| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
In this study, we have developed a novel technology of skeletal muscle tissue engineering, designated "magnetic force-based tissue engineering (Mag-TE)", for regenerative medicine and drug discovery. The most important characteristic of skeletal muscle is force generation. We constructed three dimensional skeletal muscle tissues by Mag-TE technique and showed that the tissue-engineered skeletal muscles contracted and generated force upon electrical pulse stimulation. In the present study, 1) we explored a method of myogenic differentiation of human iPS cells; 2) we demonstrated that the contractility data is indispensable for evaluation of in vitro tissue-engineered skeletal muscle grafts; 3) we developed micro devices for high throughput screening of muscular disease drugs.
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