Molecular mechanisms of flexible decision making
| Project/Area Number |
26290008
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurophysiology / General neuroscience
|
|---|
| Research Institution | University of Yamanashi (2016)
Juntendo University (2014-2015) |
|---|
Principal Investigator |
UKA Takanori 山梨大学, 総合研究部, 教授 (50372933)
|
|---|
| Research Collaborator |
SUDA Yuki
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 脳・神経 |
|---|
| Outline of Final Research Achievements |
Flexible decision making is a hallmark of human cognition. Subanesthetic dose of ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, impairs such flexibility, but how it affects decision making circuits remains unclear. We recorded single unit activity in the lateral intraparietal area (LIP) while monkeys switched between a direction discrimination task and a depth discrimination task. Ketamine administration increased neural sensitivity to irrelevant information, and delayed the onset of decision-related neural activity. These results suggest that ketamine affected "what" information to process and "when" to process it.
|
Report
(4 results)
Research Products
(7 results)
