| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
During cerebral cortical development, immature neurons show multi-step mode of migration. It was reported that the neuronal migration is associated with several neurological disorders, such as lissencephaly and dyslexia. While we and others have revealed that cytoskeletal regulation plays important roles in the neuronal migration, our recent study has indicated that endocytic pathways are also important. In this study, we have analyzed the “role-allocation” of various types of endocytosis in the neuronal migration. We show here that clathrin-independent endocytosis promotes the N-cadherin internalization, which regulates the immature neurite pruning, an essential step of the multipolar-to-bipolar transition of migrating neurons. The bipolar-shaped neurons undergo the long-distance migration, which is shown to be controlled by Dynamin- and Rab5-dependent endocytic pathways. Thus, our findings show that different endocytic machineries regulate the multi-step neuronal migration.
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