| Project/Area Number |
26290020
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Hokkaido University |
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Principal Investigator |
MINAMI Masabumi 北海道大学, 薬学研究科(研究院), 教授 (20243040)
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| Co-Investigator(Renkei-kenkyūsha) |
KANEDA Katsuyuki 金沢大学, 医薬保健研究域, 教授 (30421366)
IDE Soichiro 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主席研究員 (30389118)
YAMANAKA Akihiro 名古屋大学, 環境医学研究所, 教授 (60323292)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 脳・神経 / 薬理学 / 情動 / 不安 / 抑うつ / 分界条床核 / 扁桃体 / 腹側被蓋野 / 精神疾患 / 神経科学 |
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| Outline of Final Research Achievements |
Mammals including humans are thought to have acquired and evolved neuronal mechanisms for negative emotion, such as depression and anxiety, as a biological defense system that protects themselves by suppressing their activities and raising vigilance against the surroundings, when they are in dangerous condition. Therefore, in order to understand the neuronal mechanisms of depressive disorders and anxiety disorders, it is necessary to clarify the neuronal mechanisms for negative emotion from the viewpoint as a biological defense system and to analyze the changes of such mechanisms in patients and disease model animals. We have been studying with focusing on the bed nucleus of the stria terminalis (BNST), and demonstrated that activation of BNST neurons by CRF suppresses the dopaminergic neurons in the ventral tegmental area (VTA) to produce pain-induced negative emotion, and that neuroplastic alteration in the BNST induces sustained suppression of VTA dopaminergic neurons.
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