| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Outline of Final Research Achievements |
High-dimensional structure of chromatin has an important role for transcription regulation. Chromatin consists of the heterochromatin, which is localized close to the centromere and telomere, and the euchromatin. We found that ATF7 contributes to heterochromatin formation by recruiting histone H3K9 methyltransferases, and that the stress-induced phosphorylation of ATF7 by p38 causes the disruption of heterochromatin and transcriptional induction. This effect was maintained for long period. Thus, it was shown that ATF7 plays an important role for regulation of the high-dimensional structure of chromatin.
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