| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
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| Outline of Final Research Achievements |
In this study, protein nanospheres were constructed for drug delivery system (DDS). Component proteins were consisting of hydrophobic thermo-responsive protein and poly-aspartic acids. This protein could be assembled and formed nanoapheres by mild heating. Molecular recognizing functional proteins could be displayed on the surface of nanospheres. On the other hand, hydrophobic anti-cancer drugs could be incorporated into the inside of nanospheres. These modified nanosphres could recognized cancer cells specifically, and kill cells by releasing anti-cancer drugs.
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