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Regulation of metabolism by RB tumor suppressor gene

Research Project

Project/Area Number 26290037
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Tumor biology
Research InstitutionKanazawa University

Principal Investigator

Takahashi Chiaki  金沢大学, がん進展制御研究所, 教授 (50283619)

Co-Investigator(Renkei-kenkyūsha) Hayashi Naoyuki  金沢大学, がん進展制御研究所, 助教 (50253456)
Kitajima Syunsuke  金沢大学, がん進展制御研究所, 特任助教 (90566465)
Shamma Awad  金沢大学, がん進展制御研究所, 助教 (50402839)
Kohno Susumu  金沢大学, がん進展制御研究所, 研究員 (30625463)
Sasaki Nobunari  金沢大学, がん進展制御研究所, 研究員 (40415170)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywordsがん代謝 / RB / 解糖系 / 脂質代謝 / PGAM / がん抑制遺伝子 / がん / 代謝 / がん幹細胞 / コレステロール / 糖代謝 / グルタミン
Outline of Final Research Achievements

We found that PGAM1 and 2 mediate function of RB tumor suppressor to regulate glycolysis. We also clarified how RB controls transcription of these genes. A further study demonstrated that PGAMs mediate RB function to control differentiation. On the other hand, we investigated the clinical significance of the RB function to control cholesterol synthesis. RB loss via increasing cholesterol synthesis recruits androgen receptor (AR) to nucleus and reduces ROS. These phenomenons were antagonized addition of statins, Lastly, we performed lipidomics analysis of RB-inactivated cells, which indicated that RB status gives significant impact on the quantitative and qualitative status of fatty acids,

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (55 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (13 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 13 results,  Acknowledgement Compliant: 9 results,  Open Access: 7 results) Presentation (31 results) (of which Int'l Joint Research: 12 results,  Invited: 12 results) Book (5 results) Remarks (5 results)

  • [Int'l Joint Research] Dana-Farmer Cancer Institute/Broad Institute(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] The RB-IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity.2017

    • Author(s)
      Kitajima S, Yoshida A, Susumu K, Li F, Suzuki S, Nagatani N, Nishimoto Y, Sasaki N, Hayato M, Wan Y, Thai T C, Okahashi N, Matsuda F, Shimizu H, Nishiuchi T, Suzuki Y, Tominaga K, Gotoh N, Suzuki M, Ewen M E, Barbie D A, Hirose O, Tanaka T and Takahashi C
    • Journal Title

      Oncogene

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] MicroRNA-140 mediates RB tumor suppressor function to control stem cell-like activity through interleukin-6.2017

    • Author(s)
      Yoshida A, Kitajima S, Li F, Chaoyang C, Yujiro T, Susumu K, Wan Y, Naoyuki H, Hayato M, Nishimoto Y, Nagatani N, Nishiuchi T, Thai T C, Suzuki S, Nakao S, Tanaka T, Hirose O, Barbie D A and Takahashi C.
    • Journal Title

      Oncotarget

      Volume: 印刷中 Issue: 8 Pages: 13872-85

    • DOI

      10.18632/oncotarget.14681

    • NAID

      120006226780

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Glucoraphanin ameliorates obesity and insulin resistance through adipose tissue browning and reduction of metabolic endotoxemia in mice.2017

    • Author(s)
      Nagata N, Xu L, Kohno S, Ushida Y, Aoki Y, Umeda R, Fuke N, Zhuge F, Ni Y, Nagashimada M, Takahashi C, Suganuma H, Kaneko S and Ota T.
    • Journal Title

      Diabetes

      Volume: 印刷中 Issue: 5 Pages: 1222-1236

    • DOI

      10.2337/db16-0662

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Therapeutic strategy for targeting aggressive malignant gliomas by disrupting their energy balance.2016

    • Author(s)
      Hegazy AM, Yamada D, Kobayashi M, Kohno S, Ueno M, Ali MA, Ohta K, Tadokoro Y, Ino Y, Todo T, Soga T, Takahashi C and Hirao A.
    • Journal Title

      J Biol Chem

      Volume: 291 Pages: 170-184

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RB tumor suppressor functions shared by stem cell and cancer cell strategies.2016

    • Author(s)
      Kohno S, Kitajima S, Sasaki N and Takahashi C.
    • Journal Title

      World J Stem Cells

      Volume: 8 Issue: 4 Pages: 170-184

    • DOI

      10.4252/wjsc.v8.i4.170

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Primary Culture of Mouse Thyroid Calcitonin-producing Cell (C cell) Tumors.2015

    • Author(s)
      Kitajima S, Li F, Takahashi C.
    • Journal Title

      Bio-Protocol

      Volume: 5-24

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] An in vitro system to characterize prostate cancer progression identified signaling required for self-renewal.2015

    • Author(s)
      Salah M, Nishimoto Y, Kohno S, Kondoh A, Kitajima S, Muranaka H, Nishiuchi T, Ibrahim A, Yoshida A, Takahashi C.
    • Journal Title

      Mol Carcinog.

      Volume: in press Issue: 12 Pages: 1974-1989

    • DOI

      10.1002/mc.22444

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Undifferentiated State Induced by Rb-P53 Double Inactivation in Mouse Thyroid Neuroendocrine Cells and Embryonic Fibroblasts2015

    • Author(s)
      Kitajima S, Kohno S, Kondoh A, Sasaki N, Nishimoto Y, Li F, Mohammed MS, Muranaka H, Nagatani N, Suzuki M, Kido Y, Takahashi C
    • Journal Title

      STEM CELLS

      Volume: - Issue: 5 Pages: 1657-1669

    • DOI

      10.1002/stem.1971

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Metabolic characterization of cultured mammalian cells by mass balance analysis, tracer labeling experiments and computer-aided simulations.2015

    • Author(s)
      Okahashi N, Kohno S, Kitajima S, Matsuda F, Takahashi C, Shimizu H.
    • Journal Title

      J Biosci Bioeng.

      Volume: 120 Issue: 6 Pages: 725-731

    • DOI

      10.1016/j.jbiosc.2015.04.003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pleiotropic functions of RB protein in tumor suppression.2015

    • Author(s)
      Hayashi N. and Takahashi C.
    • Journal Title

      Archives in Cancer Res

      Volume: epub

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] RECK-mediated β1-integrin regulation by TGF-β1 is critical for wound contraction in mice.2015

    • Author(s)
      Gutierrez J, Droppelmann CA, Contreras O, Takahashi C and Brandan E.
    • Journal Title

      PLoS One

      Volume: Aug 6 Issue: 8 Pages: e0135005-e0135005

    • DOI

      10.1371/journal.pone.0135005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Retinoblastoma Protein and MyoD Function Together to Effect the Repression of Fra-1 and In Turn Cyclin D1 During Terminal Cell Cycle Arrest Associated with Myogenesis.2014

    • Author(s)
      Rajabi H M, Takahashi C and Ewen M E.
    • Journal Title

      J Biol Chem

      Volume: 289 Issue: 34 Pages: 23417-23427

    • DOI

      10.1074/jbc.m113.532572

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Association of a murine leukaemia stem cell gene signature based on nucleostemin promoter activity with prognosis of acute myeloid leukaemia in patients.2014

    • Author(s)
      Ali MA, Naka K, Yoshida A, Fuse K, Kasada A, Hoshii T, Tadokoro Y, Ueno M, Ohta K, Kobayashi M, Takahashi C, Hirao A.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 450 Issue: 1 Pages: 837-843

    • DOI

      10.1016/j.bbrc.2014.06.066

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Regulation of metabolism by RB tumor suppressor gene2017

    • Author(s)
      Takahashi C.
    • Organizer
      AACR Annual Meeting 2017
    • Place of Presentation
      Washington/USA
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] RB function in controlling glycolysis.2016

    • Author(s)
      Kohno S, Kitajima S and Takahashi C.
    • Organizer
      Keystone Symposia
    • Place of Presentation
      Banff, Canada/Fairmont Banff Springs
    • Year and Date
      2016-02-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cooperative roles of Rb and SREBP-1 in controlling fatty acid metabolism and carcinogenesis.2016

    • Author(s)
      Muranaka H, Tada H, Hayashi A, Minami K, Kitajima S, Tange S, Suzuki T, Matsuzaka T, Shimano H and Takahashi C
    • Organizer
      Keystone Symposia
    • Place of Presentation
      Banff, Canada/Fairmont Banff Springs
    • Year and Date
      2016-02-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Metabolic regulation by RB tumor suppressor gene.2016

    • Author(s)
      Takahashi C.
    • Organizer
      2016 International Symposium of Cancer Center of Excellence-Innovative Research in Cancer Prevention and Treatment
    • Place of Presentation
      CHANG YUNG-FA FOUNDATION International Convention Center/台北
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Metabolic regulation by RB tumor suppressor gene.2016

    • Author(s)
      Takahashi C.
    • Organizer
      日仏交流セミナー「癌・疾病における細胞・個体老化」
    • Place of Presentation
      京都/コープイン京都
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] RBがん抑制遺伝子による代謝制御2016

    • Author(s)
      髙橋智聡
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜/パシフィコ横浜
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] CONTROL OF GLUCOSE METABOLISM BY RB.2016

    • Author(s)
      Kohno S, Takahashi C
    • Organizer
      Translational research in cancer cell metabolism
    • Place of Presentation
      Palacio Euskalduna Jauregia /ビルバオ スペイン
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phosphoglyceratemutases (PGAMs) mediate RB function to control differentiation.2016

    • Author(s)
      Kohno S and Takahashi C.
    • Organizer
      Fourth International Rb Meeting
    • Place of Presentation
      Hilton Columbus Downtown /コロンバス オハイオ州
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Metabolic Bases for Inflammatory Phenotype Associated with RB-deficiency in Mammary Cells.2016

    • Author(s)
      Nishimoto Y, Kitajima S and Takahashi C
    • Organizer
      Fourth International Rb Meeting
    • Place of Presentation
      Hilton Columbus Downtown /コロンバス オハイオ州
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] RBがん抑制遺伝子による代謝制御と細胞未分化性2016

    • Author(s)
      髙橋智聡, 北嶋俊輔, 河野晋
    • Organizer
      第68回日本細胞生物学会大会
    • Place of Presentation
      京都/京都テルサ
    • Related Report
      2016 Annual Research Report
  • [Presentation] Metabolic rewiring in Rb deficient cells during cancer progression.2016

    • Author(s)
      Kohno S, Okahashi N, Kitajima S Suzuki S, Tanaka T, Matsuda F, Shimizu H and Takahashi C.
    • Organizer
      AACR Annual Meeting 2016
    • Place of Presentation
      New Orleans USA/Ernest N. Morial Convention Center
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] RBがん抑制遺伝子による代謝制御2015

    • Author(s)
      髙橋智聡
    • Organizer
      第46回高松宮妃癌研究基金国際シンポジウム
    • Place of Presentation
      東京 パレスホテル東京
    • Year and Date
      2015-11-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cooperative roles of Rb and SREBP-1 in controlling fatty acid metabolism and carcinogenesis.2015

    • Author(s)
      Muranaka H, Tada H, Hayashi A, Minami K, Kitajima S, Tange S, Suzuki T, Matsuzaka T, Shimano H, Takahashi C.
    • Organizer
      Cancer and Metabolism conference
    • Place of Presentation
      英国 Cambridge/Robinson College
    • Year and Date
      2015-09-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] RB1不活性化シグナチャー解析による新規分子標的探索2015

    • Author(s)
      髙橋智聡
    • Organizer
      第19回日本がん分子標的治療学会学術集会
    • Place of Presentation
      松山 松山全日空ホテル
    • Year and Date
      2015-06-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Metabolic functions of RB tumor suppressor in controlling undifferentiated state.2015

    • Author(s)
      Takahashi C
    • Organizer
      2015 the Catholic Univ. of Korea Seoul St Mary’s Hospital Comprehensive Cancer Institute International Symposium
    • Place of Presentation
      韓国 ソウル  St Mary’s Hospital
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] がん代謝とがん幹細胞-RBがん抑制遺伝子研究から2015

    • Author(s)
      髙橋智聡
    • Organizer
      第28回原研研究集会
    • Place of Presentation
      長崎県・長崎市・長崎大学
    • Year and Date
      2015-03-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The metabolic function of RB in controlling mevalonate (MVA) pathway regulates tumor progression2015

    • Author(s)
      Sasaki N, Kitajima S, Muranaka H, Shamma A, Kohno S, Takahashi C
    • Organizer
      Keystone Symposia
    • Place of Presentation
      Vancouver・Canada・Fairmont Hotel
    • Year and Date
      2015-01-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] RBによるメバロン酸経路を介したがん悪性進展制御機構.2014

    • Author(s)
      佐々木信成, 村中勇人, 北嶋俊輔, 河野晋, Shamma A, 髙橋智聡
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      神奈川県・横浜市・パシフィコ横浜
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] がん抑制遺伝子RBによるSREBP-1の制御とがんにおける役割の解析2014

    • Author(s)
      村中勇人, 北嶋俊輔, 佐々木信成, 河野晋, 吉田晶代, 丹下正一朗, 鈴木健之, 林昭夫, 多田秀昭, Shamma A, 髙橋智聡
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      神奈川県・横浜市・パシフィコ横浜
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] In vitro乳腺発がんモデルにおけるがん抑制遺伝子Rb, p53の機能とその作用機構の解析2014

    • Author(s)
      西本裕希, Mohammed M, 吉田晶代, 西内巧, 北嶋俊輔, 髙橋智聡
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      神奈川県・横浜市・パシフィコ横浜
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] RBがん抑制遺伝子の代謝制御機構2014

    • Author(s)
      髙橋智聡
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      神奈川県・横浜市・パシフィコ横浜
    • Year and Date
      2014-11-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] マウスにおいてRb1はmiR-140を介して腫瘍抑制的に作用する2014

    • Author(s)
      吉田晶代, 北嶋俊輔, 林直之, 広瀬修, 髙橋智聡.マウスにおいてRb1はmiR-140を介して腫瘍抑制的に作用する
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      神奈川県・横浜市・パシフィコ横浜
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] がん幹細胞と代謝- RBがん抑制遺伝子研究からのアプローチ2014

    • Author(s)
      高橋智聡
    • Organizer
      第13回 福井臨床薬理を考える会
    • Place of Presentation
      福井県・福井市・ユアーズホテル
    • Year and Date
      2014-11-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] がん代謝と細胞老化制御におけるRB機能2014

    • Author(s)
      髙橋智聡
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      神奈川県・横浜市・パシフィコ横浜
    • Year and Date
      2014-09-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The metabolic function of RB in controlling mevalonate (MVA) pathway and tumor progression.2014

    • Author(s)
      Sasaki N, Muranaka H, Kitajima S, Kohno S, Shamma A and Takahashi C
    • Organizer
      第37回日本癌学会学術総会
    • Place of Presentation
      神奈川県・横浜市・パシフィコ横浜
    • Year and Date
      2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Rbによるサイトカインを介したがん悪性化制御機構の解明2014

    • Author(s)
      北嶋俊輔, 吉田晶代, 河野晋, 鈴木佐和子, 田中知明, 後藤典子, 髙橋智聡
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      神奈川県・横浜市・パシフィコ横浜
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] RBの中心代謝制御機能2014

    • Author(s)
      河野晋, 北嶋俊輔, 吉田晶代, 鈴木佐和子, 田中知明, 佐々木信成, 村中勇人, 髙橋智聡
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      神奈川県・横浜市・パシフィコ横浜
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] RB functions in rewiring metabolic pathways in cancer cells2014

    • Author(s)
      Chiaki Takahashi
    • Organizer
      熊本大学HIGOプログラム最先端研究セミナー
    • Place of Presentation
      熊本県・熊本市・熊本大学発生研
    • Year and Date
      2014-07-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] マウス由来腫瘍細胞のRb1 不活性化シグニチャーとヒト乳癌の臨床像との関連2014

    • Author(s)
      吉田晶代, 北嶋俊輔, 廣瀬修, 田中知明, 髙橋智聡
    • Organizer
      第12回日本臨床腫瘍学会学術集会
    • Place of Presentation
      福岡県・福岡市・福岡国際会議場
    • Year and Date
      2014-07-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] RB不活性化によって誘導されるがん幹細胞様未分化状態におけるPgam2の役割2014

    • Author(s)
      河野晋, 北嶋俊輔, 佐々木信成, 村中勇人, 鈴木佐和子, 田中知明, 岡橋伸幸, 松田史生, 清水浩, 髙橋智聡
    • Organizer
      第2回がんと代謝研究会
    • Place of Presentation
      東京都・葛飾区・東京理科大学
    • Year and Date
      2014-07-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Reductive glutamine metabolism in p53-null soft tissue sarcoma cells.2014

    • Author(s)
      Okahashi N, Matsuda F, Kohno S, Takahashi C and Shimizu H.
    • Organizer
      Metabolomics 2014.
    • Place of Presentation
      山形県・鶴岡市・慶応大学鶴岡キャンパス
    • Year and Date
      2014-06-05
    • Related Report
      2014 Annual Research Report
  • [Book] 『代謝変化とエピジェテックス制御』「RBがん抑制遺伝子産物による細胞未分化性制御」2016

    • Author(s)
      河野晋、北嶋俊輔、佐々木信成、髙橋智聡.
    • Total Pages
      7
    • Publisher
      生化学
    • Related Report
      2016 Annual Research Report
  • [Book] 生体の科学 がん細胞の中の多様性・多層性2016

    • Author(s)
      西本裕希、高橋智聡
    • Publisher
      医学書院
    • Related Report
      2015 Annual Research Report
  • [Book] マウス甲状腺C細胞および線維芽細胞は高度な未分化性を獲得する. BioMedサーカス.com 最新研究情報「執筆者自身による研究論文レビュー 第35回」2015

    • Author(s)
      北嶋俊輔, 河野晋, 髙橋智聡
    • Publisher
      BioMedサーカス.com
    • Related Report
      2015 Annual Research Report
  • [Book] 家族性腫瘍学 ― 家族性腫瘍の最新研究動向 ― II. 各論 原因遺伝子 RB1. 日本臨牀2015

    • Author(s)
      髙橋智聡
    • Publisher
      日本臨牀
    • Related Report
      2015 Annual Research Report
  • [Book] ニッチ細胞の遺伝子変異が発がんを誘導する?骨芽細胞の場合2014

    • Author(s)
      高橋 智聡
    • Total Pages
      2
    • Publisher
      羊土社
    • Related Report
      2014 Annual Research Report
  • [Remarks] 髙橋智聡研究室HP

    • URL

      http://omb.w3.kanazawa-u.ac.jp/index.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 金沢大学がん進展制御研究所HP

    • URL

      http://ganken.cri.kanazawa-u.ac.jp

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
  • [Remarks] 高橋智聡研究室HP

    • URL

      http://omb.w3.kanazawa-u.ac.jp

    • Related Report
      2015 Annual Research Report
  • [Remarks] Tha Takahashi Lab

    • URL

      http://omb.w3.kanazawa-u.ac.jp

    • Related Report
      2014 Annual Research Report
  • [Remarks] 金沢大学がん進展制御研究所

    • URL

      http://www.kanazawa-u.ac.jp/~ganken/

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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