| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Outline of Final Research Achievements |
Social maltreatment early in life can lead to the development of impaired interpersonal relationships and profound social disorders. However, the underlying cellular and molecular mechanisms involved are largely unknown. Here, we found that isolation of neonatal rats induced social dominance over non-isolated control rats from the same litter in juveniles that was glucocorticoid-dependent. Furthermore, neonatal isolation inactivated the actin-depolymerizing factor (ADF)/cofilin in the juvenile medial prefrontal cortex (mPFC). Isolation-induced inactivation of ADF/cofilin resulted in the decrease of glutamate synaptic AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptor (AMPAR) contents by the increase of stable actin fractions at dendritic spines in the juvenile mPFC. Thus, neonatal isolation affects spines in the mPFC by reducing actin dynamics, leading to abnormal social behavior later in life.
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