Functional mapping of fish social brain

• Project/Area Number: 26290003
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Neurophysiology / General neuroscience
• Research Institution: Okayama University (2015-2016); The University of Tokyo (2014)
• Principal Investigator: Takeuchi Hideaki 岡山大学, 自然科学研究科, 准教授 (00376534)
• Co-Investigator(Kenkyū-buntansha): 久保 健雄 東京大学, 理学(系)研究科(研究院), 教授 (10201469) ; 横井 佐織 北海道大学, 薬学研究科(研究院), 助教 (10772048)
• Co-Investigator(Renkei-kenkyūsha): KAMEI Yasuhiro 基礎生物学研究所, 生物機能解析センター, 特任准教授 (70372563)
• Research Collaborator: Isoe Yasuko 岡山大学, 大学院自然科学研究科, 助教(特別契約職員) (60786119)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
• Keywords: 硬骨魚類 / 神経ペプチド / 社会行動 / ゲノム編集 / 配偶者選択 / 個体認知 / オキシトシン / 神経科学 / 脳・神経 / 遺伝子 / 行動発達 / 脳機能地図 / 行動学 / 生態学 / 社会性行動 / メダカ / ホルモン / バソトシン / 社会脳 / 小型魚類 / 条件的遺伝子操作法 / IR-LEGO

Outline of Final Research Achievements

Male medaka fish in a triad relationship (two males and one female) hold a position between the rival male and a female (mate-guarding), which results in improvement of mating success. Behavioral analysis of mutant males revealed that vasotocin system is required for dominance in mate-guarding (PLoS Genetics 2015). Our study also suggested mate-guarding behavior has an effect on visual familiarity and female mate preference. Previously we found that female medaka prefer to mate with visually-familiarized males (Science 2014). We showed that mate-guarding behaviors blocked visual familiarization of a female with the rival in a triad relationship, suggesting that female mate preference for familiar mates may help ascertain social dominance in males（Frontiers in Zoology, 2016).

Research Products

• [Int'l Joint Research] エモリー大学(米国)
• [Int'l Joint Research] Emory University(米国)
• [Journal Article] Mate-guarding behavior enhances male reproductive success via familiarization with mating partners in medaka fish. (2016)
  • Author(s): Yokoi S, Ansai S, Kinoshita M, Naruse K, Kamei Y, Young LJ, Okuyama T, Takeuchi H.
  • Journal Title: Frontiers in Zoology Volume: 13 Issue: 1 Pages: 21-21
  • DOI: 10.1186/s12983-016-0152-2
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Ontogeny and sexual differences in swimming proximity to conspecifics in response to visual cues in medaka fish (2016)
  • Author(s): Y. Isoe, Y. Konagaya, S. Yokoi, T. Kubo, H. Takeuchi
  • Journal Title: Zool. Sci. Volume: 33 Issue: 3 Pages: 246-246
  • DOI: 10.2108/zs150213
  • NAID: 210000176073
  • Peer Reviewed
• [Journal Article] Ontogeny and sexual differences in swimming proximity to conspecifics in response to visual cues in medaka fish (2016)
  • Author(s): Yasuko Isoe, Yumi Konagaya, Saori Yokoi, Takeo Kubo, Hideaki Takeuchi
  • Journal Title: Zoological Science Volume: XXX
  • NAID: 210000176073
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Mate-guarding behavior enhances male reproductive success via familiarization with mating partners in medaka fish (2016)
  • Author(s): Saori Yokoi, Ansai Satoshi, Masato Kinoshita, Kiyoshi Naruse, LarryJ Young, Teruhiro Okuyama and Hideaki Takeuchi
  • Journal Title: Frontiers in Zoology Volume: XXX
  • NAID: 120006331985
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] An Essential Role of the Arginine Vasotocin System in Mate-Guarding Behaviors in Triadic Relationships of Medaka Fish (Oryzias latipes). (2015)
  • Author(s): Yokoi S, Okuyama T, Kamei Y, Naruse K, Taniguchi Y, Ansai S, Kinoshita M, Young LJ, Takemori N, Kubo T, Takeuchi H
  • Journal Title: PLoS Genetics Volume: なし Issue: 2 Pages: e1005009-e1005009
  • DOI: 10.1371/journal.pgen.1005009
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Genetic control of startle behavior in medaka fish (2014)
  • Author(s): Tsuboko S, Kimura T, Shinya M, Suehiro Y, Okuyama T, Shimada A, Takeda H, Naruse K, Kubo T, Takeuchi H
  • Journal Title: PLoS one Volume: 9 Issue: 11 Pages: e112527-e112527
  • DOI: 10.1371/journal.pone.0112527
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] メダカの三角関係の分子神経基盤 (2017)
  • Author(s): 竹内秀明
  • Organizer: I―URIC フロンティアコロキウム
  • Place of Presentation: ホテルアソシア静岡
  • Year and Date: 2017-03-02
  • Invited
• [Presentation] 三角関係(オス、オス、メス)においてライバルへのメスの目移りを防ぐオスメダカ） (2016)
  • Author(s): 横井佐織、竹内秀明
  • Organizer: 第26回日本行動神経内分泌研究会
  • Place of Presentation: ホテル・サンミ倶楽部
  • Year and Date: 2016-04-28
• [Presentation] Exploring the neural geography of the social brain using medaka fish (2016)
  • Author(s): Hideaki Takeuchi (Keynote lecture)
  • Organizer: 17th Australia & New Zealand Zebrafish Meeting
  • Place of Presentation: Flinders, Australia
  • Year and Date: 2016-02-03
  • Int'l Joint Research / Invited
• [Presentation] Exploring the neural geography of the social brain using medaka fish (2016)
  • Author(s): Hideaki Takeuchi (Keynote lecture)
  • Organizer: 3rd Medaka Strategic Meeting
  • Place of Presentation: Flinders, Australia
  • Year and Date: 2016-02-01
  • Int'l Joint Research / Invited
• [Presentation] メダカの個体認知を介した社会行動の神経機構」 (2016)
  • Author(s): 竹内秀明
  • Organizer: 日本神経科学学会
  • Place of Presentation: 横浜
  • Int'l Joint Research / Invited
• [Presentation] メダカの恋の三角関係の神経分子基盤 (2016)
  • Author(s): 竹内秀明
  • Organizer: OCUテニュアトラック研究集会
  • Place of Presentation: 大阪市立大学
  • Invited
• [Presentation] メダカを用いた個体記憶を介した社会的意思決定機構の解明 (2015)
  • Author(s): 竹内秀明
  • Organizer: 共感性領域・自己制御精神領域合同シンポジウム・個体と社会の関係を科学する
  • Place of Presentation: 東京
  • Year and Date: 2015-12-19
  • Invited
• [Presentation] Neural mechanism of female preference mediated by social memory (2015)
  • Author(s): Hideaki Takeuchi
  • Organizer: Symposium on Memory and Mind, Tohoku Forum for Creativity
  • Place of Presentation: 仙台
  • Year and Date: 2015-09-28
  • Int'l Joint Research / Invited
• [Presentation] メダカの三角関係を生み出す分子基盤 (2015)
  • Author(s): 竹内秀明
  • Organizer: 日本動物学会関東支部公開講演会「動物の行動を科学する」
  • Place of Presentation: 東京
  • Year and Date: 2015-08-01
  • Invited
• [Presentation] Analysis of mechanism underlying brain growth accompanied by neurogenesis using medaka fish (Oryzias latipes) (2014)
  • Author(s): Yasuko Isoe, Teruhiro Okuyama, Masahito Hoki, Yuji Suehiro, Genki Yamagishi,Kiyoshi Naruse, Masato Kinoshita, Yasuhiro Kamei, Shigenori Nonaka Atushi Shimizu, Takeo Kubo, Hideaki Takeuchi
  • Organizer: Neuroscience 2014/ SfN(北米神経学会)
  • Place of Presentation: アメリカ・ワシントンD.C.
  • Year and Date: 2014-11-17
• [Presentation] Analysis of mechanism underlying brain growth accompanied by neurogenesis using medaka fish (Oryzias latipes) (2014)
  • Author(s): Yasuko Isoe, Teruhiro Okuyama, Masahito Hoki, Yuji Suehiro, Genki Yamagishi,Kiyoshi Naruse, Masato Kinoshita, Yasuhiro Kamei, Shigenori Nonaka Atushi Shimizu, Takeo Kubo, Hideaki Takeuchi
  • Organizer: Neuro2014 / The 36th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 名古屋
  • Year and Date: 2014-09-09
• [Presentation] Analysis of mechanism underlying brain growth accompanied by neurogenesis using medaka fish (Oryzias latipes) (2014)
  • Author(s): Yasuko Isoe, Teruhiro Okuyama, Masahito Hoki, Yuji Suehiro, Genki Yamagishi,Kiyoshi Naruse, Masato Kinoshita, Yasuhiro Kamei, Shigenori Nonaka Atushi Shimizu, Takeo Kubo, Hideaki Takeuchi
  • Organizer: 2014 International Congress of Neuroethology/The Japanese Society for comparative Physiology and Biochemistry
  • Place of Presentation: 札幌
  • Year and Date: 2014-07-29
• [Presentation] Searching for genes affecting visually-evoked startle response properties with inbred strains of Medaka (Oryzias latipes) -- Genetically Affected Escape Modes in Solitary and Collective States of Medaka Fish (2014)
  • Author(s): 坪子理美、木村哲晃 、新屋みのり、末廣勇司、奥山輝大、島田敦子、武田洋幸、成瀬清、久保健雄、竹内秀明
  • Organizer: 2014 International Congress of Neuroethology/The Japanese Society for comparative Physiology and Biochemistry
  • Place of Presentation: 札幌
  • Year and Date: 2014-07-28
• [Presentation] Analysis of mechanism underlying brain growth accompanied by neurogenesis using medaka fish (Oryzias latipes) (2014)
  • Author(s): Yasuko Isoe, Teruhiro Okuyama, Masahito Hoki, Yuji Suehiro, Genki Yamagishi,Kiyoshi Naruse, Masato Kinoshita, Yasuhiro Kamei, Shigenori Nonaka Atushi Shimizu, Takeo Kubo, Hideaki Takeuchi
  • Organizer: 2nd Strategic Meeting for Medaka Research
  • Place of Presentation: スペイン・セビリア
  • Year and Date: 2014-04-11
• [Presentation] Searching for genes affecting visually-evoked startle response properties with medaka inbred strains (2014)
  • Author(s): 坪子理美、木村哲晃 、新屋みのり、末廣勇司、奥山輝大、島田敦子、武田洋幸、成瀬清、久保健雄、竹内秀明
  • Organizer: 2nd Strategic Meeting for Medaka Research
  • Place of Presentation: セビリア・スペイン
  • Year and Date: 2014-04-10 – 2014-04-12
• [Presentation] Behavioral polymorphism in medaka strains: genetic factor matters? (2014)
  • Author(s): Mu-Yun Wang, Takeo Kubo and Hideaki Takeuchi
  • Organizer: 2nd Strategic Meeting for Medaka Research
  • Place of Presentation: セビリア・スペイン
  • Year and Date: 2014-04-10 – 2014-04-12
• [Presentation] Proximate and ultimate causes of socially-regulated mating preference in medaka fish (2014)
  • Author(s): Hideaki Takeuchi
  • Organizer: 2nd Strategic Meeting for Medaka Research
  • Place of Presentation: スペイン・セビリア
  • Year and Date: 2014-04-10
  • Invited
• [Book] 「社会的記憶“異性の好み”を生み出す神経機構」生体の科学 (2016)
  • Author(s): 竹内秀明
  • Total Pages: 4
  • Publisher: 医学書院
• [Book] 「メダカを用いた“魚類社会脳”の 分子神経基盤の解明」ブレインサイエンス・レビュー2017 (2016)
  • Author(s): 竹内秀明
  • Total Pages: 20
  • Publisher: クバプロ
• [Book] 新・生命科学シリーズ 動物行動の分子生物学 (2014)
  • Author(s): 竹内秀明
  • Total Pages: 27
  • Publisher: 裳華房
• [Remarks] 岡山大学大学院自然科学研究科（理学部生物学科） 分子行動学研究室
  • URL: https://sites.google.com/view/molecular-ethology-laboratory/%E3%83%9B%E3%83%BC%E3%83%A0
• [Remarks] Researchmap
  • URL: http://researchmap.jp/Takeuchi/?lang=japanese
• [Remarks] Researchmap
  • URL: http://researchmap.jp/takeuchi/?lang=japanese
• [Remarks] 恋敵からメスを守るオスメダカ
  • URL: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/stay-away-from-my-girl.html
• [Remarks] 恋敵からメスを守るオスメダカ
  • URL: http://www.s.u-tokyo.ac.jp/ja/press/4154/