Regulation mechanisms for tissue-specific post-transcriptional pre-mRNA processing.
| Project/Area Number |
26291003
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Molecular biology
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
|
|---|
| Keywords | 遺伝子発現 / 新生RNA / 線虫 / 組織特異性 / 転写後プロセシング / mRNA / ChIP-seq / 代謝標識 / RNAseq / mRNA前駆体 |
|---|
| Outline of Final Research Achievements |
We revealed binding regions of LST-3 genome wide and mechanisms for splicing regulation by LST-3. We have analyzed tissue-specific alternative splicing patterns of the lev-11 gene, encoding tropomyosin, in C. elegans. We published a review article on alternative splicing regulation in C. elegans. We tried TU-tagging to label nascent RNAs in tissue-specific manners in living worms.
|
Report
(5 results)
Research Products
(31 results)
-
-
-
-
-
-
-
[Journal Article] RBFOX and SUP-12 sandwich a guanine base to form a stable complex and regulate tissue-specific splicing.2014
Author(s)
Kuwasako K, Takahashi M, Unzai S, Tsuda K, Yoshikawa S, He F, Kobayashi N, Guntert P, Shirouzu M, Ito T, Tanaka A, Yokoyama S, Hagiwara M, Kuroyanagi H, and Muto Y.
-
Journal Title
Nat. Struct. Mol. Biol.
Volume: 21(9)
Issue: 9
Pages: 778-86
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Book] 遺伝子発現制御機構2017
Author(s)
田村隆明、浦聖惠（編）
Total Pages
264
Publisher
東京化学同人
ISBN
9784807909179
Related Report
-
-
-
-
-
-
-
-
