Development of therapy methodology for neuronal regeneration using neural circuit formation factor LOTUS
Project/Area Number |
26290024
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Yokohama City University |
Principal Investigator |
TAKEI Kohtaro 横浜市立大学, 生命医科学研究科, 教授 (40202163)
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Co-Investigator(Renkei-kenkyūsha) |
NOGI Terukazu 横浜市立大学, 生命医科学研究科, 准教授 (40379102)
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Research Collaborator |
KURIHARA Yuji
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
|
Keywords | 神経再生 / LOTUS / Nogo受容体 / 再生医療技術 / 脊髄損傷 / アンタゴニスト / 機能回復 / 再生医療 / 脳, 神経 / 生体分子 / 神経科学 / 脳神経疾患 / 脳神経 / 生体機能利用 / 再生医学 / 移植再生医療 |
Outline of Final Research Achievements |
After spinal cord injury (SCI), primates hardly recover the locomotor function, and the basic therapy has not been established. However, rodents, such as mice and rats, show a partial spontaneous recovery of the locomotor function. It has been considered that limitation of neuronal regeneration is mainly caused by axon growth inhibitors and a common receptor of these ligands, Nogo receptor-1 (NgR1). We found LOTUS suppressed axonal growth inhibition induced by interaction between these NgR1 ligands and NgR1. First, we found that lotus-deficient mice showed delayed locomotor functional recovery of behavioral outcome, whereas functional recovery in was found in LOTUS-Tg mice overexpressing LOTUS in neurons. These findings suggest that LOTUS may contribute to promotion of functional recovery after SCI.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Crmp4 deletion promotes recovery from spinal cord injury by neuroprotection and limited scar formation.2015
Author(s)
Nagai, J., Kitamura, Y., Owada, K., Yamashita, N., Takei, K., Goshima, Y., Ohshima, T.
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Journal Title
Sci. Rep.
Volume: 5
Issue: 1
Pages: 8269-8269
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Association of cerebrospinal fluid levels of lateral olfactory usher substance protein with disease activity in multiple sclerosis.2015
Author(s)
Takahashi, K., Kurihara, Y., Suzuki, Y., Goshima, Y., Tanaka, F., and Takei, K.
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Journal Title
JAMA Neurology
Volume: 72
Pages: 176-179
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] LOTUS suppresses axon growth inhibition by blocking interaction between Nogo receptor-1 and all four types of its ligand.2014
Author(s)
Kurihara, Y., Iketani, M., Ito, H., Nishiyama, K., Sakakibara, Y., Goshima, and Y. Takei, K.
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Journal Title
Molecular Cellular Neuroscience
Volume: 61
Pages: 211-218
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] lexinA4-dependent retrograde Semaphorin3A signaling regulates the dendritic localization of GluA2-containing AMPA receptors.2014
Author(s)
1) Yamashita, N., Usui, H., Nakamura, F., Chen, S., Sasaki, Y., Hida, T., Suto, F., Taniguchi, M., Takei, K., Goshima, Y.
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Journal Title
Nature Communications
Volume: 5
Issue: 1
Pages: 3424-3424
DOI
Related Report
Peer Reviewed / Open Access
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