Body map reorganization by remodeling of neural circuit in CNS
| Project/Area Number |
26290010
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
Miyata Mariko 東京女子医科大学, 医学部, 教授 (70281631)
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| Co-Investigator(Renkei-kenkyūsha) |
Takeuchi Yuichi 東京女子医科大学, 医学部, 助教 (70588384)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Keywords | 視床 / 改編 / 内側毛帯線維 / 体部位情報 / 神経損傷 / 体性感覚野 / 疼痛 / dysgranular area / シナプス除去 / 発達期 / 神経切断 / 神経回路改編 / 神経科学 / 内側毛帯 / リモデリング / 神経回路 |
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| Outline of Final Research Achievements |
Neural circuits in the somatosensory system are remodeled during development and/ or by peripheral nerve injury . However, the link between local circuit remodeling and somatotopic reorganization remains unclear.In the present study, we discovered that remodeling of lemniscal fibers (excitatory afferent fibers in the somatosensory thalamus) caused by transection of the primary whisker sensory nerve actually mediated somatotopic reorganization with highly correlated anatomical remodeling and functional rewiring. Specifically, lemniscal fibers carrying genetically visualized whisker-specific information significantly retracted from the whisker sensory thalamus after the transection, whereas those not carrying whisker information ectopically invaded the whisker sensory thalamus.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] The synaptic targeting of mGluR1 by its carboxyl-terminal domain Is crucial for cerebellar function2014
Author(s)
Yoshiaki Ohtani, Mariko Miyata, Kouichi Hashimoto, Toshihide Tabata, Yasushi Kishimoto, Masahiro Fukaya, Daisuke Kase, Hidetoshi Kassai, Kazuki Nakao, Tatsumi Hirata, Masahiko Watanabe, Masanobu Kano, Atsu Aiba
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Journal Title
Journal of Neuroscience
Volume: 34
Issue: 7
Pages: 2702-2712
DOI
Related Report
Peer Reviewed
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[Presentation] Type I metabotropic glutamate receptor is crucial for visual experience-dependent maintenance of mature connectivity of retinogeniculate synapses2016
Author(s)
Madoka Narushima, Motokazu Uchigashima, Yuki Yagasaki, Takeshi Harada, Yasuyuki Nagumo, Naofumi Uesaka, Kouichi Hashimoto, Atsu Aiba, Masahiko Watanabe, Mariko Miyata, Masanobu Kano
Organizer
10th FENS Forum of Neuroscience 2016
Place of Presentation
Bella Center(Denmark,Copenhagen)
Year and Date
2016-07-03
Related Report
Int'l Joint Research
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[Presentation] Assembly of Neocortical Circuitry by FoxG1, a Gene Associated with Neurocognitive Disorders.2016
Author(s)
Miyoshi, G., Ueta, U., Osaki, H., Yagasaki, Y., Hanashima, C., Fishell, G., Miata, M
Organizer
the 93rd Annual Meeting of the Physiological Society of Japan
Place of Presentation
札幌コンベンションセンター（北海道札幌市）
Year and Date
2016-03-22
Related Report
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