| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Outline of Final Research Achievements |
In this study, we tried to clarify voltage-sensing mechanism of the voltage-gated channels which generate and regulate bioelectronic signals as represented by the heartbeat and brain functions. We focused on the voltage-gated H+ channel consisting of a minimum voltage-sensor unit, and analyzed the voltage-sensor movement by membrane voltage and the structural rearrangement toward the channel opening. We demonstrated the molecular basis of the voltage-sensing mechanism.
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