Function and dynamics of stress-induced lncRNA

• Project/Area Number: 26291018
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Functional biochemistry
• Research Institution: The University of Tokyo
• Principal Investigator: Ohta Kunihiro 東京大学, 大学院総合文化研究科, 教授 (90211789)
• Co-Investigator(Kenkyū-buntansha): 坪井 貴司 東京大学, 大学院総合文化研究科, 教授 (80415231)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2014: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
• Keywords: クロマチン / lncRNA / ヒストン修飾 / アンチセンスRNA / ノンコーディングRNA / 転写制御 / グルコース / 膵臓 / β細胞 / ストレス応答 / 発現制御 / ゲノム / 遺伝子発現 / マイクロアレイ

Outline of Final Research Achievements

We analyzed the role and dynamics of glucose-starved stress responsive long noncoding RNA (lncRNA) and antisense RNA (asRNA). We found the reciprocal expression control between lncRNA and asRNA synthesized in pairs and the histone H3K4 methylation-dependent control of asRNA expression. We observed transportation of asRNA to the cytoplasm and degradation of asRNA by nonsense-mediated degradation system. We also demonstrated that gene regulation is locally controlled by interaction between nascent lncRNA and Tup-type transcriptional repressor. In addition, we identified some lncRNAs associated with the downstream gene activation in mouse pancreatic β-cells.

Research Products

• [Int'l Joint Research] Boston College(米国)
• [Journal Article] The histone variant H2A.Z promotes initiation of meiotic recombination in fission yeast. (2018)
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  • Journal Title: Nucleic Acids Res. Volume: 46 Issue: 2 Pages: 609-620
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  • Peer Reviewed / Open Access
• [Journal Article] Replication stress induces accumulation of FANCD2 at central region of large fragile genes. (2018)
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  • NAID: 120006488604
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• [Journal Article] Interplay between chromatin modulators and histone acetylation regulates the formation of accessible chromatin in the upstream regulatory region of fission yeast <i>fbp1</i> (2017)
  • Author(s): Akira Adachi、?Satoshi Senmatsu、?Ryuta Asada、?Takuya Abe、?Charles S. Hoffman、?Kunihiro Ohta、?Kouji Hirota
  • Journal Title: Genes & Genetic Systems Volume: 92 Issue: 6 Pages: 267-276
  • DOI: 10.1266/ggs.17-00018
  • NAID: 130006731266
  • ISSN: 1341-7568, 1880-5779
  • Year and Date: 2017-12-01
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Correlation of Meiotic DSB Formation and Transcription Initiation Around Fission Yeast Recombination Hotspots. (2017)
  • Author(s): . Yamada, M. Okamura, H. Murakami, K.Ohta, T. Yamada
  • Journal Title: Genetics Volume: in press Issue: 2 Pages: 801-809
  • DOI: 10.1534/genetics.116.197954
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Transcriptomes and Raman spectra are linked linearly through a shared low-dimensional subspace (2017)
  • Author(s): Kobayashi-Kirschvink, K. J., Nakaoka, H., Oda, A., Kamei, K. F., Nosho, K., Fukushima, H., Kanesaki, Y., Yajima, S., Masaki, H., Ohta, K., Wakamoto, Y.
  • Journal Title: bioRxiv Volume: NA Pages: 235580-235580
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  • Open Access
• [Journal Article] Multimerization is required for antigen binding activity of an engineered IgM/IgG chimeric antibody recognizing a skin-related antigen (2017)
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  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 8212-8212
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lysophosphatidylinositol-induced activation of the cation channel TRPV2 triggers glucagon-like peptide-1 secretion in enteroendocrine L cells (2017)
  • Author(s): Kazuki Harada、 Tetsuya Kitaguchi、 Taichi Kamiya、 Kyaw Htet Aung、 Kazuaki Nakamura、 Kunihiro Ohta and Takashi Tsuboi
  • Journal Title: J. Biol. Chem Volume: 292 Issue: 26 Pages: 10855-10864
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Recruitment and delivery of the fission yeast Rst2 transcription factor via a local genome structure counteracts repression by Tup1-family corepressors (2017)
  • Author(s): Ryuta Asada?Miki Umeda?Akira Adachi?Satoshi Senmatsu?Takuya Abe?Hiroshi IwasakiKunihiro Ohta?Charles S. Hoffman?Kouji Hirota
  • Journal Title: Nucleic Acids Research Volume: 45 Issue: 16 Pages: 9361-9371
  • DOI: 10.1093/nar/gkx555
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Histone H3 threonine 11 phosphorylation is catalyzed directly by the meiosis-specific kinase Mek1 and provides a molecular readout of Mek1 activity in vivo. (2017)
  • Author(s): Ryan Kniewel、 Hajime Murakami、 Yan Liu、 Masaru Ito、 Kunihiro Ohta、 Nancy M. Hollingsworth and Scott Keeney
  • Journal Title: Genetics Volume: 207 Issue: 4 Pages: 1313-1333
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Generation of a cGMP indicator with an expanded dynamic range by optimization of amino acid linkers between a fluorescent protein and PDE5α. (2017)
  • Author(s): Matsuda S, Harada K, Ito M, Takizawa M, Wongso D, Tsuboi T, Kitaguchi T
  • Journal Title: ACS Sensors Volume: 2 Issue: 1 Pages: 46-57
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  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Histone deacetylases control module-specific phenotypic plasticity in beetle weapons. (2016)
  • Author(s): Ozawa T., Mizuhara T., Arata M., Shimada M., Niimi T., Okada K., Okada Y., Ohta K.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 113 Issue: 52 Pages: 15042-15047
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• [Journal Article] B cell-based seamless engineering of antibody Fc domains. (2016)
  • Author(s): Hashimoto K., Kurosawa K., Murayama A., Seo H., Ohta K.
  • Journal Title: PLoS One Volume: 11 Issue: 12 Pages: e0167232-e0167232
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• [Journal Article] Role of non-coding RNA transcription around gene regulatory elements in transcription factor recruitment. (2016)
  • Author(s): Takemata N. and Ohta K.
  • Journal Title: RNA Biology Volume: 20 Issue: 1 Pages: 1-5
  • DOI: 10.1080/15476286.2016.1248020
  • Peer Reviewed / Open Access
• [Journal Article] Three-dimensional reconstruction of single-cell chromosome structure using recurrence plots (2016)
  • Author(s): Hirata Y, Oda A, Ohta K, Aihara K
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 34982-34982
  • DOI: 10.1038/srep34982
  • Peer Reviewed / Open Access
• [Journal Article] RNA decay systems enhance reciprocal switching of sense and antisense transcripts in response to glucose starvation (2016)
  • Author(s): A.Miki, J.Galipon, S.Sawai, T.Inada, and K.Ohta
  • Journal Title: Genes to Cells Volume: 21 Issue: 12 Pages: 1276-1289
  • DOI: 10.1111/gtc.12443
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] <i>Arabidopsis</i> AtRRP44 has ribonuclease activity that is required to complement the growth defect of yeast <i>rrp44</i> Mutant (2016)
  • Author(s): Kumakura, N., Otsuki, H., Ito, M. et al.
  • Journal Title: Plant Biotechnology Volume: 33 Issue: 2 Pages: 77-85
  • DOI: 10.5511/plantbiotechnology.16.0316a
  • NAID: 130005164800
  • ISSN: 1342-4580, 1347-6114
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Analysis of novel Sir3 binding regions in Saccharomyces cerevisiae. (2016)
  • Author(s): Mitsumori R., OhashI T., Kugou K., Ichino A., Taniguchi K., Ohta K., Uchida H., Oki M.
  • Journal Title: J. Biochem. Volume: 印刷中 Issue: 1 Pages: 11-17
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  • NAID: 40020880710
  • Peer Reviewed / Open Access
• [Journal Article] Wide and high resolution tension measurement using FRET in embryo. (2016)
  • Author(s): Satoshi Yamashita, Takashi Tsuboi, Nanako Ishinabe, Tetsuya Kitaguchi, Tatsuo Michiue
  • Journal Title: Scientific Reports Volume: 該当なし Issue: 1 Pages: 28535-28535
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• [Journal Article] Loss of function mutations in ATP2A2 and psychoses: A case report and literature survey (2016)
  • Author(s): Nakamura T, Kazuno A, Nakajima K, Kusumi I, Tsuboi T, Kato T.
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 70 Issue: 8 Pages: 342
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  • Peer Reviewed / Open Access
• [Journal Article] Gliotransmitter release from astrocytes: functional, developmental and pathological implications in the brain (2016)
  • Author(s): Kazuki Harada, Taichi Kamiya, Takashi Tsuboi
  • Journal Title: Frontiers in Neuroscience Volume: 9 Pages: 499-499
  • DOI: 10.3389/fnins.2015.00499
  • Open Access
• [Journal Article] Local potentiation of stress-responsive genes by upstream noncoding transcription. (2016)
  • Author(s): Takemata N, Oda A, Yamada T, Galipon J, Miyoshi T, Suzuki Y, Sugano S, Hoffman CS, Hirota K, Ohta K.
  • Journal Title: Nucleic Acids Res. Volume: 印刷中 Issue: 11 Pages: 5174-89
  • DOI: 10.1093/nar/gkw142
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing. (2016)
  • Author(s): Tashiro S, Handa T, Matsuda A, Ban T, Takigawa T, Miyasato K, Ishii K, Kugou K, Ohta K, Hiraoka Y, Masukata H, Kanoh J.
  • Journal Title: Nature Commun. Volume: 7 Issue: 1 Pages: 10393-10393
  • DOI: 10.1038/ncomms10393
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Glycerophospholipid regulation of modality-specific sensory axon guidance in the spinal cord. (2015)
  • Author(s): Guy AT, Nagatsuka Y, Ooashi N, Inoue M, Nakata A, Greimel P, Inoue A, Nabetani T, Murayama A, Ohta K, Ito Y, Aoki J, Hirabayashi Y, Kamiguchi H
  • Journal Title: Science Volume: 349 Issue: 6251 Pages: 974-977
  • DOI: 10.1126/science.aab3516
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Low glucose-induced ghrelin secretion is mediated by ATP-sensitive potassium channel. (2015)
  • Author(s): Manami Oya, Tetsuya Kitaguchi, Kazuki Harada, Rika Numano, Takahiro Sato, Masayasu Kojima and Takashi Tsuboi.
  • Journal Title: J Endocrinol Volume: 226 Issue: 1 Pages: 25-34
  • DOI: 10.1530/joe-15-0090
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Integrative function of adrenaline receptors for glucagon-like peptide-1 exocytosis in enteroendocrine L cell line GLUTag (2015)
  • Author(s): Kazuki Harada, Tetsuya Kitaguchi, Takashi Tsuboi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 印刷中 Issue: 4 Pages: 1053-1058
  • DOI: 10.1016/j.bbrc.2015.03.151
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Y-maze avoidance: an automated and rapid associative learning paradigm in zebrafish. (2015)
  • Author(s): Aoki R, Tsuboi T, Okamoto H.
  • Journal Title: Neurosci Res. Volume: 91 Pages: 69-72
  • DOI: 10.1016/j.neures.2014.10.012
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Dynamic transition of transcription and chromatin landscape during fission yeast adaptation to glucose starvation (2015)
  • Author(s): Oda A, Takemata N, Hirata Y, Miyoshi T, Suzuki Y, Sugano S, and Ohta K
  • Journal Title: Genes to Cells Volume: 5 Issue: 5 Pages: 392-407
  • DOI: 10.1111/gtc.12229
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Antagonistic controls of chromatin and mrna start site selection by Tup family corepressors and the CCAAT-binding factor. (2015)
  • Author(s): Asada R, Takemata N, Hoffman CS, Ohta K, Hirota K.
  • Journal Title: Mol Cell Biol. Volume: 35 Issue: 5 Pages: 847-855
  • DOI: 10.1128/mcb.00924-14
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 3D chromosome structure reconstruction from single-cell Hi-C data using recurrence plots (2018)
  • Author(s): Arisa Oda Yoshito Hirata Kunihiro Ohta & Kazuyuki Aihara
  • Organizer: 6th Annual Winter q-bio Meeting
  • Int'l Joint Research
• [Presentation] 分裂酵母における減数分裂期組換え開始制御機構 (2018)
  • Author(s): 仮屋園 遼
  • Organizer: 酵母研究若手の会
• [Presentation] グルタミン誘導性グルカゴン様ペプチド-1分泌機構の解析 (2017)
  • Author(s): 神谷泰智, 原田一貴, 坪井貴司
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: オークラアクトシティー浜松（静岡県浜松市）
  • Year and Date: 2017-03-30
• [Presentation] グルカゴン様ペプチド-1分泌小腸内分泌L細胞に対するS-エクオールの効果 (2017)
  • Author(s): 佐田尚子, 神谷泰智, 原田一貴，坪井貴司
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: オークラアクトシティー浜松（静岡県浜松市）
  • Year and Date: 2017-03-30
• [Presentation] アストロサイトからのグリア伝達物質放出メカニズムの可視化解析. (2017)
  • Author(s): 滝澤舞, 原田一貴, 坪井貴司
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: オークラアクトシティー浜松（静岡県浜松市）
  • Year and Date: 2017-03-29
• [Presentation] Reconstruction of single-cell chromosome 3D structure using recurrence plots (2017)
  • Author(s): Arisa Oda, Yoshito Hirata, Kunihiro Ohta, Kazuyuki Aihara
  • Organizer: The 5th Annual Winter q-bio Meeting
  • Place of Presentation: Grand Hyatt,Kauai（ハワイ、アメリカ）
  • Year and Date: 2017-02-21
  • Int'l Joint Research
• [Presentation] Dynamics of antisense RNAs from stress responsive loci (2017)
  • Author(s): Atsuko Miki
  • Organizer: The 5th Annual Winter q-bio Meeting
  • Place of Presentation: Grand Hyatt,Kauai（ハワイ、アメリカ）
  • Year and Date: 2017-02-21
  • Int'l Joint Research
• [Presentation] 1細胞 Hi-C データを用いた染色体三次元構造解析手法 (2017)
  • Author(s): 小田有沙、平田祥人、太田邦史、合原一幸
  • Organizer: 第34回染色体ワークショップ・第15回核ダイナミクス研究会
  • Place of Presentation: かずさアカデミアホール（千葉県木更津市）
  • Year and Date: 2017-01-11
• [Presentation] 制限酵素を用いた人為的ゲノム再編誘導 (2017)
  • Author(s): 小田有沙、中村隆宏、村本伸彦、田中秀典、 久郷和人、光川典宏、太田邦史
  • Organizer: 第35回染色体ワークショップ 第16回核ダイナミクス研究会
• [Presentation] Hi-Cのデータから染色体の立体構造を解く (2017)
  • Author(s): 小田 有沙、平田 祥人、太田 邦史、合原 一幸
  • Organizer: 2017年度生命科学系学会合同年次大会
  • Invited
• [Presentation] Transcriptional dynamics of sense and antisense long noncoding RNAs during glucose starvation (2017)
  • Author(s): Arisa Oda Tetsuhiro Hatakeyama Kunihiko Kaneko & Kunihiro Ohta
  • Organizer: The 9th International Fission Yeast Meeting
  • Int'l Joint Research
• [Presentation] B細胞由来培養細胞を利用した抗体分子進化基盤技術の開発 (2017)
  • Author(s): 橋本 講司、 黒澤 恒平、 村山 晃歩、 瀬尾 秀宗、 太田 邦史
  • Organizer: 第69 回日本生物工学会大会
• [Presentation] Decay regulation of antisense RNAs from stress responsive loci (2017)
  • Author(s): Atsuko Miki、 Josephine Galipon、 Satoshi Sawai、 Toshifumi Inada、 and Kunihiro Ohta
  • Organizer: 9th INTERNATIONAL FISSION YEAST MEETING
  • Int'l Joint Research
• [Presentation] 分裂酵母グルコース飢餓ストレス応答性アンチセンスRNAの発現制御 (2017)
  • Author(s): 三木 敦子、ジョゼフィーヌ・ガリポン、澤井哲、稲田利文、太田 邦史
  • Organizer: 第19回日本RNA学会年会
• [Presentation] Dynamic transcription regulation by sense and antisense lncRNAs in stress response (2017)
  • Author(s): Arisa Oda、 Tetsuhiro Hatakeyama、 Kunihiko Kaneko、Kunihiro Ohta
  • Organizer: THE 43rd NAITO CONFERENCE
  • Int'l Joint Research
• [Presentation] Stimuli-specific activation of chromosomal sites by non-coding RNA transcription (2017)
  • Author(s): Kunihiro Ohta、 Naomichi Takemata、 Arisa Oda、 Kengo Okazaki、 TakatomiYamada、ShintaroYamada
  • Organizer: THE 43rd NAITO CONFERENCE
  • Int'l Joint Research / Invited
• [Presentation] Stability control of antisense long non-coding RNAs from stress-responsive loci and their role in gene regulation (2017)
  • Author(s): Atsuko Miki、 Josephine Galipon、 Satoshi Sawai、Toshifumi Inada、 Kunihiro Ohta
  • Organizer: THE 43rd NAITO CONFERENCE
  • Int'l Joint Research
• [Presentation] Roles of conserved meiotic chromosomal protein Hop1 in DSB formation and axis-loop interaction in fission yeast (2017)
  • Author(s): Ryo Kariyazozno、 A.Oda、 T.Sakuno、 Yoshinori Watanabe、 Kunihiro Ohta
  • Organizer: EMBO Conference Meiosis
  • Int'l Joint Research
• [Presentation] 分裂酵母グルコース飢餓におけるfbp1+ アンチセンスRNAの発現制御 (2017)
  • Author(s): 三木 敦子
  • Organizer: ConBio2017
• [Presentation] マウス膵β細胞株MIN6の飢餓ストレスに対するlncRNAを介した遺伝子発現制御機構の探索 (2017)
  • Author(s): 土屋 一郎
  • Organizer: ConBio2017
• [Presentation] 免疫系培養細胞を利用した抗体の分子進化工学 (2017)
  • Author(s): 橋本 講司
  • Organizer: ConBio2017
• [Presentation] 新規抗体作製技術ADLibシステムにおける抗体遺伝子多様化の解析 (2017)
  • Author(s): 村山 晃歩
  • Organizer: ConBio2017
• [Presentation] 抗体遺伝子多様化におけるDNA脱メチル化酵素の機能解析 (2017)
  • Author(s): 高村 夏生
  • Organizer: ConBio2017
• [Presentation] 染色体弛緩による相同組換え活性化を利用した新規抗体作製技術ADLibシステム (2017)
  • Author(s): 瀬尾 秀宗
  • Organizer: ConBio2017
  • Invited
• [Presentation] グルコース飢餓への細胞応答とクロマチン構造 (2017)
  • Author(s): 太田 邦史
  • Organizer: ConBio2017
  • Invited
• [Presentation] 減数分裂期組換えホットスポットのシグネイチャーと軸-ループ染色体高次構造 (2017)
  • Author(s): 仮屋園 遼
  • Organizer: ConBio2017
  • Invited
• [Presentation] Hi-Cのデータから染色体の立体構造を解く (2017)
  • Author(s): 小田 有沙
  • Organizer: ConBio2017
  • Invited
• [Presentation] グルタミン酸によるインクレチン分泌制御機構の解析 (2016)
  • Author(s): 阪口秀和, 原田一貴, 坪井貴司
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-12-01
• [Presentation] アストロサイトからのペプチドホルモン放出メカニズムの可視化解析 (2016)
  • Author(s): 滝澤舞, 原田一貴, 坪井貴司
  • Organizer: 第39回日本分子生物学会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-12-01
• [Presentation] リゾリン脂質によるグルカゴン様ペプチド-1分泌制御機構 (2016)
  • Author(s): 原田一貴, 北口哲也, 神谷泰智, 太田邦史, 坪井貴司
  • Organizer: 第39回日本分子生物学会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-12-01
• [Presentation] グルタミン依存性グルカゴン様ペプチド-1分泌機構の解析 (2016)
  • Author(s): 神谷泰智, 原田一貴, 坪井貴司
  • Organizer: 第39回日本分子生物学会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-12-01
• [Presentation] 腸内細菌代謝産物によるインクレチン分泌制御機構の解析 (2016)
  • Author(s): 佐田尚子, 原田一貴, 神谷泰智, 坪井貴司
  • Organizer: 第39回日本分子生物学会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-12-01
• [Presentation] 1細胞 Hi-Cによる染色体三次元構造解析手法 (2016)
  • Author(s): 小田有沙、平田祥人、太田邦史、合原一幸
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-11-30
• [Presentation] lncRNAによるストレス種特異的な遺伝子発現の制御 (2016)
  • Author(s): 岡﨑賢吾、竹俣直道、小田有沙、山田貴富、Josephine Galipon、三好知一郎、鈴木穣、菅野純夫、Charles S Hoffman、廣田耕志、太田邦史
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-11-30
• [Presentation] マウス膵β細胞株MIN6における飢餓ストレスに対するlncRNAを介した遺伝子発現制御の探索 (2016)
  • Author(s): 土屋一郎、石井智子、吉田（大澤）奈摘、太田邦史
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-11-30
• [Presentation] ストレス応答性MAPキナーゼによる分裂酵母ヘテロクロマチンの制御 (2016)
  • Author(s): 竹俣直道、太田邦史
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-11-30
• [Presentation] Induced guidance of transcription factors to their target sites by non-coding RNA transcription (2016)
  • Author(s): Kunihiro Ohta, Naomichi Takemata, Arisa Oda
  • Organizer: The 10th 3R Symposium
  • Place of Presentation: ホテル一畑（島根県松江市）
  • Year and Date: 2016-11-13
  • Int'l Joint Research / Invited
• [Presentation] Stress-activated MAP kinase promotes heterochromatin assembly in fission yeast (2016)
  • Author(s): Naomichi Takemata
  • Organizer: The 10th 3R Symposium
  • Place of Presentation: ホテル一畑（島根県松江市）
  • Year and Date: 2016-11-13
  • Int'l Joint Research
• [Presentation] Are TET family proteins involved in DNA rearrangements at immunoglobulin locus? (2016)
  • Author(s): Natsuki Takamura, Sakiko Kondo, Kohei Kurosawa, Koji Hashimoto,Hidetaka Seo, Kunihiro Ohta
  • Organizer: The 10th 3R Symposium
  • Place of Presentation: ホテル一畑（島根県松江市）
  • Year and Date: 2016-11-13
  • Int'l Joint Research
• [Presentation] Distinct regulation of ribosome-bound long non-coding RNAs transcribed from stress responsive genes (2016)
  • Author(s): Atsuko Miki , Josephine Galipon , Satoshi Sawai , Toshihumi Inada , Kunihiro Ohta
  • Organizer: RNA2016
  • Place of Presentation: 京都国際会館(京都府京都市）
  • Year and Date: 2016-06-28
  • Int'l Joint Research
• [Presentation] そっくりな親子と似ていない親子、その分かれ目は ～人類の成長と繁栄はその多様性のなかにある～ (2016)
  • Author(s): 太田邦史
  • Organizer: 公益社団法人日本包装技術協会中部支部第５３回定時総会、記念講演会
  • Place of Presentation: ホテルキャッスルプラザ（愛知県名古屋市）
  • Year and Date: 2016-06-10
  • Invited
• [Presentation] Promoter-associated noncoding RNAs reorganize genomic distribution of the ATF/CREB transcription factor Atf1 (2016)
  • Author(s): 竹俣直道ら
  • Organizer: Keystone Symposia Conference"Chromatin and Epigenetics"
  • Place of Presentation: Whistler Conference Centre（バンクーバー、カナダ）
  • Year and Date: 2016-03-20
  • Int'l Joint Research
• [Presentation] Transcriptional dynamics of long noncoding RNAs in glucose starvation stress response (2016)
  • Author(s): 小田有沙ら
  • Organizer: The Fourth Annual Winter q-Bio Meeting
  • Place of Presentation: シェラトンワイキキ（ハワイ、アメリカ）
  • Year and Date: 2016-02-15
  • Int'l Joint Research
• [Presentation] 分裂酵母の飢餓ストレス応答性IncRNA (2016)
  • Author(s): 小田有沙ら
  • Organizer: 第３３回染色体ワークショップ・第１４回核ダイナミクス研究会
  • Place of Presentation: 松島一の坊（宮城県宮城郡松島町）
  • Year and Date: 2016-01-12
• [Presentation] 長鎖非コードＲＮＡはストレスに応答して転写因子の結合をゲノムワイドに制御する (2016)
  • Author(s): 竹俣直道ら
  • Organizer: 第３３回染色体ワークショップ・第１４回核ダイナミクス研究会
  • Place of Presentation: 松島一の坊（宮城県宮城郡松島町）
  • Year and Date: 2016-01-12
• [Presentation] 分裂酵母グルコース飢餓における fbp1+センスアンチセンス lncRNA の分解制御 (2015)
  • Author(s): 三木敦子ら
  • Organizer: BMB2015
  • Place of Presentation: 神戸ポートアイランド（兵庫県神戸市）
  • Year and Date: 2015-12-01
• [Presentation] グルコース飢餓ストレス時のセンス・アンチセンス長鎖非コードＲＮＡを介した遺伝子発現制御 (2015)
  • Author(s): 小田有沙ら
  • Organizer: BMB2015
  • Place of Presentation: 神戸ポートアイランド（兵庫県神戸市）
  • Year and Date: 2015-12-01
  • Invited
• [Presentation] グルコース飢餓ストレス時の長鎖非コードＲＮＡを介した分裂酵母のの遺伝子発現制御 (2015)
  • Author(s): 小田有沙ら
  • Organizer: 第２７回高遠・分子細胞生物学シンポジウム
  • Place of Presentation: 延暦寺会館（滋賀県大津市）
  • Year and Date: 2015-08-26
• [Presentation] Transcriptional dynamics of sense and antisense long noncodings RNAs in stress response (2015)
  • Author(s): 小田有沙
  • Organizer: QBiC Symposium2015
  • Place of Presentation: 理化学研究所生命システム研究センター（大阪府吹田市）
  • Year and Date: 2015-08-24
  • Int'l Joint Research
• [Presentation] 分裂酵母グルコース飢餓における fbp1+センスアンチセンス lncRNA の分解制御 (2015)
  • Author(s): 三木敦子ら
  • Organizer: 第17回ＲＮＡ学会年会
  • Place of Presentation: ホテルライフォート札幌（北海道札幌市）
  • Year and Date: 2015-07-15
• [Presentation] グルコース濃度変動ストレス応答時のセンス・アンチセンス長鎖非コード依存的な遺伝子発現制御 (2015)
  • Author(s): 小田有沙ら
  • Organizer: 第17回ＲＮＡ学会年会
  • Place of Presentation: ホテルライフォート札幌（北海道札幌市）
  • Year and Date: 2015-07-15
• [Presentation] グルコース飢餓ストレス応答性のセンス・アンチセンス非コード RNA 依存 的な遺伝子発現制御機構 (2015)
  • Author(s): 石井智子ら
  • Organizer: 第17回ＲＮＡ学会年会
  • Place of Presentation: ホテルライフォート札幌（北海道札幌市）
  • Year and Date: 2015-07-15
• [Presentation] 分裂酵母のストレス応答性IncRNAの発現解析 (2015)
  • Author(s): 小田有沙ら
  • Organizer: 第４回ＮＧＳ現場の会
  • Place of Presentation: つくば国際会議場（茨城県つくば市）
  • Year and Date: 2015-07-01
• [Presentation] Transcriptial dynamics of sense and antisense long noncoding RNAs in stress response (2015)
  • Author(s): 小田有沙ら
  • Organizer: Pombe2015
  • Place of Presentation: 生田神社会館（兵庫県神戸市）
  • Year and Date: 2015-06-21
  • Int'l Joint Research / Invited
• [Presentation] Distinct decay dynamics of ribosome-bound lncRNA and mRNAs (2015)
  • Author(s): 三木敦子ら
  • Organizer: Pombe2015
  • Place of Presentation: 生田神社会館（兵庫県神戸市）
  • Year and Date: 2015-06-21
  • Int'l Joint Research
• [Presentation] Long noncoding RNAs stimulate promoter binding of the transcription factor Atf1 by antagonizing the Grougho/Tup1-like corepressors Tup11 and Tup12 (2015)
  • Author(s): 竹俣直道ら
  • Organizer: Pombe2015
  • Place of Presentation: 生田神社会館（兵庫県神戸市）
  • Year and Date: 2015-06-21
  • Int'l Joint Research
• [Presentation] Transcriptional dynamics of sntisense long noncoding RNAs in stress response (2015)
  • Author(s): Oda A et al.
  • Organizer: THIRD ANNUAL WINTER Q-BIO MEETING
  • Place of Presentation: ハワイ（アメリカ）、The Westin Maui Resort & Spa
  • Year and Date: 2015-02-16 – 2015-02-20
• [Presentation] Glucose starvation-dependent transcriptional switching by sense and antisense lncRNAs in fission yeast (2015)
  • Author(s): Oda A et al.
  • Organizer: International Symposium on Genome Science 2015
  • Place of Presentation: 東京、一橋講堂
  • Year and Date: 2015-01-20 – 2015-01-21
• [Presentation] 分裂酵母fbp1におけるクロマチン構造・ゲノム高次構造変化による遺伝子発現制御機構の解明 (2014)
  • Author(s): 浅田 隆大, 竹俣 直道, Charles Hoffmann, 太田 邦史, 廣田 耕志
  • Organizer: 第32回染色体ワークショップ・第13回核ダイナミクス研究会
  • Place of Presentation: 広島県、安芸グランドホテル
  • Year and Date: 2014-12-15 – 2015-12-17
• [Presentation] 長鎖ノンコーディング RNA は転写因子の呼び込みをポジティブフィードバック的に促進する (2014)
  • Author(s): 竹俣 直道, 廣田 耕志, 山田 貴富, 小田 有沙 , Josephine Galipon, 三好 知一郎, Charles Hoffman, 太田 邦史
  • Organizer: 第32回染色体ワークショップ・第13回核ダイナミクス研究会
  • Place of Presentation: 広島県、安芸グランドホテル
  • Year and Date: 2014-12-15 – 2014-12-17
• [Presentation] 分裂酵母グルコース飢餓におけるfbp1+センス・アンチセンスlncRNAの制御 (2014)
  • Author(s): 三木敦子,Josephine Galipom,小田有沙, 太田邦史
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 神奈川県、パシフィコ横浜
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] センス及びアンチセンスlong noncoding RNAによる遺伝子発現の切り替え制御」 (2014)
  • Author(s): 小田有沙、竹俣直道、石井智子、Galipon Josehine、三好知一郎、鈴木穣、菅野純夫、Hoffman Charles、太田邦史
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 神奈川県、パシフィコ横浜
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] Promoter-associated lncRNA recruits transcriptional activator through a positive feedback mechanism (2014)
  • Author(s): 竹俣直道ら
  • Organizer: The 9th 3R Symposium
  • Place of Presentation: 静岡県、御殿場高原リゾート「時之栖」
  • Year and Date: 2014-11-17 – 2014-11-21
• [Presentation] Balanced regulation of sense and antisense lncRNA transcripts in fission yeast glucose starvation (2014)
  • Author(s): Atsuko Miki, Josephine Galipon, Arisa Oda, Kunihiro Ohta
  • Organizer: 2014 CSHL Conference on Regulatory & Non-Coding RNAs
  • Place of Presentation: アメリカ、Cold Spring Harbor
  • Year and Date: 2014-08-26 – 2014-08-30
• [Presentation] Epigenetics and dynamics of non-coding genome (2014)
  • Author(s): 太田邦史
  • Organizer: 高等研カンファレンス2014「Chromatin Decoding」
  • Place of Presentation: 京都府、公益財団法人国際高等研究所
  • Year and Date: 2014-05-12 – 2014-05-15
• [Presentation] LncRNA transcription enhances interaction of transcriptional activator with chromatin through a positive feedback mechanism (2014)
  • Author(s): 竹俣直道ら
  • Organizer: 高等研カンファレンス2014「Chromatin Decoding」
  • Place of Presentation: 京都府、公益財団法人国際高等研究所
  • Year and Date: 2014-05-12 – 2014-05-15
• [Book] 生命デザイン学入門 (2016)
  • Author(s): 小川（西秋）葉子、太田邦史
  • Total Pages: 224
  • Publisher: 岩波ジュニア新書
• [Remarks] 太田研ホームページ
  • URL: http://www.ohta-lab.c.u-tokyo.ac.jp/index.html
• [Patent(Industrial Property Rights)] 空間的な近さの概念を用いた生体分子データの３次元構造の再構成方法 (2016)
  • Inventor(s): 平田祥人ら
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-023214
  • Filing Date: 2016-02-10