| Project/Area Number |
26290021
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Tanaka Kohichi 東京医科歯科大学, 難治疾患研究所, 教授 (80171750)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | アストロサイト / ゲノム編集 / 脳神経疾患 / 神経科学 / 脳・神経 |
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| Outline of Final Research Achievements |
Astrocytes were thought to be a homogenous population of cells. However, several studies have demonstrated that astrocytes from different regions show heterogeneity in their expression of ion channels and coupling molecules. To dissect astrocyte heterogeneity, we decode the origin of astrocytes in different brain regions. To elucidate the embryonic origins of astrocyte in a specific brain region, we applied a recombinase-based intersectional genetic strategy in mice. Astrocytes in dorsal forebrain, thalamus, hypothalamus, cerebellum/midbrain, and spinal cord are derived from Emx1-, Olig3-, Nkx2.1-, En1, Hoxb8-positive domain of the ventricular zone, respectively. In addition, intersectional approach can control the activity of astrocytes in a region-specific manner. We can demonstrate that astrocytes in different brain regions contribute to different brain functions.
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