| Project/Area Number |
26290039
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
渡部 昌実 岡山大学, 大学病院, 教授 (70444677)
村田 等 岡山大学, 医歯(薬)学総合研究科, 講師 (90579096)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Keywords | 炎症 / がん / 転移 / S100A8/A9 / S100A8/A9受容体 / 癌 / 細胞 / シグナル伝達 |
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| Outline of Final Research Achievements |
We succeeded to uncover that the functional receptors for S100A8/A9 were not restricted to RAGE and TLR4. Our advanced study showed that EMMPRIN also played a pivotal role in cancer metastasis in response to S100A8/A9. This discovery further spurred us to identify the unknown receptors, resulting in novel findings, NPTNa;, NPTNb;, MCAM and ALCAM receptors, we then named the collection of receptors “S100 Soil Sensor Receptors, shortly termed SSSRs” in our context of studies. We figured out that these novel receptors, especially EMMPRIN, NPTNb;, MCAM were cooperatively acting with each other at specific stages such as epithelial-methenchymal trandition (EMT), floating, adhesion, and invasion, and in the elaborate cancer metastatic processes. Our ongoing studies will help us to achieve better understanding of cancer behaviors and also the establishment of an innovative method for the prevention of cancer metastasis.
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