A new approach using radioisotopes for peptide drug discovery
| Project/Area Number |
26289369
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nuclear engineering
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| Research Institution | National Institutes for Quantum and Radiological Science and Technology (2016)
Japan Atomic Energy Agency (2014-2015) |
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Principal Investigator |
ISHIOKA NORIKO 国立研究開発法人量子科学技術研究開発機構, 放射性生物応用研究部, 上席研究員(定常) (30354963)
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| Co-Investigator(Kenkyū-buntansha) |
山田 圭一 群馬大学, 理工学部, 准教授 (70323334)
山口 藍子 群馬大学, 医学(系)研究科(研究院), 寄付講座教員 (80609032)
大島 康宏 国立研究開発法人日本原子力研究開発機構, 原子力科学研究部門 量子ビーム応用研究センター, 研究員 (00588676)
渡辺 茂樹 国立研究開発法人日本原子力研究開発機構, 原子力科学研究部門 量子ビーム応用研究センター, 研究副主幹 (10450305)
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| Co-Investigator(Renkei-kenkyūsha) |
HANAOKA Hirofumi 群馬大学, 医学(系)研究科(研究院), 特任准教授 (50361390)
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| Research Collaborator |
SASAKI Ichiro
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | 放射性同位体 / ペプチド / 医薬品開発 / スクリーニング / 癌 / ペプチド創薬 / ペプチド薬剤 |
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| Outline of Final Research Achievements |
Molecularly targeted drugs, which selectively exert effects on disease-causing substances, are expected to populate a new generation of drugs with few side effects. Peptides have great potential as candidates for molecularly targeted drugs, but currently the methods for developing peptide drugs are limited. We aim to establish an innovative drug discovery system to effectively develop peptide drugs by utilizing radioisotopes (RIs) that can be detected even at low concentrations. In this study, we performed basic research on selection of peptides having affinity for target molecule (HER2) from RI-labeled random peptide libraries consisting of D-amino acids.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Simultaneous analysis of silicon and boron dissolved in water by combination of electrodialytic salt removal and ion-exclusion chromatography with corona charged aerosol detection2016
Author(s)
M. Mori, K. Sagara, K. Arai, N. Nakatani, S. Ohira, K. Toda, H. Itabashi, D. Kozaki, Y. Sugo, S. Watanabe, N. S. Ishioka, and K. Tanaka
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Journal Title
J. Chromatography A
Volume: 1431
Pages: 131-137
DOI
Related Report
Peer Reviewed
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