Reversion of the exhausted immunity by metformin
| Project/Area Number |
26290056
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor therapeutics
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| Research Institution | Okayama University |
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Principal Investigator |
Udono Heiichiro 岡山大学, 医歯(薬)学総合研究科, 教授 (50260659)
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| Co-Investigator(Kenkyū-buntansha) |
榮川 伸吾 岡山大学, 医歯(薬)学総合研究科, 助教 (40635265)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Keywords | 免疫疲弊 / CD8 T細胞 / アポトーシス / メトホルミン / 解糖系 / 酸化的リン酸化 / CD8T細胞 / 記憶T細胞 / エフェクター・メモリー / サイトカイン / AMPK / 腫瘍微小環境 |
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| Outline of Final Research Achievements |
Long term uptake of anti-diabetes drug, metformin, has been shown to reduce cancer incidence and mortality. However, the underlying mechanism of this effect is not yet understood. Immune system against cancers, particularly, CD8T cells (killer cells) undergoes exhaustion in tumors, which allows for tumor growth. We found that metformin reactivates exhausted CD8T cells in tumors to fight against cancer cells through elevation of their glycolysis, leading to the retardation of tumor growth.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Mapping the Interactome of a Major Mammalian Endoplasmic Reticulum Heat Shock Protein 90.2017
Author(s)
Hong F, Mohammad Rachidi S, Lundgren D, Han D, Huang X, Zhao H, Kimura Y, Hirano H, Ohara O, Udono H, Meng S, Liu B, Li Z.
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Journal Title
PLoS One
Volume: 12(1)
Issue: 1
Pages: e0169260-e0169260
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Study about the Efficacy of Metformin to Immune Function in Cancer Patients.2016
Author(s)
Watanabe M, Yamamoto H, Eikawa S, Shien K, Shien T, Soh J, Hotta K, Wada J, Hinotsu S, Fujiwara T, Kiura K, Doihara H, Miyoshi S, Udono H, Toyooka S.
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Journal Title
Acta Med Okayama
Volume: 70(4)
Pages: 327-330
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The induction of antigen-specific CTL by in situ Ad-REIC gene therapy.2016
Author(s)
Ariyoshi Y, Watanabe M, Eikawa S, Yamazaki C, Sadahira T, Hirata T, Araki M, Ebara S, Nasu Y, Udono H, Kumon H.
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Journal Title
Gene Ther.
Volume: gt.2016.7
Issue: 5
Pages: 408-414
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Phase Ia Study of FoxP3+ CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody, KW-0761, in Cancer Patients.2015
Author(s)
2.Kurose K, Ohue Y, Wada H, Iida S, Ishida T, Kojima T, Doi T, Suzuki S, Isobe M, Funakoshi T, Kakimi K, Nishikawa H, Udono H, Oka M, Ueda R, Nakayama E.
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Journal Title
Clin Cancer Res.
Volume: 21
Issue: 19
Pages: 4327-36
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Detection and Tracking of NY-ESO-1-Specific CD8+ T Cells by High-Throughput T Cell Receptor β (TCRB) Gene Rearrangements Sequencing in a Peptide-Vaccinated Patient.2015
Author(s)
Miyai M, Eikawa S, Hosoi A, Iino T, Matsushita H, Isobe M, Uenaka A, Udono H, Nakajima J, Nakayama E, Kakimi K.
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Journal Title
PLoS One
Volume: 10(8)
Issue: 8
Pages: e0136086-e0136086
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] HSP90α plays an important role in piRNA biogenesis and retrotransposon repression in mouse2014
Author(s)
Ichiyanagi, T., Ichiyanagi, K., Ogawa, A., Kuramochi-Miyagawa, S., Nakano, T., Chuma, S., Sasaki, H.
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Journal Title
Nucleic Acids Res
Volume: 42
Issue: 19
Pages: 11903-11
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 変貌するがん免疫治療2016
Author(s)
鵜殿平一郎
Organizer
熊本呼吸器フォーラム分科会
Place of Presentation
ホテルニューオータニ熊本（熊本）
Year and Date
2016-02-18
Related Report
Invited
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