CH 1st International Workshop - Micro/Flow Chemistry & Engineering -
    • Place of Presentation
      京都市
    • Year and Date
      2015-01-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Quantitative Evaluating of Mass Transfer Promotion in Gas-Liquid Slug Flow Considering Wettability Effect of Wall2015

    • Author(s)
      Takashi Fukuda, Kazua Sato, Taisuke Maki, and Kazuhiro Mae
    • Organizer
      The Kyoto University SGU-CH 1st International Workshop - Micro/Flow Chemistry & Engineering -
    • Place of Presentation
      京都市
    • Year and Date
      2015-01-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Flow Synthesis of Plasmonic Nanoshells Using a Microreactor2015

    • Author(s)
      Junji Hosokawa, Satoshi Watanabe, Kazuhiro Mae, and Minoru T. Miyahara
    • Organizer
      The Kyoto University SGU-CH 1st International Workshop - Micro/Flow Chemistry & Engineering -
    • Place of Presentation
      京都市
    • Year and Date
      2015-01-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] マイクロリアクターを利用した微粒子設計法2014

    • Author(s)
      前 一廣
    • Organizer
      化学工学会 第20回関西地区分離技術講演会
    • Place of Presentation
      大阪市
    • Year and Date
      2014-12-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Analysis of mass transfer promotion in miniturized gas-liquid slug flow including wall liquid film effect2014

    • Author(s)
      Takashi Fukuda, Kazua Sato, Taisuke Maki, Kazuhiro Mae
    • Organizer
      10th International Conference on Separation Science and Technology
    • Place of Presentation
      奈良市
    • Year and Date
      2014-11-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] マイクロリアクター技術の特徴と産学連携の重要性2014

    • Author(s)
      前 一廣
    • Organizer
      化学工学会関西支部 マイクロ化学プロセス最前線シリーズ-産学の“絆”によるマイクロリアクター技術の実用化
    • Place of Presentation
      神戸市
    • Year and Date
      2014-10-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 装置小型化に向けた気液スラグ流によるガス吸収操作の検討2014

    • Author(s)
      福田 貴史, 下村 遥, 牧 泰輔, 前 一廣, 松岡 亮, 藤澤 彰利, 野一色 公二
    • Organizer
      化学工学会 第46回秋季大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Ptナノ粒子生成反応および数値流体力学計算による2液混合状態分布評価2014

    • Author(s)
      浅野 周作, 大屋 智和, 牧 泰輔, 前 一廣
    • Organizer
      化学工学会 第46回秋季大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-09-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Flow continuous synthesis of gold nanoshells2014

    • Author(s)
      Satoshi Watanabe, Tatsumasa Hiratsuka, Yusuke Asahi, Kazuhiro Mae, Minoru T. Miyahara
    • Organizer
      13th International Conference on Micro Reaction Technology
    • Place of Presentation
      ハンガリー ブダペスト
    • Year and Date
      2014-06-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Methodology of microreactor design for rapid heating, rapid quenching, and isothermal operation2014

    • Author(s)
      Takashi Fukuda, Akira Nishihara, Taisuke Maki, Kazuhiro Mae
    • Organizer
      13th International Conference on Micro Reaction Technology
    • Place of Presentation
      ハンガリー ブダペスト
    • Year and Date
      2014-06-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Evaluation of fluid segment size distribution in micro mixers by preparation of nano particles2014

    • Author(s)
      Taisuke Maki, Shusaku Asano, Masashi Furuta, Sumito Sogo, Kazuhiro Mae
    • Organizer
      13th International Conference on Micro Reaction Technology
    • Place of Presentation
      ハンガリー ブダペスト
    • Year and Date
      2014-06-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Quantitative evaluation of mass transfer promotion in gas-liquid slug flow considering wettability effect of wall2014

    • Author(s)
      Takashi Fukuda, Kazua Sato, Taisuke Maki, Kazuhiro mae
    • Organizer
      13th International Conference on Micro Reaction Technology
    • Place of Presentation
      ハンガリー ブダペスト
    • Year and Date
      2014-06-24
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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