Skeletal muscle tissue engineering by magnetic force-based nanotechnology
| Project/Area Number |
26289315
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Kyushu University |
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Principal Investigator |
Ito Akira 九州大学, 工学(系)研究科(研究院), 准教授 (60345915)
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| Co-Investigator(Kenkyū-buntansha) |
清水 一憲 名古屋大学, 工学(系)研究科(研究院), 准教授 (70402500)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | ティッシュエンジニアリング / 骨格筋 / 再生医療 / iPS細胞 / 磁性ナノ粒子 / 薬剤スクリーニング / マイクロデバイス / 筋ジストロフィ / ナノバイオテクノロジー / 三次元培養 / 筋分化 / バイオテクノロジー / ナノバイオ |
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| Outline of Final Research Achievements |
In this study, we have developed a novel technology of skeletal muscle tissue engineering, designated "magnetic force-based tissue engineering (Mag-TE)", for regenerative medicine and drug discovery. The most important characteristic of skeletal muscle is force generation. We constructed three dimensional skeletal muscle tissues by Mag-TE technique and showed that the tissue-engineered skeletal muscles contracted and generated force upon electrical pulse stimulation. In the present study, 1) we explored a method of myogenic differentiation of human iPS cells; 2) we demonstrated that the contractility data is indispensable for evaluation of in vitro tissue-engineered skeletal muscle grafts; 3) we developed micro devices for high throughput screening of muscular disease drugs.
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Report
(4 results)
Research Products
(23 results)
