| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Outline of Final Research Achievements |
Diacylglycerol kinase (DGK) contains ten isozymes. We have recently found that DGK isozymes play pivotal roles in a wide variety of signal transduction pathways and are involved in pathogenesis of refractory diseases. Thus, we planned to find (1) novel pathways consist of DGK isozymes and to reveal their patho-physiological functions. We obtained interesting results concerning new metabolic pathways that are composed of DGKα, δ, η and ζ, and their patho-physiological functions (e.g., cancer, immunity, bipolar disorder, obsessive-compulsive disorder, and Parkinson’s disease).
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