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In vitro reconstitution of the initiation process of transcription-coupled nucleotide-excision repair

Research Project

Project/Area Number 26291005
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Molecular biology
Research InstitutionNagoya University (2015-2017)
Nagasaki University (2014)

Principal Investigator

OGI Tomoo  名古屋大学, 環境医学研究所, 教授 (80508317)

Co-Investigator(Kenkyū-buntansha) 真下 知士  大阪大学, 医学系研究科, 准教授 (80397554)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
KeywordsDNA修復 / 転写と共役したヌクレオチド除去修復 / DNA損傷 / 修復
Outline of Final Research Achievements

Transcription-coupled nucleotide-excision repair (TC-NER) is one of the versatile DNA repair process that removes major UV-induced DNA lesions from actively transcribed genes. To investigate the initiation process of TC-NER reaction, we focused on a molecular mechanism that involves DNA-damage induced ubiquitination of RNA polymerase IIo (RNA pol IIo). The process is dependent on a recently identified TC-NER factor, UVSSA.
To determine the ubiquitination sites, we performed in vitro ubiquitination assay as well as SILAC-based High-Resolution Accurate Mass (HRAM) spectrometry. From the studies, we identified UVSSA-dependent ubiquitination sites required for the efficient TC-NER activity.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (68 results)

All 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (4 results) Journal Article (13 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 13 results,  Open Access: 12 results,  Acknowledgement Compliant: 2 results) Presentation (50 results) (of which Int'l Joint Research: 9 results,  Invited: 27 results) Remarks (1 results)

  • [Int'l Joint Research] Sussex Univ. GDSC(英国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] LUMC(オランダ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Sussex Univ. GDSC(英国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] LUMC(オランダ)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Functional and clinical relevance of novel mutations in a large cohort of patients with Cockayne syndrome.2018

    • Author(s)
      Calmels N, Botta E, Jia N, Fawcett H, Nardo T, Nakazawa Y, Lanzafame M, Moriwaki S, Sugita K, Kubota M, Obringer C, Spitz MA, Stefanini M, Laugel V, Orioli D, Ogi T, Lehmann A.
    • Journal Title

      Journal of Medical Genetics

      Volume: 55 Issue: 5 Pages: 329-343

    • DOI

      10.1136/jmedgenet-2017-104877

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Common TFIIH recruitment mechanism in global genome and transcription-coupled repair subpathways.2017

    • Author(s)
      Okuda M, Nakazawa Y, Guo C, Ogi T, Nishimura Y.
    • Journal Title

      Nucleic Acids Research

      Volume: 45 Issue: 22 Pages: 13043-13055

    • DOI

      10.1093/nar/gkx970

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PCNA ubiquitylation ensures timely completion of unperturbed DNA replication in fission yeast.2017

    • Author(s)
      Daigaku Y, Etheridge TJ, Nakazawa Y, Nakayama M, Watson AT, Miyabe I, Ogi T, Osborne MA, Carr AM.
    • Journal Title

      PLoS Genetics

      Volume: 13 Issue: 5 Pages: e1006789-e1006789

    • DOI

      10.1371/journal.pgen.1006789

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An XPA gene splicing mutation resulting in trace protein expression in an elderly xeroderma pigmentosum group A patient without neurological abnormalities.2017

    • Author(s)
      Takahashi Y, Endo Y, Kusaka A, Nakamaura S, Nakazawa Y, Ogi T, Uryu M, Tsuji M, Furue M, Moriwaki S.
    • Journal Title

      British Journal of Dermatology

      Volume: 印刷中 Issue: 1 Pages: 253-257

    • DOI

      10.1111/bjd.15051

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Analysis of clinical symptoms and ABCC6 mutations in 76 Japanese patients with pseudoxanthoma elasticum.2017

    • Author(s)
      Iwanaga A, Okubo Y, Yozaki M, Koike Y, Kuwatsuka Y, Tomimura S, Yamamoto Y, Tamura H, Ikeda S, Maemura K, Tsuiki E, Kitaoka T, Endo Y, Mishima H, Yoshiura KI, Ogi T, Tanizaki H, Wataya-Kaneda M, Hattori T, Utani A.
    • Journal Title

      Journal of Dermatology

      Volume: 印刷中 Issue: 6 Pages: 644-650

    • DOI

      10.1111/1346-8138.13727

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A ten-year follow up of a child with mild case of xeroderma pigmentosum complementation group D diagnosed by whole genome sequencing.2016

    • Author(s)
      Ono R, Masaki T, Mayca Pozo F, Nakazawa Y, Swagemakers SM, Nakano E, Sakai W, Takeuchi S, Kanda F, Ogi T, van der Spek PJ, Sugasawa K, Nishigori C.
    • Journal Title

      Photodermatol Photoimmunol Photomed.

      Volume: 未定 Issue: 4 Pages: 174-180

    • DOI

      10.1111/phpp.12240

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage.2016

    • Author(s)
      Quek H, Luff J, Cheung K, Kozlov S, Gatei M, Lee CS, Bellingham MC, Noakes PG, Lim YC, Barnett NL, Dingwall S, Wolvetang E, Mashimo T, Roberts TL, Lavin MF.
    • Journal Title

      Journal of Leukocyte Biology

      Volume: - Issue: 4 Pages: 927-947

    • DOI

      10.1189/jlb.4vma0716-316r

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Generation of a new model rat: Nrf2 knockout rats are sensitive to aflatoxin B1 toxicity.2016

    • Author(s)
      Taguchi K, Takaku M, Egner PA, Morita M, Kaneko T, Mashimo T, Kensler TW, Yamamoto M.
    • Journal Title

      Toxicol Sci

      Volume: in press Issue: 1 Pages: 40-52

    • DOI

      10.1093/toxsci/kfw065

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency.2015

    • Author(s)
      Guo C, Nakazawa Y, Woodbine L, Bjorkman A, Shimada M, Fawcett H, Jia N, Ohyama K, Li TS,Nagayama Y, Mitsutake N, Pan-Hammarström Q, Gennery AR, Lehmann AR, Jeggo PA, Ogi T.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 136 (4) Issue: 4 Pages: 1007-1017

    • DOI

      10.1016/j.jaci.2015.06.007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] SETDB1, HP1 and SUV39 promote repositioning of 53BP1 to extend resection during homologous recombination in G2 cells2015

    • Author(s)
      Meryem Alagoz, Yoko Katsuki, Hideaki Ogiwara, Tomoo Ogi, Atsushi Shibata, Andreas Kakarougkas, and Penny Jeggo
    • Journal Title

      Nucleic Acids Research

      Volume: 43(16) Issue: 16 Pages: 7931-7944

    • DOI

      10.1093/nar/gkv722

    • NAID

      120006986903

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Novel compound heterozygous DNA ligase IV mutations in an adolescent with a slowly-progressing radiosensitive-severe combined immunodeficiency2015

    • Author(s)
      Tamura S, Higuchi K, Tamaki M, Inoue C, Awazawa R, Mitsuki N, Nakazawa Y, Mishima H, Takahashi K, Kondo O, Imai K, Morio T, Ohara O,et al
    • Journal Title

      Clin Immunol

      Volume: 160 Issue: 2 Pages: 255-260

    • DOI

      10.1016/j.clim.2015.07.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A rapid, comprehensive system for assaying DNA repair activity and cytotoxic effects of DNA-damaging reagents.2015

    • Author(s)
      Nan Jia, Yuka Nakazawa, Chaowan Guo, Mayuko Shimada, Mieran Sethi, Yoshito Takahashi, Hiroshi Ueda, Yuji Nagayama, Tomoo Ogi
    • Journal Title

      Nature Protocols

      Volume: 10 Issue: 1 Pages: 12-24

    • DOI

      10.1038/nprot.2014.194

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hypomorphic PCNA mutation underlies a human DNA repair disorder.2014

    • Author(s)
      Baple EL, Chambers H, Cross HE, Fawcett H, Nakazawa Y, Chioza BA, Harlalka GV, Mansour S, Sreekantan-Nair A, Patton MA, Muggenthaler M, Rich P, Wagner K, Coblentz R, Stein CK, Last JI, Taylor AM, Jackson AP, Ogi T, Lehmann AR, Green CM, Crosby AH.
    • Journal Title

      Journal of Clinical Investigation

      Volume: 124 Issue: 7 Pages: 3137-3146

    • DOI

      10.1172/jci74593

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] Very mild Japanese Cockayne syndrome (type-IV) cases with a N-terminal truncation mutation in the ERCC6 / CSB gene.2018

    • Author(s)
      Ogi T
    • Organizer
      国際シンポジウム「早老症と関連疾患」
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Human genetic disorders associated with deficiencies in the DNA repair system.2017

    • Author(s)
      Ogi T.
    • Organizer
      International Symposium on Immune Diversity and Cancer Therapy Kobe 2017
    • Place of Presentation
      神戸ポートピアホテル(兵庫県神戸市)
    • Year and Date
      2017-01-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Human genetic disorders associated with TC-NER deficiency.2017

    • Author(s)
      Ogi T.
    • Organizer
      第2回神戸大学バイオシグナル総合研究センター国際シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Very mild CS type-IV cases with mutation in the CSB gene.2017

    • Author(s)
      Ogi T.
    • Organizer
      Cockayne Syndrome Meeting.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Human genetics disorders associated with DNA repair deficiency.2017

    • Author(s)
      Ogi T.
    • Organizer
      6th US-Japan DNA Repair Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] DNA損傷依存的なRNAポリメラーゼの修飾とヒト疾患.2017

    • Author(s)
      荻 朋男
    • Organizer
      国立遺伝学研究所・研究集会「染色体構築と安定化を担う分子機構」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Molecular pathogenesis underlying Cockayne syndrome and UV-sensitive syndrome.2017

    • Author(s)
      Jia N, Guo C, Oka Y, Nakazawa Y, Shimada M, Miyazaki H, Ogi T.
    • Organizer
      第40回日本分子生物学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Very mild CS type-IV cases with mutations in the CSB gene.2017

    • Author(s)
      Jia N, Guo C, Oka Y, Nakazawa Y, Shimada M, Miyazaki H, Ogi T.
    • Organizer
      第24回DNA複製・組換え・修復ワークショップ
    • Related Report
      2017 Annual Research Report
  • [Presentation] ゲノム不安定性を示す遺伝性疾患群の疾患責任遺伝子変異の探索.2017

    • Author(s)
      中沢由華、千住千佳子、岡泰由、嶋田繭子、宮崎仁美、郭朝万、賈楠、荻朋男.
    • Organizer
      第40回日本分子生物学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Identification of pathogenic mutations in patients with rare diseases using multi-omics analysis.2017

    • Author(s)
      Oka Y, Nakazawa Y, Ogi T.
    • Organizer
      日本プロテオーム学会2017年大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] DNA修復機構の異常と疾患.2017

    • Author(s)
      荻 朋男
    • Organizer
      太陽紫外線防御研究委員会第27回シンポジウム
    • Place of Presentation
      佐治敬三メモリアルホール(大阪府大阪市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] DNA修復・損傷応答機構の異常により発症する疾患の病態解明.2017

    • Author(s)
      荻朋男
    • Organizer
      奈良先端科学技術大学院大学ワークショップ
    • Place of Presentation
      奈良先端科学技術大学院大学(奈良県生駒市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] DNA修復システムの異常により発症するヒト疾患の分子病態.2016

    • Author(s)
      荻朋男
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ゲノム不安定性を示す遺伝性疾患群の病態解析と新規疾患責任遺伝子変異探索.2016

    • Author(s)
      中沢由華、岡泰由、郭朝万、賈楠、唐田清伸、嶋田繭子、宮﨑仁美、千住千佳子、荻朋男.
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] コケイン症候群と紫外線高感受性症候群の分子病態解析.2016

    • Author(s)
      賈楠、中沢由華、郭朝万、唐田清伸、岡泰由、嶋田繭子、宮﨑仁美、千住千佳子、荻朋男.
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] トランスオミクス解析を用いた希少遺伝性疾患原因因子の新規同定法の開発.2016

    • Author(s)
      岡泰由、郭 朝万、賈楠、唐田清伸、中沢由華、荻朋男.
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] ゲノム不安定性により先天性小頭症を示すヒト遺伝性疾患の症例解析と病態解明研究2016

    • Author(s)
      荻朋男
    • Organizer
      日本遺伝学会第88回大会
    • Place of Presentation
      日本大学国際関係学部(静岡県三島市)
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] DNA損傷応答と遺伝病疾患2016

    • Author(s)
      荻朋男
    • Organizer
      平成28年度若手放射線生物学研究会専門研究会
    • Place of Presentation
      東京工業大学(東京都目黒区)
    • Year and Date
      2016-09-03
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 次世代ゲノム解析と精密質量分析を基盤としたマルチオミクスデータの臨床診断へ応用2016

    • Author(s)
      荻朋男
    • Organizer
      サーモフィッシャーサイエンティフィック 質量分析フォーラム2016
    • Place of Presentation
      ザ・リッツ・カールトン大阪(大阪府大阪市), 東京コンファレンスセンター・品川(東京都港区)
    • Year and Date
      2016-08-02
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] New DNA-repair gene mutations associated with Cokayne syndrome like progeroid disorders.2016

    • Author(s)
      Ogi T
    • Organizer
      2016 Spring International Conference of the Korean Society for Gerontology The 15th Korea-Japan Gerontologist Joint Meeting,
    • Place of Presentation
      Daegu(韓国)
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ハイコンテントイメージングシステムを利用した難治性遺伝性疾患の臨床診断2016

    • Author(s)
      荻朋男
    • Organizer
      サーモフィッシャーサイエンティフィック バイオサイエンス事業本部2016HCAユーザーミーティング
    • Place of Presentation
      サーモフィッシャーサイエンティフィック株式会社三田オフィス(東京都港区)、サーモフィッシャーサイエンティフィック株式会社大阪営業所(大阪府大阪市)
    • Year and Date
      2016-05-26
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Genetics disorders associated with defects in transcription coupled nucleotide excision repair.2016

    • Author(s)
      Ogi T.
    • Organizer
      10th Quinquennial Conference on Responses to DNA damage: from molecule to disease
    • Place of Presentation
      Egmond aan Zee(オランダ)
    • Year and Date
      2016-04-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 「紫外線から遺伝子を守る」紫外線DNA損傷を修復する分子メカニズムとその破綻により発症する疾患の病態解明2016

    • Author(s)
      荻 朋男
    • Organizer
      太陽紫外線防御研究委員会第26回シンポジウム
    • Place of Presentation
      グランフロント大阪(大阪府大阪市)
    • Year and Date
      2016-03-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] TC-NER因子UVSSAによるRNAポリメラーゼIIのユビキチン化に関する分子機能解析.2016

    • Author(s)
      郭朝万、中沢由華、嶋田繭子、唐田清伸、賈楠、岡泰由、宮﨑仁美、千住千佳子、荻朋男.
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] DNA修復システムの異常とゲノムDNAの不安定化により発症する疾患の分子病態2016

    • Author(s)
      荻朋男
    • Organizer
      第42回北里医学学会総会
    • Place of Presentation
      小田急ホテルセンチュリー相模大野(神奈川県相模原市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Human genetic disorders associated with deficiencies in the DNA repair system.2016

    • Author(s)
      Ogi T
    • Organizer
      上海交通大学医学院附属上海新華医院セミナー
    • Place of Presentation
      Shanghai(中国)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] DNA修復の異常により発症するゲノム不安定性疾患の分子病態解明研究2016

    • Author(s)
      荻朋男
    • Organizer
      東北大学学際科学フロンティア研究所 第1回ワークショップ「多様な核酸サイエンス」
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 次世代マルチオミクス解析を用いた希少性難治性遺伝性疾患原因因子の新規同定法の開発2016

    • Author(s)
      荻朋男
    • Organizer
      第29回バイオメディカル分析化学シンポジウム ランチョンセミナー
    • Place of Presentation
      京都大学(京都府京都市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Human genetic disorders associated with deficiencies in the DNA repair system.2016

    • Author(s)
      荻朋男
    • Organizer
      京都大学放射線生物研究センター第32回国際シンポジウム” Growing Edge of Radiation Biology, from principles to applications”
    • Place of Presentation
      ホテルコープイン京都(京都府京都市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] コケイン症候群のゲノム診断2016

    • Author(s)
      荻朋男
    • Organizer
      日本コケイン症候群ネットワーク勉強会
    • Place of Presentation
      東京ビジネスアットセンター東京駅(東京都千代田区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ゲノム不安定性を示す難治性遺伝性疾患群の症例収集とゲノム・分子機能解析による病態解明研究2015

    • Author(s)
      中沢 由華、荻 朋男、唐田 清伸、郭 朝万、岡 泰由、 賈 楠、嶋田 繭子、宮崎 仁美、千住 千佳子
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency2015

    • Author(s)
      郭 朝万、中沢 由華、嶋田 繭子、賈 楠、唐田 清伸、 岡 泰由、宮崎 仁美、千住 千佳子、荻 朋男
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 各種コケイン症候群の分子診断2015

    • Author(s)
      賈 楠、中沢 由華、荻 朋男、唐田 清伸、郭 朝万、岡 泰由、 嶋田 繭子、 宮崎 仁美、 千住 千佳子
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] XRCC4deficiencyinhumansubjectscausesamarkedneurologicalphenotypebut no overt immunodeficiency2015

    • Author(s)
      郭 朝万、中沢 由華、嶋田 繭子、賈 楠、唐田 清伸、岡 泰由、宮崎 仁美、千住 千佳子、荻 朋男
    • Organizer
      第23回DNA複製・組換え・修復ワークショップ
    • Place of Presentation
      焼津グランドホテル(静岡県焼津市)
    • Year and Date
      2015-10-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] ゲノム不安定性を示す難治性遺伝性疾患群の症例収集とゲノム・分子機能解析による病態解明研究2015

    • Author(s)
      中沢 由華、荻 朋男、郭 朝万、唐田 清伸、岡 泰由、賈 楠、嶋田 繭子、宮崎 仁美、千住 千佳子
    • Organizer
      第23回DNA複製・組換え・修復ワークショップ
    • Place of Presentation
      焼津グランドホテル(静岡県焼津市)
    • Year and Date
      2015-10-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 転写の異常により発症する疾患の診断法と分子病態2015

    • Author(s)
      荻 朋男
    • Organizer
      第67回日本皮膚科学会西部支部学術大会
    • Place of Presentation
      長崎ブリックホール(長崎県長崎市)
    • Year and Date
      2015-10-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ヒトXRCC4遺伝子機能の欠損は神経変性と強い放射線感受性を示すが正常な免疫機能を保持する2015

    • Author(s)
      荻 朋男
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ゲノム不安定性疾患の症例収集と新規DNA修復遺伝子の同定2015

    • Author(s)
      荻 朋男
    • Organizer
      遺伝研研究集会
    • Place of Presentation
      国立遺伝学研究所(静岡県三島市)
    • Year and Date
      2015-10-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 放射線感受性および各種発達異常を示す遺伝性疾患の新規責任遺伝子の同定と分子機能解析2014

    • Author(s)
      中沢由華、郭朝万、嶋田繭子、宮崎仁美、唐田清伸、荻朋男
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Molecular and functional study on the initiation of transcription coupled nucleo tide excision repair2014

    • Author(s)
      Guo C, Nakazawa Y, Shimada M, Jia N, Karata K, Miyazaki H, Ogi T.
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 転写と共役したヌクレオチド除去修復のin vitro反応系の構築2014

    • Author(s)
      唐田清伸、郭朝万、荻朋男
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] コケイン症候群様の臨床症状を示す遺伝性疾患の責任遺伝子探索2014

    • Author(s)
      宮崎仁美、中沢由華、郭朝万、嶋田繭子、賈楠、唐田清伸、荻朋男
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] エキソーム解析を用いたDNA修復機構欠損性疾患の新規責任遺伝子の探索2014

    • Author(s)
      嶋田繭子、中沢由華、郭朝万、賈楠、宮崎仁美、唐田清伸、荻朋男
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Molecular cloning and characterisation of new human DNA repair genes2014

    • Author(s)
      Ogi T
    • Organizer
      The 9th 3R Symposium
    • Place of Presentation
      御殿場高原ホテル(静岡県御殿場市)
    • Year and Date
      2014-11-17 – 2014-11-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Molecular characterization and functional analysis of XRCC4, a novel pathological gene for radiation sensitivity and developmental abnormalities2014

    • Author(s)
      Guo C, Nakazawa Y, Shimada M, Woodbine L, Jia N, Karata K, Miyazaki H, Lehmann A, Jeggo PA, Ogi T.
    • Organizer
      The 9th 3R Symposium
    • Place of Presentation
      御殿場高原ホテル(静岡県御殿場市)
    • Year and Date
      2014-11-17 – 2014-11-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] ERCC1/XPF deficiency causes three NER- deficient disorders: a patient with various symptoms of xeroderma pigmentosum, Cockayne syndrome & Fanconi anemia.2014

    • Author(s)
      Nakazawa Y, Kashiyama K, Pilz DT, Guo C, Shimada M, Sasaki K, Fawcett H, Wing JF, Lewin SO, Carr L, Li TS, Yoshiura K, Utani A, Hirano A, Greenblatt D, Nardo T, Stefanini M, McGibbon D, Sarkany R, Fassihi H, Mitsutake N, Lehmann AR, Ogi T.
    • Organizer
      The 9th 3R Symposium
    • Place of Presentation
      御殿場高原ホテル(静岡県御殿場市)
    • Year and Date
      2014-11-17 – 2014-11-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] ゲノム不安定性疾患群の新規責任遺伝子の同定と分子機能解析2014

    • Author(s)
      荻朋男
    • Organizer
      第57回日本甲状腺学会学術集会
    • Place of Presentation
      コングレコンベンションセンター(大阪府大阪市)
    • Year and Date
      2014-11-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ヒストンH3K9メチル化酵素類のDNA二重鎖切断修復反応への関与2014

    • Author(s)
      荻朋男
    • Organizer
      第87回日本生化学会大会 シンポジウム
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 転写共役ヌクレオチド除去修復の開始反応の分子機構2014

    • Author(s)
      荻朋男
    • Organizer
      日本放射線影響学会第57回大会 ワークショップ
    • Place of Presentation
      鹿児島県民交流センター(鹿児島県鹿児島市)
    • Year and Date
      2014-10-01 – 2014-10-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] DNA修復機構の異常により発症する先天性疾患とゲノム不安定性/発がん2014

    • Author(s)
      荻朋男
    • Organizer
      第20回日本家族性腫瘍学会学術集会 教育講演
    • Place of Presentation
      コラッセ福島(福島県福島市)
    • Year and Date
      2014-06-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Remarks] 長崎大学 がん・ゲノム不安定性研究拠点ホームページ

    • URL

      http://www.nrgic.prj.nagasaki-u.ac.jp/

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2022-02-28  

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