| Project/Area Number |
26290024
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Yokohama City University |
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Principal Investigator |
TAKEI Kohtaro 横浜市立大学, 生命医科学研究科, 教授 (40202163)
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| Co-Investigator(Renkei-kenkyūsha) |
NOGI Terukazu 横浜市立大学, 生命医科学研究科, 准教授 (40379102)
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| Research Collaborator |
KURIHARA Yuji
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | 神経再生 / LOTUS / Nogo受容体 / 再生医療技術 / 脊髄損傷 / アンタゴニスト / 機能回復 / 再生医療 / 脳, 神経 / 生体分子 / 神経科学 / 脳神経疾患 / 脳神経 / 生体機能利用 / 再生医学 / 移植再生医療 |
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| Outline of Final Research Achievements |
After spinal cord injury (SCI), primates hardly recover the locomotor function, and the basic therapy has not been established. However, rodents, such as mice and rats, show a partial spontaneous recovery of the locomotor function. It has been considered that limitation of neuronal regeneration is mainly caused by axon growth inhibitors and a common receptor of these ligands, Nogo receptor-1 (NgR1). We found LOTUS suppressed axonal growth inhibition induced by interaction between these NgR1 ligands and NgR1. First, we found that lotus-deficient mice showed delayed locomotor functional recovery of behavioral outcome, whereas functional recovery in was found in LOTUS-Tg mice overexpressing LOTUS in neurons. These findings suggest that LOTUS may contribute to promotion of functional recovery after SCI.
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