Development of tissue regeneration technology of respiratory system
| Project/Area Number |
26290068
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical genome science
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
Kurisaki Akira 国立研究開発法人産業技術総合研究所, 創薬基盤研究部門, 上級主任研究員 (60346616)
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| Co-Investigator(Kenkyū-buntansha) |
高田 仁実 国立研究開発法人産業技術総合研究所, 創薬基盤研究部門, 研究員 (80641068)
石嶺 久子 国立研究開発法人産業技術総合研究所, 幹細胞工学研究センター, 研究員 (90736737)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 幹細胞 / 分化 / 細胞 / 遺伝子 / 転写因子 / 肺 / 再生 / タンパク / 疾患 / 移植・再生医療 / 再生医学 / 発生・分化 / 蛋白質 |
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| Outline of Final Research Achievements |
Stem cell differentiation technologies using pluripotent stem cells, especially iPS cells, are currently applied for the understanding of intractable diseases, drug discovery, and development of regenerative medicine. In this research, we are developing a novel differentiation method that generates lung progenitor cells in vitro. We have screened novel genes selectively expressed in the developing lung and found several factors that can induce lung progenitor cells. When these generated progenitor-like cells were cultured in a differentiation medium, several lung tissue cell markers were induced in vitro.
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| Academic Significance and Societal Importance of the Research Achievements |
肺気腫や慢性気管支炎などの慢性閉塞性肺疾患は、咳や喀痰、息切れなどで慢性呼吸不全を伴う難病である。本疾患には気管支拡張剤や去痰剤の対症療法が施されているが、現在のところ効果的な治療法は存在しない。本研究では肺組織のもととなる肺前駆細胞の新たな作製方法を開発しており、このような難病の新たな治療技術の開発に貢献することが期待される。
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] A role for KLF4 in promoting the metabolic shift via TCL1 during induced pluripotent stem cell generation.2017
Author(s)
Nishimura K, Aizawa S, Nugroho FL, Shiomitsu E, Tran YTH, Bui PL, Borisova E, Sakuragi Y, Takada H, Kurisaki A, Hayashi Y, Fukuda A, Nakanishi M, Hisatake K
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Journal Title
Stem Cell Reports
Volume: 8
Issue: 3
Pages: 787-801
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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