Cellular and network mechanisms for the oscillatory synchronization between adjacent columns/areas
Project/Area Number |
26290006
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Neurophysiology / General neuroscience
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Research Institution | Kagoshima University (2016-2017) Osaka University (2014-2015) |
Principal Investigator |
KANG Youngnam 鹿児島大学, 医歯学総合研究科, 客員研究員 (50177755)
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Co-Investigator(Kenkyū-buntansha) |
豊田 博紀 大阪大学, 歯学研究科, 准教授 (00432451)
佐藤 元 大阪大学, 歯学研究科, 助教 (10432452)
齋藤 充 鹿児島大学, 医歯学域歯学系, 教授 (50347770)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2014: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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Keywords | Insular cortex / CB1 receptor / GPR119 / PPARalpha / Oscillation / Synchronization / oscillation / synchronization / θリズム / δリズム / 島皮質 / 味覚野 / 胃腸関連領野 / anadamide / 高次脳機能 / 周期的同期化 / コヒーレンス / バレル皮質 / GPR119 receptor / バレル野 / 機能的カラム / GABAB受容体 |
Outline of Final Research Achievements |
Activation of CB1R by AEA in pyramidal cells in the gustatory insular (Gu-I) cortex caused oscillatory synchronization at theta rhythm, which subsequently propagated into the adjacent gastrointestinal insular (GI-I) cortex. This propagating oscillatory synchronization at theta rhythm was abolished by co-application of GPR119 agonist, and the opposing action between CB1R and GPR119 was found to be mediated by the downregulation and upregulation of cAMP. Prior to the propagation of theta rhythm oscillatory synchronization from Gu-I into GI-I, GABA(B)-mediated feedforward inhibition was caused. A microcut between Gu-I and GI-I revealed the independent oscillations at theta and delta rhythms, respectively, in Gu-I and GI-I, disclosing no feedback from GI-I to Gu-I. These observations suggest that the recognition of umami or sweet taste facilitates the feeding behavior, regardless of hunger or satiety condition.
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Report
(5 results)
Research Products
(38 results)
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[Journal Article] Inhibition of GluR Current in Microvilli of Sensory Neurons via Na(+)-Microdomain Coupling among GluR, HCN channel and Na(+)/K(+) Pump.2018
Author(s)
Kawasaki Y, Saito M, Won J, Bae JY, Sato H, Toyoda H, Kuramoto E, Kogo M, Tanaka T, Kaneko T, Oh SB, Bae YC, Kang Y.
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Journal Title
Front. Cell. Neurosci.
Volume: 印刷中
Pages: 113-113
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A distinct functional distribution of α and γ motoneurons in the rat trigeminal motor nucleus.2017
Author(s)
Morita-Isogai, Y., Sato, H., Saito, M., Kuramoto, E., Yin, D., Kaneko, T., Yamashiro, T., Takada, K., Oh, S.B., Toyoda, H., & Kang, Y.
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Journal Title
Brain Structure and Function
Volume: -
Issue: 7
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A role of CB1R in inducing θ-rhythm coordination between the gustatory and gastrointestinal insula.2016
Author(s)
Kang, Y., Sato, H., Saito, M.,Yin, D., Park, S.K., Oh, S.B., Bae, Y.C. & Toyoda, H.
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 32529-32529
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The Possible Role of TASK Channels in Rank-Ordered Recruitment of Motoneurons in the Dorsolateral Part of the Trigeminal Motor Nucleus.2016
Author(s)
Okamoto K, Emura N, Sato H, Fukatsu Y, Saito M, Tanaka C, Morita Y, Nishimura K, Kuramoto E, Xu Yin D, Furutani K, Okazawa M, Kurachi Y, Kaneko T, Maeda Y, Yamashiro T, Takada K, Toyoda H, Kang Y.
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Journal Title
eNeuro
Volume: 3(3)
Issue: 3
Pages: 3-3
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Generation of resonance-dependent oscillation by mGluR-I activation switches single spiking to bursting in mesencephalic trigeminal sensory neurons2015
Author(s)
Chung, G., Saito, M., Kawasaki, Y., Kawano, T., Yin, D., Lee, S., Kogo, M., Takada, M., Bae, Y., Oh, S.B & Kang, Y.
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Journal Title
European Journal of Neuroscience
Volume: 41
Issue: 8
Pages: 998-1012
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Enhanced lateral inhibition in the barrel cortex by deletion of phospholipase C-related catalytically inactive protein-1/2 in mice2015
Author(s)
Toyoda, H., Saito, M., Sato, H., Kawano, T., Kawakami, S., Yatani, H., Kanematsu, T., Hirata, M. & Kang, Y.
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Journal Title
Pflugers Archiv; European Journal of Physiology
Volume: in press
Related Report
Peer Reviewed / Open Access
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