• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of tissue regeneration technology of respiratory system

Research Project

Project/Area Number 26290068
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Medical genome science
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

Kurisaki Akira  国立研究開発法人産業技術総合研究所, 創薬基盤研究部門, 上級主任研究員 (60346616)

Co-Investigator(Kenkyū-buntansha) 高田 仁実  国立研究開発法人産業技術総合研究所, 創薬基盤研究部門, 研究員 (80641068)
石嶺 久子  国立研究開発法人産業技術総合研究所, 幹細胞工学研究センター, 研究員 (90736737)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords幹細胞 / 分化 / 細胞 / 遺伝子 / 転写因子 / 肺 / 再生 / タンパク / 疾患 / 移植・再生医療 / 再生医学 / 発生・分化 / 蛋白質
Outline of Final Research Achievements

Stem cell differentiation technologies using pluripotent stem cells, especially iPS cells, are currently applied for the understanding of intractable diseases, drug discovery, and development of regenerative medicine. In this research, we are developing a novel differentiation method that generates lung progenitor cells in vitro. We have screened novel genes selectively expressed in the developing lung and found several factors that can induce lung progenitor cells. When these generated progenitor-like cells were cultured in a differentiation medium, several lung tissue cell markers were induced in vitro.

Academic Significance and Societal Importance of the Research Achievements

肺気腫や慢性気管支炎などの慢性閉塞性肺疾患は、咳や喀痰、息切れなどで慢性呼吸不全を伴う難病である。本疾患には気管支拡張剤や去痰剤の対症療法が施されているが、現在のところ効果的な治療法は存在しない。本研究では肺組織のもととなる肺前駆細胞の新たな作製方法を開発しており、このような難病の新たな治療技術の開発に貢献することが期待される。

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (6 results)

All 2017 2016 2014

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Formation of Stomach Tissue by Organoid Culture Using Mouse Embryonic Stem Cells.2017

    • Author(s)
      Noguchi TK, Kurisaki A.
    • Journal Title

      Methods Mol Biol.

      Volume: 1597 Pages: 217-228

    • DOI

      10.1007/978-1-4939-6949-4_16

    • ISBN
      9781493969470, 9781493969494
    • Related Report
      2016 Annual Research Report
  • [Journal Article] A role for KLF4 in promoting the metabolic shift via TCL1 during induced pluripotent stem cell generation.2017

    • Author(s)
      Nishimura K, Aizawa S, Nugroho FL, Shiomitsu E, Tran YTH, Bui PL, Borisova E, Sakuragi Y, Takada H, Kurisaki A, Hayashi Y, Fukuda A, Nakanishi M, Hisatake K
    • Journal Title

      Stem Cell Reports

      Volume: 8 Issue: 3 Pages: 787-801

    • DOI

      10.1016/j.stemcr.2017.01.026

    • NAID

      120007129229

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] ヒト肺前駆細胞の新たな作製方法2017

    • Author(s)
      横須賀 俊喜、栗崎 晃
    • Organizer
      第16回 産総研・産技連LS-BT合同研究発表会
    • Place of Presentation
      茨城県つくば市(産業技術総合研究所つくばセンター共用講堂)
    • Year and Date
      2017-01-31
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヒトiPS細胞を用いた肺前駆細胞分化方法の検討2017

    • Author(s)
      林 信光、栗崎 晃
    • Organizer
      第16回 産総研・産技連LS-BT合同研究発表会
    • Place of Presentation
      茨城県つくば市(産業技術総合研究所つくばセンター共用講堂)
    • Year and Date
      2017-01-31
    • Related Report
      2016 Annual Research Report
  • [Presentation] 樹立方法の違いによるヒトiPS細胞の品質と分化への影響2016

    • Author(s)
      栗崎 晃、山川哲生、久保陽子、大高真奈美、中西真人
    • Organizer
      第89回 日本組織培養学会
    • Place of Presentation
      大阪府豊中市(千里ライフサイエンスセンター)
    • Year and Date
      2016-05-24
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 肺細胞作製方法2014

    • Inventor(s)
      二宮直登、浅島誠、栗崎晃
    • Industrial Property Rights Holder
      独立行政法人 産業技術総合研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-103934
    • Filing Date
      2014-05-20
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2023-03-23  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi