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A new approach using radioisotopes for peptide drug discovery

Research Project

Project/Area Number 26289369
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Nuclear engineering
Research InstitutionNational Institutes for Quantum and Radiological Science and Technology (2016)
Japan Atomic Energy Agency (2014-2015)

Principal Investigator

ISHIOKA NORIKO  国立研究開発法人量子科学技術研究開発機構, 放射性生物応用研究部, 上席研究員(定常) (30354963)

Co-Investigator(Kenkyū-buntansha) 山田 圭一  群馬大学, 理工学部, 准教授 (70323334)
山口 藍子  群馬大学, 医学(系)研究科(研究院), 寄付講座教員 (80609032)
大島 康宏  国立研究開発法人日本原子力研究開発機構, 原子力科学研究部門 量子ビーム応用研究センター, 研究員 (00588676)
渡辺 茂樹  国立研究開発法人日本原子力研究開発機構, 原子力科学研究部門 量子ビーム応用研究センター, 研究副主幹 (10450305)
Co-Investigator(Renkei-kenkyūsha) HANAOKA Hirofumi  群馬大学, 医学(系)研究科(研究院), 特任准教授 (50361390)
Research Collaborator SASAKI Ichiro  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Keywords放射性同位体 / ペプチド / 医薬品開発 / スクリーニング / 癌 / ペプチド創薬 / ペプチド薬剤
Outline of Final Research Achievements

Molecularly targeted drugs, which selectively exert effects on disease-causing substances, are expected to populate a new generation of drugs with few side effects. Peptides have great potential as candidates for molecularly targeted drugs, but currently the methods for developing peptide drugs are limited. We aim to establish an innovative drug discovery system to effectively develop peptide drugs by utilizing radioisotopes (RIs) that can be detected even at low concentrations. In this study, we performed basic research on selection of peptides having affinity for target molecule (HER2) from RI-labeled random peptide libraries consisting of D-amino acids.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (20 results)

All 2017 2016 2015 2014

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 1 results) Presentation (13 results) (of which Int'l Joint Research: 3 results) Book (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Synthesis and properties of silylated phenylalanine derivatives2016

    • Author(s)
      K. Yamada, S. Watanabe, S. Watanabe, T. Takahashi, T. Moriguchi, H. Oku, N. S. Ishioka, K. Shinozuka
    • Journal Title

      Peptide Science 2015

      Volume: 52 Pages: 93-94

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Medical application of radiohalogenated peptides : synthesis and in vitro evaluation of F(p-131I)KCCYSL for targeting HER22016

    • Author(s)
      I. Sasaki, S. Watanabe, Y. Ohshima, Y. Sugo, K. Yamada, H. Hanaoka, N. S. Ishioka
    • Journal Title

      Peptide Science 2015

      Volume: 52 Pages: 243-246

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous analysis of silicon and boron dissolved in water by combination of electrodialytic salt removal and ion-exclusion chromatography with corona charged aerosol detection2016

    • Author(s)
      M. Mori, K. Sagara, K. Arai, N. Nakatani, S. Ohira, K. Toda, H. Itabashi, D. Kozaki, Y. Sugo, S. Watanabe, N. S. Ishioka, and K. Tanaka
    • Journal Title

      J. Chromatography A

      Volume: 1431 Pages: 131-137

    • DOI

      10.1016/j.chroma.2015.12.064

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exploring of peptides with affinity to HER2 from random peptide libraries using radioisotope;Random hexapeptide libraries with fixed amino acid sequence at 1 and 2 positions2015

    • Author(s)
      I. Sasaki, H. Hanaoka, K. Yamada, Sh. Watanabe, Y. Sugo, Y. Ohshima, H. Suzuki, N. S. Ishioka
    • Journal Title

      Peptide Science 2014

      Volume: - Pages: 257-260

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] In vitro Studies on Cellular Binding and Stability of 64Cu-Labeled Peptide for Tumor Imagin2015

    • Author(s)
      Y. Sugo, Y. Ohshima, I. Sasaki, N. S. Ishioka
    • Journal Title

      Peptide Science 2014

      Volume: - Pages: 303-306

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] Improvement and optimization of clinically promising 76Br isolation using dry distillation approach for its future automation2017

    • Author(s)
      Sh. Watanabe, A. Shimada, Sa. Watanabe, H. Hanaoka, N. S. Ishioka
    • Organizer
      the International union of materials research society-International conference of advanced materials (IUMRS-ICAM) 2017
    • Place of Presentation
      京都大学吉田キャンパス(京都府堺区)
    • Year and Date
      2017-08-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis and Biological Evaluation of N-Methylated Cyclic Pentapeptides against Malignant Breast Cancer Cell Lines2016

    • Author(s)
      K. Yamada, S. Rokudai, R. Kawabata, M. Nishiyama K. Shinozuka
    • Organizer
      3rd International Symposium of Gunma University Medical Innovation
    • Place of Presentation
      桐生市市民文化会館(群馬県桐生市)
    • Year and Date
      2016-12-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 131I標識ペプチドの医学的応用-HER2標的としたF(p-131I)KCCYSLの合成とin vitro評価-2016

    • Author(s)
      佐々木一郎, 渡辺茂樹, 大島康宏, 須郷由美, 山田圭一, 花岡宏史, 石岡典子
    • Organizer
      第53回アイソトープ・放射線研究発表会
    • Place of Presentation
      東京大学弥生講堂(東京都文京区)
    • Year and Date
      2016-07-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Synthesis and properties of silylated phenylalanine derivatives and its application to bioactive cyclic peptides2015

    • Author(s)
      K. Yamada, S. Watanabe, S. Watanabe, S. Torii, N. S. Ishioka, and K. Shinozuka
    • Organizer
      2nd International Symposium of Gunma University Medical Innovation
    • Place of Presentation
      群馬大学(群馬県前橋市)
    • Year and Date
      2015-12-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis and properties of silylated phenylalanine derivatives2015

    • Author(s)
      K. Yamada, S. Watanabe, S. Watanabe, T. Takahashi, T. Moriguchi, H. Oku, N. S. Ishioka, K. Shinozuka
    • Organizer
      52nd Japanese Peptide Symposium
    • Place of Presentation
      東海大学(神奈川県平塚市)
    • Year and Date
      2015-11-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] Medical application of radiohalogenated peptides : synthesis and in vitro evaluation of F(p-131I)KCCYSL for targeting HER22015

    • Author(s)
      I. Sasaki, S. Watanabe, Y. Ohshima, Y. Sugo, K. Yamada, H. Hanaoka, N. S. Ishioka
    • Organizer
      52nd Japanese Peptide Symposium
    • Place of Presentation
      東海大学(神奈川県平塚市)
    • Year and Date
      2015-11-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] シリル化フェニルアラニンの合成と放射性臭素による標識化2015

    • Author(s)
      渡邉早貴, 渡辺茂樹, 山田圭一, 奥浩之, 森口朋尚, 石岡典子, 篠塚和夫
    • Organizer
      日本化学会第95春季年会
    • Place of Presentation
      日本大学(千葉県、船橋市)
    • Year and Date
      2015-03-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] RI 標識ランダムペプチドライブラリーを利用したがん親和性ペプチドの新規選抜法に関する 研究2014

    • Author(s)
      佐々木一郎, 花岡宏史, 山田圭一, 渡辺茂樹, 須郷由美, 大島康宏, 石岡典子
    • Organizer
      日本化学会関東支部群馬地区地域懇談会
    • Place of Presentation
      群馬大学(群馬県、桐生市)
    • Year and Date
      2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Synthesis and biological evaluation of N-methylated cyclic pentapeptides against malignant breast cancer cell lines2014

    • Author(s)
      K. Yamada, C. Takano, K. Matsumoto, H. Ueno, S. Watanabe, T. Moriguchi, H. Oku, S. Torii, K. Shinozuka
    • Organizer
      1st International Symposium of Gunma University Medical Innovation & 6th International Conference on Advanced Micro-Devise Engineering
    • Place of Presentation
      群馬大学(群馬県、桐生市)
    • Year and Date
      2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 放射性同位元素を利用したがんのペプチド創薬に関する研究2014

    • Author(s)
      佐々木一郎, 花岡宏史, 山田圭一, 渡辺茂樹, 須郷由美, 大島康宏, 石岡典子
    • Organizer
      日本原子力学会関東甲越支部、第13 回若手研究者発表討論会
    • Place of Presentation
      電力中央研究所(東京都、狛江市)
    • Year and Date
      2014-11-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Exploring of Peptides with Affinity to HER2 from Random Peptide Libraries Using Radioisotope: Random Hexapeptide Libraries with Fixed Amino Acid Sequence at 1 and 2 Positions2014

    • Author(s)
      佐々木一郎, 花岡宏史, 山田圭一, 渡辺茂樹, 須郷由美, 大島康宏, 鈴木博元, 石岡典子
    • Organizer
      第51 回ペプチド討論会
    • Place of Presentation
      徳島大学(徳島県、徳島市)
    • Year and Date
      2014-10-22 – 2014-10-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] In vitro Studies on Cellular Binding and Stability of 64Cu-Labeled Peptide for Tumor Imaging2014

    • Author(s)
      須郷由美, 大島康宏, 佐々木一郎, 石岡典子
    • Organizer
      第51 回ペプチド討論会
    • Place of Presentation
      徳島大学(徳島県、徳島市)
    • Year and Date
      2014-10-22 – 2014-10-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Isolation of 76Br from irradiated Cu2 76Se targets using dry distillation: evaluations and improvement for routine production2014

    • Author(s)
      Sh. Watanabe, Sa. Watanabe, Y. Ohshima, Y. Sugo, I. Sasaki, H. Hanaoka, N. S. Ishioka
    • Organizer
      15th International Workshop on Targetry and Target Chemistry
    • Place of Presentation
      Hotel Diplomat(Prague, Czech Republic)
    • Year and Date
      2014-08-17 – 2014-08-21
    • Related Report
      2014 Annual Research Report
  • [Book] ルールに囚われない薬剤設計 -経口吸収される非メチル化環状ペプチドの開発-、月刊「化学」4月号2015

    • Author(s)
      山田圭一
    • Total Pages
      2
    • Publisher
      化学同人
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] ペプチド化合物及びペプチド化合物の製造方法2015

    • Inventor(s)
      山田圭一, 渡邉早貴, 篠塚和夫, 渡辺茂樹, 石岡典子他2名
    • Industrial Property Rights Holder
      山田圭一, 渡邉早貴, 篠塚和夫, 渡辺茂樹, 石岡典子他2名
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-047082
    • Filing Date
      2015-03-10
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2021-01-27  

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